ATE362364T1 - Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten - Google Patents
Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonistenInfo
- Publication number
- ATE362364T1 ATE362364T1 AT03710114T AT03710114T ATE362364T1 AT E362364 T1 ATE362364 T1 AT E362364T1 AT 03710114 T AT03710114 T AT 03710114T AT 03710114 T AT03710114 T AT 03710114T AT E362364 T1 ATE362364 T1 AT E362364T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- substituted azabicyclo
- compounds
- muscarine receptor
- hexane derivatives
- Prior art date
Links
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 title abstract 3
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
- 210000005095 gastrointestinal system Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2003/001333 WO2004089363A1 (en) | 2003-04-10 | 2003-04-10 | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE362364T1 true ATE362364T1 (de) | 2007-06-15 |
Family
ID=33156168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03710114T ATE362364T1 (de) | 2003-04-10 | 2003-04-10 | Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7592359B2 (de) |
| EP (1) | EP1615634B1 (de) |
| JP (1) | JP2006514978A (de) |
| CN (1) | CN100406009C (de) |
| AT (1) | ATE362364T1 (de) |
| AU (1) | AU2003214535B2 (de) |
| BR (1) | BR0318242A (de) |
| CA (1) | CA2521788A1 (de) |
| DE (1) | DE60313898T2 (de) |
| EA (1) | EA009059B1 (de) |
| WO (1) | WO2004089363A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ537584A (en) | 2002-07-08 | 2006-07-28 | Ranbaxy Lab Ltd | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| WO2004089898A1 (en) | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| BRPI0409302A (pt) | 2003-04-11 | 2006-04-11 | Ranbaxy Lab Ltd | derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos |
| WO2006054162A1 (en) * | 2004-11-19 | 2006-05-26 | Ranbaxy Laboratories Limited | Azabicyclic muscarinic receptor antagonists |
| US20080255188A1 (en) * | 2005-07-11 | 2008-10-16 | Naresh Kumar | Muscarinic Receptor Antagonists |
| WO2007039884A1 (en) | 2005-10-05 | 2007-04-12 | Ranbaxy Laboratories Limited | 3 -azabicyclooctane derivatives as muscarinic receptor antagonists |
| US20100222393A1 (en) * | 2005-12-30 | 2010-09-02 | Naresh Kumar | Muscarinic receptor antagonists |
| WO2007110782A1 (en) | 2005-12-30 | 2007-10-04 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| WO2008029349A2 (en) * | 2006-09-04 | 2008-03-13 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| US20090326004A1 (en) | 2008-06-03 | 2009-12-31 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| US9012489B2 (en) * | 2011-08-03 | 2015-04-21 | Boehringer Ingelheim International Gmbh | Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament |
| EP4196118A1 (de) | 2020-08-13 | 2023-06-21 | Boehringer Ingelheim International GmbH | Behandlung der kognitiven beeinträchtigung im zusammenhang mit schizophrenie |
| CN117567449A (zh) | 2020-10-13 | 2024-02-20 | 勃林格殷格翰国际有限公司 | 再加工方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL267508A (de) | 1960-07-26 | |||
| SE8800207D0 (sv) | 1988-01-22 | 1988-01-22 | Kabivitrum Ab | Nya aminer, deras anvendning och framstellning |
| GB8906166D0 (en) | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| RU2049777C1 (ru) | 1989-08-16 | 1995-12-10 | Пфайзер Инк. | Азабицикло-хинолон-карбоновые кислоты или их фармацевтически приемлемые кислотно-аддитивные соли и промежуточные продукты для их получения |
| US5281601A (en) | 1989-12-12 | 1994-01-25 | Pfizer Inc. | Muscarinic receptor antagonists |
| GB8928042D0 (en) | 1989-12-12 | 1990-02-14 | Pfizer Ltd | Muscarinic receptor antagonists |
| GB9202443D0 (en) | 1992-02-05 | 1992-03-18 | Fujisawa Pharmaceutical Co | A novel substituted-acetamide compound and a process for the preparation thereof |
| FI100051B (fi) | 1992-02-18 | 1997-09-15 | Favorit Oy | Kompostori |
| JP3429338B2 (ja) | 1992-07-27 | 2003-07-22 | 杏林製薬株式会社 | 新規なアリールグリシンアミド誘導体及びその製造法 |
| JPH06135958A (ja) | 1992-10-28 | 1994-05-17 | Tanabe Seiyaku Co Ltd | ベンゾシクロヘプテン誘導体及びその製法 |
| NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| EP0823423B1 (de) | 1995-04-28 | 2004-06-16 | Banyu Pharmaceutical Co., Ltd. | 1,4-disubstituierte piperidinderivate |
| CA2179574A1 (en) | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
| DE69615214T2 (de) | 1995-10-13 | 2002-06-27 | Banyu Pharmaceutical Co., Ltd. | Substituierte heteroaromatische derivate |
| WO1997045414A1 (en) | 1996-05-31 | 1997-12-04 | Banyu Pharmaceutical Co., Ltd. | 1,4-disubstituted piperidine derivatives |
| PE92198A1 (es) | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
| EP0937041B1 (de) * | 1996-11-11 | 2003-04-23 | Christian R. Noe | Verwendung eines pharmazeutisch geeigneten Salzes von (3R,2'R)-3-[(Cyclopentyl-hydroxyphenylacetyl)oxy]-1,1-dimethyl-pyrrolidinium zur Herstellung eines Arzneimittels |
| KR20000057548A (ko) | 1996-12-13 | 2000-09-25 | 알프레드 엘. 미첼슨 | 광학적 전송물질 및 결합재 |
| US7232835B2 (en) * | 2002-12-10 | 2007-06-19 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists |
-
2003
- 2003-04-10 CA CA002521788A patent/CA2521788A1/en not_active Abandoned
- 2003-04-10 EA EA200501594A patent/EA009059B1/ru not_active IP Right Cessation
- 2003-04-10 CN CNB038265370A patent/CN100406009C/zh not_active Expired - Fee Related
- 2003-04-10 DE DE60313898T patent/DE60313898T2/de not_active Expired - Fee Related
- 2003-04-10 AT AT03710114T patent/ATE362364T1/de not_active IP Right Cessation
- 2003-04-10 JP JP2004570503A patent/JP2006514978A/ja active Pending
- 2003-04-10 EP EP03710114A patent/EP1615634B1/de not_active Expired - Lifetime
- 2003-04-10 AU AU2003214535A patent/AU2003214535B2/en not_active Ceased
- 2003-04-10 BR BRPI0318242-8A patent/BR0318242A/pt not_active IP Right Cessation
- 2003-04-10 US US10/552,617 patent/US7592359B2/en not_active Expired - Fee Related
- 2003-04-10 WO PCT/IB2003/001333 patent/WO2004089363A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US7592359B2 (en) | 2009-09-22 |
| DE60313898D1 (de) | 2007-06-28 |
| EA009059B1 (ru) | 2007-10-26 |
| CA2521788A1 (en) | 2004-10-21 |
| CN1794984A (zh) | 2006-06-28 |
| EA200501594A1 (ru) | 2006-08-25 |
| EP1615634B1 (de) | 2007-05-16 |
| WO2004089363A1 (en) | 2004-10-21 |
| BR0318242A (pt) | 2006-04-04 |
| AU2003214535A1 (en) | 2004-11-01 |
| US20070287732A1 (en) | 2007-12-13 |
| CN100406009C (zh) | 2008-07-30 |
| AU2003214535B2 (en) | 2009-09-03 |
| AU2003214535A8 (en) | 2004-11-01 |
| JP2006514978A (ja) | 2006-05-18 |
| EP1615634A1 (de) | 2006-01-18 |
| DE60313898T2 (de) | 2008-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |