ATE362364T1 - Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten - Google Patents

Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten

Info

Publication number: ATE362364T1
Authority: AT; Austria
Prior art keywords: receptor antagonists; substituted azabicyclo; compounds; muscarine receptor; hexane derivatives
Prior art date: 2003-04-10

Application number

AT03710114T

Other languages

English (en)

Inventor

Anita Mehta

Arundutt Viswanatham Silamkoti

Jang Bahadur Gupta

Original Assignee

Ranbaxy Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-10

Filing date

2003-04-10

Publication date

2007-06-15

2003-04-10 Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd

2007-06-15 Application granted granted Critical

2007-06-15 Publication of ATE362364T1 publication Critical patent/ATE362364T1/de

Links

VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 title abstract 3
UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 2
108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
230000001404 mediated effect Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
210000005095 gastrointestinal system Anatomy 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000241 respiratory effect Effects 0.000 abstract 1
230000002485 urinary effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT03710114T 2003-04-10 2003-04-10 Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten ATE362364T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IB2003/001333 WO2004089363A1 (en)	2003-04-10	2003-04-10	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE362364T1 true ATE362364T1 (de)	2007-06-15

Family

ID=33156168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03710114T ATE362364T1 (de)	2003-04-10	2003-04-10	Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten

Country Status (11)

Country	Link
US (1)	US7592359B2 (de)
EP (1)	EP1615634B1 (de)
JP (1)	JP2006514978A (de)
CN (1)	CN100406009C (de)
AT (1)	ATE362364T1 (de)
AU (1)	AU2003214535B2 (de)
BR (1)	BR0318242A (de)
CA (1)	CA2521788A1 (de)
DE (1)	DE60313898T2 (de)
EA (1)	EA009059B1 (de)
WO (1)	WO2004089363A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60230683D1 (de)	2002-07-08	2009-02-12	Ranbaxy Lab Ltd	3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat
US7517905B2 (en)	2003-04-09	2009-04-14	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
CA2522071A1 (en)	2003-04-11	2004-10-21	Ranbaxy Laboratories Limited	Azabicyclo derivatives as muscarinic receptor antagonists
EP1828174A1 (de) *	2004-11-19	2007-09-05	Ranbaxy Laboratories Limited	Azabicyclische antagonisten des muskarinrezeptors
US20080255188A1 (en) *	2005-07-11	2008-10-16	Naresh Kumar	Muscarinic Receptor Antagonists
EP1934184A1 (de)	2005-10-05	2008-06-25	Ranbaxy Laboratories, Ltd.	3 -azabicyclooctanderivate als antagonisten des muscarinrezeptors
KR20080089461A (ko)	2005-12-30	2008-10-06	랜박시 래보러터리스 리미티드	무스카린 수용체 길항제
WO2007110782A1 (en)	2005-12-30	2007-10-04	Ranbaxy Laboratories Limited	Muscarinic receptor antagonists
WO2008029349A2 (en) *	2006-09-04	2008-03-13	Ranbaxy Laboratories Limited	Muscarinic receptor antagonists
US20090326004A1 (en)	2008-06-03	2009-12-31	Ranbaxy Laboratories Limited	Muscarinic receptor antagonists
US9012489B2 (en) *	2011-08-03	2015-04-21	Boehringer Ingelheim International Gmbh	Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
BR112022026698A2 (pt)	2020-08-13	2023-02-23	Boehringer Ingelheim Int	Tratamento da deficiência cognitiva associada à esquizofrenia
CA3195702A1 (en)	2020-10-13	2022-04-21	Boehringer Ingelheim International Gmbh	Process of reworking

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL267508A (de)	1960-07-26
SE8800207D0 (sv)	1988-01-22	1988-01-22	Kabivitrum Ab	Nya aminer, deras anvendning och framstellning
GB8906166D0 (en)	1989-03-17	1989-05-04	Pfizer Ltd	Therapeutic agents
PL166381B1 (pl)	1989-08-16	1995-05-31	Pfizer	Sposób wytwarzania nowych podstawionych kwasów 7-azabicyklochinolonokarboksylowych PL PL PL PL
US5281601A (en)	1989-12-12	1994-01-25	Pfizer Inc.	Muscarinic receptor antagonists
GB8928042D0 (en)	1989-12-12	1990-02-14	Pfizer Ltd	Muscarinic receptor antagonists
GB9202443D0 (en)	1992-02-05	1992-03-18	Fujisawa Pharmaceutical Co	A novel substituted-acetamide compound and a process for the preparation thereof
FI100051B (fi)	1992-02-18	1997-09-15	Favorit Oy	Kompostori
JP3429338B2 (ja)	1992-07-27	2003-07-22	杏林製薬株式会社	新規なアリールグリシンアミド誘導体及びその製造法
JPH06135958A (ja)	1992-10-28	1994-05-17	Tanabe Seiyaku Co Ltd	ベンゾシクロヘプテン誘導体及びその製法
NO2005012I1 (no)	1994-12-28	2005-06-06	Debio Rech Pharma Sa	Triptorelin og farmasoytisk akseptable salter derav
AU700837B2 (en)	1995-04-28	1999-01-14	Banyu Pharmaceutical Co., Ltd.	1,4-di-substituted piperidine derivatives
CA2179574A1 (en)	1995-06-26	1996-12-27	Tomomi Okada	Substituted piperidine derivative and medicine comprising the same
ATE205490T1 (de) *	1995-10-13	2001-09-15	Banyu Pharma Co Ltd	Substituierte heteroaromatische derivate
AU2793197A (en)	1996-05-31	1998-01-05	Banyu Pharmaceutical Co., Ltd.	1,4-disubstituted piperidine derivatives
PE92198A1 (es)	1996-08-01	1999-01-09	Banyu Pharma Co Ltd	Derivados de 1,4-piperidina disustituida que contienen fluor
DK0937041T3 (da)	1996-11-11	2003-08-11	Christian R Noe	Anvendelse af et farmaceutisk egnet salt af (3R,2'R)-3-[(cyclopentil-hydroxyphenylacetyl)oxyl]-1,1-dimethyl-pyrrolidinium til fremstilling af et lægemiddel
KR20000057548A (ko)	1996-12-13	2000-09-25	알프레드 엘. 미첼슨	광학적 전송물질 및 결합재
DE60227576D1 (de) *	2002-12-10	2008-08-21	Ranbaxy Lab Ltd	3,6-DISUBSTITUIERTE AZABICYCLO i3.1.0 -HEXANDERIVATIVE ALS ANTAGONISTEN DES MUSCARINREZEPTORS

2003
- 2003-04-10 JP JP2004570503A patent/JP2006514978A/ja active Pending
- 2003-04-10 CA CA002521788A patent/CA2521788A1/en not_active Abandoned
- 2003-04-10 EA EA200501594A patent/EA009059B1/ru not_active IP Right Cessation
- 2003-04-10 US US10/552,617 patent/US7592359B2/en not_active Expired - Fee Related
- 2003-04-10 WO PCT/IB2003/001333 patent/WO2004089363A1/en not_active Ceased
- 2003-04-10 AT AT03710114T patent/ATE362364T1/de not_active IP Right Cessation
- 2003-04-10 EP EP03710114A patent/EP1615634B1/de not_active Expired - Lifetime
- 2003-04-10 BR BRPI0318242-8A patent/BR0318242A/pt not_active IP Right Cessation
- 2003-04-10 CN CNB038265370A patent/CN100406009C/zh not_active Expired - Fee Related
- 2003-04-10 DE DE60313898T patent/DE60313898T2/de not_active Expired - Fee Related
- 2003-04-10 AU AU2003214535A patent/AU2003214535B2/en not_active Ceased

Also Published As

Publication number	Publication date
DE60313898D1 (de)	2007-06-28
AU2003214535B2 (en)	2009-09-03
AU2003214535A8 (en)	2004-11-01
CA2521788A1 (en)	2004-10-21
US7592359B2 (en)	2009-09-22
US20070287732A1 (en)	2007-12-13
BR0318242A (pt)	2006-04-04
JP2006514978A (ja)	2006-05-18
EA200501594A1 (ru)	2006-08-25
CN1794984A (zh)	2006-06-28
EP1615634B1 (de)	2007-05-16
AU2003214535A1 (en)	2004-11-01
CN100406009C (zh)	2008-07-30
EP1615634A1 (de)	2006-01-18
DE60313898T2 (de)	2008-01-17
EA009059B1 (ru)	2007-10-26
WO2004089363A1 (en)	2004-10-21

Legal Events

Date	Code	Title	Description
2007-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60231341D1 (de)	2009-04-09	Fluor- und sulfonylaminohaltige, 3,6-disubstituierptorantagonisten
DE60309057D1 (de)	2006-11-23	Azabicycloderivate als antagonisten des muscarinischen rezeptors
DE602005020655D1 (de)	2010-05-27	Carboxamid-spirolactam-cgrp-rezeptor-antagonisten
IL182317A0 (en)	2007-07-24	Cgrp receptor antagonists
TW200505903A (en)	2005-02-16	CGRP receptor antagonists
ATE396969T1 (de)	2008-06-15	3,6-disubstituierte azabicyclo (3.1.0)hexanderivate, die sich als muscarinrezeptorantagonisten eignen
WO2004091514A3 (en)	2005-09-15	Cgrp receptor antagonists
WO2005072308A3 (en)	2007-03-22	Cgrp receptor antagonists
ATE362364T1 (de)	2007-06-15	Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
EP1804919A4 (de)	2009-11-25	Cgrp-rezeptorantagonisten
DE60227576D1 (de)	2008-08-21	3,6-DISUBSTITUIERTE AZABICYCLO i3.1.0 -HEXANDERIVATIVE ALS ANTAGONISTEN DES MUSCARINREZEPTORS
TW200621244A (en)	2006-07-01	Modulators of muscarinic receptors
EA200501593A1 (ru)	2006-06-30	Азабициклические производные в качестве антагонистов мускаринового рецептора
WO2006041830A3 (en)	2006-06-01	Cgrp receptor antagonists
ATE386738T1 (de)	2008-03-15	Flavaxat-derivate als muscarin-rezeptor antagonisten
WO2004067510A8 (en)	2005-03-24	3,6-disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2006035282A3 (en)	2006-05-18	Muscarinic receptor antagonists
WO2006044449A3 (en)	2006-11-23	Cgrp receptor antagonists
HK1079708A1 (zh)	2006-04-13	可用作毒蕈碱性受体拮抗剂的3，6-二取代氮杂二环[3．1．10]己烷衍生物
WO2006054162A8 (en)	2006-07-20	Azabicyclic muscarinic receptor antagonists
MX2007006382A (es)	2007-07-11	Moduladores de receptores muscarinicos.
WO2006018708A3 (en)	2006-04-20	Pyrrolidine derivatives as muscarinic receptor antagonists
ATE419246T1 (de)	2009-01-15	Als antagonisten des muscarinrezeptors geeignete xanthinderivate
EA200801591A1 (ru)	2008-12-30	Антагонисты мускаринового рецептора
WO2006032994A3 (en)	2006-05-04	Muscarinic receptor antagonists