ATE362367T1 - Phenoxyessigsäure-derivate als peroxisom- proliferator-aktivierte rezeptor (ppar) dual- agonisten - Google Patents
Phenoxyessigsäure-derivate als peroxisom- proliferator-aktivierte rezeptor (ppar) dual- agonistenInfo
- Publication number
- ATE362367T1 ATE362367T1 AT04796767T AT04796767T ATE362367T1 AT E362367 T1 ATE362367 T1 AT E362367T1 AT 04796767 T AT04796767 T AT 04796767T AT 04796767 T AT04796767 T AT 04796767T AT E362367 T1 ATE362367 T1 AT E362367T1
- Authority
- AT
- Austria
- Prior art keywords
- ppar
- acid derivatives
- activated receptor
- peroxisome proliferator
- phenoxyacetic acid
- Prior art date
Links
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title 2
- 239000000556 agonist Substances 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- LCPDWSOZIOUXRV-UHFFFAOYSA-N phenoxyacetic acid Chemical class OC(=O)COC1=CC=CC=C1 LCPDWSOZIOUXRV-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51656103P | 2003-10-31 | 2003-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE362367T1 true ATE362367T1 (de) | 2007-06-15 |
Family
ID=34549548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04796767T ATE362367T1 (de) | 2003-10-31 | 2004-10-28 | Phenoxyessigsäure-derivate als peroxisom- proliferator-aktivierte rezeptor (ppar) dual- agonisten |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7015329B2 (de) |
| EP (1) | EP1684752B1 (de) |
| JP (1) | JP2007527416A (de) |
| KR (1) | KR20060109925A (de) |
| CN (1) | CN1897939A (de) |
| AR (1) | AR046311A1 (de) |
| AT (1) | ATE362367T1 (de) |
| AU (1) | AU2004285530A1 (de) |
| BR (1) | BRPI0416106A (de) |
| CA (1) | CA2544317A1 (de) |
| CR (1) | CR8377A (de) |
| DE (1) | DE602004006529T2 (de) |
| EA (1) | EA009804B1 (de) |
| EC (1) | ECSP066536A (de) |
| ES (1) | ES2287786T3 (de) |
| IL (1) | IL175310A0 (de) |
| NO (1) | NO20062511L (de) |
| TW (1) | TW200528438A (de) |
| UA (1) | UA84035C2 (de) |
| WO (1) | WO2005041959A1 (de) |
| ZA (1) | ZA200604420B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA87467C2 (xx) | 2003-09-19 | 2009-07-27 | Янссен Фармацевтика Н.В | 4-((феноксіалкіл)тіо)феноксіоцтова кислота та її аналоги$4-((феноксиалкил)тио)феноксиуксусная кислота и ее аналоги |
| ATE362367T1 (de) * | 2003-10-31 | 2007-06-15 | Janssen Pharmaceutica Nv | Phenoxyessigsäure-derivate als peroxisom- proliferator-aktivierte rezeptor (ppar) dual- agonisten |
| US20080045580A1 (en) * | 2004-10-11 | 2008-02-21 | Dr Reddy's Laboratories Limited | Novel Isoxazole Compounds Having Ppar Agonist Activity |
| JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| PE20080188A1 (es) * | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
| KR101922515B1 (ko) | 2006-09-08 | 2019-02-20 | 로드아일랜드하스피틀 | 알코올 유발성 간 질환의 치료, 예방 및 역행 |
| KR20090066289A (ko) | 2006-09-08 | 2009-06-23 | 로드아일랜드하스피틀 | 알코올 유발성 뇌 질환의 치료, 예방 및 역행 |
| WO2008128126A1 (en) | 2007-04-11 | 2008-10-23 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| ES2423793T3 (es) * | 2008-05-26 | 2013-09-24 | Genfit | Compuestos agonistas de PPAR, preparación y usos para el tratamiento de la diabetes y/o dislipidemias |
| EP2593447B1 (de) | 2010-07-15 | 2016-08-17 | Bayer Intellectual Property GmbH | 3-pyridyl-heteroarylcarboxamidverbindungen als schädlingsbekämpfungsmittel |
| CN103298469A (zh) | 2010-08-31 | 2013-09-11 | 首尔大学校产学协力财团 | PPARδ激动剂的胎儿重编程的用途 |
| BR112013009823A2 (pt) | 2010-10-22 | 2016-07-05 | Bayer Ip Gmbh | novos compostos heterocíclicos como pesticidas |
| ES2640916T3 (es) | 2012-04-26 | 2017-11-07 | Bristol-Myers Squibb Company | Derivados de imidazotiadiazol e imidazopirazina como inhibidores del receptor 4 activados por proteasa (PAR4) para tratar agregación plaquetaria |
| MX2014012803A (es) | 2012-04-26 | 2015-01-15 | Squibb Bristol Myers Co | Peptidos agonistas de receptor activado por proteasa tipo 4 (par4). |
| KR102750722B1 (ko) * | 2022-03-16 | 2025-01-09 | 재단법인 대구경북첨단의료산업진흥재단 | 싸이아다이아졸 화합물 및 이를 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물 |
| CN118359543A (zh) * | 2023-01-18 | 2024-07-19 | 哈尔滨三联药业股份有限公司 | 五元杂环类化合物及其医药用途 |
| CN118063343B (zh) * | 2024-02-19 | 2026-07-24 | 上海应用技术大学 | 一种肼基苯氧乙酸乙酯类α-葡萄糖苷酶抑制剂及其制备方法与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69941777D1 (de) * | 1998-03-10 | 2010-01-21 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| US6242493B1 (en) * | 1998-03-13 | 2001-06-05 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| AU4167099A (en) | 1998-06-19 | 2000-01-05 | Nissan Chemical Industries Ltd. | Heterocyclic compounds as hypoglycemic agents |
| AUPP609198A0 (en) | 1998-09-22 | 1998-10-15 | Curtin University Of Technology | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| NZ515087A (en) | 1999-04-28 | 2003-11-28 | Aventis Pharma Gmbh | Tri-aryl acid derivatives as PPAR receptor ligands |
| HRP20010795A2 (en) | 1999-04-28 | 2003-02-28 | Aventis Pharma Gmbh | Di-aryl acid derivatives as ppar receptor ligands |
| WO2001016120A1 (en) | 1999-08-27 | 2001-03-08 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
| JP4790969B2 (ja) * | 2000-08-11 | 2011-10-12 | 日本ケミファ株式会社 | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
| US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| CA2510793A1 (en) * | 2002-12-20 | 2004-07-15 | Bayer Pharmaceuticals Corporation | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| ATE362367T1 (de) * | 2003-10-31 | 2007-06-15 | Janssen Pharmaceutica Nv | Phenoxyessigsäure-derivate als peroxisom- proliferator-aktivierte rezeptor (ppar) dual- agonisten |
-
2004
- 2004-10-28 AT AT04796767T patent/ATE362367T1/de not_active IP Right Cessation
- 2004-10-28 JP JP2006538316A patent/JP2007527416A/ja not_active Withdrawn
- 2004-10-28 DE DE602004006529T patent/DE602004006529T2/de not_active Expired - Fee Related
- 2004-10-28 EA EA200600878A patent/EA009804B1/ru not_active IP Right Cessation
- 2004-10-28 AU AU2004285530A patent/AU2004285530A1/en not_active Abandoned
- 2004-10-28 KR KR1020067010610A patent/KR20060109925A/ko not_active Withdrawn
- 2004-10-28 EP EP04796767A patent/EP1684752B1/de not_active Expired - Lifetime
- 2004-10-28 CA CA002544317A patent/CA2544317A1/en not_active Abandoned
- 2004-10-28 BR BRPI0416106-8A patent/BRPI0416106A/pt not_active IP Right Cessation
- 2004-10-28 US US10/975,785 patent/US7015329B2/en not_active Expired - Fee Related
- 2004-10-28 UA UAA200605139A patent/UA84035C2/ru unknown
- 2004-10-28 CN CNA2004800382161A patent/CN1897939A/zh active Pending
- 2004-10-28 WO PCT/US2004/036028 patent/WO2005041959A1/en not_active Ceased
- 2004-10-28 ES ES04796767T patent/ES2287786T3/es not_active Expired - Lifetime
- 2004-10-29 AR ARP040103979A patent/AR046311A1/es not_active Application Discontinuation
- 2004-10-29 TW TW093132849A patent/TW200528438A/zh unknown
-
2005
- 2005-11-15 US US11/274,656 patent/US7498351B2/en not_active Expired - Fee Related
-
2006
- 2006-04-27 IL IL175310A patent/IL175310A0/en unknown
- 2006-04-28 EC EC2006006536A patent/ECSP066536A/es unknown
- 2006-05-02 CR CR8377A patent/CR8377A/es unknown
- 2006-05-30 ZA ZA200604420A patent/ZA200604420B/en unknown
- 2006-05-31 NO NO20062511A patent/NO20062511L/no not_active Application Discontinuation
-
2009
- 2009-01-23 US US12/358,703 patent/US20090131489A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200604420B (en) | 2007-10-31 |
| US7015329B2 (en) | 2006-03-21 |
| CA2544317A1 (en) | 2005-05-12 |
| EA200600878A1 (ru) | 2006-10-27 |
| NO20062511L (no) | 2006-07-27 |
| US20050096362A1 (en) | 2005-05-05 |
| ES2287786T3 (es) | 2007-12-16 |
| WO2005041959A1 (en) | 2005-05-12 |
| EP1684752A1 (de) | 2006-08-02 |
| EA009804B1 (ru) | 2008-04-28 |
| DE602004006529T2 (de) | 2008-01-31 |
| AR046311A1 (es) | 2005-11-30 |
| UA84035C2 (ru) | 2008-09-10 |
| IL175310A0 (en) | 2006-09-05 |
| EP1684752B1 (de) | 2007-05-16 |
| DE602004006529D1 (de) | 2007-06-28 |
| AU2004285530A1 (en) | 2005-05-12 |
| CR8377A (es) | 2008-11-24 |
| CN1897939A (zh) | 2007-01-17 |
| ECSP066536A (es) | 2006-12-20 |
| JP2007527416A (ja) | 2007-09-27 |
| US20090131489A1 (en) | 2009-05-21 |
| US20060074246A1 (en) | 2006-04-06 |
| BRPI0416106A (pt) | 2007-01-02 |
| US7498351B2 (en) | 2009-03-03 |
| KR20060109925A (ko) | 2006-10-23 |
| TW200528438A (en) | 2005-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |