ATE338743T1 - Substituierte phenylpropionsäurederivate als agonisten für den humanen peroxisomproliferatoraktivierten rezeptor alpha (ppar) - Google Patents

Substituierte phenylpropionsäurederivate als agonisten für den humanen peroxisomproliferatoraktivierten rezeptor alpha (ppar)

Info

Publication number: ATE338743T1
Authority: AT; Austria
Prior art keywords: ppar; agonists; acid derivatives; activated receptor; receptor alpha
Prior art date: 2001-12-19

Application number

AT02804964T

Other languages

English (en)

Inventor

Lindstedt Eva-Lotte Alstermark

Anna Christina Olsson

Lanna Li

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-19

Filing date

2002-12-18

Publication date

2006-09-15

2002-12-18 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE338743T1 publication Critical patent/ATE338743T1/de

Links

101000741788 Homo sapiens Peroxisome proliferator-activated receptor alpha Proteins 0.000 title 1
102000012141 Peroxisome proliferator-activated receptor alpha Human genes 0.000 title 1
239000000556 agonist Substances 0.000 title 1
102000054223 human PPARA Human genes 0.000 title 1
YPGCWEMNNLXISK-UHFFFAOYSA-N hydratropic acid Chemical class OC(=O)C(C)C1=CC=CC=C1 YPGCWEMNNLXISK-UHFFFAOYSA-N 0.000 title 1
108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT02804964T 2001-12-19 2002-12-18 Substituierte phenylpropionsäurederivate als agonisten für den humanen peroxisomproliferatoraktivierten rezeptor alpha (ppar) ATE338743T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE0104334A SE0104334D0 (sv)	2001-12-19	2001-12-19	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE338743T1 true ATE338743T1 (de)	2006-09-15

Family

ID=20286433

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT02804964T ATE338743T1 (de)	2001-12-19	2002-12-18	Substituierte phenylpropionsäurederivate als agonisten für den humanen peroxisomproliferatoraktivierten rezeptor alpha (ppar)
AT02788145T ATE363466T1 (de)	2001-12-19	2002-12-18	Substituierte phenylpropionsäurederivate als agonisten des menschlichen peroxisom-proliferator-aktiverten rezeptors alpha(ppar)

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT02788145T ATE363466T1 (de)	2001-12-19	2002-12-18	Substituierte phenylpropionsäurederivate als agonisten des menschlichen peroxisom-proliferator-aktiverten rezeptors alpha(ppar)

Country Status (30)

Country	Link
US (2)	US7256307B2 (de)
EP (2)	EP1458672B1 (de)
JP (4)	JP3784804B2 (de)
KR (2)	KR20040074092A (de)
CN (3)	CN100406427C (de)
AR (2)	AR038045A1 (de)
AT (2)	ATE338743T1 (de)
AU (2)	AU2002366315A1 (de)
BR (2)	BR0214988A (de)
CA (2)	CA2470491A1 (de)
CY (2)	CY1106276T1 (de)
DE (2)	DE60214594T2 (de)
DK (2)	DK1458672T3 (de)
ES (2)	ES2271381T3 (de)
HU (2)	HUP0402022A3 (de)
IL (3)	IL162330A0 (de)
IS (2)	IS7309A (de)
MX (2)	MXPA04006004A (de)
MY (1)	MY132565A (de)
NO (2)	NO20043023L (de)
NZ (2)	NZ533274A (de)
PL (2)	PL370672A1 (de)
PT (2)	PT1458673E (de)
RU (2)	RU2303031C2 (de)
SE (1)	SE0104334D0 (de)
SI (2)	SI1458672T1 (de)
TW (2)	TWI253444B (de)
UA (2)	UA77460C2 (de)
WO (2)	WO2003051821A1 (de)
ZA (2)	ZA200404657B (de)

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Publication number	Publication date
HK1068604A1 (en)	2005-04-29
PL370672A1 (en)	2005-05-30
CN1620422A (zh)	2005-05-25
KR20040074092A (ko)	2004-08-21
EP1458672A1 (de)	2004-09-22
PL370673A1 (en)	2005-05-30
AU2002366315A1 (en)	2003-06-30
US7256307B2 (en)	2007-08-14
KR20040074094A (ko)	2004-08-21
MY132565A (en)	2007-10-31
US7514471B2 (en)	2009-04-07
TW200410925A (en)	2004-07-01
JP3784804B2 (ja)	2006-06-14
WO2003051822A1 (en)	2003-06-26
IS7313A (is)	2004-06-15
SI1458672T1 (sl)	2007-10-31
JP2005526704A (ja)	2005-09-08
CA2469302A1 (en)	2003-06-26
SI1458673T1 (sl)	2007-02-28
EP1458673A1 (de)	2004-09-22
PT1458673E (pt)	2006-12-29
HK1068870A1 (en)	2005-05-06
IL162331A0 (en)	2005-11-20
RU2004116917A (ru)	2005-11-10
MXPA04006003A (es)	2004-09-27
US20050113362A1 (en)	2005-05-26
DE60220441T2 (de)	2008-01-24
BR0214986A (pt)	2004-12-14
DK1458673T3 (da)	2006-12-11
DK1458672T3 (da)	2007-09-17
ZA200404657B (en)	2005-08-29
BR0214988A (pt)	2004-12-14
EP1458673B1 (de)	2006-09-06
PT1458672E (pt)	2007-07-18
NZ533276A (en)	2006-04-28
CY1106276T1 (el)	2011-10-12
JP2005336209A (ja)	2005-12-08
CN1293044C (zh)	2007-01-03
IL162330A (en)	2009-06-15
RU2004116918A (ru)	2005-11-10
DE60214594D1 (de)	2006-10-19
NZ533274A (en)	2005-12-23
UA77460C2 (en)	2006-12-15
IL162330A0 (en)	2005-11-20
CN1620423A (zh)	2005-05-25
DE60220441D1 (de)	2007-07-12
CY1106784T1 (el)	2012-05-23
CN100406427C (zh)	2008-07-30
EP1458672B1 (de)	2007-05-30
JP2006298924A (ja)	2006-11-02
SE0104334D0 (sv)	2001-12-19
NO20043164L (no)	2004-07-16
MXPA04006004A (es)	2004-09-27
CA2470491A1 (en)	2003-06-26
TW200410918A (en)	2004-07-01
ATE363466T1 (de)	2007-06-15
CN1896045A (zh)	2007-01-17
HUP0402022A3 (en)	2009-06-29
US20050171204A1 (en)	2005-08-04
ES2286310T3 (es)	2007-12-01
AR038045A1 (es)	2004-12-22
DE60214594T2 (de)	2007-09-13
ES2271381T3 (es)	2007-04-16
HUP0402133A2 (hu)	2005-02-28
WO2003051821A1 (en)	2003-06-26
TWI255807B (en)	2006-06-01
HUP0402133A3 (en)	2010-07-28
ZA200404658B (en)	2006-02-22
AR038047A1 (es)	2004-12-22
JP3820249B2 (ja)	2006-09-13
TWI253444B (en)	2006-04-21
JP2005526011A (ja)	2005-09-02
RU2303031C2 (ru)	2007-07-20
IS7309A (is)	2004-06-14
NO20043023L (no)	2004-07-15
RU2300517C2 (ru)	2007-06-10
AU2002352427A1 (en)	2003-06-30
UA77987C2 (en)	2007-02-15
HUP0402022A2 (hu)	2005-01-28

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