ATE362925T1 - Zusammensetungen und verfahren zur modulation von apoptose in cellen, die proteine der bc1-2- familie exprimieren - Google Patents
Zusammensetungen und verfahren zur modulation von apoptose in cellen, die proteine der bc1-2- familie exprimierenInfo
- Publication number
- ATE362925T1 ATE362925T1 AT00959287T AT00959287T ATE362925T1 AT E362925 T1 ATE362925 T1 AT E362925T1 AT 00959287 T AT00959287 T AT 00959287T AT 00959287 T AT00959287 T AT 00959287T AT E362925 T1 ATE362925 T1 AT E362925T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- agents
- methods
- cells expressing
- family proteins
- Prior art date
Links
- 230000006907 apoptotic process Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 102000051485 Bcl-2 family Human genes 0.000 abstract 2
- 108700038897 Bcl-2 family Proteins 0.000 abstract 2
- 230000002424 anti-apoptotic effect Effects 0.000 abstract 2
- 102000018832 Cytochromes Human genes 0.000 abstract 1
- 108010052832 Cytochromes Proteins 0.000 abstract 1
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000001640 apoptogenic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14996899P | 1999-08-20 | 1999-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE362925T1 true ATE362925T1 (de) | 2007-06-15 |
Family
ID=22532570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00959287T ATE362925T1 (de) | 1999-08-20 | 2000-08-18 | Zusammensetungen und verfahren zur modulation von apoptose in cellen, die proteine der bc1-2- familie exprimieren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090203770A1 (de) |
| EP (1) | EP1218368B1 (de) |
| JP (1) | JP2003507474A (de) |
| AT (1) | ATE362925T1 (de) |
| AU (1) | AU781272B2 (de) |
| CA (1) | CA2382465C (de) |
| DE (1) | DE60034957T2 (de) |
| ES (1) | ES2287029T3 (de) |
| WO (1) | WO2001014365A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7101917B2 (en) | 2003-04-14 | 2006-09-05 | Hoffmann-La Roche Inc. | Mitochrondrial permeability transition pore affinity labels and modulators |
| EP3401684B1 (de) * | 2008-10-10 | 2022-03-16 | Dana Farber Cancer Institute, Inc. | Chemische modulatoren pro-apoptotischer bax- und bcl-2 polypeptide |
| DK3178321T3 (da) | 2009-10-07 | 2019-08-26 | Dow Agrosciences Llc | Synergistiske fungicide blandninger af epoxiconazol til bekæmpelse af svamp i korn |
| EP2643300A1 (de) * | 2010-11-24 | 2013-10-02 | Stemergie Biotechnology SA | Inhibitoren der aktivität des komplexes iii der mitochondrialen elektronentransportkette und verwendung zur behandlung von krankheiten |
| EP2938191B1 (de) | 2012-12-28 | 2018-01-31 | Dow AgroSciences LLC | Synergistische fungizide gemische zur pilzbekämpfung in getreidepflanzen |
| BR112015015243B8 (pt) | 2012-12-31 | 2022-08-23 | Dow Agrosciences Llc | Composto contendo picolinamidas macrocíclicas, composição e método para controle e prevenção de doença em planta |
| WO2015100182A1 (en) | 2013-12-26 | 2015-07-02 | Dow Agrosciences Llc | Use of macrocyclic picolinamides as fungicides |
| EP3099170A4 (de) | 2013-12-26 | 2017-06-21 | Dow AgroSciences LLC | Verwendung makrocyclischer picolinamide als fungizide |
| EP3139916A4 (de) * | 2014-05-06 | 2017-11-15 | Dow AgroSciences LLC | Makrocyclische picolinamide als fungizide |
| WO2016007529A1 (en) | 2014-07-08 | 2016-01-14 | Dow Agrosciences Llc | Macrocyclic picolinamides as fungicides |
| BR112017000104A2 (pt) | 2014-07-08 | 2017-10-31 | Dow Agrosciences Llc | picolinamidas macrocíclicas como fungicidas |
| MX2017008444A (es) | 2014-12-30 | 2017-10-02 | Dow Agrosciences Llc | Picolinamidas como fungicidas. |
| US20170290333A1 (en) | 2014-12-30 | 2017-10-12 | Dow Agrosciences Llc | Picolinamide compounds with fungicidal activity |
| AU2015374459A1 (en) | 2014-12-30 | 2017-06-29 | Dow Agrosciences Llc | Picolinamide compounds with fungicidal activity |
| WO2016109634A1 (en) | 2014-12-30 | 2016-07-07 | Dow Agrosciences Llc | Fungicidal compositions |
| EP3240408B1 (de) | 2014-12-30 | 2020-04-08 | Dow Agrosciences LLC | Picolinamide mit fungizider aktivität |
| MX2017008439A (es) | 2014-12-30 | 2017-10-02 | Dow Agrosciences Llc | Compuestos de picolinamida con actividad fungicida. |
| WO2018045012A1 (en) | 2016-08-30 | 2018-03-08 | Dow Agrosciences Llc | Pyrido-1,3-oxazine-2,4-dione compounds with fungicidal activity |
| US10111432B2 (en) | 2016-08-30 | 2018-10-30 | Dow Agrosciences Llc | Picolinamide N-oxide compounds with fungicidal activity |
| US10214490B2 (en) | 2016-08-30 | 2019-02-26 | Dow Agrosciences Llc | Picolinamides as fungicides |
| US10172358B2 (en) | 2016-08-30 | 2019-01-08 | Dow Agrosciences Llc | Thiopicolinamide compounds with fungicidal activity |
| BR102018000183B1 (pt) | 2017-01-05 | 2023-04-25 | Dow Agrosciences Llc | Picolinamidas, composição para controle de um patógeno fúngico, e método para controle e prevenção de um ataque por fungos em uma planta |
| TW201842851A (zh) | 2017-05-02 | 2018-12-16 | 美商陶氏農業科學公司 | 用於穀類中的真菌防治之協同性混合物 |
| TWI774761B (zh) | 2017-05-02 | 2022-08-21 | 美商科迪華農業科技有限責任公司 | 用於穀物中的真菌防治之協同性混合物 |
| US11191269B2 (en) | 2017-05-02 | 2021-12-07 | Dow Agrosciences Llc | Use of an acyclic picolinamide compound as a fungicide for fungal diseases on turfgrasses |
| BR102019004480B1 (pt) | 2018-03-08 | 2023-03-28 | Dow Agrosciences Llc | Picolinamidas como fungicidas |
| KR20210076072A (ko) | 2018-10-15 | 2021-06-23 | 코르테바 애그리사이언스 엘엘씨 | 옥시피콜린아미드의 합성 방법 |
| CN114554848A (zh) | 2019-10-18 | 2022-05-27 | 科迪华农业科技有限责任公司 | 用于合成吡啶酰胺的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05155877A (ja) * | 1991-08-15 | 1993-06-22 | Kaiyo Bio Technol Kenkyusho:Kk | 新規物質ウラウチマイシンａ、ウラウチマイシンｂおよ びそれらの製造法 |
| US5539094A (en) * | 1993-11-12 | 1996-07-23 | La Jolla Cancer Research Foundation | DNA encoding Bcl-2-associated proteins |
| JPH07196489A (ja) * | 1993-12-28 | 1995-08-01 | Kobe Steel Ltd | ヒト腫瘍細胞に対する選択的細胞障害剤 |
| WO1999014257A1 (en) * | 1997-09-15 | 1999-03-25 | Eastman Chemical Company | Monoesters and macrocyclic diester of phthalic acid and synthesis thereof |
| JP4463420B2 (ja) * | 1998-02-06 | 2010-05-19 | 明治製菓株式会社 | 新規抗真菌化合物とその製法 |
| ES2546386T3 (es) * | 1999-07-20 | 2015-09-23 | Dow Agrosciences, Llc | Amidas aromáticas heterocíclicas fungicidas y sus composiciones, métodos de uso y preparación |
| US7241804B1 (en) * | 2000-08-18 | 2007-07-10 | Fred Hutchinson Cancer Research Center | Compositions and methods for modulating apoptosis in cells over-expressing Bcl-2 family member proteins |
-
2000
- 2000-08-18 JP JP2001518696A patent/JP2003507474A/ja not_active Withdrawn
- 2000-08-18 ES ES00959287T patent/ES2287029T3/es not_active Expired - Lifetime
- 2000-08-18 EP EP00959287A patent/EP1218368B1/de not_active Expired - Lifetime
- 2000-08-18 WO PCT/US2000/022891 patent/WO2001014365A1/en not_active Ceased
- 2000-08-18 CA CA2382465A patent/CA2382465C/en not_active Expired - Fee Related
- 2000-08-18 AT AT00959287T patent/ATE362925T1/de not_active IP Right Cessation
- 2000-08-18 AU AU70634/00A patent/AU781272B2/en not_active Ceased
- 2000-08-18 DE DE60034957T patent/DE60034957T2/de not_active Expired - Lifetime
-
2007
- 2007-06-25 US US11/768,111 patent/US20090203770A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003507474A (ja) | 2003-02-25 |
| AU781272B2 (en) | 2005-05-12 |
| EP1218368A4 (de) | 2003-04-16 |
| EP1218368B1 (de) | 2007-05-23 |
| CA2382465C (en) | 2010-05-18 |
| AU7063400A (en) | 2001-03-19 |
| DE60034957D1 (de) | 2007-07-05 |
| EP1218368A1 (de) | 2002-07-03 |
| ES2287029T3 (es) | 2007-12-16 |
| CA2382465A1 (en) | 2001-03-01 |
| US20090203770A1 (en) | 2009-08-13 |
| WO2001014365A1 (en) | 2001-03-01 |
| DE60034957T2 (de) | 2008-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1218368 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |