ATE363279T1 - Thiazol-imidazol- und oxazolverbindungen und behandlung von mit proteinalterung verbundenen erkrankungen - Google Patents

Thiazol-imidazol- und oxazolverbindungen und behandlung von mit proteinalterung verbundenen erkrankungen

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Publication number
ATE363279T1
ATE363279T1 AT01904934T AT01904934T ATE363279T1 AT E363279 T1 ATE363279 T1 AT E363279T1 AT 01904934 T AT01904934 T AT 01904934T AT 01904934 T AT01904934 T AT 01904934T AT E363279 T1 ATE363279 T1 AT E363279T1
Authority
AT
Austria
Prior art keywords
alkyl
damage
bond
disease
diabetes
Prior art date
Application number
AT01904934T
Other languages
English (en)
Inventor
Dilip Wagle
Sara Vasan
John Egan
Original Assignee
Alteon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alteon Inc filed Critical Alteon Inc
Application granted granted Critical
Publication of ATE363279T1 publication Critical patent/ATE363279T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
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    • C07D277/34—Oxygen atoms
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    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
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    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Thiazole And Isothizaole Compounds (AREA)
AT01904934T 2000-01-19 2001-01-19 Thiazol-imidazol- und oxazolverbindungen und behandlung von mit proteinalterung verbundenen erkrankungen ATE363279T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US17699500P 2000-01-19 2000-01-19
US18327400P 2000-02-17 2000-02-17
US25910700P 2000-12-29 2000-12-29
US25929100P 2000-12-29 2000-12-29
US25923701P 2001-01-02 2001-01-02
US25923901P 2001-01-02 2001-01-02

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ATE363279T1 true ATE363279T1 (de) 2007-06-15

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US (2) US6960605B2 (de)
EP (2) EP1248615B1 (de)
JP (1) JP2004501863A (de)
KR (1) KR100766158B1 (de)
CN (1) CN1426303A (de)
AT (1) ATE363279T1 (de)
AU (1) AU782500B2 (de)
CA (1) CA2397627A1 (de)
DE (1) DE60128651T2 (de)
ES (1) ES2287096T3 (de)
MX (1) MXPA02007099A (de)
NZ (1) NZ520143A (de)
WO (1) WO2001052847A1 (de)

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EP1359910A4 (de) * 2000-12-29 2006-07-05 Alteon Inc Methode zur behandlung von glaukom ii b
JP2006508893A (ja) 2002-03-15 2006-03-16 イーライ・リリー・アンド・カンパニー ステロイドホルモン核内レセプターモジュレーターとしてのジヒドロインドール−２−オン誘導体
US7049333B2 (en) 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
DE60323130D1 (de) * 2002-11-25 2008-10-02 Hoffmann La Roche Indolderivaten
US20050137239A1 (en) * 2003-12-17 2005-06-23 Hines Michelle D. Thiazole derivatives
TWI349550B (en) 2003-12-26 2011-10-01 A thiazole derivative and adenosine a2a receptor antagonist containing the same
WO2005097766A1 (en) * 2004-03-31 2005-10-20 Lexicon Genetics, Inc. 2-aminomethylthiazole-5-carboxamides as protein kinase modulators
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CA2397627A1 (en) 2001-07-26
WO2001052847A8 (en) 2002-09-26
US6960605B2 (en) 2005-11-01
EP1785134A2 (de) 2007-05-16
AU3286401A (en) 2001-07-31
KR100766158B1 (ko) 2007-10-10
US20020022622A1 (en) 2002-02-21
AU782500B2 (en) 2005-08-04
KR20030016218A (ko) 2003-02-26
EP1248615B1 (de) 2007-05-30
US20060014781A1 (en) 2006-01-19
DE60128651D1 (de) 2007-07-12
JP2004501863A (ja) 2004-01-22
WO2001052847A1 (en) 2001-07-26
MXPA02007099A (es) 2004-08-23
CN1426303A (zh) 2003-06-25
ES2287096T3 (es) 2007-12-16
NZ520143A (en) 2005-01-28
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EP1785134A3 (de) 2009-02-18
EP1248615A1 (de) 2002-10-16

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