ATE364610T1 - Kristalline polymorphe form von irinotecan- hyrochlorid - Google Patents

Kristalline polymorphe form von irinotecan- hyrochlorid

Info

Publication number
ATE364610T1
ATE364610T1 AT03743335T AT03743335T ATE364610T1 AT E364610 T1 ATE364610 T1 AT E364610T1 AT 03743335 T AT03743335 T AT 03743335T AT 03743335 T AT03743335 T AT 03743335T AT E364610 T1 ATE364610 T1 AT E364610T1
Authority
AT
Austria
Prior art keywords
hyrochloride
irinotecan
polymorphous form
crystalline polymorphous
crystalline
Prior art date
Application number
AT03743335T
Other languages
English (en)
Inventor
Romualdo Forino
Natale Barbugian
Massimo Zampieri
Attilio Tomasi
Original Assignee
Pfizer Italia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Italia Srl filed Critical Pfizer Italia Srl
Application granted granted Critical
Publication of ATE364610T1 publication Critical patent/ATE364610T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03743335T 2002-03-01 2003-02-26 Kristalline polymorphe form von irinotecan- hyrochlorid ATE364610T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36068402P 2002-03-01 2002-03-01

Publications (1)

Publication Number Publication Date
ATE364610T1 true ATE364610T1 (de) 2007-07-15

Family

ID=27789001

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03743335T ATE364610T1 (de) 2002-03-01 2003-02-26 Kristalline polymorphe form von irinotecan- hyrochlorid

Country Status (23)

Country Link
EP (1) EP1487840B1 (de)
JP (1) JP2005525367A (de)
KR (1) KR20040091083A (de)
CN (1) CN1276923C (de)
AR (1) AR038618A1 (de)
AT (1) ATE364610T1 (de)
AU (1) AU2003215594A1 (de)
BR (1) BR0308133A (de)
CA (1) CA2477926A1 (de)
DE (1) DE60314378T2 (de)
DK (1) DK1487840T3 (de)
ES (1) ES2287495T3 (de)
IL (1) IL163820A0 (de)
MX (1) MXPA04008484A (de)
NO (1) NO20044138L (de)
NZ (1) NZ534999A (de)
PE (1) PE20030923A1 (de)
PL (1) PL372318A1 (de)
PT (1) PT1487840E (de)
RU (1) RU2300535C2 (de)
TW (1) TWI270374B (de)
WO (1) WO2003074527A1 (de)
ZA (1) ZA200406927B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ541990A (en) * 2003-02-25 2009-04-30 Yakult Honsha Kk Method for preparing polymorphism of irinotecan hydrochloride
ES2245891B1 (es) * 2004-07-09 2006-11-16 Clinmet S.L. "metodo para la obtencion de un excipiente universal para la administracion oral de principios activos farmaceuticos y composiciones de excipientes resultantes del metodo".
PL1828196T3 (pl) 2004-12-21 2013-02-28 Sigma Tau Ind Farmaceuti Stereoselektywny sposób wytwarzania i krystaliczne formy kamptotecyny
WO2006082279A1 (en) 2005-02-07 2006-08-10 Fermion Oy Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin
CA2591071C (en) 2005-02-08 2014-04-29 Fermion Oy Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof
PL1928883T3 (pl) 2005-02-08 2014-03-31 Fermion Oy Sposób otrzymywania chlorowodorku irynotekanu
EP2082741A1 (de) * 2005-09-20 2009-07-29 Scinopharm Singapore Pte, Ltd. Neue Kristallform von Irinotecan-Hydrochlorid
CN101318964B (zh) * 2007-06-07 2010-12-15 上海迪赛诺医药发展有限公司 盐酸伊立替康新晶型及其制备方法
FR2918279B1 (fr) * 2007-07-05 2010-10-22 Aventis Pharma Sa Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan
IT1391757B1 (it) * 2008-11-11 2012-01-27 Antibioticos Spa Irinotecan cloridrato cristallino e metodi per la sua preparazione
CN101659667B (zh) * 2009-09-07 2011-11-02 重庆泰濠制药有限公司 一种盐酸伊立替康的纯化方法
US8546573B2 (en) 2009-11-18 2013-10-01 Cadila Healthcare Limited Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
CN102866126B (zh) * 2011-07-05 2016-03-23 重庆华邦制药有限公司 一种定量测定化合物中晶型比例的方法
CN102311443B (zh) * 2011-08-24 2014-07-16 上海北卡医药技术有限公司 盐酸伊立替康的新晶型及其制备方法
RU2529831C2 (ru) * 2012-11-30 2014-09-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) Способ лечения рака толстой кишки
EA035674B1 (ru) 2014-07-18 2020-07-24 Санофи Способ определения того, является ли пациент, предположительно страдающий от рака, кандидатом для терапии афлиберцептом
KR102293907B1 (ko) * 2015-06-30 2021-08-26 한미약품 주식회사 이리노테칸 함유 경구용 고형제제 및 그 제조방법
KR102066402B1 (ko) * 2017-12-22 2020-01-15 대화제약 주식회사 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물
US10919905B2 (en) 2019-05-16 2021-02-16 Scinopharm Taiwan, Ltd. Polymorphism for irinotecan free base

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
IT1282673B1 (it) * 1996-02-23 1998-03-31 Ist Naz Stud Cura Dei Tumori Derivati della camptotecina e loro uso come agenti antitumorali
GB9918885D0 (en) * 1999-08-10 1999-10-13 Pharmacia & Upjohn Spa Pharmaceutical formulations in hydroxypropymethycellulose capsules

Also Published As

Publication number Publication date
WO2003074527A1 (en) 2003-09-12
DE60314378T2 (de) 2008-02-28
CN1276923C (zh) 2006-09-27
CN1642958A (zh) 2005-07-20
ZA200406927B (en) 2006-06-28
IL163820A0 (en) 2005-12-18
MXPA04008484A (es) 2004-12-06
AU2003215594A1 (en) 2003-09-16
RU2004129307A (ru) 2005-04-10
ES2287495T3 (es) 2007-12-16
NZ534999A (en) 2007-03-30
HK1075044A1 (en) 2005-12-02
PE20030923A1 (es) 2003-10-29
BR0308133A (pt) 2005-01-04
DE60314378D1 (en) 2007-07-26
KR20040091083A (ko) 2004-10-27
CA2477926A1 (en) 2003-09-12
NO20044138L (no) 2004-11-29
DK1487840T3 (da) 2007-07-16
TW200303753A (en) 2003-09-16
TWI270374B (en) 2007-01-11
AR038618A1 (es) 2005-01-19
JP2005525367A (ja) 2005-08-25
PL372318A1 (en) 2005-07-11
EP1487840A1 (de) 2004-12-22
PT1487840E (pt) 2007-09-11
EP1487840B1 (de) 2007-06-13
RU2300535C2 (ru) 2007-06-10

Similar Documents

Publication Publication Date Title
ATE364610T1 (de) Kristalline polymorphe form von irinotecan- hyrochlorid
IL230659A (en) Calicheamicin derivative-carrier conjugates
IS7471A (is) Ný efnasambönd
ATE368042T1 (de) Cephemverbindungen
FI20021262A7 (fi) Sokerien kiteytys
DE10393374D2 (de) Zusammensetzung
ATE428701T1 (de) Kristalline form von bisä(e)-7-ä4-(4-fluorphenyl)-6-isopropyl-2-
NO20044046L (no) Substituerte hydroksyetylaminer
DK1522539T3 (da) Krystallinsk komposition indeholdende excitalopram
DE50311918D1 (de) Nockenwellenversteller
IS7381A (is) Efnasambönd
EP1559433A4 (de) Stabilisierte zusammensetzung
DE60321190D1 (de) Knopf
IS7414A (is) Oxó-azabísýklísk efnasambönd
NO20045659L (no) Forbindelser
DE60327447D1 (de) Pflaster
IS7827A (is) Ný efnasambönd
SE0500163L (sv) Sammansättning
ATE496887T1 (de) Substituierte 5-aminomethyl-1h-pyrrol-2-carbons ureamide
IS7833A (is) Efnasambönd með sameinaða heteróhringi
FI20021531A0 (fi) Muurausmenetelmä
DE50202991D1 (de) Hochtemperaturfestes Klebemittel
EP1561467A4 (de) Zusammensetzung zur wiederherstellung geschädigter haut
NO20055097D0 (no) Krystallinske N-formyl-hydroksylaminforbindelser
NO20044140D0 (no) New Composition

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1487840

Country of ref document: EP

REN Ceased due to non-payment of the annual fee