ATE364704T1 - Mutanten von op-1 - Google Patents

Mutanten von op-1

Info

Publication number
ATE364704T1
ATE364704T1 AT99954771T AT99954771T ATE364704T1 AT E364704 T1 ATE364704 T1 AT E364704T1 AT 99954771 T AT99954771 T AT 99954771T AT 99954771 T AT99954771 T AT 99954771T AT E364704 T1 ATE364704 T1 AT E364704T1
Authority
AT
Austria
Prior art keywords
proteins
finger
domain
sub
tgf
Prior art date
Application number
AT99954771T
Other languages
English (en)
Inventor
Hermann Oppermann
Mei-Sheng Tai
John Mccartney
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stryker Corp filed Critical Stryker Corp
Application granted granted Critical
Publication of ATE364704T1 publication Critical patent/ATE364704T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT99954771T 1998-10-07 1999-10-07 Mutanten von op-1 ATE364704T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10341898P 1998-10-07 1998-10-07
US09/374,958 US6677432B1 (en) 1998-10-07 1999-08-16 Mutations of the C-terminal portion of TGF-β superfamily proteins

Publications (1)

Publication Number Publication Date
ATE364704T1 true ATE364704T1 (de) 2007-07-15

Family

ID=26800441

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99954771T ATE364704T1 (de) 1998-10-07 1999-10-07 Mutanten von op-1

Country Status (8)

Country Link
US (1) US6677432B1 (de)
EP (1) EP1117804B1 (de)
JP (3) JP3971107B2 (de)
AT (1) ATE364704T1 (de)
AU (1) AU772930B2 (de)
CA (1) CA2344974C (de)
DE (1) DE69936312T2 (de)
WO (1) WO2000020607A2 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586388B2 (en) * 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
DE68929472T2 (de) * 1988-04-08 2004-05-13 Stryker Corp., Kalamazoo Biosynthetische knochenbildende Proteine, und sie enthaltende knochenbildende Vorrichtungen
US6919308B2 (en) * 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US20030185792A1 (en) * 1996-01-22 2003-10-02 Curis, Inc. Morphogen analogs of bone morphogenic proteins
CA2244228A1 (en) * 1996-01-22 1997-07-24 Creative Biomolecules, Inc. Morphogen analogs and methods for producing them
US6683156B1 (en) 1996-08-27 2004-01-27 University Of South Florida Method for diagnosing selected adenocarcinomas
US7211644B1 (en) * 1996-08-27 2007-05-01 University Of South Florida Diagnostic markers of human female infertility
US8106001B2 (en) * 1996-08-27 2012-01-31 University Of South Florida Diagnostic markers of human female infertility
US6294662B1 (en) 1996-08-27 2001-09-25 University Of South Florida Nucleic acids encoding an endometrial bleeding associated factor (ebaf)
AU1103900A (en) * 1998-10-07 2000-04-26 Stryker Corporation Modified tgf-beta superfamily proteins
DE10026713A1 (de) * 2000-05-30 2001-12-06 Walter Sebald Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
JP4685294B2 (ja) * 2001-09-18 2011-05-18 株式会社カネカ 新規ペプチド、生産方法、新規吸着体、吸着器および吸着方法
JP4654029B2 (ja) * 2002-06-17 2011-03-16 トラソス インコーポレイテッド 単一ドメインｔｄｆ関連化合物およびその類似体
US7456153B2 (en) 2002-11-14 2008-11-25 Adherex Technologies Inc. Compounds and methods for modulating functions of classical cadherins
WO2005097825A2 (en) * 2004-03-31 2005-10-20 Xencor, Inc. Bmp-7 variants with improved properties
US7795389B2 (en) 2004-09-28 2010-09-14 The Board Of Regents Of The University Of Texas System Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins
EP1698691A1 (de) * 2005-03-04 2006-09-06 Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH Mutanten von Wachstumsfaktoren mit verbesserter biologischer Eigenschaft
EP1885750B1 (de) * 2005-05-27 2011-08-17 BBS - Bioactive Bone Substitutes Oy Knochenmorphogenetisches protein 4 und osteogene vorrichtungen und pharmazeutische produkte, die dieses enthalten
US7659250B2 (en) * 2005-12-22 2010-02-09 Centocor, Inc. BMP-7 variant compositions, methods and uses
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604938D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
WO2008014054A2 (en) * 2006-07-27 2008-01-31 Centocor, Inc. Bmp-7 variant compositions, methods and uses
US20100184659A1 (en) 2006-12-21 2010-07-22 Warren Jaworowicz Sustained-Release Formulations Comprising Crystals, Macromolecular Gels, and Particulate Suspensions of Biologic Agents
US20100204124A1 (en) 2009-02-12 2010-08-12 Mary Elizabeth Pecquet Goad Compositions and Methods for Minimally-Invasive Systemic Delivery of Proteins Including TGF-Beta Superfamily Members
WO2010093925A2 (en) 2009-02-12 2010-08-19 Stryker Corporation PERIPHERAL ADMINISTRATION OF PROTEINS INCLUDING TGF-β SUPERFAMILY MEMBERS FOR TREATMENT OF SYSTEMIC DISORDERS AND DISEASE
US8952130B2 (en) 2009-02-24 2015-02-10 The Salk Institute For Biological Studies Designer ligands of TGF-β superfamily
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
US20110224410A1 (en) 2009-09-17 2011-09-15 Hile David Buffers for Controlling the pH of Bone Morphogenetic Proteins
CA2785038A1 (en) 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
CU24181B1 (es) * 2012-11-09 2016-04-25 Ct De Inmunología Molecular POLIPÉPTIDOS DERIVADOS DEL TGFß
AU2015374114B2 (en) 2014-12-29 2018-07-26 Bioventus, Llc Systems and methods for improved delivery of osteoinductive molecules in bone repair
CN109311957A (zh) * 2015-08-25 2019-02-05 伊斯迪德股份公司 诱导组织形成的化合物及其应用
AU2016311298A1 (en) 2015-08-25 2018-02-08 Histide Ag Compounds for inducing tissue formation and uses thereof
KR102404717B1 (ko) 2016-05-31 2022-05-31 재단법인 목암생명과학연구소 Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드
JP7562082B2 (ja) * 2018-11-05 2024-10-07 味の素株式会社 フローマイクロリアクターを用いるリフォールディングされたタンパク質の製造方法及びタンパク質のリフォールディング装置

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5011691A (en) 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5250302A (en) 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
ES2118723T3 (es) 1989-10-17 1998-10-01 Stryker Corp Dispositivos osteogenicos.
CA2070393A1 (en) 1989-10-18 1991-04-19 Charles M. Cohen Biosynthetic constructs of tgf-beta
GB8927546D0 (en) 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5071655A (en) * 1990-01-12 1991-12-10 Baylink David J Pharmaceutical combination for treatment of bone-wasting diseases
AU660019B2 (en) 1991-03-11 1995-06-08 Stryker Corporation Protein-induced morphogenesis
DE4131545C2 (de) 1991-09-21 1995-02-02 Krupp Industrietech Federbein für hydraulischen Radantrieb
EP0690871A4 (de) 1993-01-12 1999-10-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-5
CA2165776A1 (en) 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-6
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
DE69434651T2 (de) 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
FR2720069A1 (fr) 1994-05-19 1995-11-24 Inst Nat Sante Rech Med Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques.
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof

Also Published As

Publication number Publication date
DE69936312D1 (de) 2007-07-26
WO2000020607A2 (en) 2000-04-13
WO2000020607A9 (en) 2001-03-29
JP2008237223A (ja) 2008-10-09
JP2002526115A (ja) 2002-08-20
DE69936312T2 (de) 2008-02-14
EP1117804B1 (de) 2007-06-13
EP1117804A2 (de) 2001-07-25
JP5149070B2 (ja) 2013-02-20
CA2344974C (en) 2011-03-29
AU772930B2 (en) 2004-05-13
US6677432B1 (en) 2004-01-13
CA2344974A1 (en) 2000-04-13
AU1103800A (en) 2000-04-26
JP2005290016A (ja) 2005-10-20
JP4294010B2 (ja) 2009-07-08
JP3971107B2 (ja) 2007-09-05
WO2000020607A3 (en) 2000-07-06

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