ATE364704T1 - Mutanten von op-1 - Google Patents

Mutanten von op-1

Info

Publication number: ATE364704T1
Authority: AT; Austria
Prior art keywords: proteins; finger; domain; sub; tgf
Prior art date: 1998-10-07

Application number

AT99954771T

Other languages

English (en)

Inventor

Hermann Oppermann

Mei-Sheng Tai

John Mccartney

Original Assignee

Stryker Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-07

Filing date

1999-10-07

Publication date

2007-07-15

1999-10-07 Application filed by Stryker Corp filed Critical Stryker Corp

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE364704T1 publication Critical patent/ATE364704T1/de

Links

102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 3
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 3
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
102000035118 modified proteins Human genes 0.000 abstract 2
108091005573 modified proteins Proteins 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
230000000921 morphogenic effect Effects 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT99954771T 1998-10-07 1999-10-07 Mutanten von op-1 ATE364704T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10341898P	1998-10-07	1998-10-07
US09/374,958 US6677432B1 (en)	1998-10-07	1999-08-16	Mutations of the C-terminal portion of TGF-β superfamily proteins

Publications (1)

Publication Number	Publication Date
ATE364704T1 true ATE364704T1 (de)	2007-07-15

Family

ID=26800441

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99954771T ATE364704T1 (de)	1998-10-07	1999-10-07	Mutanten von op-1

Country Status (8)

Country	Link
US (1)	US6677432B1 (de)
EP (1)	EP1117804B1 (de)
JP (3)	JP3971107B2 (de)
AT (1)	ATE364704T1 (de)
AU (1)	AU772930B2 (de)
CA (1)	CA2344974C (de)
DE (1)	DE69936312T2 (de)
WO (1)	WO2000020607A2 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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DE68929453T2 (de) *	1988-04-08	2003-11-20	Stryker Corp., Kalamazoo	Osteogene Vorrichtungen
US6586388B2 (en) *	1988-04-08	2003-07-01	Stryker Corporation	Method of using recombinant osteogenic protein to repair bone or cartilage defects
US6919308B2 (en) *	1988-04-08	2005-07-19	Stryker Corporation	Osteogenic devices
US20030185792A1 (en) *	1996-01-22	2003-10-02	Curis, Inc.	Morphogen analogs of bone morphogenic proteins
US6273598B1 (en) *	1996-01-22	2001-08-14	Creative Biomolecules, Inc.	Computer system and methods for producing morphogen analogs of human OP-1
US6683156B1 (en)	1996-08-27	2004-01-27	University Of South Florida	Method for diagnosing selected adenocarcinomas
US8106001B2 (en) *	1996-08-27	2012-01-31	University Of South Florida	Diagnostic markers of human female infertility
US6294662B1 (en)	1996-08-27	2001-09-25	University Of South Florida	Nucleic acids encoding an endometrial bleeding associated factor (ebaf)
US7211644B1 (en) *	1996-08-27	2007-05-01	University Of South Florida	Diagnostic markers of human female infertility
JP3762222B2 (ja) *	1998-10-07	2006-04-05	ストライカー・コーポレーション	改変型ＴＧＦ−βスーパーファミリータンパク質
DE10026713A1 (de) *	2000-05-30	2001-12-06	Walter Sebald	Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
JP4685294B2 (ja) *	2001-09-18	2011-05-18	株式会社カネカ	新規ペプチド、生産方法、新規吸着体、吸着器および吸着方法
EP1572950B1 (de) *	2002-06-17	2012-10-10	Thrasos, Inc.	Einzeldomäne-tdf-verwandte verbindungen und analoge davon
CA2504768A1 (en) *	2002-11-14	2004-05-27	Adherex Technologies, Inc.	Compounds and methods for modulating functions of classical cadherins
CA2561809A1 (en) *	2004-03-31	2005-10-20	Xencor, Inc.	Bmp-7 variants with improved properties
US7795389B2 (en)	2004-09-28	2010-09-14	The Board Of Regents Of The University Of Texas System	Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins
EP1698691A1 (de) *	2005-03-04	2006-09-06	Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH	Mutanten von Wachstumsfaktoren mit verbesserter biologischer Eigenschaft
WO2006125867A1 (en) *	2005-05-27	2006-11-30	Bbs-Bioactive Bone Substitutes Oy	Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof
US7659250B2 (en) *	2005-12-22	2010-02-09	Centocor, Inc.	BMP-7 variant compositions, methods and uses
GB0604938D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
GB0604964D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Protein folding
GB0604966D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
WO2008014054A2 (en) *	2006-07-27	2008-01-31	Centocor, Inc.	Bmp-7 variant compositions, methods and uses
EP2120859B1 (de)	2006-12-21	2013-11-20	Stryker Corporation	Formulierungen mit verzögerter freisetzung mit kristallen von bmp-7
US20100204123A1 (en)	2009-02-12	2010-08-12	Mary Elizabeth Pecquet Goad	Peripheral Administration of Proteins Including TGF-beta Superfamily Members for Treatment of Systemic Disorders and Disease
EP2396026A2 (de)	2009-02-12	2011-12-21	Stryker Corporation	Zusammensetzungen und verfahren für die minimal invasive systemische abgabe von proteinen einschliesslich mitglieder der tgf-superfamilie
US8952130B2 (en)	2009-02-24	2015-02-10	The Salk Institute For Biological Studies	Designer ligands of TGF-β superfamily
WO2010110974A1 (en)	2009-03-24	2010-09-30	Stryker Corporation	Methods and compositions for tissue engineering
WO2011031856A1 (en)	2009-09-09	2011-03-17	Stryker Corporation	Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
EP2352750B1 (de)	2009-09-17	2012-06-13	Stryker Corporation	Puffer zur steuerung des ph-wertes knochenmorphogenetischer proteine
CA2785038A1 (en)	2009-12-22	2011-07-21	Stryker Corporation	Bmp-7 variants with reduced immunogenicity
CU24181B1 (es) *	2012-11-09	2016-04-25	Ct De Inmunología Molecular	POLIPÉPTIDOS DERIVADOS DEL TGFß
KR20170100634A (ko)	2014-12-29	2017-09-04	바이오벤터스 엘엘씨	골 복구에서의 골유도 분자의 전달 향상을 위한 시스템 및 방법
CA2995310A1 (en)	2015-08-25	2017-03-02	Histide Ag	Compounds for inducing tissue formation and uses thereof
JP2019502674A (ja) *	2015-08-25	2019-01-31	ヒスタイドアクツィエンゲゼルシャフト	組織形成誘導用化合物及びその使用
KR102404717B1 (ko)	2016-05-31	2022-05-31	재단법인 목암생명과학연구소	Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드
WO2020095894A1 (ja) *	2018-11-05	2020-05-14	味の素株式会社	フローマイクロリアクターを用いるリフォールディングされたタンパク質の製造方法及びタンパク質のリフォールディング装置

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5011691A (en)	1988-08-15	1991-04-30	Stryker Corporation	Osteogenic devices
US5250302A (en)	1988-04-08	1993-10-05	Stryker Corporation	Osteogenic devices
US5266683A (en)	1988-04-08	1993-11-30	Stryker Corporation	Osteogenic proteins
WO1991005802A1 (en)	1989-10-17	1991-05-02	Creative Biomolecules, Inc.	Osteogenic devices
JPH05501500A (ja)	1989-10-18	1993-03-25	クリエイティブ・バイオマリキュールズ・インコーポレーテッド	ＴＧＦ―βの生合成構築物
GB8927546D0 (en)	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
US5071655A (en) *	1990-01-12	1991-12-10	Baylink David J	Pharmaceutical combination for treatment of bone-wasting diseases
DK0575555T3 (da)	1991-03-11	2001-11-05	Curis Inc	Proteininduceret morfogenese
DE4131545C2 (de)	1991-09-21	1995-02-02	Krupp Industrietech	Federbein für hydraulischen Radantrieb
EP0690871A4 (de)	1993-01-12	1999-10-20	Univ Johns Hopkins Med	Wachstums-differenzierungsfaktor-5
JPH09503903A (ja)	1993-07-09	1997-04-22	ザジョーンズホプキンスユニバーシティースクールオブメディシン	増殖分化因子−６
EP0733109B9 (de)	1993-12-07	2006-07-05	Genetics Institute, LLC	Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US5399677A (en)	1993-12-07	1995-03-21	Genetics Institute, Inc.	Mutants of bone morphogenetic proteins
FR2720069A1 (fr)	1994-05-19	1995-11-24	Inst Nat Sante Rech Med	Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques.
US5674292A (en)	1995-06-07	1997-10-07	Stryker Corporation	Terminally sterilized osteogenic devices and preparation thereof

1999
- 1999-08-16 US US09/374,958 patent/US6677432B1/en not_active Expired - Lifetime
- 1999-10-07 AT AT99954771T patent/ATE364704T1/de not_active IP Right Cessation
- 1999-10-07 DE DE69936312T patent/DE69936312T2/de not_active Expired - Lifetime
- 1999-10-07 CA CA2344974A patent/CA2344974C/en not_active Expired - Fee Related
- 1999-10-07 JP JP2000574702A patent/JP3971107B2/ja not_active Expired - Fee Related
- 1999-10-07 EP EP99954771A patent/EP1117804B1/de not_active Expired - Lifetime
- 1999-10-07 WO PCT/US1999/023371 patent/WO2000020607A2/en not_active Ceased
- 1999-10-07 AU AU11038/00A patent/AU772930B2/en not_active Ceased
2005
- 2005-06-17 JP JP2005178654A patent/JP4294010B2/ja not_active Expired - Fee Related
2008
- 2008-05-20 JP JP2008132454A patent/JP5149070B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2344974C (en)	2011-03-29
JP5149070B2 (ja)	2013-02-20
EP1117804A2 (de)	2001-07-25
WO2000020607A3 (en)	2000-07-06
WO2000020607A9 (en)	2001-03-29
WO2000020607A2 (en)	2000-04-13
AU1103800A (en)	2000-04-26
DE69936312T2 (de)	2008-02-14
CA2344974A1 (en)	2000-04-13
EP1117804B1 (de)	2007-06-13
AU772930B2 (en)	2004-05-13
JP2008237223A (ja)	2008-10-09
JP3971107B2 (ja)	2007-09-05
JP2002526115A (ja)	2002-08-20
US6677432B1 (en)	2004-01-13
JP2005290016A (ja)	2005-10-20
JP4294010B2 (ja)	2009-07-08
DE69936312D1 (de)	2007-07-26

Legal Events

Date	Code	Title	Description
2007-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69936312D1 (de)	2007-07-26	Mutanten von op-1
DE69933216D1 (de)	2006-10-26	Erythropoietin-analog-menschliches serum-albumin fusionsprotein
ATE290872T1 (de)	2005-04-15	Nukleoside und oligonukleoside mit thiol-gruppe
CA2345024A1 (en)	2000-04-13	Modified tgf-.beta. superfamily proteins
EP1712623A3 (de)	2008-10-15	Selektion von Proteinen unter Verwendung von RNA-protein-fusionen
BG101103A (bg)	1997-10-31	Теломераза при бозайници
EE03693B1 (et)	2002-04-15	Isoleeritud dimeerne fibroblastide aktivatsioonivalk alfa ja selle kasutusalad
DE69937291D1 (de)	2007-11-22	Antikörper varianten und fragmente davon
DE69931507D1 (de)	2006-06-29	Interferon-beta fusionsproteine und deren verwendungen
ATE321777T1 (de)	2006-04-15	Ölkörper und damit assoziierte proteine als affinitätsmatrix
WO2003000853A3 (en)	2003-12-04	Protein aggregation assays and uses thereof
DE69839444D1 (de)	2008-06-19	Smad 6 und dessen anwendungen
DE69435307D1 (de)	2010-09-16	Bazillus Thuringiensis und dessen insektizide Proteine
ATE348159T1 (de)	2007-01-15	Mutierte mitglieder der tgf-beta-superfamilie, einschliesslich morphogenetischer proteine
TR200100056T2 (tr)	2001-11-21	Nörotrofik faktörler
FR2766193B1 (fr)	2001-09-14	Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique
ATE227561T1 (de)	2002-11-15	Verwendung von alpha-alkylglucosiden und deren estern als antimikrobielle emulgatoren
DE69800720D1 (de)	2001-05-31	Reagenz zur Färbung von Blutzellen
ATE363070T1 (de)	2007-06-15	Auswertung von biologischen mitteln in lebenden zielzellen
EP0749312A4 (de)	1999-04-28	DIROFILARIA IMMITIS - Gp29 - PROTEINE, NUKLEINSÄUREMOLEKÜLE UND IHRE VERWENDUNGEN
ID21034A (id)	1999-04-08	Protein kinase dan penggunaannya
DE69803925D1 (de)	2002-03-28	Methode zur kalt-sterilisation von öfen des tunnel-typs im pharmazeutischen bereich und öfen zur anwendung dieser methode
TR200000416T2 (tr)	2000-07-21	Neisseria loctoferrin bağlayıcı protein.
PT929299E (pt)	2004-02-27	1,2,3,4-tetra-hidro-2-dibenzofuranaminas e 2-aminociclo-hepta ¬b\| benzofuranos substituidos
PT723552E (pt)	2003-02-28	Oligopeptidos derivados de fragmentos de proteina reactiva c