ATE364704T1 - Mutanten von op-1 - Google Patents
Mutanten von op-1Info
- Publication number
- ATE364704T1 ATE364704T1 AT99954771T AT99954771T ATE364704T1 AT E364704 T1 ATE364704 T1 AT E364704T1 AT 99954771 T AT99954771 T AT 99954771T AT 99954771 T AT99954771 T AT 99954771T AT E364704 T1 ATE364704 T1 AT E364704T1
- Authority
- AT
- Austria
- Prior art keywords
- proteins
- finger
- domain
- sub
- tgf
- Prior art date
Links
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
- 102000035118 modified proteins Human genes 0.000 abstract 2
- 108091005573 modified proteins Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000921 morphogenic effect Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10341898P | 1998-10-07 | 1998-10-07 | |
| US09/374,958 US6677432B1 (en) | 1998-10-07 | 1999-08-16 | Mutations of the C-terminal portion of TGF-β superfamily proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE364704T1 true ATE364704T1 (de) | 2007-07-15 |
Family
ID=26800441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99954771T ATE364704T1 (de) | 1998-10-07 | 1999-10-07 | Mutanten von op-1 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6677432B1 (de) |
| EP (1) | EP1117804B1 (de) |
| JP (3) | JP3971107B2 (de) |
| AT (1) | ATE364704T1 (de) |
| AU (1) | AU772930B2 (de) |
| CA (1) | CA2344974C (de) |
| DE (1) | DE69936312T2 (de) |
| WO (1) | WO2000020607A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6919308B2 (en) * | 1988-04-08 | 2005-07-19 | Stryker Corporation | Osteogenic devices |
| US6586388B2 (en) * | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
| EP1225225A3 (de) * | 1988-04-08 | 2003-01-08 | Stryker Corporation | Osteogene Vorrichtungen |
| ATE364629T1 (de) * | 1996-01-22 | 2007-07-15 | Curis Inc | Methoden zur herstellung von op-1 morphogen analoge |
| US20030185792A1 (en) * | 1996-01-22 | 2003-10-02 | Curis, Inc. | Morphogen analogs of bone morphogenic proteins |
| US8106001B2 (en) * | 1996-08-27 | 2012-01-31 | University Of South Florida | Diagnostic markers of human female infertility |
| US6683156B1 (en) | 1996-08-27 | 2004-01-27 | University Of South Florida | Method for diagnosing selected adenocarcinomas |
| US7211644B1 (en) * | 1996-08-27 | 2007-05-01 | University Of South Florida | Diagnostic markers of human female infertility |
| US6294662B1 (en) | 1996-08-27 | 2001-09-25 | University Of South Florida | Nucleic acids encoding an endometrial bleeding associated factor (ebaf) |
| EP1117805A2 (de) * | 1998-10-07 | 2001-07-25 | STRYKER CORPORATION (a Michigan corporation) | Modifizierte proteine der tgf-beta superfamilie |
| DE10026713A1 (de) * | 2000-05-30 | 2001-12-06 | Walter Sebald | Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta |
| JP4685294B2 (ja) * | 2001-09-18 | 2011-05-18 | 株式会社カネカ | 新規ペプチド、生産方法、新規吸着体、吸着器および吸着方法 |
| EP2392659B1 (de) * | 2002-06-17 | 2015-01-14 | Thrasos Innovation, Inc. | TDF-zugehörige Einzeldomänenverbindungen und Analoge davon |
| CA2504768A1 (en) | 2002-11-14 | 2004-05-27 | Adherex Technologies, Inc. | Compounds and methods for modulating functions of classical cadherins |
| JP2008500816A (ja) * | 2004-03-31 | 2008-01-17 | ゼンコー・インコーポレイテッド | 改善された性質を有するｂｍｐ−７変異体 |
| US7795389B2 (en) | 2004-09-28 | 2010-09-14 | The Board Of Regents Of The University Of Texas System | Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins |
| EP1698691A1 (de) * | 2005-03-04 | 2006-09-06 | Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH | Mutanten von Wachstumsfaktoren mit verbesserter biologischer Eigenschaft |
| WO2006125867A1 (en) * | 2005-05-27 | 2006-11-30 | Bbs-Bioactive Bone Substitutes Oy | Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof |
| US7659250B2 (en) * | 2005-12-22 | 2010-02-09 | Centocor, Inc. | BMP-7 variant compositions, methods and uses |
| GB0604938D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Proteins, nucleic acids and medicaments |
| GB0604964D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Protein folding |
| GB0604966D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Medicaments and proteins |
| JP2009544325A (ja) * | 2006-07-27 | 2009-12-17 | セントカー・インコーポレーテツド | Ｂｍｐ−７変異体組成物、方法および使用 |
| ES2447516T3 (es) | 2006-12-21 | 2014-03-12 | Stryker Corporation | Formulaciones de liberación sostenida que comprenden cristales BMP-7 |
| JP5819734B2 (ja) | 2009-02-12 | 2015-11-24 | ストライカー コーポレイションＳｔｒｙｋｅｒ Ｃｏｒｐｏｒａｔｉｏｎ | ＴＧＦ−βスーパーファミリーメンバー含有タンパク質の最小に侵襲性の全身送達のための組成物および方法 |
| CA2752157A1 (en) | 2009-02-12 | 2010-08-19 | Stryker Corporation | Peripheral administration of proteins including tgf-.beta. superfamily members for systemic treatment of disorders and disease |
| KR101558642B1 (ko) | 2009-02-24 | 2015-10-12 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | Ｔｇｆ-베타 슈퍼패밀리의 설계자 리간드 |
| US20120148539A1 (en) | 2009-03-24 | 2012-06-14 | Moulay Hicham Alaoui-Ismaili | Methods and Compositions for Tissue Engineering |
| WO2011031856A1 (en) | 2009-09-09 | 2011-03-17 | Stryker Corporation | Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint |
| ES2387379T3 (es) | 2009-09-17 | 2012-09-21 | Stryker Corporation | Tampones para controlar el pH de las proteínas morfogenéticas óseas |
| AU2010341565A1 (en) | 2009-12-22 | 2012-07-12 | Stryker Corporation | BMP-7 variants with reduced immunogenicity |
| CU24181B1 (es) * | 2012-11-09 | 2016-04-25 | Ct De Inmunología Molecular | POLIPÉPTIDOS DERIVADOS DEL TGFß |
| AU2015374114B2 (en) | 2014-12-29 | 2018-07-26 | Bioventus, Llc | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
| CN109311956A (zh) | 2015-08-25 | 2019-02-05 | 伊斯迪德股份公司 | 诱导组织形成的化合物及其应用 |
| EP3341397B1 (de) * | 2015-08-25 | 2024-12-18 | Histide AG | Verbindungen zur induzierung von gewebebildung und verwendungen davon |
| US11512126B2 (en) | 2016-05-31 | 2022-11-29 | Mogam Institute For Biomedicak Research | AB6 family designer ligands of TGF-β superfamily |
| WO2020095894A1 (ja) * | 2018-11-05 | 2020-05-14 | 味の素株式会社 | フローマイクロリアクターを用いるリフォールディングされたタンパク質の製造方法及びタンパク質のリフォールディング装置 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5250302A (en) | 1988-04-08 | 1993-10-05 | Stryker Corporation | Osteogenic devices |
| ATE167486T1 (de) | 1989-10-17 | 1998-07-15 | Stryker Corp | Osteogene vorrichtungen |
| CA2070393A1 (en) | 1989-10-18 | 1991-04-19 | Charles M. Cohen | Biosynthetic constructs of tgf-beta |
| GB8927546D0 (en) | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
| US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
| DK0575555T3 (da) | 1991-03-11 | 2001-11-05 | Curis Inc | Proteininduceret morfogenese |
| DE4131545C2 (de) | 1991-09-21 | 1995-02-02 | Krupp Industrietech | Federbein für hydraulischen Radantrieb |
| EP1439190A1 (de) | 1993-01-12 | 2004-07-21 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-5 |
| JPH09503903A (ja) | 1993-07-09 | 1997-04-22 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 増殖分化因子−６ |
| AU689184B2 (en) | 1993-12-07 | 1998-03-26 | Genetics Institute, Llc | BMP-12, BMP-13 and tendon-inducing compositions thereof |
| US5399677A (en) | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
| FR2720069A1 (fr) | 1994-05-19 | 1995-11-24 | Inst Nat Sante Rech Med | Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques. |
| US5674292A (en) | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
-
1999
- 1999-08-16 US US09/374,958 patent/US6677432B1/en not_active Expired - Lifetime
- 1999-10-07 CA CA2344974A patent/CA2344974C/en not_active Expired - Fee Related
- 1999-10-07 JP JP2000574702A patent/JP3971107B2/ja not_active Expired - Fee Related
- 1999-10-07 EP EP99954771A patent/EP1117804B1/de not_active Expired - Lifetime
- 1999-10-07 AT AT99954771T patent/ATE364704T1/de not_active IP Right Cessation
- 1999-10-07 AU AU11038/00A patent/AU772930B2/en not_active Ceased
- 1999-10-07 DE DE69936312T patent/DE69936312T2/de not_active Expired - Lifetime
- 1999-10-07 WO PCT/US1999/023371 patent/WO2000020607A2/en not_active Ceased
-
2005
- 2005-06-17 JP JP2005178654A patent/JP4294010B2/ja not_active Expired - Fee Related
-
2008
- 2008-05-20 JP JP2008132454A patent/JP5149070B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69936312T2 (de) | 2008-02-14 |
| JP2005290016A (ja) | 2005-10-20 |
| EP1117804A2 (de) | 2001-07-25 |
| DE69936312D1 (de) | 2007-07-26 |
| JP4294010B2 (ja) | 2009-07-08 |
| JP2002526115A (ja) | 2002-08-20 |
| EP1117804B1 (de) | 2007-06-13 |
| AU772930B2 (en) | 2004-05-13 |
| JP5149070B2 (ja) | 2013-02-20 |
| WO2000020607A2 (en) | 2000-04-13 |
| WO2000020607A3 (en) | 2000-07-06 |
| AU1103800A (en) | 2000-04-26 |
| JP2008237223A (ja) | 2008-10-09 |
| CA2344974A1 (en) | 2000-04-13 |
| JP3971107B2 (ja) | 2007-09-05 |
| WO2000020607A9 (en) | 2001-03-29 |
| US6677432B1 (en) | 2004-01-13 |
| CA2344974C (en) | 2011-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |