ATE366726T1 - Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole - Google Patents

Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole

Info

Publication number: ATE366726T1
Authority: AT; Austria
Prior art keywords: stereoselective synthesis; trifluoromethyl; substituted alcohols; aryl; alkyl
Prior art date: 2003-10-16

Application number

AT04789408T

Other languages

English (en)

Inventor

Jinhua J Song

Zhulin Tan

Jinghua Xu

Nathan K Yee

Chris H Senanayake

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-16

Filing date

2004-09-30

Publication date

2007-08-15

2004-09-30 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE366726T1 publication Critical patent/ATE366726T1/de

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
230000000707 stereoselective effect Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
150000001298 alcohols Chemical class 0.000 title 1
125000001424 substituent group Chemical group 0.000 abstract 4
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 1
125000006730 (C2-C5) alkynyl group Chemical group 0.000 abstract 1
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000005133 alkynyloxy group Chemical group 0.000 abstract 1
125000003435 aroyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
-1 chloro, hydroxy Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000003003 spiro group Chemical group 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT04789408T 2003-10-16 2004-09-30 Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole ATE366726T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US51174403P	2003-10-16	2003-10-16

Publications (1)

Publication Number	Publication Date
ATE366726T1 true ATE366726T1 (de)	2007-08-15

Family

ID=34520036

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04789408T ATE366726T1 (de)	2003-10-16	2004-09-30	Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole

Country Status (8)

Country	Link
US (1)	US7507843B2 (de)
EP (1)	EP1675839B1 (de)
JP (1)	JP4468369B2 (de)
AT (1)	ATE366726T1 (de)
CA (1)	CA2542741A1 (de)
DE (1)	DE602004007539T2 (de)
ES (1)	ES2290769T3 (de)
WO (1)	WO2005040145A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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JP4324480B2 (ja) *	2002-03-26	2009-09-02	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	グルココルチコイドミメティクス、その製法、医薬組成物、及び使用
HRP20050185A2 (en) *	2002-08-29	2006-05-31	Boehringer Ingelheim Pharmaceuticals Inc.	-3 (sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
UY28526A1 (es) *	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7795272B2 (en) *	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US7635711B2 (en) *	2004-12-27	2009-12-22	Boehringer-Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AR060536A1 (es)	2006-04-20	2008-06-25	Glaxo Group Ltd	Agonista del receptor de glucocorticoides y composiciones farmaceuticas
JP2010512331A (ja) *	2006-12-06	2010-04-22	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	グルココルチコイド模倣薬、それらの製造方法、医薬組成物、及びこれらの使用
DK2300472T3 (da) *	2008-06-06	2012-04-10	Boehringer Ingelheim Int	Glucocorticoidmimetika, fremgangsmåder til disses fremstilling, farmaceutiske sammensætninger samt anvendelser deraf
US20110130578A1 (en) *	2009-06-03	2011-06-02	Boehringer Ingelheim International Gmbh	Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
JP5472217B2 (ja)	2011-06-29	2014-04-16	信越化学工業株式会社	２，２−ビス（フルオロアルキル）オキシラン類を用いた光酸発生剤の製造方法

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US7186864B2 (en) *	2002-05-29	2007-03-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) *	2002-06-06	2006-07-11	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AU2003259747A1 (en) *	2002-08-21	2004-03-11	Boehringer Ingelheim Pharmaceuticals, Inc.	Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
HRP20050185A2 (en) *	2002-08-29	2006-05-31	Boehringer Ingelheim Pharmaceuticals Inc.	-3 (sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
CA2512257A1 (en) *	2003-01-03	2004-07-29	Boehringer Ingelheim Pharmaceuticals, Inc.	1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
US20040224992A1 (en) *	2003-02-27	2004-11-11	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

2004
- 2004-09-30 DE DE602004007539T patent/DE602004007539T2/de not_active Expired - Lifetime
- 2004-09-30 ES ES04789408T patent/ES2290769T3/es not_active Expired - Lifetime
- 2004-09-30 EP EP04789408A patent/EP1675839B1/de not_active Expired - Lifetime
- 2004-09-30 WO PCT/US2004/032257 patent/WO2005040145A1/en not_active Ceased
- 2004-09-30 CA CA002542741A patent/CA2542741A1/en not_active Abandoned
- 2004-09-30 US US10/955,165 patent/US7507843B2/en not_active Expired - Lifetime
- 2004-09-30 JP JP2006535528A patent/JP4468369B2/ja not_active Expired - Lifetime
- 2004-09-30 AT AT04789408T patent/ATE366726T1/de active

Also Published As

Publication number	Publication date
WO2005040145A1 (en)	2005-05-06
DE602004007539T2 (de)	2007-10-25
US20050131241A1 (en)	2005-06-16
EP1675839B1 (de)	2007-07-11
JP2007509069A (ja)	2007-04-12
JP4468369B2 (ja)	2010-05-26
DE602004007539D1 (de)	2007-08-23
CA2542741A1 (en)	2005-05-06
EP1675839A1 (de)	2006-07-05
ES2290769T3 (es)	2008-02-16
US7507843B2 (en)	2009-03-24

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