MX2009005449A - Compuesto heteromonociclico y uso del mismo. - Google Patents

Compuesto heteromonociclico y uso del mismo.

Info

Publication number
MX2009005449A
MX2009005449A MX2009005449A MX2009005449A MX2009005449A MX 2009005449 A MX2009005449 A MX 2009005449A MX 2009005449 A MX2009005449 A MX 2009005449A MX 2009005449 A MX2009005449 A MX 2009005449A MX 2009005449 A MX2009005449 A MX 2009005449A
Authority
MX
Mexico
Prior art keywords
formula
compound
group
group represented
alkylamino
Prior art date
Application number
MX2009005449A
Other languages
English (en)
Inventor
Takanobu Kuroita
Hiroki Sakamoto
Hideyuki Igawa
Minoru Sasaki
Kouhei Asano
Tsuyoshi Maekawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MX2009005449A publication Critical patent/MX2009005449A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de la presente invención representado por la fórmula (I): (ver fórmula (I)) en donde R1 es un grupo oxo, =N-R o similar; un grupo representado por la fórmula: (ver fórmula) es un grupo representado por la formula: (ver fórmulas) R2 es un grupo representado por la fórmula: (ver fórmula) R3 y R4 son cada uno H, o C1-C6 alquilo, C3-C6 cicloalquilo, C1-C6 alcoxi, C1-C6 alquilamino, di(C1-C6)alquilamino o C1-C6 alquiltio, cada uno de los cuales es opcionalmente substituido; y R5 es H, o un grupo C1-C6 alquilo, C2-C6 alquenilo, cíclico, cada uno de los cuales es opcionalmente substituido, -CO-R8 o -O-R8', o una sal del mismo. El compuesto de la presente invención es útil como un fármaco para la profilaxis o tratamiento de enfermedades circulatorias, enfermedades metabólicas y/o enfermedades del sistema nervioso central.
MX2009005449A 2006-11-24 2007-11-21 Compuesto heteromonociclico y uso del mismo. MX2009005449A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006317839 2006-11-24
JP2007232106 2007-09-06
PCT/JP2007/073004 WO2008062905A2 (en) 2006-11-24 2007-11-21 Heteromonocyclic compound and use thereof

Publications (1)

Publication Number Publication Date
MX2009005449A true MX2009005449A (es) 2009-06-02

Family

ID=39205144

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005449A MX2009005449A (es) 2006-11-24 2007-11-21 Compuesto heteromonociclico y uso del mismo.

Country Status (21)

Country Link
US (2) US20100056526A1 (es)
EP (2) EP2256115A1 (es)
JP (1) JP2010510962A (es)
KR (1) KR20090085117A (es)
AR (1) AR063912A1 (es)
AU (1) AU2007322608A1 (es)
BR (1) BRPI0719060A2 (es)
CA (1) CA2670404A1 (es)
CL (1) CL2007003352A1 (es)
CO (1) CO6231035A2 (es)
CR (1) CR10847A (es)
EA (1) EA200970510A1 (es)
EC (1) ECSP099461A (es)
IL (1) IL198819A0 (es)
MA (1) MA30985B1 (es)
MX (1) MX2009005449A (es)
NO (1) NO20092415L (es)
PE (1) PE20081228A1 (es)
TN (1) TN2009000199A1 (es)
TW (1) TW200829581A (es)
WO (1) WO2008062905A2 (es)

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Also Published As

Publication number Publication date
AU2007322608A1 (en) 2008-05-29
BRPI0719060A2 (pt) 2014-02-04
IL198819A0 (en) 2010-02-17
CO6231035A2 (es) 2010-12-20
CA2670404A1 (en) 2008-05-29
EP2074117A2 (en) 2009-07-01
CL2007003352A1 (es) 2008-07-04
MA30985B1 (fr) 2009-12-01
AU2007322608A2 (en) 2009-07-16
US20080207654A1 (en) 2008-08-28
CR10847A (es) 2009-07-13
WO2008062905A2 (en) 2008-05-29
TW200829581A (en) 2008-07-16
JP2010510962A (ja) 2010-04-08
TN2009000199A1 (en) 2010-10-18
ECSP099461A (es) 2009-11-30
EA200970510A1 (ru) 2009-12-30
PE20081228A1 (es) 2008-10-29
EP2256115A1 (en) 2010-12-01
US20100056526A1 (en) 2010-03-04
AR063912A1 (es) 2009-02-25
KR20090085117A (ko) 2009-08-06
WO2008062905A3 (en) 2008-12-04
NO20092415L (no) 2009-08-17

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