ATE366803T1 - Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit - Google Patents

Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit

Info

Publication number
ATE366803T1
ATE366803T1 AT00960038T AT00960038T ATE366803T1 AT E366803 T1 ATE366803 T1 AT E366803T1 AT 00960038 T AT00960038 T AT 00960038T AT 00960038 T AT00960038 T AT 00960038T AT E366803 T1 ATE366803 T1 AT E366803T1
Authority
AT
Austria
Prior art keywords
cell viability
cytokine production
improved cell
high cytokine
pkr
Prior art date
Application number
AT00960038T
Other languages
English (en)
Inventor
Allan Lau
Laura Browning
Michael Kiefer
Original Assignee
Genetrol Biotherapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetrol Biotherapeutics filed Critical Genetrol Biotherapeutics
Application granted granted Critical
Publication of ATE366803T1 publication Critical patent/ATE366803T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00960038T 1999-09-08 2000-09-08 Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit ATE366803T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15285499P 1999-09-08 1999-09-08

Publications (1)

Publication Number Publication Date
ATE366803T1 true ATE366803T1 (de) 2007-08-15

Family

ID=22544735

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00960038T ATE366803T1 (de) 1999-09-08 2000-09-08 Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit

Country Status (8)

Country Link
EP (1) EP1214399B1 (de)
JP (1) JP2003509025A (de)
AT (1) ATE366803T1 (de)
AU (1) AU7126000A (de)
CA (1) CA2383563A1 (de)
DE (1) DE60035515T2 (de)
HK (1) HK1048135A1 (de)
WO (1) WO2001018185A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031859A1 (en) * 1999-09-08 2001-10-18 Lau Allan S. High level cytokine production with enhanced cell viability
CA2384880C (en) 1999-09-27 2010-09-21 Genentech, Inc. Methods for making recombinant proteins using apoptosis inhibitors
CN1527721A (zh) * 2000-09-12 2004-09-08 基因特罗生物治疗公司 含治疗性蛋白混合物的组合物及其生产方法
WO2002022786A1 (en) 2000-09-14 2002-03-21 Genetrol Biotherapeutics, Inc. Method and cell composition for screening compounds for anti-inflammatory activity
WO2005083060A1 (en) 2004-03-01 2005-09-09 Kitakyushu Foundation For The Advancement Of Industry, Science And Technology Human cell strains for protein production, provided by selecting strains with high intracellular protein and mutating with carcinogens
US9005974B2 (en) 2005-12-09 2015-04-14 Academish Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for influencing the stability of cells
BRPI0619579B8 (pt) 2005-12-09 2022-01-25 Academisch Medisch Centrum Bij De Univ Van Amsterdam Métodos para aumentar a expectativa de vida replicativa e/ou estabilidade de uma célula produtora de anticorpo, para expressar um gene de uma célula b codificando a cadeia pesada de ig e/ou cadeia leve de ig, para produzir linhagem de células b, para obter anticorpos, e, método ex vivo para produzir anticorpos capazes de especificamente ligar um antígeno de interesse
DK2454283T3 (en) 2009-07-15 2018-05-07 Aimm Therapeutics Bv METHODS AND PROCEDURES FOR MANUFACTURING HIGH EFFICIENCY ANTIBODIES
DK2646466T3 (en) 2010-12-02 2017-06-06 Aimm Therapeutics Bv METHODS AND METHODS FOR MANUFACTURING HIGH EFFICIENCY ANTIBODIES
EP3099709B1 (de) 2014-01-31 2019-12-25 AIMM Therapeutics B.V. Mittel und verfahren zur herstellung von stabilen antikörpern

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840565A (en) * 1995-08-22 1998-11-24 The Regents Of The University Of California Methods for enhancing the production of viral vaccines in PKR-deficient cell culture
AU3583797A (en) * 1996-06-28 1998-01-21 Regents Of The University Of California, The Enhancement of cancer cell death

Also Published As

Publication number Publication date
EP1214399B1 (de) 2007-07-11
CA2383563A1 (en) 2001-03-15
HK1048135A1 (zh) 2003-03-21
DE60035515T2 (de) 2008-04-17
JP2003509025A (ja) 2003-03-11
AU7126000A (en) 2001-04-10
EP1214399A1 (de) 2002-06-19
WO2001018185A1 (en) 2001-03-15
DE60035515D1 (de) 2007-08-23

Similar Documents

Publication Publication Date Title
DE69634360D1 (de) Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon
ATE359358T1 (de) Verfahren und medien zur kontrolle der sialysierung von proteinen, die von säugetierzellen produziert werden
EA200501774A1 (ru) Культуры e1-иммортализованных клеток и способы их культивирования с целью повышения выхода их продукции
DK1651758T3 (da) Fremgangsmåde tl fremstilling af L-lysin eller L-threonin ved anvendelse af Escherichia bakterier med svækket æblesyreenzymaktivitet
ATE482267T1 (de) Tierzellen und verfahren für die replikation von influenza viren
DK1650307T3 (da) Fremgangsmåde til fremstilling af rekombinante proteiner ved anvendelse af apoptoseinhibitorer
ES2120946T3 (es) Sistemas y medios de cultivo celular.
ATE368103T1 (de) Isolierung, vermehrung und gezielte differenzierung von zäugetierstammzellen des zentralnervensystems
WO2004081205A8 (en) Differentiation of human embryonic stem cells to cardiomyocytes
BR9805900B1 (pt) processo para integrar um fragmento de dna no genoma de uma célula de uma planta manocotiledÈnea.
DE69937966D1 (de) Produktion lymphoider gewebsspezifischer zellen von hämatopoietischen vorläuferzellen in einem dreidimensionalen system
WO2004090096A3 (en) Methods for neural differentiation of embryonic stem cells using protease passaging techniques
DE60138127D1 (de) Stoffwechseländerungen in gärungen zur produktion rekombinanter proteine
ATE366803T1 (de) Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit
WO2000077236A3 (en) Methods for enhancing the production of cytokines in cell cultur e
UA92157C2 (ru) Способ продуцирования гормона роста
DE60307615D1 (de) Zellkulturmedium
EP1687413B8 (de) Verfahren zur differenzierung einer mesenchym-stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit
GB2429211A (en) Feeder independent extended culture of embryonic stem cells
DK1554374T3 (da) Fremgangsmåde til storskala T-lymfocytdyrkning i et homogent system
AR043862A1 (es) Procedimiento para la obtencion de estirpes celulares de mastocitos a partir de tejidos de cerdo y procedimiento para la produccion de moleculas de tipo de la heparina
ATE449162T1 (de) Herstellung von tcr gamma delta t-zellen
WO2005054447A3 (en) Müller stem cells
ATE396275T1 (de) Verfahren zur hestellung eines extrakts für zellfreie proteinsynthese und damit hergestellter zellextrakt
NZ515762A (en) Method of producing a heparin-binding protein by expressing it in a mammalian cell that can be cultured in anaerobic conditions

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties