ATE368107T1 - Antisense oligonukleotide die anomales splicing verhindern und deren verwendung - Google Patents

Antisense oligonukleotide die anomales splicing verhindern und deren verwendung

Info

Publication number
ATE368107T1
ATE368107T1 AT94916064T AT94916064T ATE368107T1 AT E368107 T1 ATE368107 T1 AT E368107T1 AT 94916064 T AT94916064 T AT 94916064T AT 94916064 T AT94916064 T AT 94916064T AT E368107 T1 ATE368107 T1 AT E368107T1
Authority
AT
Austria
Prior art keywords
splicing
mrna molecule
anomal
prevent
antisense oligonucleotides
Prior art date
Application number
AT94916064T
Other languages
English (en)
Inventor
Ryszard Kole
Zbigniew Dominski
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE368107T1 publication Critical patent/ATE368107T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl

Landscapes

  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT94916064T 1993-05-11 1994-05-10 Antisense oligonukleotide die anomales splicing verhindern und deren verwendung ATE368107T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6247193A 1993-05-11 1993-05-11

Publications (1)

Publication Number Publication Date
ATE368107T1 true ATE368107T1 (de) 2007-08-15

Family

ID=22042714

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94916064T ATE368107T1 (de) 1993-05-11 1994-05-10 Antisense oligonukleotide die anomales splicing verhindern und deren verwendung

Country Status (15)

Country Link
US (4) US5665593A (de)
EP (2) EP0698092B1 (de)
JP (3) JPH08510130A (de)
CN (1) CN1123038A (de)
AT (1) ATE368107T1 (de)
AU (1) AU6786594A (de)
CA (1) CA2162361C (de)
DE (1) DE69435005T2 (de)
DK (1) DK0698092T3 (de)
ES (1) ES2290951T3 (de)
FI (1) FI955428A7 (de)
NO (1) NO954550L (de)
NZ (1) NZ266386A (de)
PT (1) PT698092E (de)
WO (1) WO1994026887A1 (de)

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US5665593A (en) 1997-09-09
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CA2162361A1 (en) 1994-11-24
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ES2290951T3 (es) 2008-02-16
DE69435005D1 (de) 2007-09-06
US5916808A (en) 1999-06-29
CA2162361C (en) 2008-10-21
PT698092E (pt) 2007-10-29
JPH08510130A (ja) 1996-10-29
FI955428A7 (fi) 1996-01-04
NO954550D0 (no) 1995-11-10
DK0698092T3 (da) 2007-11-26
DE69435005T2 (de) 2008-04-17
EP0698092A1 (de) 1996-02-28
US5627274A (en) 1997-05-06
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EP1897942A1 (de) 2008-03-12
JP2008092960A (ja) 2008-04-24
CN1123038A (zh) 1996-05-22
AU6786594A (en) 1994-12-12
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