ATE368229T1 - Diagnostischer test zur bestimmung der konzentration einer transienten proteolytischen aktivität in zusammengesetzten biologischen medien - Google Patents
Diagnostischer test zur bestimmung der konzentration einer transienten proteolytischen aktivität in zusammengesetzten biologischen medienInfo
- Publication number
- ATE368229T1 ATE368229T1 AT03747454T AT03747454T ATE368229T1 AT E368229 T1 ATE368229 T1 AT E368229T1 AT 03747454 T AT03747454 T AT 03747454T AT 03747454 T AT03747454 T AT 03747454T AT E368229 T1 ATE368229 T1 AT E368229T1
- Authority
- AT
- Austria
- Prior art keywords
- thrombin
- activity
- determining
- measured
- blood
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title 1
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 230000002797 proteolythic effect Effects 0.000 title 1
- 230000001052 transient effect Effects 0.000 title 1
- 108090000190 Thrombin Proteins 0.000 abstract 6
- 229960004072 thrombin Drugs 0.000 abstract 6
- 230000000694 effects Effects 0.000 abstract 4
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- 239000000523 sample Substances 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 206010010356 Congenital anomaly Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000035602 clotting Effects 0.000 abstract 1
- 239000013068 control sample Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000001960 triggered effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02076744 | 2002-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE368229T1 true ATE368229T1 (de) | 2007-08-15 |
Family
ID=29286179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03747454T ATE368229T1 (de) | 2002-05-01 | 2003-05-01 | Diagnostischer test zur bestimmung der konzentration einer transienten proteolytischen aktivität in zusammengesetzten biologischen medien |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8802386B2 (de) |
| EP (1) | EP1504269B1 (de) |
| JP (1) | JP4718833B2 (de) |
| CN (1) | CN100350252C (de) |
| AT (1) | ATE368229T1 (de) |
| AU (1) | AU2003232720B9 (de) |
| CA (1) | CA2484554C (de) |
| DE (1) | DE60315151T2 (de) |
| DK (1) | DK1504269T3 (de) |
| ES (1) | ES2291661T3 (de) |
| WO (1) | WO2003093831A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004059055A1 (de) * | 2004-12-07 | 2006-06-08 | Dade Behring Marburg Gmbh | Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials |
| JP4931826B2 (ja) * | 2005-01-07 | 2012-05-16 | スティヒティング・カトリーケ・ユニフェルジテイト | 止血アッセイ |
| DE102005008066A1 (de) | 2005-02-22 | 2006-08-24 | Haemosys Gmbh | Verfahren zur Bestimmung der Gesamtgerinnungsaktivität einer Blut- oder Plasmaprobe |
| EP1717588A1 (de) | 2005-04-29 | 2006-11-02 | Synapse B.V. | Bestimmung der Thrombinaktivität in Vollblut |
| DE602005023433D1 (de) | 2005-07-07 | 2010-10-21 | Asulab Sa | System zur differenziellen Bestimmung der Menge eines proteolytischen Enzyms in einer Körperflüssigkeit |
| EP2029768B1 (de) * | 2006-06-06 | 2013-02-13 | Thrombinoscope B.V. | Verfahren zur bestimmung der thrombinaktivität in plasma |
| JP2010508036A (ja) * | 2006-11-02 | 2010-03-18 | トロームビノスコープ ベスローテン フェンノートシャップ | 細胞を含む複合性の生物学的媒体において一過性のプロテイン分解活性の濃度を測定するための方法 |
| ATE516504T1 (de) | 2008-02-07 | 2011-07-15 | Synapse Bv | Um den einfluss von störfaktoren korrigierte messung des zeitlichen verlaufs einer enzymatischen aktivität bei der reaktion eines enzyms mit einem substrat |
| FR2933496B1 (fr) * | 2008-07-02 | 2012-10-05 | Lfb Biotechnologies | Procede de mesure du taux de facteur vii active dans un echantillon |
| WO2010006605A2 (en) * | 2008-07-16 | 2010-01-21 | Radiometer Medical Aps | Thrombin substrate and assay for determining the level of bioactive thrombin in a sample |
| DE102009040879B4 (de) * | 2009-09-09 | 2012-12-06 | Andreas Hettich Gmbh & Co. Kg | Verfahren zur Bestimmung der Gerinnungszeit |
| CA2811493C (en) * | 2010-09-15 | 2020-06-16 | Debiopharm International Sa | Method for separating target molecules or particles from fibrinogen-containing samples including blood components |
| EP2465941A1 (de) | 2010-12-20 | 2012-06-20 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur simultanen Bestimmung mehrerer Gerinnungsproteasen |
| AU2012281017B2 (en) * | 2011-07-13 | 2017-07-20 | T2 Biosystems, Inc. | NMR methods for monitoring blood clot formation |
| RU2518247C2 (ru) * | 2011-07-26 | 2014-06-10 | Общество с ограниченной ответственностью "ГемаКор Лабс" (ООО "ГемаКор Лабс") | Способ определения пространственно-временного распределения активности протеолитического фермента в гетерогенной системе, устройство для реализации указанного способа и способ диагностики нарушений системы гемостаза по изменению пространственно-временного распределения активности протеолитического фермента в гетерогенной системе |
| US20140296146A1 (en) * | 2011-08-23 | 2014-10-02 | Synapse B.V. | Thermostable Inhibitors of Activation of the Blood Clotting System Through Contact with Foreign Surfaces |
| EP2677037B1 (de) | 2012-06-21 | 2016-04-13 | Synapse B.V. | Gleichzeitige Messung der Thrombinerzeugung und Gerinnselfestigkeit in Plasma und im gesamten Blut |
| WO2014098056A1 (ja) | 2012-12-18 | 2014-06-26 | 第一三共株式会社 | トロンビン産生の測定方法 |
| US10633645B2 (en) * | 2015-12-30 | 2020-04-28 | General Electric Company | Calcium controlled activation of platelets via electrical stimulation |
| EP3363912B1 (de) | 2017-02-17 | 2020-10-28 | Synapse B.V. | Selbstkalibrierter assay zur bestimmung der erzeugung von proteolytischem enzym, dedizierte mittel und verwendungen davon |
| CN110082447B (zh) * | 2019-05-09 | 2024-05-31 | 同济大学 | 同步表征水样溶解性有机质结构/理化/浓度特性的仪器 |
| EP4004560A4 (de) * | 2019-07-31 | 2022-11-30 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Verfahren und kits zur identifizierung des ursprungs eines thrombus und optimierung der behandlung nach einem ischämischen ereignis |
| CN112067575A (zh) * | 2020-09-09 | 2020-12-11 | 吴俊� | 血液纤维蛋白溶解功能检测方法 |
| CN114958963B (zh) * | 2022-07-29 | 2023-09-05 | 深圳传世生物医疗有限公司 | 一种作用于凝血酶的抗凝药物检测试剂盒及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6740496B1 (en) * | 1999-03-04 | 2004-05-25 | Synapse B.V. | Determination of biologically active forms of proteolytic enzymes |
| ATE264401T1 (de) * | 1999-03-04 | 2004-04-15 | Synapse Bv | Bestimmung von biologisch aktiven formen von proteolytischen enzymen |
-
2003
- 2003-05-01 CA CA2484554A patent/CA2484554C/en not_active Expired - Fee Related
- 2003-05-01 CN CNB038099381A patent/CN100350252C/zh not_active Expired - Fee Related
- 2003-05-01 ES ES03747454T patent/ES2291661T3/es not_active Expired - Lifetime
- 2003-05-01 JP JP2004501999A patent/JP4718833B2/ja not_active Expired - Lifetime
- 2003-05-01 DK DK03747454T patent/DK1504269T3/da active
- 2003-05-01 DE DE60315151T patent/DE60315151T2/de not_active Expired - Lifetime
- 2003-05-01 US US10/514,269 patent/US8802386B2/en active Active
- 2003-05-01 AT AT03747454T patent/ATE368229T1/de active
- 2003-05-01 AU AU2003232720A patent/AU2003232720B9/en not_active Ceased
- 2003-05-01 EP EP03747454A patent/EP1504269B1/de not_active Expired - Lifetime
- 2003-05-01 WO PCT/EP2003/004705 patent/WO2003093831A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60315151T2 (de) | 2008-04-10 |
| AU2003232720B2 (en) | 2009-10-29 |
| ES2291661T3 (es) | 2008-03-01 |
| AU2003232720B9 (en) | 2009-12-03 |
| DE60315151D1 (de) | 2007-09-06 |
| DK1504269T3 (da) | 2007-12-03 |
| WO2003093831A1 (en) | 2003-11-13 |
| US8802386B2 (en) | 2014-08-12 |
| CN100350252C (zh) | 2007-11-21 |
| CA2484554A1 (en) | 2003-11-13 |
| JP4718833B2 (ja) | 2011-07-06 |
| CA2484554C (en) | 2012-12-04 |
| AU2003232720A1 (en) | 2003-11-17 |
| CN1650170A (zh) | 2005-08-03 |
| JP2005528097A (ja) | 2005-09-22 |
| EP1504269B1 (de) | 2007-07-25 |
| US20060051828A1 (en) | 2006-03-09 |
| EP1504269A1 (de) | 2005-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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