ATE368229T1 - Diagnostischer test zur bestimmung der konzentration einer transienten proteolytischen aktivität in zusammengesetzten biologischen medien - Google Patents
Diagnostischer test zur bestimmung der konzentration einer transienten proteolytischen aktivität in zusammengesetzten biologischen medienInfo
- Publication number
- ATE368229T1 ATE368229T1 AT03747454T AT03747454T ATE368229T1 AT E368229 T1 ATE368229 T1 AT E368229T1 AT 03747454 T AT03747454 T AT 03747454T AT 03747454 T AT03747454 T AT 03747454T AT E368229 T1 ATE368229 T1 AT E368229T1
- Authority
- AT
- Austria
- Prior art keywords
- thrombin
- activity
- determining
- measured
- blood
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title 1
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 230000002797 proteolythic effect Effects 0.000 title 1
- 230000001052 transient effect Effects 0.000 title 1
- 108090000190 Thrombin Proteins 0.000 abstract 6
- 229960004072 thrombin Drugs 0.000 abstract 6
- 230000000694 effects Effects 0.000 abstract 4
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- 239000000523 sample Substances 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 206010010356 Congenital anomaly Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000035602 clotting Effects 0.000 abstract 1
- 239000013068 control sample Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000001960 triggered effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02076744 | 2002-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE368229T1 true ATE368229T1 (de) | 2007-08-15 |
Family
ID=29286179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03747454T ATE368229T1 (de) | 2002-05-01 | 2003-05-01 | Diagnostischer test zur bestimmung der konzentration einer transienten proteolytischen aktivität in zusammengesetzten biologischen medien |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8802386B2 (de) |
| EP (1) | EP1504269B1 (de) |
| JP (1) | JP4718833B2 (de) |
| CN (1) | CN100350252C (de) |
| AT (1) | ATE368229T1 (de) |
| AU (1) | AU2003232720B9 (de) |
| CA (1) | CA2484554C (de) |
| DE (1) | DE60315151T2 (de) |
| DK (1) | DK1504269T3 (de) |
| ES (1) | ES2291661T3 (de) |
| WO (1) | WO2003093831A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004059055A1 (de) * | 2004-12-07 | 2006-06-08 | Dade Behring Marburg Gmbh | Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials |
| ES2357112T3 (es) | 2005-01-07 | 2011-04-18 | Stichting Katholieke Universiteit | Ensayo de hemostasia. |
| DE102005008066A1 (de) * | 2005-02-22 | 2006-08-24 | Haemosys Gmbh | Verfahren zur Bestimmung der Gesamtgerinnungsaktivität einer Blut- oder Plasmaprobe |
| EP1717588A1 (de) * | 2005-04-29 | 2006-11-02 | Synapse B.V. | Bestimmung der Thrombinaktivität in Vollblut |
| EP1742063B1 (de) | 2005-07-07 | 2010-09-08 | Asulab S.A. | System zur differenziellen Bestimmung der Menge eines proteolytischen Enzyms in einer Körperflüssigkeit |
| EP2029768B1 (de) * | 2006-06-06 | 2013-02-13 | Thrombinoscope B.V. | Verfahren zur bestimmung der thrombinaktivität in plasma |
| US8343730B2 (en) | 2006-11-02 | 2013-01-01 | Thrombinoscope B.V. | Method for determining the course of proteolytic activity |
| ATE516504T1 (de) | 2008-02-07 | 2011-07-15 | Synapse Bv | Um den einfluss von störfaktoren korrigierte messung des zeitlichen verlaufs einer enzymatischen aktivität bei der reaktion eines enzyms mit einem substrat |
| FR2933496B1 (fr) * | 2008-07-02 | 2012-10-05 | Lfb Biotechnologies | Procede de mesure du taux de facteur vii active dans un echantillon |
| EP2316035A2 (de) * | 2008-07-16 | 2011-05-04 | Radiometer Medical ApS | Thrombinsubstrat und testverfahren zur bestimmung des spiegels von biologisch aktivem thrombin in einer probe |
| DE102009040879B4 (de) * | 2009-09-09 | 2012-12-06 | Andreas Hettich Gmbh & Co. Kg | Verfahren zur Bestimmung der Gerinnungszeit |
| DK3067431T3 (da) * | 2010-09-15 | 2019-10-14 | Debiopharm Int Sa | Indretning omfattende blodkomponenter til at adskille målmolekyler eller partikler fra prøver |
| EP2465941A1 (de) | 2010-12-20 | 2012-06-20 | Siemens Healthcare Diagnostics Products GmbH | Verfahren zur simultanen Bestimmung mehrerer Gerinnungsproteasen |
| WO2013010080A1 (en) * | 2011-07-13 | 2013-01-17 | T2 Biosystems, Inc. | Nmr methods for monitoring blood clot formation |
| RU2518247C2 (ru) * | 2011-07-26 | 2014-06-10 | Общество с ограниченной ответственностью "ГемаКор Лабс" (ООО "ГемаКор Лабс") | Способ определения пространственно-временного распределения активности протеолитического фермента в гетерогенной системе, устройство для реализации указанного способа и способ диагностики нарушений системы гемостаза по изменению пространственно-временного распределения активности протеолитического фермента в гетерогенной системе |
| US20140296146A1 (en) | 2011-08-23 | 2014-10-02 | Synapse B.V. | Thermostable Inhibitors of Activation of the Blood Clotting System Through Contact with Foreign Surfaces |
| EP2677037B1 (de) | 2012-06-21 | 2016-04-13 | Synapse B.V. | Gleichzeitige Messung der Thrombinerzeugung und Gerinnselfestigkeit in Plasma und im gesamten Blut |
| WO2014098056A1 (ja) | 2012-12-18 | 2014-06-26 | 第一三共株式会社 | トロンビン産生の測定方法 |
| US10633645B2 (en) * | 2015-12-30 | 2020-04-28 | General Electric Company | Calcium controlled activation of platelets via electrical stimulation |
| EP3363912B1 (de) | 2017-02-17 | 2020-10-28 | Synapse B.V. | Selbstkalibrierter assay zur bestimmung der erzeugung von proteolytischem enzym, dedizierte mittel und verwendungen davon |
| CN110082447B (zh) * | 2019-05-09 | 2024-05-31 | 同济大学 | 同步表征水样溶解性有机质结构/理化/浓度特性的仪器 |
| EP4004560A4 (de) | 2019-07-31 | 2022-11-30 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Verfahren und kits zur identifizierung des ursprungs eines thrombus und optimierung der behandlung nach einem ischämischen ereignis |
| CN112067575A (zh) * | 2020-09-09 | 2020-12-11 | 吴俊� | 血液纤维蛋白溶解功能检测方法 |
| CN114958963B (zh) * | 2022-07-29 | 2023-09-05 | 深圳传世生物医疗有限公司 | 一种作用于凝血酶的抗凝药物检测试剂盒及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6740496B1 (en) * | 1999-03-04 | 2004-05-25 | Synapse B.V. | Determination of biologically active forms of proteolytic enzymes |
| WO2000052199A1 (en) * | 1999-03-04 | 2000-09-08 | Synapse B.V. | Determination of biologically active forms of proteolytic enzymes |
-
2003
- 2003-05-01 AT AT03747454T patent/ATE368229T1/de active
- 2003-05-01 ES ES03747454T patent/ES2291661T3/es not_active Expired - Lifetime
- 2003-05-01 CN CNB038099381A patent/CN100350252C/zh not_active Expired - Fee Related
- 2003-05-01 CA CA2484554A patent/CA2484554C/en not_active Expired - Fee Related
- 2003-05-01 AU AU2003232720A patent/AU2003232720B9/en not_active Ceased
- 2003-05-01 US US10/514,269 patent/US8802386B2/en active Active
- 2003-05-01 JP JP2004501999A patent/JP4718833B2/ja not_active Expired - Lifetime
- 2003-05-01 WO PCT/EP2003/004705 patent/WO2003093831A1/en not_active Ceased
- 2003-05-01 DK DK03747454T patent/DK1504269T3/da active
- 2003-05-01 DE DE60315151T patent/DE60315151T2/de not_active Expired - Lifetime
- 2003-05-01 EP EP03747454A patent/EP1504269B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN100350252C (zh) | 2007-11-21 |
| DK1504269T3 (da) | 2007-12-03 |
| ES2291661T3 (es) | 2008-03-01 |
| DE60315151T2 (de) | 2008-04-10 |
| CN1650170A (zh) | 2005-08-03 |
| US20060051828A1 (en) | 2006-03-09 |
| AU2003232720B9 (en) | 2009-12-03 |
| AU2003232720B2 (en) | 2009-10-29 |
| JP4718833B2 (ja) | 2011-07-06 |
| CA2484554A1 (en) | 2003-11-13 |
| EP1504269A1 (de) | 2005-02-09 |
| WO2003093831A1 (en) | 2003-11-13 |
| JP2005528097A (ja) | 2005-09-22 |
| US8802386B2 (en) | 2014-08-12 |
| DE60315151D1 (de) | 2007-09-06 |
| AU2003232720A1 (en) | 2003-11-17 |
| EP1504269B1 (de) | 2007-07-25 |
| CA2484554C (en) | 2012-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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