ATE368650T1 - Kondensierte azepinderivate und ihre verwendung als als antidiuretisches mittel - Google Patents

Kondensierte azepinderivate und ihre verwendung als als antidiuretisches mittel

Info

Publication number: ATE368650T1
Authority: AT; Austria
Prior art keywords: sup; azepine derivatives; antidiuretic agent; condensed; condensed azepine
Prior art date: 2000-06-26

Application number

AT01940792T

Other languages

English (en)

Inventor

Doreen Mary Ashworth

Gary Robert William Pitt

Peter Hudson

Christopher Martyn Yea

Richard Jeremy Franklin

Graeme Semple

Paul David Jenkins

Original Assignee

Ferring Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-26

Filing date

2001-06-21

Publication date

2007-08-15

2001-06-21 Application filed by Ferring Bv filed Critical Ferring Bv

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE368650T1 publication Critical patent/ATE368650T1/de

Links

229940124538 antidiuretic agent Drugs 0.000 title abstract 2
239000003160 antidiuretic agent Substances 0.000 title abstract 2
150000001538 azepines Chemical class 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 1
102000002852 Vasopressins Human genes 0.000 abstract 1
108010004977 Vasopressins Proteins 0.000 abstract 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000018 receptor agonist Substances 0.000 abstract 1
229940044601 receptor agonist Drugs 0.000 abstract 1
229960003726 vasopressin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

AT01940792T 2000-06-26 2001-06-21 Kondensierte azepinderivate und ihre verwendung als als antidiuretisches mittel ATE368650T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0015601.8A GB0015601D0 (en)	2000-06-26	2000-06-26	Novel antidiuretic agents

Publications (1)

Publication Number	Publication Date
ATE368650T1 true ATE368650T1 (de)	2007-08-15

Family

ID=9894399

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01940792T ATE368650T1 (de)	2000-06-26	2001-06-21	Kondensierte azepinderivate und ihre verwendung als als antidiuretisches mittel

Country Status (21)

Country	Link
US (1)	US7176195B2 (de)
EP (1)	EP1294698B1 (de)
JP (2)	JP3935071B2 (de)
KR (1)	KR100805808B1 (de)
CN (1)	CN1308313C (de)
AT (1)	ATE368650T1 (de)
AU (2)	AU2001274290B9 (de)
CA (1)	CA2412555A1 (de)
CZ (1)	CZ304037B6 (de)
DE (1)	DE60129697T2 (de)
GB (1)	GB0015601D0 (de)
HU (1)	HU229315B1 (de)
IL (1)	IL153358A0 (de)
MX (1)	MXPA02012779A (de)
NO (1)	NO324217B1 (de)
NZ (1)	NZ523066A (de)
PL (1)	PL359187A1 (de)
RU (1)	RU2269517C2 (de)
UA (1)	UA73177C2 (de)
WO (1)	WO2002000626A1 (de)
ZA (1)	ZA200300403B (de)

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US7138393B2 (en)	1998-07-24	2006-11-21	Wyeth	Biologically active vasopressin agonist metabolites
GB0000079D0 (en)	2000-01-05	2000-02-23	Ferring Bv	Novel antidiuretic agents
GB0115515D0 (en) *	2001-06-25	2001-08-15	Ferring Bv	Oxytocin agonisys
GB0210397D0 (en)	2002-05-07	2002-06-12	Ferring Bv	Pharmaceutical formulations
EP2426122A1 (de) *	2002-10-24	2012-03-07	Merck Patent GmbH	Methylenharnstoffderivate als Inhibitoren von RAF Kinase
ATE552236T1 (de)	2003-01-14	2012-04-15	Cytokinetics Inc	Verbindungen, zusammensetzungen und verfahren zur behandlung von herzinsuffizienz
ATE482747T1 (de) *	2003-04-11	2010-10-15	High Point Pharmaceuticals Llc	Neue amide derivate und deren pharmazeutische verwendungen
US7700583B2 (en)	2003-04-11	2010-04-20	High Point Pharmaceuticals, Llc	11β-hydroxysteroid dehydrogenase type 1 active compounds
AU2004237778B2 (en) *	2003-05-02	2008-08-14	Worcester Polytechnic Institute	Composite gas separation modules having high tamman temperature intermediate layers
EP1512687A1 (de) *	2003-09-05	2005-03-09	Ferring B.V.	Piperazine als Oxytocin-Agonisten
EP1530967B1 (de) *	2003-11-13	2006-05-03	Ferring B.V.	Blisterverpackung und feste Dosierungsform enthaltend Desmopressin
ES2522579T3 (es)	2004-06-17	2014-11-17	Cytokinetics, Inc.	Compuestos, composiciones y métodos
US7176222B2 (en)	2004-07-27	2007-02-13	Cytokinetics, Inc.	Syntheses of ureas
EP1627876A1 (de) *	2004-08-20	2006-02-22	Ferring B.V.	Kondensierte heterocyclische Verbindungen und ihre Verwendung als antidiuretische Mittel
EP1632494A1 (de)	2004-08-24	2006-03-08	Ferring B.V.	Vasopressin v1a antagonisten
CA2588768A1 (en) *	2004-11-17	2006-05-26	Kissei Pharmaceutical Co., Ltd.	Aromatic amide derivatives, medicinal compositions containing the same, medical uses of both
US7538223B2 (en)	2005-08-04	2009-05-26	Cytokinetics, Inc.	Compounds, compositions and methods
ES2419007T3 (es) *	2005-12-15	2013-08-19	Cytokinetics, Inc.	Ciertas entidades químicas, composiciones y procedimientos
US7825120B2 (en)	2005-12-15	2010-11-02	Cytokinetics, Inc.	Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
WO2007078815A2 (en)	2005-12-16	2007-07-12	Cytokinetics, Inc.	Certain chemical entities, compositions, and methods
WO2007078839A2 (en)	2005-12-19	2007-07-12	Cytokinetics, Inc.	Compounds, compositions and methods
SE528446C2 (sv) *	2006-03-02	2006-11-14	Ferring Int Ct Sa	Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
JP2010526825A (ja) *	2007-05-10	2010-08-05	エーエムアールテクノロジーインコーポレイテッド	アリール置換およびヘテロアリール置換テトラヒドロベンゾ−１，４−ジアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
AU2008283929B2 (en)	2007-08-06	2013-10-10	Serenity Pharmaceuticals, Llc	Methods and devices for desmopressin drug delivery
US11963995B2 (en)	2008-05-21	2024-04-23	Ferring B.V.	Methods comprising desmopressin
US20100286045A1 (en)	2008-05-21	2010-11-11	Bjarke Mirner Klein	Methods comprising desmopressin
PL2712622T3 (pl) *	2008-05-21	2017-01-31	Ferring B.V.	Ulegająca rozpadowi w ustach desmopresyna do zwiększania początkowego okresu snu niezakłócanego przez nokturię
GB201005623D0 (en)	2010-04-01	2010-05-19	Vantia Ltd	New polymorph
EP2681196B1 (de) *	2011-03-04	2015-09-09	Life Technologies Corporation	Verbindungen und verfahren zur konjugation von biomolekülen
GB201105537D0 (en) *	2011-03-31	2011-05-18	Vantia Ltd	New process
CN103159641A (zh) *	2011-12-14	2013-06-19	天津泰普药品科技发展有限公司	托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法
RU2480468C1 (ru) *	2012-02-16	2013-04-27	Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация"	КРИСТАЛЛИЧЕСКАЯ МОДИФИКАЦИЯ ПАРА-МЕТОКСИАНИЛИДА 6-ГИДРОКСИ-4-ОКСО-2,4-ДИГИДРО-1Н-ПИРРОЛО[3,2,1-ij]ХИНОЛИН-5-КАРБОНОВОЙ КИСЛОТЫ
CN103373960B (zh) *	2012-04-24	2017-03-01	江苏康缘药业股份有限公司	一种托伐普坦中间体及其制备方法
WO2020154581A1 (en) *	2019-01-24	2020-07-30	Assia Chemical Industries Ltd	Solid state forms of fedovapagon-salicyclic acid co-crystal
AU2024310586A1 (en)	2023-06-30	2026-02-12	Chong Kun Dang Pharmaceutical Corp.	New preparation method of compound and new crystalline form

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IL104853A (en) *	1992-02-27	1997-11-20	Yamanouchi Pharma Co Ltd	Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them
US5512563A (en) *	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
US5516774A (en)	1993-07-29	1996-05-14	American Cyanamid Company	Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
ES2284741T3 (es) *	1994-06-15	2007-11-16	Otsuka Pharmaceutical Company, Limited	Derivados de benzoheterociclicos utilizados como moduladores de vasoprsinao de oxitocina.
AU8592598A (en) *	1997-07-30	1999-02-22	Wyeth	Tricyclic vasopressin agonists
BR9811585A (pt) *	1997-07-30	2000-09-26	American Home Prod	Agonistas de vasopressinas tricìclicas
GB2355454A (en) *	1999-10-20	2001-04-25	Ferring Bv	Antidiuretic agents
GB0000079D0 (en) *	2000-01-05	2000-02-23	Ferring Bv	Novel antidiuretic agents

2000
- 2000-06-26 GB GBGB0015601.8A patent/GB0015601D0/en not_active Ceased
2001
- 2001-06-21 AU AU2001274290A patent/AU2001274290B9/en not_active Ceased
- 2001-06-21 CA CA002412555A patent/CA2412555A1/en not_active Abandoned
- 2001-06-21 EP EP01940792A patent/EP1294698B1/de not_active Expired - Lifetime
- 2001-06-21 HU HU0301339A patent/HU229315B1/hu not_active IP Right Cessation
- 2001-06-21 WO PCT/GB2001/002737 patent/WO2002000626A1/en not_active Ceased
- 2001-06-21 PL PL01359187A patent/PL359187A1/xx not_active IP Right Cessation
- 2001-06-21 JP JP2002505374A patent/JP3935071B2/ja not_active Expired - Fee Related
- 2001-06-21 CN CNB018118135A patent/CN1308313C/zh not_active Expired - Fee Related
- 2001-06-21 UA UA20021210560A patent/UA73177C2/uk unknown
- 2001-06-21 AT AT01940792T patent/ATE368650T1/de not_active IP Right Cessation
- 2001-06-21 RU RU2003101970/04A patent/RU2269517C2/ru not_active IP Right Cessation
- 2001-06-21 AU AU7429001A patent/AU7429001A/xx active Pending
- 2001-06-21 US US10/311,301 patent/US7176195B2/en not_active Expired - Fee Related
- 2001-06-21 DE DE60129697T patent/DE60129697T2/de not_active Expired - Lifetime
- 2001-06-21 CZ CZ20024157A patent/CZ304037B6/cs not_active IP Right Cessation
- 2001-06-21 MX MXPA02012779A patent/MXPA02012779A/es active IP Right Grant
- 2001-06-21 KR KR1020027017214A patent/KR100805808B1/ko not_active Expired - Fee Related
- 2001-06-21 IL IL15335801A patent/IL153358A0/xx unknown
- 2001-06-21 NZ NZ523066A patent/NZ523066A/en not_active IP Right Cessation
2002
- 2002-12-18 NO NO20026094A patent/NO324217B1/no not_active IP Right Cessation
2003
- 2003-01-15 ZA ZA200300403A patent/ZA200300403B/xx unknown
2005
- 2005-01-19 JP JP2005011930A patent/JP2005104990A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
EP1294698A1 (de)	2003-03-26
MXPA02012779A (es)	2003-09-22
AU2001274290B9 (en)	2006-06-29
HUP0301339A2 (hu)	2003-08-28
NO20026094L (no)	2003-02-24
JP3935071B2 (ja)	2007-06-20
JP2005104990A (ja)	2005-04-21
HUP0301339A3 (en)	2004-10-28
GB0015601D0 (en)	2000-08-16
HK1059780A1 (en)	2004-07-16
PL359187A1 (en)	2004-08-23
AU7429001A (en)	2002-01-08
NO324217B1 (no)	2007-09-10
KR20030010738A (ko)	2003-02-05
NO20026094D0 (no)	2002-12-18
UA73177C2 (en)	2005-06-15
NZ523066A (en)	2004-03-26
WO2002000626A1 (en)	2002-01-03
ZA200300403B (en)	2004-04-02
US7176195B2 (en)	2007-02-13
HU229315B1 (en)	2013-10-28
EP1294698B1 (de)	2007-08-01
IL153358A0 (en)	2003-07-06
AU2001274290B2 (en)	2006-06-01
CZ304037B6 (cs)	2013-09-04
RU2269517C2 (ru)	2006-02-10
DE60129697T2 (de)	2008-06-05
KR100805808B1 (ko)	2008-02-22
CA2412555A1 (en)	2002-01-03
CN1308313C (zh)	2007-04-04
JP2004501899A (ja)	2004-01-22
US20040038962A1 (en)	2004-02-26
DE60129697D1 (de)	2007-09-13
CN1462269A (zh)	2003-12-17

Legal Events

Date	Code	Title	Description
2008-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE368650T1 (de)	2007-08-15	Kondensierte azepinderivate und ihre verwendung als als antidiuretisches mittel
TR200101961T2 (tr)	2001-12-21	1,2-halkalı kinolin türevleri
FR2838439B1 (fr)	2005-05-20	Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
TR200202288T2 (tr)	2003-01-21	Yeni indolin-2-on türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar
DK1337518T3 (da)	2009-10-19	Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren
MXPA03004549A (es)	2004-03-26	Derivados de 3-arilindola y su uso como agonistas del receptor cb2.
ATE327977T1 (de)	2006-06-15	Tetrahydrochinolin-derivate als crth2 antagonisten
PT1204654E (pt)	2003-11-28	Benzofurilpiperazinas agonistas do receptor 5-ht2c da serotonina
MY129613A (en)	2007-04-30	Cannabinoid receptor binding compounds
SE0302760D0 (sv)	2003-10-20	New compounds
YU87101A (sh)	2004-07-15	Derivati benzena, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže
SE0201544D0 (sv)	2002-05-17	Novel compounds and thier use
DE60003949D1 (de)	2003-08-21	5-aryl-1h-1,2,4 triazolverbindungen als cyclooxygenase -2 inhibitoren und dieseenthaltende pharmazeutische zusammensetzungen
ATE377602T1 (de)	2007-11-15	Morphinanderivate und ihre medizinische anwendung
DE60100506D1 (de)	2003-08-28	1,3-dihydro-2h-indol-2-on derivate und deren verwendung als liganden der arginin-vasopressin rezeptoren v1b oder v1b und v1a
ATE457026T1 (de)	2010-02-15	Heterocyclische kondensierte verbindungen und ihre verwendung als antidiuretische mittel
BR0105563A (pt)	2002-04-02	Derivados e análogos de galantamina
SE9901077D0 (sv)	1999-03-23	Novel use
IT1302264B1 (it)	2000-09-05	Derivati a struttura n-acil vanillinamidica in grado di attivare irecettori periferici dei cannabinoidi
DE60117594D1 (de)	2006-04-27	3-oxadiazol-5-yl-1-aminoalkyl-1h-indolderivate
BR0212353A (pt)	2004-07-27	Composto, composição farmacêutica, e, uso de um composto
TR200200125T2 (tr)	2002-09-23	Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar.
CA2356985A1 (en)	2000-07-06	5ht1 antagonists for antidepressant therapy
ATE277010T1 (de)	2004-10-15	Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
GB0011071D0 (en)	2000-06-28	Organic compounds