ATE368662T1 - Piperidinyl-thiazol-carbonsäure-derivate als angiogenesis inhibitoren - Google Patents

Piperidinyl-thiazol-carbonsäure-derivate als angiogenesis inhibitoren

Info

Publication number
ATE368662T1
ATE368662T1 AT03789563T AT03789563T ATE368662T1 AT E368662 T1 ATE368662 T1 AT E368662T1 AT 03789563 T AT03789563 T AT 03789563T AT 03789563 T AT03789563 T AT 03789563T AT E368662 T1 ATE368662 T1 AT E368662T1
Authority
AT
Austria
Prior art keywords
piperidinyl
thiazole
acid derivatives
carbonic acid
angiogenesis inhibitors
Prior art date
Application number
AT03789563T
Other languages
English (en)
Inventor
Peter Knox
Michele O'sullivan
Heike Lentfer
Original Assignee
Metris Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metris Therapeutics Ltd filed Critical Metris Therapeutics Ltd
Application granted granted Critical
Publication of ATE368662T1 publication Critical patent/ATE368662T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03789563T 2002-12-24 2003-12-24 Piperidinyl-thiazol-carbonsäure-derivate als angiogenesis inhibitoren ATE368662T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0230162.0A GB0230162D0 (en) 2002-12-24 2002-12-24 Compounds useful in inhibiting angiogenesis

Publications (1)

Publication Number Publication Date
ATE368662T1 true ATE368662T1 (de) 2007-08-15

Family

ID=9950429

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789563T ATE368662T1 (de) 2002-12-24 2003-12-24 Piperidinyl-thiazol-carbonsäure-derivate als angiogenesis inhibitoren

Country Status (9)

Country Link
US (1) US20060135501A1 (de)
EP (1) EP1581528B1 (de)
JP (1) JP2006513202A (de)
AT (1) ATE368662T1 (de)
AU (2) AU2003290335A1 (de)
CA (1) CA2511506A1 (de)
DE (1) DE60315355T2 (de)
GB (1) GB0230162D0 (de)
WO (2) WO2004058750A1 (de)

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CA2564139A1 (en) * 2004-04-13 2005-12-08 Arena Pharmaceuticals, Inc. Modulators of human g protein-coupled receptors for the treatment of hyperglycemia and related disorders
EP1637529A1 (de) * 2004-09-20 2006-03-22 4Sc Ag Neue Piperidin-4-yl-Thiazol-Carboxamid-Analog als Inhibitoren für die Vermehrung von T-Zellen und ihre Verwendung
BRPI0516958A (pt) * 2004-09-20 2008-03-25 4Sc Ag inibidores da nf-capab heterocìclicos
US7601745B2 (en) 2004-09-27 2009-10-13 4Sc Ag Heterocyclic NF-kB inhibitors
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
UA97348C2 (en) * 2005-07-29 2012-02-10 4Сц Аг HETEROCYCLIC NF-kB INHIBITORS
GB0518494D0 (en) * 2005-09-09 2005-10-19 Argenta Discovery Ltd Thiazole compounds
EP1832586A1 (de) * 2006-03-10 2007-09-12 Oridis Biomed Forschungs- und Entwicklungs GmbH Thiazolpiperidinderivate zur Behandlung von Erkrankungen der Leber und des Pankreas
EP1832585A1 (de) * 2006-03-10 2007-09-12 ORIDIS BIOMED Forschungs- und Entwicklungs GmbH Thiaziol-Piperidin Derivate zur Behandlung hyperproliferativen Krankheiten
BRPI0709595A2 (pt) * 2006-03-15 2011-07-19 4Sc Ag inibidores de nf-kapab heterocìclicos
CN101405278A (zh) * 2006-03-15 2009-04-08 4Sc股份公司 新颖的杂环NF-κB抑制剂
EP1834954A1 (de) * 2006-03-15 2007-09-19 4Sc Ag Thiazole als NF-kB Hemmer (Proteasom-Hemmer)
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
WO2008013622A2 (en) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
US8420673B2 (en) 2007-01-25 2013-04-16 E I Du Pont De Nemours And Company Fungicidal amides
BRPI0814294A2 (pt) * 2007-07-19 2015-02-03 Metabolex Inc Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas.
WO2009018844A1 (en) * 2007-08-09 2009-02-12 Oridis Biomed Forschungs- Und Entwicklungs Gmbh Thiazole-piperidine derivatives for treatment of hyperproliferative diseases
DE102007047735A1 (de) 2007-10-05 2009-04-09 Merck Patent Gmbh Thiazolderivate
TWI428091B (zh) 2007-10-23 2014-03-01 Du Pont 殺真菌劑混合物
EP2070924A1 (de) * 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-Hetarylthiazol-4-carbonsäureamid-Derivative, deren Herstellung und Verwendung als Arzneimittel
EP2070925A1 (de) * 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel
CN103965187A (zh) * 2008-01-25 2014-08-06 杜邦公司 杀真菌杂环化合物
KR20100105890A (ko) * 2008-01-25 2010-09-30 이 아이 듀폰 디 네모아 앤드 캄파니 살균제 아미드
WO2009132785A1 (de) 2008-04-30 2009-11-05 Bayer Cropscience Aktiengesellschaft Thiazol-4-carbonsäureester und thioester als pflanzenschutzmittel
EP2334669B1 (de) * 2008-10-01 2015-12-23 Bayer Intellectual Property GmbH Heterocyclyl substituierte thiazole als pflanzenschutzmittel
US20110160222A1 (en) * 2008-11-26 2011-06-30 Metabolex, Inc. Modulators of glucose homeostasis for the treatment of diabetes and metabolic disorders
EP2358709B1 (de) 2008-12-02 2014-01-22 E. I. du Pont de Nemours and Company Fungizide heterocyclische verbindungen
WO2010108503A1 (en) 2009-03-24 2010-09-30 Life & Brain Gmbh Promotion of neuronal integration in neural stem cell grafts
US8410127B2 (en) * 2009-10-01 2013-04-02 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
WO2011051243A1 (en) 2009-10-29 2011-05-05 Bayer Cropscience Ag Active compound combinations
JP5827626B2 (ja) 2009-10-30 2015-12-02 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ ヘテロアリールピペリジン及びピペラジン誘導体
CN102971314B (zh) * 2010-04-28 2016-03-23 拜耳知识产权有限责任公司 酮基杂芳基哌啶和酮基杂芳基哌嗪衍生物作为杀菌剂
US8815775B2 (en) * 2010-05-18 2014-08-26 Bayer Cropscience Ag Bis(difluoromethyl)pyrazoles as fungicides
BR112012032248A2 (pt) 2010-06-23 2016-09-13 Metabolex Inc composições de 5-etil-2-{4-[-4(-4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina
WO2012104273A1 (de) 2011-02-01 2012-08-09 Bayer Cropscience Ag Heteroarylpiperidin und -piperazinderivate als fungizide
AU2017305392A1 (en) 2016-08-03 2019-02-21 Cymabay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions

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GB9410534D0 (en) * 1994-05-26 1994-07-13 Lynxvale Ltd Improvements in or relating to growth factor inhibitors
JPH11513382A (ja) * 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
US6080767A (en) * 1996-01-02 2000-06-27 Aventis Pharmaceuticals Products Inc. Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
AR012443A1 (es) * 1997-04-16 2000-10-18 Uriach & Cia Sa J Nuevas carboxamidas como inhibidores de la agregacion plaquetaria, procedimiento para su preparacion, composiciones farmaceuticas que loscontienen y uso de los mismos en la manufactura de medicamentos
AU2006281435A1 (en) * 2005-08-18 2007-02-22 F. Hoffmann-La Roche Ag Thiazolyl piperidine derivatives useful as H3 receptor modulators

Also Published As

Publication number Publication date
WO2004058750A1 (en) 2004-07-15
DE60315355T2 (de) 2008-05-08
GB0230162D0 (en) 2003-02-05
EP1581528A1 (de) 2005-10-05
AU2003290335A1 (en) 2004-07-22
AU2003294143A1 (en) 2004-07-22
DE60315355D1 (de) 2007-09-13
JP2006513202A (ja) 2006-04-20
EP1581528B1 (de) 2007-08-01
US20060135501A1 (en) 2006-06-22
WO2004058751A1 (en) 2004-07-15
CA2511506A1 (en) 2004-07-15

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