BRPI0515725A - piridinuréias de nicotinamida como inibidoras de cinase de receptor do fator de crescimento endotelial vascular (vegf) - Google Patents

piridinuréias de nicotinamida como inibidoras de cinase de receptor do fator de crescimento endotelial vascular (vegf)

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Publication number
BRPI0515725A
BRPI0515725A BRPI0515725-0A BRPI0515725A BRPI0515725A BR PI0515725 A BRPI0515725 A BR PI0515725A BR PI0515725 A BRPI0515725 A BR PI0515725A BR PI0515725 A BRPI0515725 A BR PI0515725A
Authority
BR
Brazil
Prior art keywords
nicotinamide
vegf
pyridinureas
growth factor
kinase inhibitors
Prior art date
Application number
BRPI0515725-0A
Other languages
English (en)
Inventor
Rolf Bohlmann
Martin Haberey
Holger Hess-Stumpp
Andreas Huth
Stuart Ince
Martin Krueger
Karl-Heinz Thierauch
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of BRPI0515725A publication Critical patent/BRPI0515725A/pt

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

"PIRIDINURéIA DE NICOTINAMIDA COMO INIBIDORAS DE CINASE DE RECEPTOR DO FATOR DE CRESCIMENTO ENDOTELIAL VASCULAR (VEGF)". A presente invenção refere-se a novas piridinuréias de nicotinamida como inibidores de receptor cinase VEGF, sua produção e uso como agentes farmacêuticos para prevenir ou tratar doenças que são despertadas por angiogênese persistente.
BRPI0515725-0A 2004-11-03 2005-10-28 piridinuréias de nicotinamida como inibidoras de cinase de receptor do fator de crescimento endotelial vascular (vegf) BRPI0515725A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04090420A EP1655297A1 (en) 2004-11-03 2004-11-03 Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
PCT/EP2005/011709 WO2006048249A1 (en) 2004-11-03 2005-10-28 Nicotinamide pyridinureas as vascular endothelial growth factor (vegf) receptor kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0515725A true BRPI0515725A (pt) 2008-08-05

Family

ID=34928841

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515725-0A BRPI0515725A (pt) 2004-11-03 2005-10-28 piridinuréias de nicotinamida como inibidoras de cinase de receptor do fator de crescimento endotelial vascular (vegf)

Country Status (14)

Country Link
EP (2) EP1655297A1 (pt)
JP (1) JP5069119B2 (pt)
KR (1) KR20070085609A (pt)
CN (1) CN101056870A (pt)
AU (1) AU2005300734A1 (pt)
BR (1) BRPI0515725A (pt)
CA (1) CA2586265C (pt)
ES (1) ES2394324T3 (pt)
IL (1) IL182335A0 (pt)
MX (1) MX2007005340A (pt)
NO (1) NO20072803L (pt)
RU (1) RU2007120691A (pt)
WO (1) WO2006048249A1 (pt)
ZA (1) ZA200705003B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20125425B (en) 2006-10-18 2012-03-26 Pfizer Prod Inc Biaryl ether urea compounds
AR073216A1 (es) * 2008-08-27 2010-10-20 Leo Pharma As Derivados de piridina como receptor de vegfr-2 e inhibidores de proteina tirosina quinasa y uso farmaceutico de los mismos
PL2485731T4 (pl) * 2009-10-06 2017-07-31 Millennium Pharmaceuticals, Inc. Związki heterocykliczne użyteczne jako inhibitory PDK1
ES2651470T3 (es) 2013-11-11 2018-01-26 Syngenta Participations Ag Derivados de 1-(piridazin-3-il)-imidazolidin-2-ona como herbicidas
HK1231480A1 (zh) * 2014-01-10 2017-12-22 Aurigene Discovery Technologies Limited 作为irak4抑制剂的吲唑化合物
IL311677B2 (en) 2014-01-13 2025-06-01 Aurigene Oncology Ltd Bicyclic heterocyclyl derivatives as irak4 inhibitors
CN120267671A (zh) 2017-03-31 2025-07-08 奥锐金肿瘤有限公司 用于治疗血液病的化合物和组合物
EP4410377A3 (en) 2017-10-31 2024-11-13 Curis, Inc. Compounds and compositions for treating hematological disorders
CN109942544B (zh) * 2017-12-21 2021-06-11 中国科学院合肥物质科学研究院 一类新型吲唑类衍生物激酶抑制剂
CN108467360B (zh) * 2018-06-22 2021-04-30 江苏美迪克化学品有限公司 一种阿帕替尼的制备方法及其中间体
CA3214747A1 (en) 2021-04-08 2022-10-13 Reinhard Von Roemeling Combination therapies for the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA71587C2 (uk) * 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів
GB9824579D0 (en) * 1998-11-10 1999-01-06 Novartis Ag Organic compounds
US6995162B2 (en) * 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
PT1387838E (pt) * 2001-05-08 2006-08-31 Schering Ag Derivados de cianoantranilamida e sua utilizacao como farmaco
DE50213703D1 (de) * 2001-05-08 2009-09-03 Bayer Schering Pharma Ag Selektive anthranylamidpyridinamide als vegfr-2 und vegfr-3 inhibitoren
AU2003281855A1 (en) * 2002-07-31 2004-02-23 Schering Aktiengesellschaft Vegfr-2 and vegfr-3 inhibitory anthranylamidopyridines
EP1655295A1 (en) * 2004-11-03 2006-05-10 Schering Aktiengesellschaft Anthranilamide pyridinureas as VEGF receptor kinase inhibitors
EP1657241A1 (en) * 2004-11-03 2006-05-17 Schering Aktiengesellschaft Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors

Also Published As

Publication number Publication date
ES2394324T3 (es) 2013-01-30
KR20070085609A (ko) 2007-08-27
EP1655297A1 (en) 2006-05-10
EP1807416B1 (en) 2012-08-29
JP2008518893A (ja) 2008-06-05
RU2007120691A (ru) 2008-12-10
NO20072803L (no) 2007-08-02
IL182335A0 (en) 2007-07-24
WO2006048249A1 (en) 2006-05-11
CA2586265A1 (en) 2006-05-11
JP5069119B2 (ja) 2012-11-07
EP1807416A1 (en) 2007-07-18
ZA200705003B (en) 2008-09-25
CN101056870A (zh) 2007-10-17
MX2007005340A (es) 2007-08-17
CA2586265C (en) 2013-08-06
AU2005300734A1 (en) 2006-05-11

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 4A, 5A E 6A ANUIDADES.