ATE370736T1 - Verfahren zur herstellung eines piperazinderivates - Google Patents

Verfahren zur herstellung eines piperazinderivates

Info

Publication number
ATE370736T1
ATE370736T1 AT00962874T AT00962874T ATE370736T1 AT E370736 T1 ATE370736 T1 AT E370736T1 AT 00962874 T AT00962874 T AT 00962874T AT 00962874 T AT00962874 T AT 00962874T AT E370736 T1 ATE370736 T1 AT E370736T1
Authority
AT
Austria
Prior art keywords
piperazine derivative
producing
phenylpiperazine
mirtazapine
cyanopyridine
Prior art date
Application number
AT00962874T
Other languages
English (en)
Inventor
Chiharu Maeda
Eiichi Iishi
Weiqi Wang
Yoshiyuki Imamiya
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Application granted granted Critical
Publication of ATE370736T1 publication Critical patent/ATE370736T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00962874T 1999-09-30 2000-09-27 Verfahren zur herstellung eines piperazinderivates ATE370736T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28037899 1999-09-30
PCT/JP2000/005432 WO2001025185A1 (en) 1999-09-30 2000-08-14 Process for the preparation of a piperazine derivative

Publications (1)

Publication Number Publication Date
ATE370736T1 true ATE370736T1 (de) 2007-09-15

Family

ID=17624194

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00962874T ATE370736T1 (de) 1999-09-30 2000-09-27 Verfahren zur herstellung eines piperazinderivates

Country Status (8)

Country Link
US (1) US6495685B1 (de)
EP (1) EP1136470B1 (de)
JP (3) JP4330836B2 (de)
AT (1) ATE370736T1 (de)
AU (2) AU6476300A (de)
CA (1) CA2351528C (de)
DE (1) DE60036076D1 (de)
WO (2) WO2001025185A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA83666C2 (ru) 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина
US7838029B1 (en) * 2003-07-31 2010-11-23 Watson Laboratories, Inc. Mirtazapine solid dosage forms
WO2006022182A1 (ja) * 2004-08-24 2006-03-02 Sumitomo Chemical Company, Limited ２－（４－メチル－２－フェニルピペラジン－１－イル）－３－シアノピリジンの製造方法
US7687622B2 (en) * 2005-04-14 2010-03-30 Teva Pharmaceutical Industries, Ltd Process for preparing quetiapine fumarate
CN102153620A (zh) * 2005-09-26 2011-08-17 住友化学株式会社 光学活性的哌嗪化合物的制造方法
JP5080050B2 (ja) * 2005-09-26 2012-11-21 住友化学株式会社 光学活性なピペラジン化合物の製造方法
AU2006312562A1 (en) * 2005-11-14 2007-05-18 Sumitomo Chemical Company, Limited Process for production of 2-(4-methyl-2-phenylpiperazin- 1-yl)pyridine-3-methanol
JP5635905B2 (ja) 2007-04-11 2014-12-03 メルク・シャープ・エンド・ドーム・ベー・フェー ミルタザピンの調製方法
CN101440067B (zh) * 2007-11-21 2010-08-25 上海津力化工有限公司 一种药物中间体1-甲基-3-苯基哌嗪的制备方法
JP6392344B2 (ja) * 2013-07-25 2018-09-19 ドン−ア エスティ カンパニー リミテッド ベンズアミド誘導体の製造方法、その製造に使用される新規な中間体及び該中間体の製造方法
CN103509000A (zh) * 2013-10-21 2014-01-15 山东鲁药制药有限公司 一种药物中间体1-（3-氰甲基吡啶基-2）-4-甲基-2-苯基哌嗪的合成方法
CN109988148A (zh) * 2018-01-02 2019-07-09 北京哈三联科技有限责任公司 1-（3-氰基吡啶-2）-2-苯基-4-甲基哌嗪草酸盐的制备方法
CN114878727B (zh) * 2022-05-06 2023-07-25 合肥高尔生命健康科学研究院有限公司 一种测定烟草中噁霉灵残留物的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1181322A (en) 1967-06-29 1970-02-11 Chugai Pharmaceutical Co Ltd Piperazine Derivatives and processes for preparing the same
JPS4417388B1 (de) * 1967-06-29 1969-07-31
US4217452A (en) * 1974-02-09 1980-08-12 Akzona Incorporated Synthesis for the preparation of tetracyclic compounds
NL179906C (nl) 1974-02-09 1986-12-01 Akzo Nv Werkwijze voor het bereiden van 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino (1,2-a)azepine derivaten.
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
JPS5315520A (en) 1976-07-28 1978-02-13 Chino Kiki Seisakushiyo Kk Transformer protector
JPS5942678A (ja) 1982-09-03 1984-03-09 Akai Electric Co Ltd 磁気記録再生装置における編集方法
FR2573075B1 (fr) * 1984-09-14 1987-03-20 Innothera Lab Sa Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique
US4772705A (en) 1985-07-25 1988-09-20 Pennwalt Corporation Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
RU2001128228A (ru) 1999-04-19 2003-07-20 Тева Фармасьютикал Индастриз Лтд. (Il) Новый синтез пиперазинового кольца

Also Published As

Publication number Publication date
WO2001023345A1 (en) 2001-04-05
EP1136470A4 (de) 2004-09-22
EP1136470B1 (de) 2007-08-22
WO2001025185A1 (en) 2001-04-12
CA2351528C (en) 2005-11-29
DE60036076D1 (de) 2007-10-04
JP2009167166A (ja) 2009-07-30
US6495685B1 (en) 2002-12-17
JP2013040196A (ja) 2013-02-28
EP1136470A1 (de) 2001-09-26
AU7445500A (en) 2001-04-30
JP4330836B2 (ja) 2009-09-16
JP5656952B2 (ja) 2015-01-21
AU751629B2 (en) 2002-08-22
JP5161023B2 (ja) 2013-03-13
AU6476300A (en) 2001-05-10
CA2351528A1 (en) 2001-04-05

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties