ATE370953T1 - Antidepressive indolalkylderivate von heterozyklisch-kondensierten benzodioxanmethylaminen - Google Patents

Antidepressive indolalkylderivate von heterozyklisch-kondensierten benzodioxanmethylaminen

Info

Publication number: ATE370953T1
Authority: AT; Austria
Prior art keywords: disorder; indolalkyl; antidepressive; methylamines; benzodioxane
Prior art date: 2002-09-12

Application number

AT03754498T

Other languages

English (en)

Inventor

Gary Stack

Michael Webb

Deborah Evrard

Dahui Zhou

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-12

Filing date

2003-09-11

Publication date

2007-09-15

2003-09-11 Application filed by Wyeth Corp filed Critical Wyeth Corp

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE370953T1 publication Critical patent/ATE370953T1/de

Links

-1 BENZODIOXANE METHYLAMINES Chemical class 0.000 title 1
230000001430 anti-depressive effect Effects 0.000 title 1
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
208000007848 Alcoholism Diseases 0.000 abstract 1
208000000103 Anorexia Nervosa Diseases 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
206010006550 Bulimia nervosa Diseases 0.000 abstract 1
206010068631 Childhood depression Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
208000027030 Premenstrual dysphoric disease Diseases 0.000 abstract 1
206010036618 Premenstrual syndrome Diseases 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
206010041250 Social phobia Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
229960003920 cocaine Drugs 0.000 abstract 1
201000006145 cocaine dependence Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
206010013663 drug dependence Diseases 0.000 abstract 1
208000024732 dysthymic disease Diseases 0.000 abstract 1
238000011010 flushing procedure Methods 0.000 abstract 1
208000029364 generalized anxiety disease Diseases 0.000 abstract 1
208000013403 hyperactivity Diseases 0.000 abstract 1
208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
208000024714 major depressive disease Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
208000019906 panic disease Diseases 0.000 abstract 1
208000028173 post-traumatic stress disease Diseases 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1
230000001457 vasomotor Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cosmetics (AREA)

AT03754498T 2002-09-12 2003-09-11 Antidepressive indolalkylderivate von heterozyklisch-kondensierten benzodioxanmethylaminen ATE370953T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41034702P	2002-09-12	2002-09-12
US10/659,238 US6800637B2 (en)	2002-09-12	2003-09-10	Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines

Publications (1)

Publication Number	Publication Date
ATE370953T1 true ATE370953T1 (de)	2007-09-15

Family

ID=32717176

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03754498T ATE370953T1 (de)	2002-09-12	2003-09-11	Antidepressive indolalkylderivate von heterozyklisch-kondensierten benzodioxanmethylaminen

Country Status (17)

Country	Link
US (1)	US6800637B2 (de)
EP (1)	EP1537122B9 (de)
JP (1)	JP2006510595A (de)
KR (1)	KR20050042176A (de)
CN (1)	CN100358898C (de)
AT (1)	ATE370953T1 (de)
AU (1)	AU2003272322A1 (de)
BR (1)	BR0314513A (de)
CA (1)	CA2497214A1 (de)
DE (1)	DE60315843T2 (de)
DK (1)	DK1537122T3 (de)
EC (1)	ECSP055660A (de)
ES (1)	ES2291673T3 (de)
MX (1)	MXPA05002840A (de)
NO (1)	NO20051768D0 (de)
RU (1)	RU2005107587A (de)
WO (1)	WO2004024734A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2008530229A (ja)	2005-02-17	2008-08-07	ワイス	シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
WO2008042735A1 (en) *	2006-09-29	2008-04-10	Wyeth	Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines
US8466296B2 (en) *	2007-03-26	2013-06-18	Ligand Pharmaceuticals	Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-ones
US20090042874A1 (en) *	2007-05-30	2009-02-12	Wyeth	Antidepressant heteroaryl derivatives of heterocycle-fused benzodioxans
AU2010251930A1 (en) *	2009-05-27	2011-11-24	Universite Libre De Bruxelles	3-alkyl-5-fluoroindole derivatives as myeloperoxidase inhibitors
WO2011014128A1 (en) *	2009-07-30	2011-02-03	National University Of Singapore	Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
US8623324B2 (en) *	2010-07-21	2014-01-07	Aat Bioquest Inc.	Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
EP2481740B1 (de) *	2011-01-26	2015-11-04	DemeRx, Inc.	Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin
KR20240017363A (ko) *	2021-06-02	2024-02-07	세인트 조셉스 유니버시티	플루오린화 트립타민 화합물, 이의 유사체 및 이를 사용하는 방법
WO2023108164A2 (en) *	2021-12-10	2023-06-15	GATC Health Corp	Methods of treating ptsd and neurological disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2043709C (en)	1990-06-29	2002-01-22	David W. Smith	Antimigraine alkoxypyrimidine derivatives
GB9318431D0 (en) *	1993-09-06	1993-10-20	Boots Co Plc	Therapeutic agents
AR004229A1 (es) *	1995-11-06	1998-11-04	Wyeth Corp	Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US5756532A (en) *	1995-11-06	1998-05-26	American Home Products Corporation	Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
US5869490A (en) *	1996-10-15	1999-02-09	American Home Products Corporation	Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
GB9704948D0 (en) *	1997-03-11	1997-04-30	Knoll Ag	Therapeutic agents
DE19858340A1 (de)	1998-12-17	2000-06-21	Merck Patent Gmbh	Verfahren zur Herstellung von 3-Alkanoyl- und 3-Alkylindolen
US6458802B1 (en) *	2001-03-14	2002-10-01	Wyeth	Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
US6800648B2 (en) *	2001-04-26	2004-10-05	Wyeth	Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
CN1256337C (zh) *	2001-04-30	2006-05-17	惠氏公司	抗抑郁的7,8－二氢－1,6,9－三氧杂－3－氮杂－环戊二烯并[a]萘的氮杂环基甲基衍生物
CA2447150A1 (en) *	2001-05-17	2002-11-21	Wyeth	Processes for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline

2003
- 2003-09-10 US US10/659,238 patent/US6800637B2/en not_active Expired - Fee Related
- 2003-09-11 DE DE60315843T patent/DE60315843T2/de not_active Expired - Fee Related
- 2003-09-11 WO PCT/US2003/028524 patent/WO2004024734A1/en not_active Ceased
- 2003-09-11 CN CNB038214709A patent/CN100358898C/zh not_active Expired - Fee Related
- 2003-09-11 AU AU2003272322A patent/AU2003272322A1/en not_active Abandoned
- 2003-09-11 BR BR0314513-1A patent/BR0314513A/pt not_active IP Right Cessation
- 2003-09-11 CA CA002497214A patent/CA2497214A1/en not_active Abandoned
- 2003-09-11 DK DK03754498T patent/DK1537122T3/da active
- 2003-09-11 ES ES03754498T patent/ES2291673T3/es not_active Expired - Lifetime
- 2003-09-11 AT AT03754498T patent/ATE370953T1/de not_active IP Right Cessation
- 2003-09-11 MX MXPA05002840A patent/MXPA05002840A/es active IP Right Grant
- 2003-09-11 JP JP2004536507A patent/JP2006510595A/ja active Pending
- 2003-09-11 EP EP03754498A patent/EP1537122B9/de not_active Expired - Lifetime
- 2003-09-11 RU RU2005107587/04A patent/RU2005107587A/ru not_active Application Discontinuation
- 2003-09-11 KR KR1020057003957A patent/KR20050042176A/ko not_active Withdrawn
2005
- 2005-03-10 EC EC2005005660A patent/ECSP055660A/es unknown
- 2005-04-11 NO NO20051768A patent/NO20051768D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20050042176A (ko)	2005-05-04
WO2004024734A1 (en)	2004-03-25
AU2003272322A1 (en)	2004-04-30
ES2291673T3 (es)	2008-03-01
EP1537122B9 (de)	2007-10-31
CA2497214A1 (en)	2004-03-25
ECSP055660A (es)	2005-07-06
MXPA05002840A (es)	2005-08-16
BR0314513A (pt)	2005-08-09
JP2006510595A (ja)	2006-03-30
EP1537122A1 (de)	2005-06-08
EP1537122B1 (de)	2007-08-22
US20040138222A1 (en)	2004-07-15
CN100358898C (zh)	2008-01-02
DK1537122T3 (da)	2007-12-27
NO20051768L (no)	2005-04-11
US6800637B2 (en)	2004-10-05
DE60315843D1 (de)	2007-10-04
NO20051768D0 (no)	2005-04-11
RU2005107587A (ru)	2006-01-20
DE60315843T2 (de)	2008-05-15
CN1701075A (zh)	2005-11-23

Legal Events

Date	Code	Title	Description
2008-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
BR0314429A (pt)	2005-08-23	Derivados de aza-heterociclil-metil antidepressivo e benzodioxanos fundidos por heterociclo
DE60201829D1 (de)	2004-12-09	Azaheterocyclylmethyl derivative des 2,3-dihydro-1,4-dioxino(2,3-f)quinolins als antidepressiva
BR0314277A (pt)	2005-07-26	Composto; método de tratamento de um indivìduo acometido por uma condição de depressão, ansiedade, distúrbios do pânico, de tensão pós-traumática, disfórico pré-menstrual, de deficiência da atenção, obsessivos-compulsivos e alimentares, obesidade, rubor vasomotor, dependência de álcool e cocaìna e disfunção sexual; composição farmacêutica e uso do mesmo
PL368442A1 (pl)	2005-03-21	Pochodne fenylopiperazyny jako inhibitory wychwytu zwrotnego serotoniny
CY1108464T1 (el)	2014-04-09	Παραγωγα 4-(2-φαινυλοσουλφανυλο-φαινυλο)πιπεριδινης, ως αναστολεις επαναπροσληψεως σεροτονινης
NO20076344L (no)	2008-02-27	Piperazin-piperidin-antagonister og agonister av 5-HT1A-reseptoren
DE502004011239D1 (de)	2010-07-15	Verfahren zur dehydratisierung substituierter 4-dimethylamino-2-aryl-butan-2-ol-verbindungen und verfahren zur herstellung substituierter dimethyl-(3-katalyse
DE60315843D1 (de)	2007-10-04	Antidepressive indolalkylderivate von heterozyklisch-kondensierten benzodioxanmethylaminen
DK1546151T3 (da)	2006-07-31	Antidepressive cycloalkylaminderivater af heterocyclus-annellerede benzodioxaner
WO2002088136A3 (en)	2003-03-20	Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
BR0209343A (pt)	2004-06-15	Antidepressivos de azaheterociclilmetila derivados de [1,4]-benzodioxanos oxaheterociclo-fundidos; métodos de tratamento usando tais compostos; processo para prepará-los
DK1720823T3 (da)	2009-11-09	Ny fremgangsmåde til syntese af substituerede alpha-amino-indanderivater
BR0314431A (pt)	2005-09-27	Derivados de piperidina antidepressiva dos benzodioxanos fundidos por heterocilo
NO20035673L (no)	2003-12-18	Nye heteroarylderivater, deres fremstilling og anvendelse
EA200801081A1 (ru)	2008-10-30	Способы лечения расстройств центральной нервной системы комбинацией малых доз эсциталопрама и бупропиона
ATE402136T1 (de)	2008-08-15	Verfahren zur herstellung von aminoalkoxybenzylaminen und aminoalkoxybenzonitrilen als zwischenprodukte
AR048134A1 (es)	2006-04-05	La combinacion de un inhibidor de la recaptacion de serotonina y un antagonista del receptor de la histamina 3, el agonista inverso o el agonista parcial
CR7723A (es)	2005-08-12	Derivados de azaheterociclilmetilo de benzodioxanos fusionados con heterociclos antidepresivos
EA201001799A1 (ru)	2011-06-30	Новые способы получения пиперазинильных и диазепанильных производных бензамида
HRP20070123A2 (en)	2008-10-31	Phenyl-piperazine derivatives as serotonin reuptake inhibitors
AR039723A1 (es)	2005-03-09	Terapia de combinacion en donde se utiliza un inhibidor de recaptacion de serotonina