ATE371496T1 - C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin - Google Patents

C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin

Info

Publication number
ATE371496T1
ATE371496T1 AT05708733T AT05708733T ATE371496T1 AT E371496 T1 ATE371496 T1 AT E371496T1 AT 05708733 T AT05708733 T AT 05708733T AT 05708733 T AT05708733 T AT 05708733T AT E371496 T1 ATE371496 T1 AT E371496T1
Authority
AT
Austria
Prior art keywords
pregabalin
asymmetric synthesis
bisphosphine ligands
symmetric bisphosphine
symmetric
Prior art date
Application number
AT05708733T
Other languages
English (en)
Inventor
Jian Bao
Vladimir Genukh Beylin
Derek Joseph Greene
Garrett Hoge
William Scott Kissel
Mark Eugene Marlatt
Derek Andrew Pflum
He-Ping Wu
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34961258&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE371496(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE371496T1 publication Critical patent/ATE371496T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5027—Polyphosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5045—Complexes or chelates of phosphines with metallic compounds or metals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5329—Polyphosphine oxides or thioxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5463—Compounds of the type "quasi-phosphonium", e.g. (C)a-P-(Y)b wherein a+b=4, b>=1 and Y=heteroatom, generally N or O
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
AT05708733T 2004-03-12 2005-03-09 C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin ATE371496T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55258604P 2004-03-12 2004-03-12
US58651204P 2004-07-09 2004-07-09

Publications (1)

Publication Number Publication Date
ATE371496T1 true ATE371496T1 (de) 2007-09-15

Family

ID=34961258

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05708733T ATE371496T1 (de) 2004-03-12 2005-03-09 C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin

Country Status (21)

Country Link
US (2) US20050228190A1 (de)
EP (1) EP1727620B1 (de)
JP (1) JP2007528893A (de)
KR (2) KR100847922B1 (de)
AR (1) AR051533A1 (de)
AT (1) ATE371496T1 (de)
AU (1) AU2005221401A1 (de)
BR (1) BRPI0508615A (de)
CA (1) CA2559086A1 (de)
CY (1) CY1106877T1 (de)
DE (1) DE602005002253T2 (de)
DK (1) DK1727620T3 (de)
ES (1) ES2292107T3 (de)
IL (1) IL177482A0 (de)
NO (1) NO20063574L (de)
NZ (1) NZ549004A (de)
PL (1) PL1727620T3 (de)
PT (1) PT1727620E (de)
RU (1) RU2335342C2 (de)
TW (1) TWI299990B (de)
WO (1) WO2005087370A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL189872B1 (pl) 1996-07-24 2005-10-31 Warner Lambert Co Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
CN101160281A (zh) 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
EP1768950A2 (de) * 2005-04-11 2007-04-04 Teva Pharmaceutical Industries Ltd. Herstellungsverfahren für (s)-pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
DE602006017995D1 (de) * 2005-05-10 2010-12-16 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
WO2006122255A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
US20070043241A1 (en) * 2005-05-10 2007-02-22 Lilach Hedvati Optical resolution of 3-carbamoylmethyl-5-methylhexanoic acid
ES2398579T3 (es) * 2005-09-19 2013-03-20 Teva Pharmaceutical Industries Ltd Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico
EP1904486A2 (de) * 2006-04-24 2008-04-02 Teva Pharmaceutical Industries Ltd Verfahren zur synthese von 3-isobutylglutarsäure
WO2007139933A2 (en) * 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
US20080026433A1 (en) * 2006-05-31 2008-01-31 Lilach Hedvati Use of enzymatic resolution for the preparation of intermediates of pregabalin
EP1912931A2 (de) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. (s)-prägabalin-nitril-präparat
GB0700622D0 (en) * 2007-01-12 2007-02-21 Johnson Matthey Plc Process for preparing cationic rhodium complexes
KR101036536B1 (ko) * 2007-03-22 2011-05-24 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
EP2294207B1 (de) 2008-05-21 2012-09-26 Sandoz AG Verfahren zur stereoselektiven enzymatischen Hydrolyse von 5-methyl-3-nitromethylhexansäureester
EP2297090A1 (de) * 2008-06-23 2011-03-23 Teva Pharmaceutical Industries Ltd. Stereoselektive enzymatische synthese von (s)- bzw. (r)-iso-butyl-glutarsäure
GB0812290D0 (en) * 2008-07-04 2008-08-13 Johnson Matthey Plc Process for preparing cationic rhodium complexes
WO2011056737A1 (en) 2009-11-05 2011-05-12 Boehringer Ingelheim International Gmbh Novel chiral phosphorus ligands
US20120309997A1 (en) 2010-02-12 2012-12-06 Enantia, S.L. Enantiomerically Enriched Aminodiphosphines as Ligands for the Preparation of Catalysts for Asymmetric Synthesis
GB201103092D0 (en) * 2011-02-23 2011-04-06 Univ Dublin Process
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
JP2020500937A (ja) 2016-12-06 2020-01-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規キラルジヒドロベンゾオキサホスホール配位子及びその合成
EP3551639B1 (de) 2016-12-06 2023-08-23 Boehringer Ingelheim International GmbH Neuartige chirale dihydrobenzoazaphospholliganden und synthese davon
JP6949903B2 (ja) 2019-06-24 2021-10-13 日本化学工業株式会社 光学活性ビスホスフィノメタン及びその製造方法、並びに遷移金属錯体及び不斉触媒
CN111647020A (zh) * 2020-04-09 2020-09-11 宁波赜军医药科技有限公司 一种膦氧双齿配体的合成方法
CN119707970A (zh) * 2023-09-26 2025-03-28 中国科学院大连化学物理研究所 一种钯催化不对称氢化合成吲哚啉衍生物的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5616793A (en) * 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PL189872B1 (pl) * 1996-07-24 2005-10-31 Warner Lambert Co Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
US6329429B1 (en) * 1997-06-25 2001-12-11 Warner-Lambert Company Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases
US6194459B1 (en) * 1997-08-19 2001-02-27 Warner-Lambert Company Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotors stimulants
WO1999008670A1 (en) * 1997-08-20 1999-02-25 Guglietta, Antonio Gaba analogs to prevent and treat gastrointestinal damage
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
JP2002520277A (ja) * 1998-07-09 2002-07-09 ワーナー−ランバート・カンパニー 不眠症を治療する方法
EP1094817A1 (de) * 1998-07-09 2001-05-02 Warner-Lambert Company Zusammensetzungen enthaltend gaba-analoge und koffein
EP1121114B1 (de) * 1998-10-16 2007-01-10 Warner-Lambert Company Llc Verwendung von gaba analogen zur herstellung eines arzneimittels zur behandlung von manie und bipolaren erkrankungen
BRPI0107863B8 (pt) * 2000-01-27 2017-04-25 Warner-Lambert Company método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina
MXPA02001147A (es) * 2001-03-19 2004-04-21 Warner Lambert Co Sintesis de ligandos bisfosina no-c2-simetricos como catalizadores para la hidrogenacion asimetrica.
US6696058B2 (en) * 2002-01-29 2004-02-24 Laclede, Inc. Aqueous enzymatic denture adhesives
NI200300043A (es) * 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.

Also Published As

Publication number Publication date
CY1106877T1 (el) 2012-09-26
US20050228190A1 (en) 2005-10-13
AU2005221401A1 (en) 2005-09-22
TWI299990B (en) 2008-08-21
KR100847922B1 (ko) 2008-07-22
AR051533A1 (es) 2007-01-24
WO2005087370A1 (en) 2005-09-22
CA2559086A1 (en) 2005-09-22
ES2292107T3 (es) 2008-03-01
US20090124820A1 (en) 2009-05-14
KR20060118603A (ko) 2006-11-23
PL1727620T3 (pl) 2007-12-31
RU2335342C2 (ru) 2008-10-10
KR100823758B1 (ko) 2008-04-21
BRPI0508615A (pt) 2007-07-31
DK1727620T3 (da) 2007-12-03
TW200600090A (en) 2006-01-01
EP1727620B1 (de) 2007-08-29
RU2006132505A (ru) 2008-03-27
DE602005002253D1 (de) 2007-10-11
PT1727620E (pt) 2007-11-05
IL177482A0 (en) 2006-12-10
EP1727620A1 (de) 2006-12-06
NZ549004A (en) 2009-04-30
NO20063574L (no) 2006-09-05
DE602005002253T2 (de) 2008-05-29
KR20070074671A (ko) 2007-07-12
JP2007528893A (ja) 2007-10-18

Similar Documents

Publication Publication Date Title
ATE371496T1 (de) C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
DE602004021904D1 (de) Gyraseinhibitoren und deren verwendungen
DE602006007970D1 (de) Hydroxydesoxybenzoine und ihre verwendung zur maskierung von bittergeschmack
ATE476877T1 (de) Vorbeugung von krankheiten bei kaiserschnitt- babies
DE602004029755D1 (de) Elementplatte für Druckkopf und Druckkopf mit Elementplatte
ATE365719T1 (de) O-cyclopropyl-carboxanilide und ihre verwendung als fungizide
DE602006021461D1 (de) Koaleszierendes filtrationsmedium und verfahren
ATE530517T1 (de) Nitrilverbindung und deren verwendung bei der schädlingsbekämpfung
DE602004012969D1 (de) Phenylacetamide und ihre verwendung als glukokinase-modulatoren
EP1746902A4 (de) Multilektin-affiniätschromatografie und verwendung dafür
DE60334245D1 (de) Filterpatrone mit bügel und verfahren
DE602005027165D1 (de) Aliphatische Polyesterzusammensetzung und Formkörper
DE602004023069D1 (de) Azoverbindung und salz davon
ATE519727T1 (de) 4-chlor-4-alkoxy-1,1,1-trifluor-2-butanone, deren herstellung und deren verwendung bei der herstellung von 4-alkoxy-1,1,1-trifluor-3-buten-2-onen
DE60106928D1 (de) Rutheniumkomplexe und ihre verwendung zur asymmetrischen hydrierung
ATE493396T1 (de) Neue indazolcarboxamide und ihre verwendung
DE502006008392D1 (de) Substituierte glycinamide mit antithrombotischer und faktor xa-inhibierender wirkung
DE602004028700D1 (de) Kosmetische Zusammensetzungen und deren Verwendung
ATE511507T1 (de) Piperidinylcarbonylpyrrolidine und deren verwendung als melanocortinagonisten
DE602004010284D1 (de) Aminochinolinderivate und deren verwendung als adenosin-a3-liganden
DE602005002424D1 (de) Polyhydrosiloxanverbindungen, Erzeugnisse und deren Verwendung
DE602006009296D1 (de) Oligopeptide und ihre verwendung
CR9651A (es) Intermedios utiles en la sintesis de moduladores de alquilquinolina y alqilquinazolina cinasa y metodos relacionados de sintesis
DE602005022920D1 (de) Verbesserungen bei der verwendung von mehrfachkommunikationssystemen
DE112004002972A5 (de) Gefederter und zusammenlegbarer Schlitten

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee