ATE371496T1 - C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin - Google Patents
C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalinInfo
- Publication number
- ATE371496T1 ATE371496T1 AT05708733T AT05708733T ATE371496T1 AT E371496 T1 ATE371496 T1 AT E371496T1 AT 05708733 T AT05708733 T AT 05708733T AT 05708733 T AT05708733 T AT 05708733T AT E371496 T1 ATE371496 T1 AT E371496T1
- Authority
- AT
- Austria
- Prior art keywords
- pregabalin
- asymmetric synthesis
- bisphosphine ligands
- symmetric bisphosphine
- symmetric
- Prior art date
Links
- 238000011914 asymmetric synthesis Methods 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 title 1
- 229960001233 pregabalin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5027—Polyphosphines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5045—Complexes or chelates of phosphines with metallic compounds or metals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5329—Polyphosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5463—Compounds of the type "quasi-phosphonium", e.g. (C)a-P-(Y)b wherein a+b=4, b>=1 and Y=heteroatom, generally N or O
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/822—Rhodium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55258604P | 2004-03-12 | 2004-03-12 | |
| US58651204P | 2004-07-09 | 2004-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE371496T1 true ATE371496T1 (de) | 2007-09-15 |
Family
ID=34961258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05708733T ATE371496T1 (de) | 2004-03-12 | 2005-03-09 | C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20050228190A1 (de) |
| EP (1) | EP1727620B1 (de) |
| JP (1) | JP2007528893A (de) |
| KR (2) | KR100823758B1 (de) |
| AR (1) | AR051533A1 (de) |
| AT (1) | ATE371496T1 (de) |
| AU (1) | AU2005221401A1 (de) |
| BR (1) | BRPI0508615A (de) |
| CA (1) | CA2559086A1 (de) |
| CY (1) | CY1106877T1 (de) |
| DE (1) | DE602005002253T2 (de) |
| DK (1) | DK1727620T3 (de) |
| ES (1) | ES2292107T3 (de) |
| IL (1) | IL177482A0 (de) |
| NO (1) | NO20063574L (de) |
| NZ (1) | NZ549004A (de) |
| PL (1) | PL1727620T3 (de) |
| PT (1) | PT1727620E (de) |
| RU (1) | RU2335342C2 (de) |
| TW (1) | TWI299990B (de) |
| WO (1) | WO2005087370A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100491282B1 (ko) | 1996-07-24 | 2005-05-24 | 워너-램버트 캄파니 엘엘씨 | 통증 치료용 이소부틸가바 및 그의 유도체 |
| EP1866275A1 (de) | 2005-04-06 | 2007-12-19 | Teva Pharmaceutical Industries Ltd. | Kristalline formen des pregabalins |
| US20070066846A1 (en) * | 2005-04-11 | 2007-03-22 | Asher Maymon | Process for making (S)-Pregabalin |
| US7488846B2 (en) * | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
| JP2008505980A (ja) | 2005-05-10 | 2008-02-28 | テバ ファーマシューティカル インダストリーズ リミティド | イソブチルグルタル酸を有さないプレガバリン及びその調製方法 |
| CA2604624A1 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid |
| US7763749B2 (en) * | 2005-05-10 | 2010-07-27 | Teva Pharmaceutical Industries Ltd. | Method for the preparation of Pregabalin and salts thereof |
| ES2398579T3 (es) * | 2005-09-19 | 2013-03-20 | Teva Pharmaceutical Industries Ltd | Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico |
| EP1904486A2 (de) * | 2006-04-24 | 2008-04-02 | Teva Pharmaceutical Industries Ltd | Verfahren zur synthese von 3-isobutylglutarsäure |
| TW200815323A (en) * | 2006-05-24 | 2008-04-01 | Teva Pharma | Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof |
| WO2007143152A2 (en) * | 2006-05-31 | 2007-12-13 | Teva Pharmaceutical Industries Ltd. | Preparation of (s)-pregabalin-nitrile |
| EP2071032A3 (de) * | 2006-05-31 | 2009-07-08 | Teva Pharmaceutical Industries Ltd | Enzymatische Auflösung für die Herstellung von Pregablin-Zwischenprodukten |
| GB0700622D0 (en) * | 2007-01-12 | 2007-02-21 | Johnson Matthey Plc | Process for preparing cationic rhodium complexes |
| CA2681313C (en) * | 2007-03-22 | 2012-09-11 | Teva Pharmaceutical Industries Ltd. | Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid |
| KR20090101462A (ko) * | 2007-10-03 | 2009-09-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법 |
| EA019285B1 (ru) | 2008-05-21 | 2014-02-28 | Сандоз Аг | Способ стереоселективного ферментативного гидролиза эфира 5-метил-3-нитрометилгексановой кислоты |
| US20100087525A1 (en) * | 2008-06-23 | 2010-04-08 | Lilach Hedvati | Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester |
| GB0812290D0 (en) * | 2008-07-04 | 2008-08-13 | Johnson Matthey Plc | Process for preparing cationic rhodium complexes |
| EP2496589B1 (de) | 2009-11-05 | 2014-03-05 | Boehringer Ingelheim International GmbH | Neue chirale phosphorliganden |
| CN102781948A (zh) | 2010-02-12 | 2012-11-14 | 埃南蒂亚有限公司 | 作为用于制备不对称合成的催化剂的配体的对映异构地富集的氨基二膦 |
| GB201103092D0 (en) * | 2011-02-23 | 2011-04-06 | Univ Dublin | Process |
| WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
| JP2020500937A (ja) | 2016-12-06 | 2020-01-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規キラルジヒドロベンゾオキサホスホール配位子及びその合成 |
| WO2018106621A1 (en) | 2016-12-06 | 2018-06-14 | Boehringer Ingelheim International Gmbh | Novel chiral dihydrobenzoazaphosphole ligands and synthesis thereof |
| JP6949903B2 (ja) | 2019-06-24 | 2021-10-13 | 日本化学工業株式会社 | 光学活性ビスホスフィノメタン及びその製造方法、並びに遷移金属錯体及び不斉触媒 |
| CN111647020A (zh) * | 2020-04-09 | 2020-09-11 | 宁波赜军医药科技有限公司 | 一种膦氧双齿配体的合成方法 |
| CN119707970A (zh) * | 2023-09-26 | 2025-03-28 | 中国科学院大连化学物理研究所 | 一种钯催化不对称氢化合成吲哚啉衍生物的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| US5616793A (en) * | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
| US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
| KR100491282B1 (ko) * | 1996-07-24 | 2005-05-24 | 워너-램버트 캄파니 엘엘씨 | 통증 치료용 이소부틸가바 및 그의 유도체 |
| US6329429B1 (en) * | 1997-06-25 | 2001-12-11 | Warner-Lambert Company | Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases |
| WO1999008667A2 (en) * | 1997-08-19 | 1999-02-25 | Warner-Lambert Company | Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotor stimulants |
| US6127418A (en) * | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
| WO1999008670A1 (en) * | 1997-08-20 | 1999-02-25 | Guglietta, Antonio | Gaba analogs to prevent and treat gastrointestinal damage |
| JP2002520277A (ja) * | 1998-07-09 | 2002-07-09 | ワーナー−ランバート・カンパニー | 不眠症を治療する方法 |
| NZ508490A (en) * | 1998-07-09 | 2003-08-29 | Warner Lambert Co | Use of a combination of a GABA analog and caffeine as an analgesic |
| DK1121114T3 (da) * | 1998-10-16 | 2007-04-10 | Warner Lambert Co | Anvendelse af GABA-analoger til fremstilling af et medikament til behandling af mani og bipolære lidelser |
| SK287303B6 (sk) * | 2000-01-27 | 2010-06-07 | Warner-Lambert Company | Spôsob prípravy derivátu (S)-3-kyano-5-metyl-hexánovej kyseliny, spôsob a medziprodukt na prípravu pregabalínu |
| MXPA02001147A (es) * | 2001-03-19 | 2004-04-21 | Warner Lambert Co | Sintesis de ligandos bisfosina no-c2-simetricos como catalizadores para la hidrogenacion asimetrica. |
| US6696058B2 (en) * | 2002-01-29 | 2004-02-24 | Laclede, Inc. | Aqueous enzymatic denture adhesives |
| NI200300043A (es) * | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
-
2005
- 2005-03-09 DE DE602005002253T patent/DE602005002253T2/de not_active Expired - Fee Related
- 2005-03-09 KR KR1020077014949A patent/KR100823758B1/ko not_active Expired - Fee Related
- 2005-03-09 DK DK05708733T patent/DK1727620T3/da active
- 2005-03-09 EP EP05708733A patent/EP1727620B1/de not_active Expired - Lifetime
- 2005-03-09 ES ES05708733T patent/ES2292107T3/es not_active Expired - Lifetime
- 2005-03-09 PT PT05708733T patent/PT1727620E/pt unknown
- 2005-03-09 KR KR1020067018522A patent/KR100847922B1/ko not_active Expired - Fee Related
- 2005-03-09 NZ NZ549004A patent/NZ549004A/en unknown
- 2005-03-09 RU RU2006132505/04A patent/RU2335342C2/ru not_active IP Right Cessation
- 2005-03-09 AT AT05708733T patent/ATE371496T1/de not_active IP Right Cessation
- 2005-03-09 JP JP2007502434A patent/JP2007528893A/ja not_active Withdrawn
- 2005-03-09 BR BRPI0508615-9A patent/BRPI0508615A/pt not_active IP Right Cessation
- 2005-03-09 PL PL05708733T patent/PL1727620T3/pl unknown
- 2005-03-09 AU AU2005221401A patent/AU2005221401A1/en not_active Abandoned
- 2005-03-09 CA CA002559086A patent/CA2559086A1/en not_active Abandoned
- 2005-03-09 WO PCT/IB2005/000642 patent/WO2005087370A1/en not_active Ceased
- 2005-03-10 TW TW094107381A patent/TWI299990B/zh active
- 2005-03-10 AR ARP050100918A patent/AR051533A1/es active IP Right Grant
- 2005-03-11 US US11/078,228 patent/US20050228190A1/en not_active Abandoned
-
2006
- 2006-08-07 NO NO20063574A patent/NO20063574L/no not_active Application Discontinuation
- 2006-08-14 IL IL177482A patent/IL177482A0/en unknown
-
2007
- 2007-09-17 CY CY20071101203T patent/CY1106877T1/el unknown
-
2009
- 2009-01-14 US US12/353,450 patent/US20090124820A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0508615A (pt) | 2007-07-31 |
| US20050228190A1 (en) | 2005-10-13 |
| PT1727620E (pt) | 2007-11-05 |
| CY1106877T1 (el) | 2012-09-26 |
| DE602005002253T2 (de) | 2008-05-29 |
| KR100847922B1 (ko) | 2008-07-22 |
| KR100823758B1 (ko) | 2008-04-21 |
| DE602005002253D1 (de) | 2007-10-11 |
| NO20063574L (no) | 2006-09-05 |
| NZ549004A (en) | 2009-04-30 |
| DK1727620T3 (da) | 2007-12-03 |
| RU2335342C2 (ru) | 2008-10-10 |
| EP1727620A1 (de) | 2006-12-06 |
| TWI299990B (en) | 2008-08-21 |
| EP1727620B1 (de) | 2007-08-29 |
| KR20060118603A (ko) | 2006-11-23 |
| US20090124820A1 (en) | 2009-05-14 |
| KR20070074671A (ko) | 2007-07-12 |
| WO2005087370A1 (en) | 2005-09-22 |
| ES2292107T3 (es) | 2008-03-01 |
| JP2007528893A (ja) | 2007-10-18 |
| AU2005221401A1 (en) | 2005-09-22 |
| PL1727620T3 (pl) | 2007-12-31 |
| CA2559086A1 (en) | 2005-09-22 |
| RU2006132505A (ru) | 2008-03-27 |
| AR051533A1 (es) | 2007-01-24 |
| TW200600090A (en) | 2006-01-01 |
| IL177482A0 (en) | 2006-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE371496T1 (de) | C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin | |
| DE602006007970D1 (de) | Hydroxydesoxybenzoine und ihre verwendung zur maskierung von bittergeschmack | |
| ATE476877T1 (de) | Vorbeugung von krankheiten bei kaiserschnitt- babies | |
| ATE365719T1 (de) | O-cyclopropyl-carboxanilide und ihre verwendung als fungizide | |
| DE602006021461D1 (de) | Koaleszierendes filtrationsmedium und verfahren | |
| ATE530517T1 (de) | Nitrilverbindung und deren verwendung bei der schädlingsbekämpfung | |
| ATE391718T1 (de) | Phenylacetamide und ihre verwendung als glukokinase-modulatoren | |
| ATE435859T1 (de) | Gyraseinhibitoren und deren verwendungen | |
| ATE432975T1 (de) | Flüssigwaschmittel und ihre verwendung | |
| DE602005027546D1 (de) | Aryl- und heteroarylpiperidincarboxylatderivate, deren herstellung und deren verwendung in form von faah-enzyminhibitoren | |
| EP1746902A4 (de) | Multilektin-affiniätschromatografie und verwendung dafür | |
| DE602005027899D1 (de) | Mundpflegezusammensetzung mit dem extrakt von unoxidierter kamelie | |
| DE60334245D1 (de) | Filterpatrone mit bügel und verfahren | |
| DE602005027165D1 (de) | Aliphatische Polyesterzusammensetzung und Formkörper | |
| DE502005007106D1 (de) | Substituierte phenylaminothiazole und ihre verwendung | |
| ATE519727T1 (de) | 4-chlor-4-alkoxy-1,1,1-trifluor-2-butanone, deren herstellung und deren verwendung bei der herstellung von 4-alkoxy-1,1,1-trifluor-3-buten-2-onen | |
| ATE493396T1 (de) | Neue indazolcarboxamide und ihre verwendung | |
| DE502006008392D1 (de) | Substituierte glycinamide mit antithrombotischer und faktor xa-inhibierender wirkung | |
| DE602004028700D1 (de) | Kosmetische Zusammensetzungen und deren Verwendung | |
| DE602004010284D1 (de) | Aminochinolinderivate und deren verwendung als adenosin-a3-liganden | |
| ATE319668T1 (de) | Verfahren zur synthese von (2s)-indolin-2- carbonsäure, und verwendung in der synthese von perindopril | |
| DE602005002424D1 (de) | Polyhydrosiloxanverbindungen, Erzeugnisse und deren Verwendung | |
| DE602006009296D1 (de) | Oligopeptide und ihre verwendung | |
| CR9651A (es) | Intermedios utiles en la sintesis de moduladores de alquilquinolina y alqilquinazolina cinasa y metodos relacionados de sintesis | |
| GB0522154D0 (en) | Novel catalytic materials and their use in the preparation of polymeric materials |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |