ATE371654T1 - Verfahren zur herstellung von 11-(1- piperazinyl)dibenzo(b,f)(1,4)-thiazepin, ein zwischenprodukt in der synthese des antipsychotischen arzneimittels quetiapin - Google Patents

Verfahren zur herstellung von 11-(1- piperazinyl)dibenzo(b,f)(1,4)-thiazepin, ein zwischenprodukt in der synthese des antipsychotischen arzneimittels quetiapin

Info

Publication number
ATE371654T1
ATE371654T1 AT04766244T AT04766244T ATE371654T1 AT E371654 T1 ATE371654 T1 AT E371654T1 AT 04766244 T AT04766244 T AT 04766244T AT 04766244 T AT04766244 T AT 04766244T AT E371654 T1 ATE371654 T1 AT E371654T1
Authority
AT
Austria
Prior art keywords
thiazepine
dibenzo
piperazinyl
synthesis
producing
Prior art date
Application number
AT04766244T
Other languages
English (en)
Inventor
Lukasz Kaczmarek
Katarzyna Badowska-Roslonek
Elzbieta Stolarczyk
Wieslaw Szelejewski
Original Assignee
Helm Ag
Inst Farmaceutyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helm Ag, Inst Farmaceutyczny filed Critical Helm Ag
Application granted granted Critical
Publication of ATE371654T1 publication Critical patent/ATE371654T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT04766244T 2003-07-18 2004-07-16 Verfahren zur herstellung von 11-(1- piperazinyl)dibenzo(b,f)(1,4)-thiazepin, ein zwischenprodukt in der synthese des antipsychotischen arzneimittels quetiapin ATE371654T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL361347A PL195728B1 (pl) 2003-07-18 2003-07-18 Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny

Publications (1)

Publication Number Publication Date
ATE371654T1 true ATE371654T1 (de) 2007-09-15

Family

ID=34114486

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04766244T ATE371654T1 (de) 2003-07-18 2004-07-16 Verfahren zur herstellung von 11-(1- piperazinyl)dibenzo(b,f)(1,4)-thiazepin, ein zwischenprodukt in der synthese des antipsychotischen arzneimittels quetiapin

Country Status (7)

Country Link
EP (1) EP1660469B1 (de)
AT (1) ATE371654T1 (de)
DE (1) DE602004008652D1 (de)
ES (1) ES2291922T3 (de)
PL (2) PL195728B1 (de)
PT (1) PT1660469E (de)
WO (1) WO2005012274A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7687622B2 (en) 2005-04-14 2010-03-30 Teva Pharmaceutical Industries, Ltd Process for preparing quetiapine fumarate
EP1996568A2 (de) * 2006-02-22 2008-12-03 AstraZeneca UK Limited Verfahren zur herstellung von dibenzothiazepinverbindungen
WO2009004480A2 (en) 2007-05-07 2009-01-08 Actavis Group Ptc Ehf Quetiapine salts and their polymorphs
CN102131791B (zh) 2008-06-20 2014-12-24 阿斯利康(瑞典)有限公司 二苯并硫杂氮杂*衍生物及其用途
WO2010100623A1 (en) 2009-03-04 2010-09-10 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate
PL395468A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego
CN103396382B (zh) * 2013-07-29 2015-05-20 太仓市茜泾化工有限公司 一种喹硫平中间体的制备方法
CN113698363A (zh) * 2021-09-15 2021-11-26 苏州敬业医药化工有限公司 一种11-哌嗪-二苯并[b,f][1,4]硫氮杂卓盐酸盐的纯化方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458516A (en) * 1968-02-16 1969-07-29 American Cyanamid Co 11-(piperazinyl)dibenz(b,f)(1,4)oxazepines and analogous thiazepines
HU227039B1 (en) * 2000-01-25 2010-05-28 Egis Gyogyszergyar Nyilvanosan New process for the production of quetiapine and intermediates therefor

Also Published As

Publication number Publication date
WO2005012274A1 (en) 2005-02-10
PL361347A1 (en) 2005-01-24
PL1660469T3 (pl) 2008-02-29
DE602004008652D1 (de) 2007-10-11
EP1660469A1 (de) 2006-05-31
PT1660469E (pt) 2007-10-11
PL195728B1 (pl) 2007-10-31
ES2291922T3 (es) 2008-03-01
EP1660469B1 (de) 2007-08-29

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