PL1660469T3 - Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny, związku pośredniego w syntezie leku przeciwpsychotycznego kwetiapina - Google Patents
Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny, związku pośredniego w syntezie leku przeciwpsychotycznego kwetiapinaInfo
- Publication number
- PL1660469T3 PL1660469T3 PL04766244T PL04766244T PL1660469T3 PL 1660469 T3 PL1660469 T3 PL 1660469T3 PL 04766244 T PL04766244 T PL 04766244T PL 04766244 T PL04766244 T PL 04766244T PL 1660469 T3 PL1660469 T3 PL 1660469T3
- Authority
- PL
- Poland
- Prior art keywords
- thiazepine
- dibenzo
- piperazinyl
- synthesis
- preparation
- Prior art date
Links
- 230000000561 anti-psychotic effect Effects 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004431 quetiapine Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- JLOAJISUHPIQOX-UHFFFAOYSA-N Norquetiapine Chemical compound C1CNCCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 JLOAJISUHPIQOX-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- FWULFEHVLSQUBD-UHFFFAOYSA-N phenyl n-(2-phenylsulfanylphenyl)carbamate Chemical compound C=1C=CC=CC=1OC(=O)NC1=CC=CC=C1SC1=CC=CC=C1 FWULFEHVLSQUBD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL361347A PL195728B1 (pl) | 2003-07-18 | 2003-07-18 | Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny |
| EP04766244A EP1660469B1 (en) | 2003-07-18 | 2004-07-16 | Process for the preparation of 11-(1-piperazinyl)dibenzo 'b, f! '1 ,4!-thiazepine, an intermediate in the synthesis of the antipsychotic drug quetiapine |
| PCT/EP2004/051520 WO2005012274A1 (en) | 2003-07-18 | 2004-07-16 | Process for the preparation of 11-(1-piperazinyl)dibenzo `b, f! `1 ,4!-thiazepine, an intermediate in the synthesis of the antipsychotic drug quetiapine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1660469T3 true PL1660469T3 (pl) | 2008-02-29 |
Family
ID=34114486
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL361347A PL195728B1 (pl) | 2003-07-18 | 2003-07-18 | Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny |
| PL04766244T PL1660469T3 (pl) | 2003-07-18 | 2004-07-16 | Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny, związku pośredniego w syntezie leku przeciwpsychotycznego kwetiapina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL361347A PL195728B1 (pl) | 2003-07-18 | 2003-07-18 | Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1660469B1 (pl) |
| AT (1) | ATE371654T1 (pl) |
| DE (1) | DE602004008652D1 (pl) |
| ES (1) | ES2291922T3 (pl) |
| PL (2) | PL195728B1 (pl) |
| PT (1) | PT1660469E (pl) |
| WO (1) | WO2005012274A1 (pl) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7687622B2 (en) | 2005-04-14 | 2010-03-30 | Teva Pharmaceutical Industries, Ltd | Process for preparing quetiapine fumarate |
| EP1996568A2 (en) * | 2006-02-22 | 2008-12-03 | AstraZeneca UK Limited | Process for preparing dibenzothiazepine compounds |
| WO2009004480A2 (en) | 2007-05-07 | 2009-01-08 | Actavis Group Ptc Ehf | Quetiapine salts and their polymorphs |
| CN102131791B (zh) | 2008-06-20 | 2014-12-24 | 阿斯利康(瑞典)有限公司 | 二苯并硫杂氮杂*衍生物及其用途 |
| WO2010100623A1 (en) | 2009-03-04 | 2010-09-10 | Ranbaxy Laboratories Limited | Process for the preparation of quetiapine fumarate |
| PL395468A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego |
| CN103396382B (zh) * | 2013-07-29 | 2015-05-20 | 太仓市茜泾化工有限公司 | 一种喹硫平中间体的制备方法 |
| CN113698363A (zh) * | 2021-09-15 | 2021-11-26 | 苏州敬业医药化工有限公司 | 一种11-哌嗪-二苯并[b,f][1,4]硫氮杂卓盐酸盐的纯化方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3458516A (en) * | 1968-02-16 | 1969-07-29 | American Cyanamid Co | 11-(piperazinyl)dibenz(b,f)(1,4)oxazepines and analogous thiazepines |
| HU227039B1 (en) * | 2000-01-25 | 2010-05-28 | Egis Gyogyszergyar Nyilvanosan | New process for the production of quetiapine and intermediates therefor |
-
2003
- 2003-07-18 PL PL361347A patent/PL195728B1/pl not_active IP Right Cessation
-
2004
- 2004-07-16 WO PCT/EP2004/051520 patent/WO2005012274A1/en not_active Ceased
- 2004-07-16 PL PL04766244T patent/PL1660469T3/pl unknown
- 2004-07-16 EP EP04766244A patent/EP1660469B1/en not_active Expired - Lifetime
- 2004-07-16 ES ES04766244T patent/ES2291922T3/es not_active Expired - Lifetime
- 2004-07-16 DE DE602004008652T patent/DE602004008652D1/de not_active Expired - Lifetime
- 2004-07-16 AT AT04766244T patent/ATE371654T1/de not_active IP Right Cessation
- 2004-07-16 PT PT04766244T patent/PT1660469E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005012274A1 (en) | 2005-02-10 |
| PL361347A1 (pl) | 2005-01-24 |
| ATE371654T1 (de) | 2007-09-15 |
| DE602004008652D1 (de) | 2007-10-11 |
| EP1660469A1 (en) | 2006-05-31 |
| PT1660469E (pt) | 2007-10-11 |
| PL195728B1 (pl) | 2007-10-31 |
| ES2291922T3 (es) | 2008-03-01 |
| EP1660469B1 (en) | 2007-08-29 |
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