ATE371665T1 - Zuckerderivate von hydromorphon, dihydromorphin und dihydroisomorphin, zusammensetzungen davon und verwendung zur vorbeugung und behandlung von schmerzen - Google Patents

Zuckerderivate von hydromorphon, dihydromorphin und dihydroisomorphin, zusammensetzungen davon und verwendung zur vorbeugung und behandlung von schmerzen

Info

Publication number
ATE371665T1
ATE371665T1 AT02765874T AT02765874T ATE371665T1 AT E371665 T1 ATE371665 T1 AT E371665T1 AT 02765874 T AT02765874 T AT 02765874T AT 02765874 T AT02765874 T AT 02765874T AT E371665 T1 ATE371665 T1 AT E371665T1
Authority
AT
Austria
Prior art keywords
dihydroisomorphine
dihydromorphine
hydromorphone
preventing
compositions
Prior art date
Application number
AT02765874T
Other languages
English (en)
Inventor
Feng Gao
Jahanara Miotto
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE371665T1 publication Critical patent/ATE371665T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/033—Uronic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT02765874T 2001-07-27 2002-07-24 Zuckerderivate von hydromorphon, dihydromorphin und dihydroisomorphin, zusammensetzungen davon und verwendung zur vorbeugung und behandlung von schmerzen ATE371665T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30784501P 2001-07-27 2001-07-27

Publications (1)

Publication Number Publication Date
ATE371665T1 true ATE371665T1 (de) 2007-09-15

Family

ID=23191416

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02765874T ATE371665T1 (de) 2001-07-27 2002-07-24 Zuckerderivate von hydromorphon, dihydromorphin und dihydroisomorphin, zusammensetzungen davon und verwendung zur vorbeugung und behandlung von schmerzen

Country Status (14)

Country Link
US (1) US6740641B2 (de)
EP (1) EP1412368B1 (de)
JP (1) JP4679055B2 (de)
AT (1) ATE371665T1 (de)
AU (1) AU2002329634B2 (de)
CA (1) CA2455774C (de)
CY (1) CY1107813T1 (de)
DE (1) DE60222137T2 (de)
DK (1) DK1412368T3 (de)
ES (1) ES2292806T3 (de)
IL (2) IL160085A0 (de)
MX (1) MXPA04000825A (de)
PT (1) PT1412368E (de)
WO (1) WO2003011881A2 (de)

Cited By (1)

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US10980225B2 (en) 2015-10-27 2021-04-20 Nobili S.P.A. Apparatus for dispensing a treatment liquid to a respective agricultural crop

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WO2005032474A2 (en) * 2003-09-30 2005-04-14 New River Pharmaceuticals Inc. Pharmaceutical compositions for prevention of overdose or abuse
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20070066537A1 (en) * 2002-02-22 2007-03-22 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US7338939B2 (en) * 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
US7375082B2 (en) * 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US7659253B2 (en) * 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
EP1531844B1 (de) * 2002-02-22 2014-08-20 Shire LLC Neue pharmazeutische verbindungen mit verzögerter freisetzung zur verhinderung von missbrauch kontrollierter substanzen
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
KR20050010756A (ko) * 2002-02-22 2005-01-28 뉴 리버 파마슈티칼스, 인크. 피험자 간 약물 혈청 농도의 변동성을 감소시키기 위한펩티드-약물 접합체의 용도
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
NZ544162A (en) * 2003-05-29 2008-09-26 Shire Llc Abuse resistant amphetamine compounds
KR101453107B1 (ko) * 2006-04-21 2014-10-27 디에스엠 아이피 어셋츠 비.브이. 오피오이드 수용체 길항제의 용도
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
FR2939436B1 (fr) * 2008-12-10 2010-12-17 Sanofi Aventis Synthese de morphine-6-glucuronide ou de l'un de ses derives
WO2011126910A2 (en) 2010-03-30 2011-10-13 Algynomics Inc. Compositions and methods for the treatment of somatosensory disorders
US8716350B2 (en) * 2010-03-30 2014-05-06 Algynomics Inc. Compositions and methods for the treatment of somatosensory disorders
MX2013003354A (es) 2010-09-21 2013-06-24 Purdue Pharma Lp Analogos de buprenorfina.
SG11201401856VA (en) 2011-10-26 2014-05-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
EP3333156A3 (de) 2012-11-09 2018-09-26 Purdue Pharma L.P. Benzomorphan-analoge und ihre verwendung
US9175000B2 (en) 2012-12-07 2015-11-03 Purdue Pharma L.P. Buprenorphine analogs
TWI513697B (zh) 2012-12-14 2015-12-21 Purdue Pharma Lp 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
WO2014091297A1 (en) 2012-12-14 2014-06-19 Purdue Pharma L.P. Spirocyclic morphinans and their use
US9056836B2 (en) 2013-01-31 2015-06-16 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
HU231191B1 (hu) 2013-04-15 2021-08-30 Szegedi Tudományegyetem Izotóp tartalmú morfin molekulák
EP3087078B1 (de) 2013-12-26 2019-05-15 Purdue Pharma LP 7-beta-alkyl-analoga von orvinolen
EP3087079B1 (de) 2013-12-26 2019-04-03 Purdue Pharma LP Opioidrezeptormodulierende oxabicyclo[2.2.2]oktanmorphinane
EP3087073B1 (de) 2013-12-26 2018-07-04 Purdue Pharma LP 10-substituierte morphinanhydantoine
AU2014370062A1 (en) 2013-12-26 2016-08-11 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US10550088B2 (en) 2013-12-27 2020-02-04 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
JP2017521373A (ja) 2014-05-27 2017-08-03 パーデュー、ファーマ、リミテッド、パートナーシップ スピロ環モルフィナン及びその使用
EP3154972A4 (de) 2014-06-13 2017-11-22 Purdue Pharma L.P. Azamophinanderivate und verwendung davon
NZ731586A (en) 2014-12-02 2018-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
MX2019001224A (es) 2016-07-29 2019-06-03 Janssen Pharmaceutica Nv Metodos para tratar el cancer de prostata.
US10745402B2 (en) 2017-01-02 2020-08-18 Purdue Pharma L.P. Morphinan derivatives and use thereof
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
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EP4577667A2 (de) * 2022-08-25 2025-07-02 Biosynth GmbH Verfahren zur herstellung von opioid-antagonisten freisetzenden verbindungen und deren verwendung als arzneimittel

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ES2058243T3 (es) 1988-01-12 1994-11-01 Baker Norton Pharma Derivados del acido glucuronico de antagonistas de opiaceos.
FR2680786B1 (fr) * 1991-09-04 1995-03-10 Irepa Procede de synthese de glucuronides d'epoxy-4,5 morphinanes.
EP0816375A1 (de) * 1995-11-29 1998-01-07 Rolabo Sl Glycokonjugate von opiaten
GB9711118D0 (en) 1997-05-29 1997-07-23 Rolabo Sl Compound

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10980225B2 (en) 2015-10-27 2021-04-20 Nobili S.P.A. Apparatus for dispensing a treatment liquid to a respective agricultural crop

Also Published As

Publication number Publication date
EP1412368B1 (de) 2007-08-29
WO2003011881A3 (en) 2003-10-30
DE60222137T2 (de) 2008-06-05
JP2005500357A (ja) 2005-01-06
US6740641B2 (en) 2004-05-25
JP4679055B2 (ja) 2011-04-27
AU2002329634B2 (en) 2009-01-29
CA2455774A1 (en) 2003-02-13
DK1412368T3 (da) 2008-01-02
ES2292806T3 (es) 2008-03-16
PT1412368E (pt) 2007-11-06
IL160085A0 (en) 2004-06-20
CA2455774C (en) 2011-06-07
US20030050257A1 (en) 2003-03-13
WO2003011881A2 (en) 2003-02-13
DE60222137D1 (de) 2007-10-11
EP1412368A2 (de) 2004-04-28
IL160085A (en) 2010-12-30
MXPA04000825A (es) 2004-05-17
CY1107813T1 (el) 2013-06-19

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