ATE372768T1 - N-(2-arylethyl) benzylamine als 5-ht6 rezeptor- antagoniste - Google Patents

N-(2-arylethyl) benzylamine als 5-ht6 rezeptor- antagoniste

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Publication number
ATE372768T1
ATE372768T1 AT02731094T AT02731094T ATE372768T1 AT E372768 T1 ATE372768 T1 AT E372768T1 AT 02731094 T AT02731094 T AT 02731094T AT 02731094 T AT02731094 T AT 02731094T AT E372768 T1 ATE372768 T1 AT E372768T1
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Austria
Prior art keywords
arylethyl
benzylamine
receptor antagonist
receptor
antagonists
Prior art date
Application number
AT02731094T
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English (en)
Inventor
Zhaogen Chen
Michael Cohen
Matthew Fisher
Bruno Giethlen
James Gillig
Jefferson Mccowan
Shawn Miller
John Schaus
Original Assignee
Lilly Co Eli
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Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
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Publication of ATE372768T1 publication Critical patent/ATE372768T1/de

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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EP1379239A2 (de) 2004-01-14
WO2002078693A3 (en) 2002-12-05
HUP0303651A2 (hu) 2004-03-01
PL220721B1 (pl) 2015-12-31
DK1379239T3 (da) 2008-01-07
DZ3493A1 (fr) 2002-10-10
BR0208179A (pt) 2004-03-02
US20060009511A9 (en) 2006-01-12
US20040132800A1 (en) 2004-07-08
SI1859798T1 (sl) 2016-07-29
PL364458A1 (en) 2004-12-13
HRP20030771A2 (en) 2005-08-31
JP2004532209A (ja) 2004-10-21
CA2442114A1 (en) 2002-10-10
PT1379239E (pt) 2007-12-06
SK287463B6 (sk) 2010-10-07
WO2002078693A2 (en) 2002-10-10
IL157651A0 (en) 2004-03-28
IL157651A (en) 2010-02-17
DE60222396D1 (de) 2007-10-25
HRP20030771B1 (hr) 2008-10-31
KR100894189B1 (ko) 2009-04-22
NO20034289L (no) 2003-11-28
ZA200306795B (en) 2005-02-23
US20090306110A1 (en) 2009-12-10
DK1859798T3 (en) 2016-03-21
ES2566056T3 (es) 2016-04-08
CY1110362T1 (el) 2015-04-29
CN1610547A (zh) 2005-04-27
NO20034289D0 (no) 2003-09-25
AU2002303094B2 (en) 2006-11-23
EP1379239B1 (de) 2007-09-12
DE60222396T2 (de) 2008-05-15
CZ20032614A3 (en) 2004-03-17
HU230322B1 (hu) 2016-01-28
NO326160B1 (no) 2008-10-13
SK12052003A3 (sk) 2004-09-08
EA200301073A1 (ru) 2004-02-26
HUP0303651A3 (en) 2004-08-30
PT1859798E (pt) 2016-03-31
NZ527815A (en) 2005-05-27
US8044090B2 (en) 2011-10-25
CZ305838B6 (cs) 2016-04-06
HK1061649A1 (en) 2004-09-30
ES2292758T3 (es) 2008-03-16
US20070099909A1 (en) 2007-05-03
KR20030090694A (ko) 2003-11-28
EA007493B1 (ru) 2006-10-27
IL185871A0 (en) 2008-01-06
US7157488B2 (en) 2007-01-02
CA2442114C (en) 2011-06-21
MXPA03008726A (es) 2003-12-12

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