ATE373659T1 - Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel - Google Patents

Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel

Info

Publication number: ATE373659T1
Authority: AT; Austria
Prior art keywords: sup; pyrimidine; derivatives; therapeutic agents; substituted pyrido
Prior art date: 2004-05-04

Application number

AT05733676T

Other languages

English (en)

Inventor

Michelle M Bruendl

Rocco D Gogliotti

A P Goodman

Gregory Reichard

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-04

Filing date

2005-04-22

Publication date

2007-10-15

2005-04-22 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE373659T1 publication Critical patent/ATE373659T1/de

Links

JSVMKZJNKXEGIN-UHFFFAOYSA-N 6h-pyrido[2,3-d]pyrimidin-7-one Chemical class C1=NC=NC2=NC(=O)CC=C21 JSVMKZJNKXEGIN-UHFFFAOYSA-N 0.000 title 1
-1 PYRROLYL Chemical group 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940124597 therapeutic agent Drugs 0.000 title 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
201000011529 cardiovascular cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003230 pyrimidines Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT05733676T 2004-05-04 2005-04-22 Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel ATE373659T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56790204P	2004-05-04	2004-05-04

Publications (1)

Publication Number	Publication Date
ATE373659T1 true ATE373659T1 (de)	2007-10-15

Family

ID=34966564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05733676T ATE373659T1 (de)	2004-05-04	2005-04-22	Pyrrolylsubstituierte pyrido(2,3-d)pyrimidin-7- one und derivate davon als therapeutische mittel

Country Status (10)

Country	Link
US (1)	US20080255162A1 (de)
EP (1)	EP1749004B1 (de)
JP (1)	JP2007536370A (de)
AT (1)	ATE373659T1 (de)
BR (1)	BRPI0510560A (de)
CA (1)	CA2563669A1 (de)
DE (1)	DE602005002562T2 (de)
ES (1)	ES2292130T3 (de)
MX (1)	MXPA06012829A (de)
WO (1)	WO2005105801A1 (de)

Families Citing this family (35)

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WO2007044698A1 (en)	2005-10-07	2007-04-19	Exelixis, Inc.	PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα
HRP20130902T1 (hr) *	2005-10-07	2013-11-08	Exelixis Inc.	PIRIDOPIRIMIDINONSKI INHIBITORI PI3Kalfa
CA2658725A1 (en)	2006-08-16	2008-02-21	Exelixis, Inc.	Using pi3k and mek modulators in treatments of cancer
AU2007297212B8 (en)	2006-09-15	2011-04-28	Pfizer Products Inc.	Pyrido (2, 3-d) pyrimidinone compounds and their use as pi3 inhibitors
EA020022B1 (ru) *	2007-04-10	2014-08-29	Экселиксис, Инк.	Способы лечения с применением пиридопиримидиноновых ингибиторов pi3k-альфа
WO2008127712A1 (en) *	2007-04-11	2008-10-23	Exelixis, Inc.	Pyrido [2, 3-d] pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer
CA2683784A1 (en) *	2007-04-11	2008-10-23	Exelixis, Inc.	Pyrido[2,3-d]pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer
JP5599783B2 (ja)	2008-05-30	2014-10-01	アムジエン・インコーポレーテツド	Ｐｉ３キナーゼの阻害薬
JP2012504628A (ja) *	2008-09-30	2012-02-23	エグゼリクシス，インコーポレイテッド	ＰＩ３ＫαおよびｍＴＯＲのピリドピリミジノン阻害剤
GB0913345D0 (en)	2009-07-31	2009-09-16	Astrazeneca Ab	New combination 802
US8637557B2 (en)	2009-10-19	2014-01-28	Taisho Pharmaceutical Co., Ltd	Aminothiazole derivative
WO2011061527A1 (en)	2009-11-17	2011-05-26	Astrazeneca Ab	Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
FR2955109B1 (fr)	2010-01-08	2012-09-07	Sanofi Aventis	Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique
UY33221A (es)	2010-02-09	2011-09-30	Univ California	MÉTODOS PARA TRATAR CÁNCER USANDO INHIBIDORES DE PI3K Y mTOR EN COMBINACIÓN CON INHIBIDORES DE AUTOFAGIA
GB201021992D0 (en)	2010-12-23	2011-02-02	Astrazeneca Ab	Compound
GB201021979D0 (en)	2010-12-23	2011-02-02	Astrazeneca Ab	New compound
ES2697174T3 (es) *	2012-02-10	2019-01-22	Ptc Therapeutics Inc	Compuestos para tratar atrofia muscular espinal
MX2014010176A (es)	2012-02-23	2014-11-10	Abbvie Inc	Inhibidores de cinasas de piridopirimidinona.
KR102099997B1 (ko)	2012-03-01	2020-04-13	피티씨 테라퓨틱스, 인크.	척수성 근위축증을 치료하기 위한 화합물
US9914722B2 (en)	2012-03-23	2018-03-13	Ptc Therapeutics, Inc.	Compounds for treating spinal muscular atrophy
WO2015105657A1 (en)	2013-12-19	2015-07-16	Ptc Therapeutics, Inc.	Methods for modulating the amount of rna transcripts
CA2954189A1 (en)	2014-07-26	2016-02-04	Sunshine Lake Pharma Co., Ltd.	2-amino-pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cdk inhibitors and uses thereof
US10668171B2 (en)	2015-05-30	2020-06-02	Ptc Therapeutics, Inc.	Methods for modulating RNA splicing
KR20220100719A (ko)	2015-12-10	2022-07-15	피티씨 테라퓨틱스, 인크.	헌팅턴병 치료 또는 개선을 위한 조성물
CA3043755A1 (en)	2016-11-28	2018-05-31	Ptc Therapeutics, Inc.	Methods for modulating rna splicing
AU2018282154B2 (en)	2017-06-05	2022-04-07	Ptc Therapeutics, Inc.	Compounds for treating huntington's disease
KR20200017476A (ko)	2017-06-14	2020-02-18	피티씨 테라퓨틱스, 인크.	Rna 스플라이싱의 변경 방법
WO2019005993A1 (en)	2017-06-28	2019-01-03	Ptc Therapeutics, Inc.	METHODS OF TREATING HUNTINGTON'S DISEASE
CA3067591A1 (en)	2017-06-28	2019-01-03	Ptc Therapeutics, Inc.	Methods for treating huntington's disease
AU2019243048A1 (en)	2018-03-27	2020-10-15	Ptc Therapeutics, Inc.	Compounds for treating Huntington's disease
BR112020026534A2 (pt)	2018-06-27	2021-03-23	Ptc Therapeutics, Inc.	Compostos de heteroarila para o tratamento da doença de huntington
WO2020005882A1 (en)	2018-06-27	2020-01-02	Ptc Therapeutics, Inc.	Heteroaryl compounds for treating huntington's disease
IL279688B2 (en)	2018-06-27	2025-01-01	Ptc Therapeutics Inc	Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
CN114245794B (zh)	2019-05-13	2024-09-13	Ptc医疗公司	用于治疗亨廷顿氏病的化合物
WO2021108803A1 (en)	2019-11-26	2021-06-03	Theravance Biopharma R&D Ip, Llc	Fused pyrimidine pyridinone compounds as jak inhibitors

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AU5261001A (en) *	2000-04-27	2001-11-12	Imperial Cancer Research Technology Ltd	Condensed heteroaryl derivatives
US7019002B2 (en) *	2001-12-11	2006-03-28	Pharmacia & Upjohn, S.P.A.	Pyridopyrimidinones derivatives as telomerase inhibitors
US7098332B2 (en) *	2002-12-20	2006-08-29	Hoffmann-La Roche Inc.	5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones

2005
- 2005-04-22 DE DE602005002562T patent/DE602005002562T2/de not_active Expired - Fee Related
- 2005-04-22 ES ES05733676T patent/ES2292130T3/es not_active Expired - Lifetime
- 2005-04-22 MX MXPA06012829A patent/MXPA06012829A/es unknown
- 2005-04-22 EP EP05733676A patent/EP1749004B1/de not_active Expired - Lifetime
- 2005-04-22 BR BRPI0510560-9A patent/BRPI0510560A/pt not_active Application Discontinuation
- 2005-04-22 JP JP2007512546A patent/JP2007536370A/ja not_active Withdrawn
- 2005-04-22 US US11/568,611 patent/US20080255162A1/en not_active Abandoned
- 2005-04-22 AT AT05733676T patent/ATE373659T1/de not_active IP Right Cessation
- 2005-04-22 WO PCT/IB2005/001141 patent/WO2005105801A1/en not_active Ceased
- 2005-04-22 CA CA002563669A patent/CA2563669A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2292130T3 (es)	2008-03-01
EP1749004A1 (de)	2007-02-07
EP1749004B1 (de)	2007-09-19
JP2007536370A (ja)	2007-12-13
BRPI0510560A (pt)	2007-11-20
WO2005105801A1 (en)	2005-11-10
DE602005002562T2 (de)	2008-01-31
CA2563669A1 (en)	2005-11-10
MXPA06012829A (es)	2007-01-26
DE602005002562D1 (de)	2007-10-31
US20080255162A1 (en)	2008-10-16

Legal Events

Date	Code	Title	Description
2008-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602005002562D1 (de)	2007-10-31	Pyrrolylsubstituierte pyridoä2,3-düpyrimidin-7-one und derivate davon als therapeutische mittel
EA200700902A1 (ru)	2007-10-26	3-ариламинопиридиновые производные
IL183340A0 (en)	2007-09-20	[1,2,4] triazolo[4,3-a] pyridine derivatives and pharmaceutical compositions containing them
MXPA05012894A (es)	2006-02-22	Benzofuranos 3-sustituidos como agentes terapeuticos.
EP1689406A4 (de)	2007-01-17	Heterocyclische inhibitoren von mek und verfahren zu deren anwendung
SE0401971D0 (sv)	2004-08-02	Piperidne derivatives
CR20120389A (es)	2012-08-16	COMPUESTOS SUSTITUIDOS DE N-(1H-INDAZOL-4-IL)IMIDAZO[1,2-a] PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE cFMS
ATE370139T1 (de)	2007-09-15	Pyrazolopyridin derivate als tgf beta hemmstoffe zur behandlung von krebs
WO2004108715A8 (en)	2005-12-01	3-aryloxy and 3-heteroaryloxy substituted benzo(b) thiophenes as therapeutic agents with pi3k activity
TW200508235A (en)	2005-03-01	Substituted hexahydropyrazino[1, 2-a]pyrimidine-4, 7-dione derivatives, processes for their preparation and their use as medicaments
ATE365735T1 (de)	2007-07-15	Cycloalkylsulfanyl-substituierte benzo böthiophene als therapeutische mittel
NO20070837L (no)	2007-04-16	Pyrido-pyrido pyrimidinderivater, fremstilling derav samt terapeutisk anvendelse for behandling av cancer.
MXPA05012953A (es)	2006-02-13	Benzo[b]tiofenos 3-arilsulfanil y 3-heteroarilsulfanil sustituidos como agentes terapeuticos.
EA200701930A1 (ru)	2008-02-28	Производные пиримидина для лечения гиперпролиферативных нарушений
TW200504029A (en)	2005-02-01	Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
ATE399170T1 (de)	2008-07-15	Neue tricyclische derivate als ltd4 antagonisten
DE602006020295D1 (de)	2011-04-07	Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel
EA200800223A1 (ru)	2008-06-30	ПРОИЗВОДНЫЕ ПИРИДО[2,3-d]ПИРИМИДИНА, ИХ ПОЛУЧЕНИЕ, ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ
ATE365732T1 (de)	2007-07-15	Pyrimidine als inhibitoren von phosphoinositid-3- kinasen (pi3k)
BRPI0507811A (pt)	2007-07-10	derivados de 7h-pirrolopirimidina
IL173629A0 (en)	2006-07-05	Imidazo(4,5-b) pyridine derivatives and pharmaceutical compositions containing the same
DE10310106A8 (de)	2004-12-30	Substituierte Pyrido[1,2-a]pyrimidin-Verbindungen