ATE374043T1 - Stabilisierte zusammensetzungen mit einem therapeutischen wirkstoff; zitronensäure oder einer konjugierten base und chlordioxid - Google Patents

Stabilisierte zusammensetzungen mit einem therapeutischen wirkstoff; zitronensäure oder einer konjugierten base und chlordioxid

Info

Publication number: ATE374043T1
Authority: AT; Austria
Prior art keywords: citric acid; chlorine dioxide; active substance; compositions containing; conjugate base
Prior art date: 2004-06-09

Application number

AT05752215T

Other languages

English (en)

Inventor

Robert Lyons

Robert Jordan

Original Assignee

Allergan Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-09

Filing date

2005-05-19

Publication date

2007-10-15

2005-05-19 Application filed by Allergan Inc filed Critical Allergan Inc

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE374043T1 publication Critical patent/ATE374043T1/de

Links

KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 title abstract 6
OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 3
239000004155 Chlorine dioxide Substances 0.000 title abstract 2
239000013543 active substance Substances 0.000 title abstract 2
235000019398 chlorine dioxide Nutrition 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Ophthalmology & Optometry (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT05752215T 2004-06-09 2005-05-19 Stabilisierte zusammensetzungen mit einem therapeutischen wirkstoff; zitronensäure oder einer konjugierten base und chlordioxid ATE374043T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/865,639 US20050276867A1 (en)	2004-06-09	2004-06-09	Stabilized compositions comprising a therapeutically active agent and an oxidizing preservative

Publications (1)

Publication Number	Publication Date
ATE374043T1 true ATE374043T1 (de)	2007-10-15

Family

ID=34970420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05752215T ATE374043T1 (de)	2004-06-09	2005-05-19	Stabilisierte zusammensetzungen mit einem therapeutischen wirkstoff; zitronensäure oder einer konjugierten base und chlordioxid

Country Status (14)

Country	Link
US (4)	US20050276867A1 (de)
EP (1)	EP1753461B1 (de)
JP (1)	JP5108517B2 (de)
KR (1)	KR101184166B1 (de)
CN (1)	CN100579530C (de)
AT (1)	ATE374043T1 (de)
AU (1)	AU2005253931B2 (de)
BR (1)	BRPI0511923A (de)
CA (1)	CA2570148C (de)
DE (1)	DE602005002653T2 (de)
ES (1)	ES2289713T3 (de)
MX (1)	MXPA06014096A (de)
NZ (1)	NZ589247A (de)
WO (1)	WO2005123135A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7851504B2 (en) *	2005-03-16	2010-12-14	Allergan, Inc.	Enhanced bimatoprost ophthalmic solution
US9241918B2 (en)	2005-03-16	2016-01-26	Allergan, Inc.	Enhanced bimatoprost ophthalmic solution
US9561178B2 (en) *	2006-07-25	2017-02-07	Allergan, Inc.	Cyclosporin compositions
KR20110031496A (ko) *	2008-07-15	2011-03-28	바스프 코포레이션	비세포독성 이산화염소 유체
DE102009021372A1 (de) *	2009-05-14	2010-11-18	Ursapharm Arzneimittel Gmbh	Phosphatfreie pharmazeutische Zusammensetzung zur Glaukombehandlung
CA2766345A1 (en) *	2009-06-30	2011-01-06	Allergan, Inc.	Pharmaceutical ophthalmological liquid compositions containing propionic acid derivatives as a preservative
US20110136872A1 (en) *	2009-12-09	2011-06-09	Burk Robert M	Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof
US9522153B2 (en)	2009-12-22	2016-12-20	Allergan, Inc.	Compositions and methods for lowering intraocular pressure
JP2014515383A (ja) *	2011-05-27	2014-06-30	レイショファームゲゼルシャフトミットベシュレンクテルハフツング	ＰＧＦ２α類似体を含む眼科用製剤
JP2013082682A (ja) *	2011-09-29	2013-05-09	Senju Pharmaceut Co Ltd	亜塩素酸塩を含有する水性製剤
WO2013090842A2 (en) *	2011-12-16	2013-06-20	Allergan, Inc.	Ophthalmic compositions comprising polyvinyl capralactam-polyvinyl acetate-polyethylene glycol graft copolymers
CN108310442B (zh) *	2017-01-17	2021-08-27	台北科技大学	眼科用组合物
JP7490570B2 (ja) *	2018-04-27	2024-05-27	アラーガン、インコーポレイテッド	抗微生物有効性の増強及び毒性の減少を有する亜塩素酸ナトリウム組成物
WO2020178672A1 (en) *	2019-03-06	2020-09-10	Mankind Pharma Ltd.	Ophthalmic composition of bimatoprost
US10881111B1 (en)	2019-11-26	2021-01-05	NEOCL Co., Ltd.	Composition for providing room temperature long-term constant-concentration chlorine dioxide solution in aqueous medium and preparation method thereof
US11400100B2 (en)	2019-12-11	2022-08-02	Somerset Therapeutics, Llc.	Effective benzalkonium chloride-free bimatoprost ophthalmic compositions
US12064440B2 (en)	2022-03-21	2024-08-20	Somerset Therapeutics, Llc	Ophthalmic gel compositions of bimatoprost and timolol and associated methods
KR102797918B1 (ko)	2024-05-16	2025-04-21	유한회사 네오클	이산화염소 기체를 활용한 넓은 온도범위에서의 장기 농도 유지 이산화염소 수용액 조성물과 이의 제조방법

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE578918A (de) *	1958-06-11
US3278447A (en) *	1963-12-02	1966-10-11	Cloro Bac Products Inc	Process for stabilizing chlorine dioxide solution
JPS60184002A (ja) *	1984-03-01	1985-09-19	Daiichi Seimo Kk	赤腐れ菌又は青海苔の防除剤
US4696811A (en) *	1984-07-30	1987-09-29	Ratcliff Perry A	Method and composition for prevention and treatment of oral disease
US4689215A (en) *	1984-07-30	1987-08-25	Ratcliff Perry A	Method and composition for prevention and treatment of oral disease
JP2638611B2 (ja) *	1988-06-17	1997-08-06	紀久雄及川	安定化二酸化塩素水溶液の製造法
CA2003198C (en) *	1988-11-29	1995-03-21	Anthony J. Dziabo, Jr.	Aqueous ophthalmic solutions and method for preserving same
AU4658089A (en)	1988-11-29	1990-06-26	Bio-Cide International, Inc.	Disinfectant compositions for ophthalmic devices
JPH02290240A (ja) *	1989-04-28	1990-11-30	Takasugi Seiyaku Kk	凝固状環境浄化組成物
US5279673A (en) *	1990-01-05	1994-01-18	Allergan, Inc.	Methods to disinfect contact lenses
US5246662A (en) *	1989-10-02	1993-09-21	Allergan, Inc.	Methods for generating chlorine dioxide and compositions for disinfecting
JP2759538B2 (ja) *	1990-01-24	1998-05-28	第一製薬株式会社	マコンブ種苗の赤変病防除方法
JPH04349104A (ja) *	1991-05-07	1992-12-03	Takasugi Seiyaku Kk	粉末又は粒状環境浄化組成物
US5736165A (en) *	1993-05-25	1998-04-07	Allergan	In-the-eye use of chlorine dioxide-containing compositions
US5538974A (en) *	1994-01-27	1996-07-23	Senju Pharamceutical Co., Ltd.	Ophthalmic composition for lowering intraocular pressure
JPH10211265A (ja) *	1997-01-29	1998-08-11	M Y Corp:Kk	消臭・防腐・除菌作用を有する剤
PE20020146A1 (es) *	2000-07-13	2002-03-31	Upjohn Co	Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US20020193441A1 (en) *	2001-02-21	2002-12-19	Robertson Stella M.	Prostanoid therapies for the treatment of glaucoma
US6982079B2 (en) *	2002-04-26	2006-01-03	Allergan, Inc.	Compositions for treating hyperemia

2004
- 2004-06-09 US US10/865,639 patent/US20050276867A1/en not_active Abandoned
2005
- 2005-05-19 DE DE602005002653T patent/DE602005002653T2/de not_active Expired - Lifetime
- 2005-05-19 NZ NZ589247A patent/NZ589247A/en not_active IP Right Cessation
- 2005-05-19 KR KR1020067025890A patent/KR101184166B1/ko not_active Expired - Fee Related
- 2005-05-19 WO PCT/US2005/018026 patent/WO2005123135A1/en not_active Ceased
- 2005-05-19 JP JP2007527544A patent/JP5108517B2/ja not_active Expired - Fee Related
- 2005-05-19 AU AU2005253931A patent/AU2005253931B2/en not_active Expired
- 2005-05-19 AT AT05752215T patent/ATE374043T1/de active
- 2005-05-19 BR BRPI0511923-5A patent/BRPI0511923A/pt not_active IP Right Cessation
- 2005-05-19 CN CN200580018817A patent/CN100579530C/zh not_active Expired - Fee Related
- 2005-05-19 MX MXPA06014096A patent/MXPA06014096A/es active IP Right Grant
- 2005-05-19 EP EP05752215A patent/EP1753461B1/de not_active Expired - Lifetime
- 2005-05-19 CA CA2570148A patent/CA2570148C/en not_active Expired - Lifetime
- 2005-05-19 US US11/570,200 patent/US8343949B2/en not_active Expired - Fee Related
- 2005-05-19 ES ES05752215T patent/ES2289713T3/es not_active Expired - Lifetime
2012
- 2012-11-30 US US13/690,863 patent/US8691802B2/en not_active Expired - Lifetime
2014
- 2014-04-04 US US14/245,014 patent/US20150283240A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MXPA06014096A (es)	2007-01-31
CA2570148A1 (en)	2005-12-29
CN100579530C (zh)	2010-01-13
AU2005253931B2 (en)	2011-05-19
CA2570148C (en)	2012-10-23
WO2005123135A1 (en)	2005-12-29
JP5108517B2 (ja)	2012-12-26
US20050276867A1 (en)	2005-12-15
US20150283240A1 (en)	2015-10-08
JP2008502723A (ja)	2008-01-31
BRPI0511923A (pt)	2008-01-22
US8343949B2 (en)	2013-01-01
KR101184166B1 (ko)	2012-09-19
US8691802B2 (en)	2014-04-08
AU2005253931A1 (en)	2005-12-29
WO2005123135A8 (en)	2006-06-22
ES2289713T3 (es)	2008-02-01
CN1964743A (zh)	2007-05-16
US20080300315A1 (en)	2008-12-04
DE602005002653T2 (de)	2008-07-17
HK1104212A1 (en)	2008-01-11
EP1753461A1 (de)	2007-02-21
EP1753461B1 (de)	2007-09-26
DE602005002653D1 (de)	2007-11-08
US20130090387A1 (en)	2013-04-11
NZ589247A (en)	2012-06-29
KR20070028405A (ko)	2007-03-12

Legal Events

Date

Code

Title

Description

2008-03-15

UEP

Publication of translation of european patent specification

Ref document number: 1753461

Country of ref document: EP

Publication	Publication Date	Title
ATE374043T1 (de)	2007-10-15	Stabilisierte zusammensetzungen mit einem therapeutischen wirkstoff; zitronensäure oder einer konjugierten base und chlordioxid
NO2020010I1 (no)	2020-05-13	fostamatinib eller et farmasøytisk akseptabelt salt av fostamatinib, eller et hydrat, solvat eller N-oksid av fostamatinib eller det farmasøytisk akseptable saltet av fostamatinib, spesielt fostamatinib dinatrium, eventuelt på form av et hydrat
DK1178958T3 (da)	2004-06-21	N-cyanomethylamider som proteaseinhibitorer
BR0309345A (pt)	2005-02-15	Composto ou sais farmaceuticamente aceitáveis do mesmo, composição farmacêutica, uso de um composto, e, métodos de tratamento ou profilaxia de doenças ou condições humanas, de distúrbios psicóticos ou de distúrbios de dano intelectual, e de jetlag, interrupção do hábito de fumar, dependência de nicotina, ânsias, dor e colite ulcerativa
ATE514418T1 (de)	2011-07-15	Rasch zerfallende feste darreichungsformen mit nichtbröseliger konsistenz und pullulan
DE60223254D1 (de)	2007-12-13	Verzögert freisetzende formulierungen von oxymorphon
DE60336664D1 (de)	2011-05-19	Nichtnukleosidische reverse-transkriptase-hemmer
PL361341A1 (pl)	2004-10-04	Nowa kompozycja farmaceutyczna
EA200700380A1 (ru)	2007-10-26	Конъюгаты глицеринразветвлённого полиэтиленгликоля - гормона роста человека, способ их получения и способы их применения
BG106095A (bg)	2002-06-28	Нови лекарствени състави на базата на антихолинергично активни съединения и бета-миметици
SV2005002099A (es)	2005-12-13	" nuevos compuestos " ref. pc 32096a
NO20040547L (no)	2004-03-03	Amino-ftalazinonderivater aktive som kinaseinhibitorer, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende disse.
EA200601253A1 (ru)	2006-12-29	Преимущественно линейная шипучая лекарственная форма фентанила для перорального применения и способы введения
ATE470443T1 (de)	2010-06-15	Indol-1-yl-essigsäurederivate
ATE369355T1 (de)	2007-08-15	Pyrimidinamid derivate und deren verwendung
CY1108932T1 (el)	2014-07-02	Ενωσεις 4-(ετεροκυκλυλ)-βενζολοσουλφοξιμινης για την θεραπευτικη αγωγη φλεγμονωδων ασθενειων
DK1933833T3 (da)	2011-07-25	Terapi til behandling af overaktiv blære
SE0102440D0 (sv)	2001-07-05	New compound
ATE440838T1 (de)	2009-09-15	Pharmazeutisch aktive sulfonylaminosäurederivate
SE0401655D0 (sv)	2004-06-24	New compounds
EA200702282A1 (ru)	2008-02-28	Комбинация феррохина и производного артемизинина для лечения малярии
TW200800984A (en)	2008-01-01	New compounds
NO20051261L (no)	2005-03-11	Morfin-6-glukuronidsalt
ATE402703T1 (de)	2008-08-15	Tablette enthaltend efletirizin und pseudoephedrin
DE602006016168D1 (de)	2010-09-23	1,3,5-triazepin-dionen zur Behandlung von Malaria