ATE374214T1 - Monoklonaler anti-cd-40-antikörper - Google Patents
Monoklonaler anti-cd-40-antikörperInfo
- Publication number
- ATE374214T1 ATE374214T1 AT02720634T AT02720634T ATE374214T1 AT E374214 T1 ATE374214 T1 AT E374214T1 AT 02720634 T AT02720634 T AT 02720634T AT 02720634 T AT02720634 T AT 02720634T AT E374214 T1 ATE374214 T1 AT E374214T1
- Authority
- AT
- Austria
- Prior art keywords
- antibody
- monoclonal anti
- agonistically
- antagonistically
- acting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2001/013672 WO2001083755A2 (en) | 2000-04-28 | 2001-04-27 | Human anti-cd40 antibodies and methods of making and using same |
| US09/844,684 US7063845B2 (en) | 2000-04-28 | 2001-04-27 | Human anti-CD40 antibodies |
| JP2001142482 | 2001-05-11 | ||
| JP2001310535 | 2001-10-05 | ||
| US10/040,244 US20030059427A1 (en) | 2000-04-28 | 2001-10-26 | Isolation and characterization of highly active anti-CD40 antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE374214T1 true ATE374214T1 (de) | 2007-10-15 |
Family
ID=32601004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02720634T ATE374214T1 (de) | 2001-04-27 | 2002-04-26 | Monoklonaler anti-cd-40-antikörper |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US7193064B2 (de) |
| EP (2) | EP2011802A3 (de) |
| CN (1) | CN101508734A (de) |
| AT (1) | ATE374214T1 (de) |
| AU (1) | AU2009200017A1 (de) |
| CA (1) | CA2658221C (de) |
| DK (1) | DK1391464T3 (de) |
| PT (1) | PT1391464E (de) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5397703A (en) * | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
| US20030059427A1 (en) * | 2000-04-28 | 2003-03-27 | Force Walker R. | Isolation and characterization of highly active anti-CD40 antibody |
| EP2011802A3 (de) * | 2001-04-27 | 2009-04-15 | Kyowa Hakko Kirin Co., Ltd. | Monoklonaler Antikörper gegen CD40 |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| US20080199471A1 (en) * | 2002-03-01 | 2008-08-21 | Bernett Matthew J | Optimized cd40 antibodies and methods of using the same |
| JP4680902B2 (ja) * | 2003-07-22 | 2011-05-11 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | Rg1抗体及びその使用 |
| US7485297B2 (en) * | 2003-08-12 | 2009-02-03 | Dyax Corp. | Method of inhibition of vascular development using an antibody |
| WO2005019267A2 (en) * | 2003-08-12 | 2005-03-03 | Dyax Corp. | Tie1-binding ligands |
| US7871610B2 (en) * | 2003-08-12 | 2011-01-18 | Dyax Corp. | Antibodies to Tie1 ectodomain |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
| KR101223373B1 (ko) | 2003-12-25 | 2013-01-16 | 교와 핫꼬 기린 가부시키가이샤 | 항 cd40 항체의 변이체 |
| GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| CA2580981C (en) * | 2004-09-22 | 2013-10-22 | Kirin Beer Kabushiki Kaisha | Stabilized human igg4 antibodies |
| PL1889065T3 (pl) | 2005-05-18 | 2013-12-31 | Novartis Ag | Metody diagnostyki i leczenia chorób posiadających składnik autoimmunologiczny i/lub zapalny |
| KR101536506B1 (ko) * | 2005-09-07 | 2015-07-14 | 암젠 프레몬트 인코포레이티드 | 액티빈 수용체 유사 키나제-1에 대한 인간 모노클로날 항체 |
| GEP20125628B (en) | 2006-04-21 | 2012-09-10 | Novartis Ag | Pharmaceutical compositions containing antagonist anti-cd40 antibody |
| EP2589654A1 (de) | 2006-05-03 | 2013-05-08 | The Regents of the University of Colorado, a body corporate | Synergistische Hilfsstoffkombination aus CD40-Agonisten-Antikörper/Typ1-Interferon, diese enthaltende Konjugate und ihre Verwendung als Therapeutika zur Verstärkung der Zellimmunität |
| US20090074711A1 (en) * | 2006-09-07 | 2009-03-19 | University Of Southhampton | Human therapies using chimeric agonistic anti-human cd40 antibody |
| EP2097097B1 (de) * | 2006-12-01 | 2018-05-30 | E. R. Squibb & Sons, L.L.C. | Antikörper, insbesondere menschliche antikörper, die an cd22 binden und deren verwendung |
| US20080213253A1 (en) * | 2007-01-12 | 2008-09-04 | Dyax Corp. | Combination therapy for the treatment of cancer |
| US7883705B2 (en) * | 2007-02-14 | 2011-02-08 | Kyowa Hakko Kirin Co., Ltd. | Anti FGF23 antibody and a pharmaceutical composition comprising the same |
| JO2913B1 (en) * | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| US8518410B2 (en) * | 2009-03-10 | 2013-08-27 | Baylor Research Institute | Fusion protein with HIV antigen |
| AU2010222942B2 (en) * | 2009-03-10 | 2013-01-10 | Baylor Research Institute | Anti-CD40 antibodies and uses thereof |
| EP2406288B1 (de) * | 2009-03-10 | 2016-12-14 | Baylor Research Institute | Auf antigenpräsentierende zellen gerichtete impfstoffe |
| EP2488553B1 (de) | 2009-10-12 | 2015-06-17 | Pfizer Inc. | Krebsbehandlung |
| NZ602020A (en) * | 2010-03-31 | 2014-05-30 | Boehringer Ingelheim Int | Anti-cd40 antibodies |
| CN103517990A (zh) | 2010-10-07 | 2014-01-15 | 通用医疗公司 | 癌症生物标志物 |
| AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| DK2663580T3 (en) * | 2011-01-10 | 2017-03-13 | Ct Atlantic Ltd | COMBINATION THERAPY INCLUDING TUMOR ASSOCIATED ANTI-BINDING ANTIBODIES |
| PT2683406T (pt) * | 2011-03-11 | 2019-07-08 | Beth Israel Deaconess Medical Ct Inc | Anticorpos anti-cd40 e utilização dos mesmos |
| EP2699598B1 (de) | 2011-04-19 | 2019-03-06 | Pfizer Inc | Kombinationen aus anti-4-1bb-antikörpern und adcc-induzierenden antikörpern zur behandlung von krebs |
| ES2709654T3 (es) | 2011-04-29 | 2019-04-17 | Apexigen Inc | Anticuerpos anti-CD40 y métodos de uso |
| GB201115280D0 (en) | 2011-09-05 | 2011-10-19 | Alligator Bioscience Ab | Antibodies, uses and methods |
| CN104918957B (zh) | 2012-10-30 | 2018-11-16 | 埃派斯进有限公司 | 抗-cd40抗体及其使用方法 |
| GB201316644D0 (en) * | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| GB201322583D0 (en) * | 2013-12-19 | 2014-02-05 | Alligator Bioscience Ab | Antibodies |
| EP3094652B1 (de) | 2014-01-13 | 2021-09-29 | Baylor Research Institute | Neuartige impfstoffe gegen hpv und hpv-assoziierte erkrankungen |
| EP3760208B1 (de) | 2014-06-25 | 2024-05-29 | The General Hospital Corporation | Targeting von humanem satellit ii (hsatii) |
| GB201413665D0 (en) | 2014-07-03 | 2014-09-17 | Transimmune Ag And Yale University | Method for obtaining globally activated monocytes |
| WO2016011401A1 (en) * | 2014-07-18 | 2016-01-21 | Kedl Ross M | Immunostimulatory combinations and use thereof |
| KR102443258B1 (ko) | 2014-08-12 | 2022-09-14 | 엘리게이터 바이오사이언스 에이비 | 항 cd40 항체에 의한 병용 치료제 |
| HUE054075T2 (hu) | 2014-10-29 | 2021-08-30 | Seagen Inc | CD40 elleni nem fukozilált antitestek adagolása és bevitele |
| EP3229586B1 (de) | 2014-12-10 | 2025-07-30 | Regents of the University of Minnesota | Genetisch modifizierte zellen, gewebe und organe zur behandlung von krankheiten |
| SI3240801T1 (sl) | 2014-12-31 | 2021-04-30 | Checkmate Pharmaceuticals, Inc. | Kombinirana imunoterapija tumorja |
| RU2715597C2 (ru) * | 2015-05-29 | 2020-03-02 | Эббви Инк. | Антитела к cd40 и способы их применения |
| HUE056769T2 (hu) | 2015-09-04 | 2022-03-28 | Primatope Therapeutics Inc | Humanizált anti-CD40 antitestek és felhasználásuk |
| BR112018006360A2 (pt) * | 2015-09-30 | 2018-10-09 | Janssen Biotech Inc | anticorpos agonísticos que se ligam especificamente ao cd40 humano e métodos de uso |
| US11466253B2 (en) | 2015-10-22 | 2022-10-11 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| WO2017124001A2 (en) * | 2016-01-14 | 2017-07-20 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like antibodies specific for foxp3-derived peptides |
| ES3041500T3 (en) | 2016-03-10 | 2025-11-12 | Cg Oncology Inc | Methods of treating solid tumors by combination therapy |
| EP3458485B1 (de) | 2016-05-19 | 2021-12-29 | The General Hospital Corporation | An den rezeptor il-2rbeta gebundenes interleukin-2, eine plattform zur erhöhung der aktivität von natürlichen killer- und regulatorischen t-zellen |
| WO2018089688A1 (en) | 2016-11-09 | 2018-05-17 | Jinjun Shi | Restoration of tumor suppression using mrna-based delivery system |
| EP3551034A1 (de) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Verfahren, vorrichtungen und systeme zur detektion des magen-darm-trakts |
| EP3600416B1 (de) | 2017-03-30 | 2023-06-07 | Biora Therapeutics, Inc. | Behandlung einer erkrankung des gastrointestinaltraktes mit einem immunmodulatorischen mittel, das mit einer einnehmbaren vorrichtung freigesetzt wird. |
| MA49288A (fr) | 2017-04-27 | 2020-03-04 | Juno Therapeutics Gmbh | Reactifs particulaires oligomères et leurs méthodes d'utilisation |
| US11525005B2 (en) | 2017-06-01 | 2022-12-13 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-CD40 antibody, antigen binding fragment thereof and medical use thereof |
| JP7346390B2 (ja) | 2017-09-19 | 2023-09-19 | マブ ディスカバリー ゲゼルシャフト ミット ベシュレンクテル ハフツング | アゴニスト性cd40抗体 |
| US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
| AU2018391831B2 (en) * | 2017-12-20 | 2022-08-04 | Harbour Biomed (Shanghai) Co., Ltd | Antibodies binding CTLA-4 and uses thereof |
| US20210213041A1 (en) | 2018-02-06 | 2021-07-15 | The General Hospital Corporation | Repeat rna as biomarkers of tumor immune response |
| EP3752194A4 (de) | 2018-02-13 | 2022-03-16 | Checkmate Pharmaceuticals, Inc. | Zusammensetzungen und verfahren für die tumorimmuntherapie |
| SG11202009647VA (en) | 2018-04-09 | 2020-10-29 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| CN112512572B (zh) * | 2018-04-20 | 2024-12-10 | 礼进生物医药科技(上海)有限公司 | 抗cd40抗体及其用途 |
| MA52889A (fr) | 2018-06-15 | 2021-04-21 | Flagship Pioneering Innovations V Inc | Augmentation de l'activité immunitaire par modulation de facteurs de signalisation post-cellulaires |
| US12227565B2 (en) | 2018-06-20 | 2025-02-18 | Biora Therapeutics, Inc. | Method of formulating a pharmaceutical composition comprising administering an immune modulator to the small intestine |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| CN120843603A (zh) | 2018-07-11 | 2025-10-28 | 布里格姆妇女医院 | 用于跨血脑屏障递送试剂的方法和组合物 |
| CN116063495A (zh) | 2018-09-28 | 2023-05-05 | 礼进生物医药科技(上海)有限公司 | 具有经过工程化的Fc结构域的抗CD40结合分子及其治疗用途 |
| US20210355216A1 (en) | 2018-10-05 | 2021-11-18 | INSERM (Institut National de la Santé et de la Recherche Médicale | Methods and systems for controlling the agonistic properties of antibody variable domains by light |
| WO2020106757A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| BR112021009835A2 (pt) * | 2018-11-30 | 2021-08-17 | Jiangsu Hengrui Medicine Co., Ltd. | anticorpo anti-cd40, fragmento de ligação ao antígeno e uso farmacêutico dos mesmos |
| WO2020206169A1 (en) | 2019-04-02 | 2020-10-08 | Kupper Thomas S | Methods for identifying progression of a primary melanoma |
| EP3962493A2 (de) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Verfahren zur modulation der immunreaktivität/konzentration von irf oder sting oder zur behandlung von krebs mit der verabreichung eines sting-modulators und/oder eines purinergischen rezeptormodulators oder eines postzellularen signalisierungsfaktors |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| JP7839733B2 (ja) | 2020-01-10 | 2026-04-02 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 脳腫瘍を処置するための血液脳関門を横断する免疫療法剤を送達するための方法および組成物 |
| KR20230020521A (ko) * | 2020-06-04 | 2023-02-10 | 셀벡스 피티와이 리미티드 | 아고니스트 항-cd40 항체 |
| EP4172323A1 (de) | 2020-06-29 | 2023-05-03 | Flagship Pioneering Innovations V, Inc. | Manipulierte viren zur förderung der a-otransmission und deren verwendung bei der behandlung von krebs |
| WO2022036495A1 (en) * | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| CN116234909A (zh) * | 2020-08-21 | 2023-06-06 | 上海药明生物技术有限公司 | Cd40激动剂抗体和使用方法 |
| CN112409486B (zh) * | 2020-11-26 | 2022-05-20 | 杭州百凌生物科技有限公司 | 一种抗cd40抗体及其应用 |
| US20220325287A1 (en) | 2021-03-31 | 2022-10-13 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
| CN115403670B (zh) | 2021-05-26 | 2026-03-10 | 安徽瀚海博兴生物技术有限公司 | 抗cd40抗体及其用途 |
| KR20240026507A (ko) | 2021-06-29 | 2024-02-28 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 타노트랜스미션을 촉진시키도록 엔지니어링된 면역 세포 및 이의 용도 |
| WO2023020475A1 (en) * | 2021-08-16 | 2023-02-23 | Utc Therapeutics (Shanghai) Co., Ltd. | Cd40-targetting antibodies and uses thereof |
| EP4393937A4 (de) | 2021-08-26 | 2025-12-31 | Duality Biologics Shanghai Co Ltd | Steroidverbindung und konjugat davon |
| US12234294B2 (en) | 2021-11-05 | 2025-02-25 | Kiniksa Pharmaceuticals, Gmbh | Pharmaceutical composition of a humanized anti-CD40 antibody |
| WO2023198851A1 (en) | 2022-04-14 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for controlling the tumor cell killing by light |
| WO2024077191A1 (en) | 2022-10-05 | 2024-04-11 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| WO2025186778A1 (en) | 2024-03-08 | 2025-09-12 | Janssen Biotech, Inc. | Combinations of oncolytic viruses and immunomodulators |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024401A (en) | 1975-11-17 | 1977-05-17 | General Electric Company | X-ray apparatus |
| CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US5247069A (en) * | 1986-06-13 | 1993-09-21 | Oncogen | Ligands and methods for augmenting B-cell proliferation |
| NZ226694A (en) | 1987-10-28 | 1994-04-27 | Oncogen | Human immunoglobulin produced by recombinant dna techniques |
| EP0434879A1 (de) | 1989-12-14 | 1991-07-03 | Schering-Plough | Verfahren zur Herstellung von faktorabhÀ¤ngigen menschlichen B-Zellinien |
| US6150584A (en) * | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| AU668374B2 (en) | 1991-12-10 | 1996-05-02 | Dana-Farber Cancer Institute | Reactive neutralizing human anti-GP120 recombinant antibody, DNA coding the same and use thereof |
| US5397703A (en) * | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
| US5874082A (en) * | 1992-07-09 | 1999-02-23 | Chiron Corporation | Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation |
| DE69334064T2 (de) | 1992-07-09 | 2007-05-24 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Antagonistische monoklonale Antikörper gegen menschliches CD40 |
| KR960704576A (ko) * | 1993-10-01 | 1996-10-09 | 크리스토퍼 엘. 와이트 | CD40에 대한 항체(Antibodies to CD40) |
| EP0822830B1 (de) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6001358A (en) | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
| ATE332077T1 (de) | 1997-02-28 | 2006-07-15 | Kirin Brewery | Transgene mäuse die ein menschliche antikörper exprimieren |
| CA2319448A1 (en) | 1998-02-04 | 1999-08-12 | The General Hospital Corporation | Costimulatory blockade and mixed chimerism in allotransplantation |
| US6051228A (en) * | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
| EP1073464B1 (de) | 1998-04-28 | 2004-10-06 | Smithkline Beecham Corporation | Monoklonale antikörper mit verringerter immunisierungsfähigkeit |
| WO1999061051A1 (en) | 1998-05-26 | 1999-12-02 | Genitrix, Lcc | Compositions and methods of modulating an immune response to an antigen |
| WO2000000156A2 (en) | 1998-06-26 | 2000-01-06 | Trustees Of Dartmouth College | Methods for modulating immunological responses by targeting antigen to apcs in conjuction with anti-cd40 ligands |
| US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| AU6934600A (en) | 1999-08-27 | 2001-03-26 | Board Of Regents, The University Of Texas System | Cd40 ligand and cd40 agonist compositions and methods of use |
| DE60035057T2 (de) | 1999-10-04 | 2008-01-31 | Novartis Vaccines and Diagnostics, Inc., Emeryville | CD40 Antagonist zur Behandlung von Psoriasis |
| JP2001142482A (ja) | 1999-11-10 | 2001-05-25 | Nippon Hoso Kyokai <Nhk> | 音声字幕化装置 |
| AU2001236621B2 (en) | 2000-02-01 | 2006-06-15 | Mycenax Biotech Inc. | Cd40-binding apc-activating molecules |
| US7063845B2 (en) | 2000-04-28 | 2006-06-20 | Gemini Science, Inc. | Human anti-CD40 antibodies |
| JP2001310535A (ja) | 2000-04-28 | 2001-11-06 | Canon Inc | 記録装置、および記録ヘッドの濃度むら補正方法 |
| AU2001259215A1 (en) | 2000-04-28 | 2001-11-12 | La Jolla Institute For Allergy And Immunology | Human anti-cd40 antibodies and methods of making and using same |
| US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| WO2002028905A2 (en) | 2000-10-02 | 2002-04-11 | Chiron Corporation | Human anti-cd40 antibodies |
| EP2011802A3 (de) * | 2001-04-27 | 2009-04-15 | Kyowa Hakko Kirin Co., Ltd. | Monoklonaler Antikörper gegen CD40 |
| WO2003029296A1 (en) | 2001-10-02 | 2003-04-10 | Chiron Corporation | Human anti-cd40 antibodies |
| AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| ATE485818T1 (de) | 2002-07-30 | 2010-11-15 | Karykion Inc | Zusammensetzungen aus ezetimib und verfahren zur behandlung von mit cholesterin zusammenhängenden gutartigen und bösartigen tumoren |
-
2002
- 2002-04-26 EP EP08017500A patent/EP2011802A3/de not_active Withdrawn
- 2002-04-26 DK DK02720634T patent/DK1391464T3/da active
- 2002-04-26 CA CA2658221A patent/CA2658221C/en not_active Expired - Lifetime
- 2002-04-26 EP EP08017499.8A patent/EP2009027B1/de not_active Expired - Lifetime
- 2002-04-26 AT AT02720634T patent/ATE374214T1/de active
- 2002-04-26 CN CNA2008101609045A patent/CN101508734A/zh active Pending
- 2002-04-26 PT PT02720634T patent/PT1391464E/pt unknown
-
2003
- 2003-10-23 US US10/693,629 patent/US7193064B2/en not_active Expired - Lifetime
-
2006
- 2006-12-05 US US11/633,716 patent/US7537763B2/en not_active Expired - Lifetime
-
2008
- 2008-10-06 US US12/246,325 patent/US20090123466A1/en not_active Abandoned
-
2009
- 2009-01-02 AU AU2009200017A patent/AU2009200017A1/en not_active Withdrawn
-
2010
- 2010-03-23 US US12/729,997 patent/US20100234578A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK1391464T3 (da) | 2008-01-14 |
| EP2009027B1 (de) | 2014-05-21 |
| US20040120948A1 (en) | 2004-06-24 |
| EP2011802A2 (de) | 2009-01-07 |
| US7193064B2 (en) | 2007-03-20 |
| US20070077242A1 (en) | 2007-04-05 |
| US20090123466A1 (en) | 2009-05-14 |
| US7537763B2 (en) | 2009-05-26 |
| CN101508734A (zh) | 2009-08-19 |
| CA2658221C (en) | 2012-11-27 |
| AU2009200017A1 (en) | 2009-02-05 |
| EP2011802A3 (de) | 2009-04-15 |
| EP2009027A1 (de) | 2008-12-31 |
| CA2658221A1 (en) | 2002-11-07 |
| PT1391464E (pt) | 2007-11-15 |
| US20100234578A1 (en) | 2010-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1391464T3 (da) | Anti-CD40 monoklonalt antistof | |
| EP1914243A3 (de) | Monoglonaler Antikörper gegen CD40 | |
| NO20040925L (no) | Flat belysningsanordning. | |
| NO20042474L (no) | Reguleringsventil-stromningsjusteringsanordning. | |
| NO20040671D0 (no) | Emballasje for myke, engangs-kontaktlinser. | |
| NO20041165L (no) | Avstengningsanordning. | |
| BR0215188B1 (pt) | válvula de gaveta. | |
| ITTO20020003A1 (it) | Dispositivo di verifica per veicolo. | |
| ITPD20020236A1 (it) | Dispositivo di regolazione a manopola, particolarmente | |
| BR0204689B1 (pt) | dispositivo de fixação. | |
| BR0204393B1 (pt) | conjunto de válvula. | |
| ITTO20020085U1 (it) | Proiettore per veicoli. | |
| ITTO20010754A0 (it) | Dispositivo di regolazione della posizione di un pedale. | |
| ES1049393Y (es) | Dispositivo de ambientacion olorosa multiple. | |
| ITTO20020066U1 (it) | Proiettore per veicoli. | |
| BR0116875B1 (pt) | conjunto de válvulas. | |
| ES1050791Y (es) | Dispositivo de control funcional para cafeteras de hosteleria. | |
| ES1048563Y (es) | Dispositivo condensador. | |
| ITTO20020067U1 (it) | Proiettore per veicoli. | |
| ES1050837Y (es) | Un dispositivo de union. | |
| ES1049284Y (es) | Dispositivo de cierre antivandalico. | |
| ES1050426Y (es) | Dispositivo elevador - nivelador. | |
| ES1049664Y (es) | Dispositivo autohinchador. | |
| ES1051818Y (es) | Fuente. | |
| ES1050793Y (es) | Dispositivo de fijacion de luminarias. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1391464 Country of ref document: EP |
|
| EEIH | Change in the person of patent owner |