MA55805A - Métodes de modulation de l'activité immunitaire - Google Patents

Métodes de modulation de l'activité immunitaire

Info

Publication number
MA55805A
MA55805A MA055805A MA55805A MA55805A MA 55805 A MA55805 A MA 55805A MA 055805 A MA055805 A MA 055805A MA 55805 A MA55805 A MA 55805A MA 55805 A MA55805 A MA 55805A
Authority
MA
Morocco
Prior art keywords
methods
immune activity
modulating immune
modulating
activity
Prior art date
Application number
MA055805A
Other languages
English (en)
Inventor
Anthony Michael Barsotti
Alexandra Masu Cantley
Douglas Gowers Cole
Jason Park
Original Assignee
Flagship Pioneering Innovations V Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flagship Pioneering Innovations V Inc filed Critical Flagship Pioneering Innovations V Inc
Publication of MA55805A publication Critical patent/MA55805A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA055805A 2019-05-03 2020-05-01 Métodes de modulation de l'activité immunitaire MA55805A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962843266P 2019-05-03 2019-05-03
US201962857812P 2019-06-05 2019-06-05
US201962857809P 2019-06-05 2019-06-05
US201962857797P 2019-06-05 2019-06-05

Publications (1)

Publication Number Publication Date
MA55805A true MA55805A (fr) 2022-03-09

Family

ID=70779958

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055805A MA55805A (fr) 2019-05-03 2020-05-01 Métodes de modulation de l'activité immunitaire

Country Status (4)

Country Link
US (2) US11376272B2 (fr)
EP (1) EP3962493A2 (fr)
MA (1) MA55805A (fr)
WO (1) WO2020227159A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3149482A1 (fr) 2019-08-02 2021-02-11 Mersana Therapeutics, Inc. Derives de bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] et composes apparentes utilises en tant qu'agonistes de sting (stimulateur des genes de l'interferon) pour le traitement du cancer
BR112022019919A2 (pt) 2020-04-02 2023-02-14 Mersana Therapeutics Inc Conjugado de anticorpo-fármaco compreendendo agonistas de sting
EP4319820A1 (fr) 2021-04-10 2024-02-14 Profoundbio Us Co. Agents de liaison à folr1, conjugués de ceux-ci et leurs procédés d'utilisation
EP4326769A1 (fr) 2021-04-20 2024-02-28 Institut Curie Compositions et procédés destinés à être utilisés en immunothérapie
EP4326321A1 (fr) 2021-04-20 2024-02-28 Institut Curie Compositions et procédés destinés à être utilisés en immunothérapie
JP7742892B2 (ja) 2021-04-23 2025-09-22 ジェンマブ エー/エス 抗cd70抗体、そのコンジュゲートおよびこれを使用する方法
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
CA3228655A1 (fr) * 2021-08-12 2023-02-16 Shanghai SIMR Biotechnology Co., Ltd Derive de triazole substitue, son procede de preparation, composition pharmaceutique de celui-ci et utilisation associee
WO2023025256A1 (fr) * 2021-08-26 2023-03-02 成都先导药物开发股份有限公司 Agoniste de sting pouvant être utilisé en tant que molécule effectrice d'un conjugué médicament-anticorps
CN115247148B (zh) * 2022-06-14 2023-08-11 吉林省拓华生物科技有限公司 用于培养免疫细胞的培养基及细胞的培养方法
CN114968747B (zh) * 2022-07-12 2022-10-28 杭州数列网络科技有限责任公司 自动极限压测性能测试方法、装置、电子设备及存储介质
CN116270603B (zh) * 2023-03-24 2024-08-06 黑龙江八一农垦大学 一种大豆苷元在制备用于缓解冷应激导致的肝损伤的药物中的应用
WO2024215808A2 (fr) * 2023-04-11 2024-10-17 The Regents Of The University Of California Outils pour cibler des voies de détection de nucléotides naturelles et synthétiques
WO2025072406A1 (fr) 2023-09-26 2025-04-03 Profoundbio Us Co. Agents de liaison ptk7, conjugués de ceux-ci et leurs procédés d'utilisation
TW202547866A (zh) 2024-01-10 2025-12-16 丹麥商珍美寶股份有限公司 Slitrk6結合劑、其共軛物及使用彼之方法
US20250381289A1 (en) 2024-02-29 2025-12-18 Genmab A/S Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same
CN118496135B (zh) * 2024-04-19 2024-11-15 中国海洋大学 硫脲类化合物或其药学上可接受的盐及其作为免疫抑制剂的应用
WO2025262243A1 (fr) * 2024-06-19 2025-12-26 Invios Gmbh Thiéno- et thiazolopyrimidine-2,6-diones et leur utilisation comme immunomodulateurs

Family Cites Families (309)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR104E (fr)
US5843708A (en) 1988-01-05 1998-12-01 Ciba-Geigy Corporation Chimeric antibodies
ES2052027T5 (es) 1988-11-11 2005-04-16 Medical Research Council Clonacion de secuencias de dominio variable de inmunoglobulina.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
AU7579291A (en) 1990-04-16 1991-11-11 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Use of purinergic receptor agonists as antineoplastic agents
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5397703A (en) 1992-07-09 1995-03-14 Cetus Oncology Corporation Method for generation of antibodies to cell surface molecules
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5900407A (en) 1997-02-06 1999-05-04 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with uridine triphosphates and related compounds
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
DE19939653A1 (de) 1999-08-13 2001-02-22 Thomas Huenig Verwendung CD28 spezifischer monoklonaler Antikörper zur Herstellung einer pharmazeutischen Zusammensetzung
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
DE60035057T2 (de) 1999-10-04 2008-01-31 Novartis Vaccines and Diagnostics, Inc., Emeryville CD40 Antagonist zur Behandlung von Psoriasis
CN1413113A (zh) 1999-12-22 2003-04-23 印斯拜尔药品股份有限公司 使用嘌呤能受体激动剂治疗胃肠道疾病的方法
EP1261376A1 (fr) 2000-01-27 2002-12-04 Genetics Institute, LLC Anticorps contre ctla4 (cd152), conjugues comprenant lesdits anticorps, et leurs utilisations
BR0110190A (pt) 2000-04-19 2003-12-30 Tanox Inc Antagonistas de cd40 para uso em tratamento de psorìase e outras condições inflamatórias de pele
US20030059427A1 (en) 2000-04-28 2003-03-27 Force Walker R. Isolation and characterization of highly active anti-CD40 antibody
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途
WO2002028905A2 (fr) 2000-10-02 2002-04-11 Chiron Corporation Anticorps humains anti-cd40
DE10050935A1 (de) 2000-10-11 2002-05-02 Tegenero Gmbh Verwendung CD28 spezifischer monoklonaler Antikörper zur Stimulation von Blutzellen, welche kein CD28 tragen
US8501471B2 (en) 2000-10-18 2013-08-06 Sloan-Kettering Institute For Cancer Research Uses of monoclonal antibody 8H9
CA2423843A1 (fr) 2000-10-18 2002-04-25 Sloan-Kettering Institute For Cancer Research Utilisations d'anticorps monoclonal 8h9
WO2003075846A2 (fr) 2002-03-08 2003-09-18 Sloan-Kettering Institute For Cancer Research Utilisations d'anticorps 8h9 monoclonaux
US8414892B2 (en) 2000-10-18 2013-04-09 Sloan-Kettering Institute For Cancer Research Uses of monoclonal antibody 8H9
US20020102264A1 (en) 2000-10-18 2002-08-01 Cheung Nai-Kong V. Uses of monoclonal antibody 8H9
CN1272345C (zh) 2000-12-14 2006-08-30 安斯泰来制药有限公司 沉默型抗cd-28抗体及其应用
ES2353273T3 (es) 2000-12-26 2011-02-28 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anticuerpos anti-cd28.
AR036993A1 (es) 2001-04-02 2004-10-20 Wyeth Corp Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
EP2011802A3 (fr) 2001-04-27 2009-04-15 Kyowa Hakko Kirin Co., Ltd. Anticorps monoclonal anti-CD40
WO2003028712A2 (fr) * 2001-09-28 2003-04-10 Universite Libre De Bruxelles Agonistes de recepteur purinergique et pyrimidinergique pour le traitement de maladies immunitaires mediees par le lymphocyte t cd4+ active
WO2003029296A1 (fr) 2001-10-02 2003-04-10 Chiron Corporation Anticorps humains diriges contre le cd40
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
AU2002346581A1 (en) 2001-11-26 2003-06-10 Chiron Corporation Antagonist anti-cd40 monoclonal antibody therapy for multiple sclerosis treatment
US20080199471A1 (en) 2002-03-01 2008-08-21 Bernett Matthew J Optimized cd40 antibodies and methods of using the same
DE10212108A1 (de) 2002-03-13 2003-10-02 Tegenero Ag Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung
NZ536746A (en) 2002-06-13 2007-02-23 Crucell Holland Bv An agonistic antibody or fragment thereof that immunospecifically binds and stimulates the human OX40-receptor
DE10230223A1 (de) 2002-07-04 2004-01-22 Tegenero Ag Mikropartikel mit CD28-spezifischen monoklonalen Antikörpern
US7052694B2 (en) 2002-07-16 2006-05-30 Mayo Foundation For Medical Education And Research Dendritic cell potentiation
AU2003259294A1 (en) 2002-07-30 2004-02-16 Bristol-Myers Squibb Company Humanized antibodies against human 4-1bb
US7291331B1 (en) 2002-09-11 2007-11-06 La Jolla Institute For Allergy And Immunology Methods of treating OX40 medicated recall immune responses
AU2003294462C1 (en) 2002-11-21 2011-06-30 University Of Utah Research Foundation Purinergic modulation of smell
WO2004056875A1 (fr) 2002-12-23 2004-07-08 Wyeth Anticorps anti pd-1 et utilisations
US20070104688A1 (en) 2003-02-13 2007-05-10 City Of Hope Small interfering RNA mediated transcriptional gene silencing in mammalian cells
AU2004244626A1 (en) 2003-05-23 2004-12-09 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services GITR ligand and GITR ligand-related molecules and antibodies and uses thereof
US20090191213A9 (en) 2003-07-02 2009-07-30 Novo Nordisk A/S Compositions and methods for regulating NK cell activity
GB0324498D0 (en) 2003-07-21 2003-11-26 Aventis Pharma Inc Heterocyclic compounds as P2X7 ion channel blockers
EP1600164A3 (fr) 2003-09-22 2006-05-17 TeGenero AG Utilisation d'une substance liant le CD28 dans la production d'une composition pharmaceutique à effet dose-dépendant
US7288638B2 (en) 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
WO2005041892A2 (fr) 2003-11-03 2005-05-12 Cornell Research Foundation, Inc Inhibition du recepteur des purines en tant que strategie therapeutique au niveau de la moelle epiniere et du cerveau
ES2346978T3 (es) 2003-11-04 2010-10-22 Novartis Vaccines And Diagnostics, Inc. Uso de anticuerpos monoclonantes anti-cd40 antagonistas para el tratamiento del mieloma multiple.
US8277810B2 (en) 2003-11-04 2012-10-02 Novartis Vaccines & Diagnostics, Inc. Antagonist anti-CD40 antibodies
WO2005044307A2 (fr) 2003-11-04 2005-05-19 Chiron Corporation Procedes de therapie pour des cancers lies a la cellule b
JP4746552B2 (ja) 2003-11-04 2011-08-10 ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗cd40抗体の使用
SI1680141T1 (sl) 2003-11-04 2010-12-31 Novartis Vaccines & Diagnostic Postopki terapije za trdne tumorje, ki izražajo CD-40 celično-površinski antigen
CA2544364A1 (fr) 2003-11-04 2005-05-19 Chiron Corporation Utilisation d'anticorps anti-cd40 antagonistes pour le traitement de la leucemie lymphocytique chronique
DE10352900A1 (de) 2003-11-11 2005-06-16 Tegenero Ag Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung zur Behandlung von B-CLL
US20050136055A1 (en) 2003-12-22 2005-06-23 Pfizer Inc CD40 antibody formulation and methods
KR101223373B1 (ko) 2003-12-25 2013-01-16 교와 핫꼬 기린 가부시키가이샤 항 cd40 항체의 변이체
WO2005111003A1 (fr) 2004-04-29 2005-11-24 Abbott Laboratories Analogues d’amino-tétrazoles et méthodes d’utilisation
US20050261239A1 (en) * 2004-05-23 2005-11-24 Universiteit Van Maastricht Use of ATP for the manufacture of a medicament for treating certain inflammatory conditions, oxidative stress and fatigue
US20060099203A1 (en) 2004-11-05 2006-05-11 Pease Larry R B7-DC binding antibody
WO2006003179A2 (fr) 2004-07-01 2006-01-12 Novo Nordisk A/S Anticorps anti-kir humains
JP5112863B2 (ja) 2004-07-01 2013-01-09 ノヴォ ノルディスク アー/エス ヒト抗−kir抗体
US20080057070A1 (en) 2004-11-04 2008-03-06 Chiron Corporation Antagonist Anti-Cd40 Monoclonal Antibodies and Methods for Their Use
DE102004063494A1 (de) 2004-12-23 2006-07-13 Tegenero Ag Antikörper
WO2006072625A2 (fr) 2005-01-06 2006-07-13 Novo Nordisk A/S Procedes et traitements combines anti-kir
ES2374603T3 (es) 2005-01-06 2012-02-20 Novo Nordisk A/S Agentes de unión a kir y procedimientos de uso de los mismos.
JP5154949B2 (ja) 2005-01-06 2013-02-27 ノヴォ ノルディスク アー/エス ウイルス感染を治療するための組成物および方法
US8323645B2 (en) 2005-03-24 2012-12-04 Millennium Pharmaceuticals, Inc. Antibodies that bind OV064 and methods of use therefor
US8759490B2 (en) 2005-03-24 2014-06-24 Millennium Pharamaceuticals, Inc. Antibodies that bind OV064 and methods of use therefor
AU2006230099B2 (en) 2005-03-25 2012-04-19 Gitr, Inc. GITR binding molecules and uses therefor
US20060240006A1 (en) 2005-04-20 2006-10-26 Chishih Chu Novel antibody structures derived from human germline sequences
EP1874823B1 (fr) 2005-04-27 2016-01-13 Indiana University Research and Technology Corporation Anticorps de l'isoforme de l'antigene nucleaire des cellules proliferatives cancereuses specifiques (pcnacs) et leurs utilisations
PL2161336T5 (pl) 2005-05-09 2017-10-31 Ono Pharmaceutical Co Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi
US7585960B2 (en) 2005-05-11 2009-09-08 Theramab Gmbh Nucleic acids encoding superagonistic anti-CD28 antibodies
JP5208730B2 (ja) 2005-05-18 2013-06-12 ノバルティス アーゲー Cd40シグナル伝達によって媒介される増殖性障害の診断および治療のための方法
PL1889065T3 (pl) 2005-05-18 2013-12-31 Novartis Ag Metody diagnostyki i leczenia chorób posiadających składnik autoimmunologiczny i/lub zapalny
KR100694508B1 (ko) 2005-05-24 2007-03-13 울산대학교 산학협력단 Hbbk4항체를 포함하는 암 질환 치료용 약학조성물및 이를 이용한 암의 면역치료 방법
EP1885399B1 (fr) 2005-05-26 2010-10-20 Seattle Genetics, Inc. Anticorps anti-cd40 humanisés et procédés d'utilisation
CA2612241C (fr) 2005-07-01 2018-11-06 Medarex, Inc. Anticorps monoclonaux humains diriges contre un ligand de mort programmee de type 1(pd-l1)
JP2009517339A (ja) 2005-11-01 2009-04-30 ノバルティス アーゲー 抗cd40抗体の使用
JP2009513712A (ja) 2005-11-01 2009-04-02 ノバルティス アーゲー 抗cd40抗体の使用
CN101304981A (zh) 2005-11-07 2008-11-12 艾博特公司 P2x7受体拮抗剂及使用方法
TWI461436B (zh) 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd 人類cd134(ox40)之人類單株抗體及其製造及使用方法
NZ568015A (en) 2005-12-08 2012-03-30 Medarex Inc Human monoclonal antibodies to O8E
AU2006329944A1 (en) 2005-12-09 2007-07-05 Seattle Genetics, Inc. Methods of using CD40 binding agents
US20110008368A1 (en) 2006-01-13 2011-01-13 Board Of Regents, The University Of Texas System Methods of modulating the ox40 receptor to treat cancer
US20100184802A1 (en) 2006-03-16 2010-07-22 Kelly Michael G Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof
GEP20125628B (en) 2006-04-21 2012-09-10 Novartis Ag Pharmaceutical compositions containing antagonist anti-cd40 antibody
EP1854810A1 (fr) 2006-05-09 2007-11-14 PanGenetics B.V. Anticorps monoclonal anti CD40 humain déimmunisé et antagoniste dérivé de l'anticorps ch5D12
KR100745488B1 (ko) 2006-07-04 2007-08-02 학교법인 울산공업학원 항-4-1bb 항체 및 화학 항암제를 포함하는 암 질환 예방및 치료용 약학 조성물
US8067550B2 (en) 2006-10-10 2011-11-29 Biosceptre International Limited Hybridomas producing antibodies against non functional P2X7 receptor
GB0620894D0 (en) 2006-10-20 2006-11-29 Univ Southampton Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
AU2007334264A1 (en) 2006-11-15 2008-06-26 Medarex, Inc. Human monoclonal antibodies to BTLA and methods of use
US20100189723A1 (en) 2007-01-11 2010-07-29 Peter Andreas Nicolai Reumert Wagtmann Anti-kir antibodies, formulations, and uses thereof
JP5357778B2 (ja) 2007-01-23 2013-12-04 ゼンコー・インコーポレイテッド 最適化cd40抗体および前記を使用する方法
EP2121008A4 (fr) 2007-03-22 2010-03-31 Sloan Kettering Inst Cancer Utilisations de l'anticorps monoclonal 8h9
WO2008114002A1 (fr) 2007-03-22 2008-09-25 Astrazeneca Ab Dérivés de quinoléine destinés au traitement de maladies inflammatoires
MX2009010759A (es) 2007-04-03 2009-10-28 Glaxo Group Ltd Derivados de carboxamida imidazolidina como modulares de p2x7.
AU2008236649B2 (en) 2007-04-10 2013-05-02 H. Lundbeck A/S Heteroaryl amide analogues as P2X7 antagonists
EP2703011A3 (fr) 2007-05-07 2014-03-26 MedImmune, LLC Anticorps anti-ICOS et leur utilisation dans le traitement de l'oncologie, la transplantation et les maladies auto-immunes
WO2008138876A1 (fr) 2007-05-10 2008-11-20 Glaxo Group Limited Dérivés du pyrazole utilisés comme modulateurs de p2x7
KR20080107050A (ko) 2007-06-05 2008-12-10 울산대학교 산학협력단 항-cd137 단일클론 항체를 포함하는 만성이식편대숙주 질환의 예방 또는 치료용 약학적 조성물
KR101586617B1 (ko) 2007-06-18 2016-01-20 머크 샤프 앤 도메 비.브이. 사람 프로그램된 사멸 수용체 pd-1에 대한 항체
WO2009001673A1 (fr) * 2007-06-26 2008-12-31 Josai University Corporation Immunoadjuvant contenant de l'atp
US20090028857A1 (en) 2007-07-23 2009-01-29 Cell Genesys, Inc. Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
FR2921342B1 (fr) 2007-09-20 2010-03-12 Airbus France Carenage aerodynamique arriere inferieur pour dispositif d'accrochage d'un moteur d'aeronef
JP2011500767A (ja) 2007-10-26 2011-01-06 グラクソ グループ リミテッド P2x7モジュレータとしての4−ベンゾイル−1−置換ピペラジン−2−オン誘導体
CA2699631A1 (fr) 2007-10-31 2009-05-07 Nissan Chemical Industries, Ltd. Derives de pyridazinone et leur utilisation comme inhibiteurs du recepteur p2x7
CN101970003A (zh) 2007-11-09 2011-02-09 诺华有限公司 抗cd40抗体的应用
US8106073B2 (en) 2007-11-30 2012-01-31 Astrazeneca Ab Quinoline derivatives 057
AR069747A1 (es) 2007-11-30 2010-02-17 Medarex Inc Conjugado anticuerpo monoclonal anti-b7h4- farmaco y metodos de utilizacion
CN102006890A (zh) 2007-12-04 2011-04-06 阿尔尼拉姆医药品有限公司 靶向脂质
EP2245065A1 (fr) 2008-01-23 2010-11-03 Xencor, Inc. Anticorps dirigés contre cd40 optimisés et leurs procédés d'utilisation
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
US8314068B2 (en) 2008-04-14 2012-11-20 University Hospitals Of Cleveland P2X7 inhibition of epithelial cancers and papillomas
KR101598397B1 (ko) 2008-04-22 2016-02-29 얀센 파마슈티카 엔.브이. 퀴놀린 또는 이소퀴놀린 치환된 피2엑스7 안타고니스트
EP2279003A4 (fr) 2008-05-01 2013-04-03 Gtc Biotherapeutics Inc Anticorps anti-cd137 en tant qu'agent dans le traitement d'états inflammatoires
CA2729567C (fr) 2008-06-30 2018-04-24 Kyowa Hakko Kirin Co., Ltd. Anticorps anti-cd27
KR20110036618A (ko) 2008-07-16 2011-04-07 베일러 리서치 인스티튜트 극대화된 Gag 및 Nef를 수지상 세포에 표적화시킴을 기본으로 하는 HIV 백신
US8518410B2 (en) 2009-03-10 2013-08-27 Baylor Research Institute Fusion protein with HIV antigen
AR073459A1 (es) 2008-07-18 2010-11-10 Domantis Ltd Composiciones de dominios variables de anticuerpos monovalentes para la union de cd28 y metodos de uso
EP2700651B1 (fr) 2008-07-18 2019-04-10 Bristol-Myers Squibb Company Compositions monovalentes pour la liaison au CD28 et procédés d'utilisation
US20110097339A1 (en) 2008-07-18 2011-04-28 Domantis Limited Compositions monovalent for CD28 binding and methods of use
JP5794917B2 (ja) 2008-09-12 2015-10-14 アイシス・イノベーション・リミテッドIsis Innovationlimited Pd−1特異抗体およびその使用
CA2736829C (fr) 2008-09-12 2018-02-27 Isis Innovation Limited Anticorps specifiques de pd-1 et leurs utilisations
PL2342226T3 (pl) 2008-09-26 2017-01-31 Dana-Farber Cancer Institute, Inc. Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania
WO2010042433A1 (fr) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combinaison d'anticorps cd137 et d'anticorps ctla-4 pour le traitement de maladies prolifératives
EP2367553B1 (fr) 2008-12-05 2017-05-03 Novo Nordisk A/S Traitement combiné pour améliorer la cytotoxicité induite par les cellules nk
EP4209510B1 (fr) 2008-12-09 2024-01-31 F. Hoffmann-La Roche AG Anticorps anti-pd-l1 et leur utilisation pour améliorer la fonction des lymphocytes t
EP2198873A1 (fr) 2008-12-18 2010-06-23 Aposcience AG Préparation pharmaceutique renfermant le surnageant de cultures de cellules mononucléaires sanguines
BRPI1008692B8 (pt) 2009-02-17 2021-05-25 Ucb Biopharma Sprl anticorpo antagonista tendo especificidade para ox40 humano, sequência de dna isolado, vetor de clonagem ou de expressão, célula hospedeira, processo para a produção do referido anticorpo, composição farmacêutica, uso do 5 referido anticorpo e proteína de fusão
GB0903325D0 (en) 2009-02-26 2009-04-08 Univ Aberdeen Antibody molecules
AU2010222942B2 (en) 2009-03-10 2013-01-10 Baylor Research Institute Anti-CD40 antibodies and uses thereof
GB0906274D0 (en) 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
ES2571235T3 (es) 2009-04-10 2016-05-24 Kyowa Hakko Kirin Co Ltd Procedimiento para el tratamiento de un tumor sanguíneo que utiliza el anticuerpo anti-TIM-3
EP2993188B1 (fr) 2009-04-20 2020-08-19 Kyowa Kirin Co., Ltd. Anticorps anti-cd40 comprenant une igg2 ayant trois acide aminés mutés
US8501946B2 (en) 2009-04-29 2013-08-06 Glaxo Group Limited 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine derivatives as P2X7 modulators
GB0907515D0 (en) 2009-04-30 2009-06-10 Glaxo Group Ltd Compounds
WO2010132389A2 (fr) 2009-05-14 2010-11-18 University Of Maryland, Baltimore Procédés de traitement de cancers et de maladies associées à l'expression de 4-1bb (cd137)
ES2352780B2 (es) * 2009-06-04 2011-09-15 Laboratorios Ovejero S.A. Lipopolisacárido de ochrobactrum intermedium contra la sepsis.
CA2768396A1 (fr) 2009-07-30 2011-02-03 F. Hoffmann-La Roche Ag Amides de dihydropyrimidone utilises comme modulateurs p2x7
IN2012DN00863A (fr) 2009-07-31 2015-07-10 Medarex Inc
PT3023438T (pt) 2009-09-03 2020-05-08 Merck Sharp & Dohme Anticorpos anti-gitr
WO2011031063A2 (fr) 2009-09-09 2011-03-17 울산대학교 산학협력단 Composition de prévention ou de traitement de troubles métaboliques contenant l'anticorps anti-4-1bb
US8871760B2 (en) 2009-09-21 2014-10-28 Roche Palo Alto Llc [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators
GB0919594D0 (en) 2009-11-09 2009-12-23 Glaxo Group Ltd Compounds
NO2504364T3 (fr) 2009-11-24 2018-01-06
CA2781311C (fr) 2009-12-07 2019-03-12 The Board Of Trustees Of The Leland Stanford Junior University Methodes d'amplification d'un traitement a base d'anticorps anticancereux
ES2705015T3 (es) 2009-12-29 2019-03-21 Kyowa Hakko Kirin Co Ltd Anticuerpo anti-CD27
KR20110085038A (ko) 2010-01-19 2011-07-27 울산대학교 산학협력단 항 cd137-항체 및 독소 결합물을 이용한 cd137 양성세포의 제거방법
WO2011091078A2 (fr) 2010-01-19 2011-07-28 Xencor, Inc. Variants d'anticorps possédant une activité complémentaire accrue
US8785604B2 (en) 2010-02-18 2014-07-22 Effimune Anti-CD28 humanized antibodies
PH12012501751A1 (en) 2010-03-04 2012-11-12 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
PH12018501083A1 (en) 2010-03-04 2019-02-18 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
NZ602020A (en) 2010-03-31 2014-05-30 Boehringer Ingelheim Int Anti-cd40 antibodies
US9028830B2 (en) 2010-04-08 2015-05-12 JN Biosciences, LLC Antibodies to CD122
US20120213771A1 (en) 2010-04-13 2012-08-23 Celldex Therapeutics Inc. Antibodies that bind human cd27 and uses thereof
NZ602892A (en) 2010-04-13 2014-08-29 Celldex Therapeutics Inc Antibodies that bind human cd27 and uses thereof
JP5513242B2 (ja) 2010-04-28 2014-06-04 オリンパス株式会社 撮像装置
WO2011155607A1 (fr) 2010-06-11 2011-12-15 協和発酵キリン株式会社 Anticorps anti-tim-3
JP6023706B2 (ja) 2010-07-09 2016-11-09 アデュロ・バイオテック・ホールディングス・ヨーロッパ・ベスローテン・フエンノートシャップAduro Biotech Holdings, Europe B.V. Cd27に対するアゴニスト抗体
WO2012027328A2 (fr) 2010-08-23 2012-03-01 Board Of Regents, The University Of Texas System Anticorps anti-ox40 et leurs procédés d'utilisation
SG10201912092VA (en) 2010-09-09 2020-02-27 Pfizer 4-1bb binding molecules
JP2013249256A (ja) 2010-09-15 2013-12-12 Astellas Pharma Inc 脂肪性肝疾患治療薬
CA2812046A1 (fr) 2010-09-15 2012-03-22 Alnylam Pharmaceuticals, Inc. Agents a base d'arni modifies
AR083847A1 (es) 2010-11-15 2013-03-27 Novartis Ag Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
BR112013012138B1 (pt) 2010-11-22 2022-02-22 Innate Pharma Sa Uso de um composto que inibe um receptor inibidor de célula natural killer (nkcir)
WO2012075111A1 (fr) 2010-11-30 2012-06-07 Novartis Ag Utilisation d'anticorps anti-cd40 en thérapie combinée contre des cancers associés aux cellules b
US20120149718A1 (en) 2010-12-14 2012-06-14 Brotherton-Pleiss Christine E Amido Compounds
US20120157494A1 (en) 2010-12-16 2012-06-21 Harris Iii Ralph New Isoindolyl compounds
CA2824278C (fr) 2010-12-20 2022-09-20 The Rockefeller University Modulation d'anticorps agonistes anti-tnfr
WO2012109238A2 (fr) 2011-02-07 2012-08-16 President And Fellows Of Harvard College Procédés d'augmentation des réponses immunitaires à l'aide d'agents qui se lient directement à ire-1 et activent ire-1
JP5458188B2 (ja) 2011-02-17 2014-04-02 協和発酵キリン株式会社 抗cd40抗体の高濃度製剤
WO2012114268A1 (fr) 2011-02-22 2012-08-30 Actelion Pharmaceuticals Ltd Dérivés de benzamide en tant qu'antagonistes du récepteur p2x7
GB201103955D0 (en) 2011-03-09 2011-04-20 Antitope Ltd Antibodies
PT2683406T (pt) 2011-03-11 2019-07-08 Beth Israel Deaconess Medical Ct Inc Anticorpos anti-cd40 e utilização dos mesmos
MX373443B (es) 2011-03-31 2020-05-20 Inst Nat Sante Rech Med Anticuerpos dirigidos contra icos y usos de los mismos.
EP2699598B1 (fr) 2011-04-19 2019-03-06 Pfizer Inc Combinaisons d'anticorps anti-4-1bb et d'anticorps induisant une cytotoxicité à médiation cellulaire dépendante d'un anticorps (adcc) pour le traitement du cancer
SI2699264T1 (en) 2011-04-20 2018-08-31 Medimmune Llc Antibodies and other molecules that bind b7-h1 and pd-1
US9475879B2 (en) 2011-04-21 2016-10-25 Bristol-Myers Squibb Company Antibody polypeptides that antagonize CD40
KR102030987B1 (ko) 2011-04-25 2019-11-11 다이이찌 산쿄 가부시키가이샤 항 b7-h3항체
CA2833806A1 (fr) 2011-04-28 2012-11-01 Claire Mitchell Methode de traitement d'une degenerescence maculaire par la modulation des recepteurs p2y12 ou p2x7
ES2709654T3 (es) 2011-04-29 2019-04-17 Apexigen Inc Anticuerpos anti-CD40 y métodos de uso
ES2765874T3 (es) 2011-05-25 2020-06-11 Innate Pharma Sa Anticuerpos anti-KIR para el tratamiento de trastornos inflamatorios
BR112013033974A2 (pt) 2011-07-01 2017-02-14 Biosceptre Int Ltd terapia de combinação
WO2013006490A2 (fr) 2011-07-01 2013-01-10 Cellerant Therapeutics, Inc. Anticorps se liant spécifiquement à tim3
HRP20180858T1 (hr) 2011-07-11 2018-09-21 Glenmark Pharmaceuticals S.A. Protutijela koja se vežu na ox40 i njihove uporabe
KR101995088B1 (ko) 2011-07-22 2019-07-02 이도르시아 파마슈티컬스 리미티드 P2x7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
WO2013025779A1 (fr) 2011-08-15 2013-02-21 Amplimmune, Inc. Anticorps anti-b7-h4 et leurs utilisations
KR101685262B1 (ko) 2011-08-23 2016-12-21 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 항-ox40 항체 및 이의 사용 방법
GB201115280D0 (en) 2011-09-05 2011-10-19 Alligator Bioscience Ab Antibodies, uses and methods
WO2013039954A1 (fr) 2011-09-14 2013-03-21 Sanofi Anticorps anti-gitr
GB201116092D0 (en) 2011-09-16 2011-11-02 Bioceros B V Antibodies and uses thereof
US9422351B2 (en) 2011-11-03 2016-08-23 The Trustees Of The University Of Pennsylvania Isolated B7-H4 specific compositions and methods of use thereof
UA112203C2 (uk) 2011-11-11 2016-08-10 Юсб Фарма С.А. Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини
EP2604265A1 (fr) 2011-12-17 2013-06-19 Royal College of Surgeons in Ireland (RCSI) Antagonistes P2x7 en tant que traitement auxiliaire ou principal contre l'état de mal épileptique
BR122020002414B1 (pt) 2012-03-15 2022-03-03 Janssen Biotech, Inc Uso de anticorpos anti-cd27 humanos
US20140004131A1 (en) 2012-05-04 2014-01-02 Novartis Ag Antibody formulation
AU2013267161A1 (en) 2012-05-31 2014-11-20 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-L1
KR101549637B1 (ko) 2012-06-08 2015-09-03 국립암센터 신규한 Th1 세포 전환용 에피토프 및 이의 용도
NZ702392A (en) 2012-06-08 2017-03-31 Aduro Biotech Compositions and methods for cancer immunotherapy
US9268936B2 (en) 2012-07-27 2016-02-23 Mandiant, Llc Physical memory forensics system and method
WO2014022758A1 (fr) 2012-08-03 2014-02-06 Dana-Farber Cancer Institute, Inc. Anticorps de liaison double à agent unique anti-pd-l1 et pd-l2 et procédés d'utilisation
EP2892928B1 (fr) 2012-09-03 2018-05-30 INSERM - Institut National de la Santé et de la Recherche Médicale Anticorps anti-icos pour traiter la maladie du greffon contre l'hôte
LT2904011T (lt) 2012-10-02 2017-11-10 Bristol-Myers Squibb Company Anti-kir antikūnų ir anti-pd-1 antikūnų derinys, akirtas vėžio gydymui
WO2014057687A1 (fr) 2012-10-11 2014-04-17 第一三共株式会社 Conjugué anticorps-médicament
TWI598325B (zh) 2012-10-12 2017-09-11 H 朗德貝克公司 苯甲醯胺類
TW201427947A (zh) 2012-10-12 2014-07-16 Lundbeck & Co As H 環狀胺
WO2014061277A1 (fr) 2012-10-19 2014-04-24 第一三共株式会社 Conjugué anticorps-médicament produit par liaison par l'intermédiaire d'un lieur ayant une structure hydrophile
US9789182B2 (en) 2012-10-23 2017-10-17 Bristol-Myers Squibb Company Combination of anti-KIR and anti-CTLA-4 antibodies to treat cancer
JPWO2014065402A1 (ja) 2012-10-26 2016-09-08 株式会社ペルセウスプロテオミクス 抗ヒトcd40モノクローナル抗体及びその利用
JP2016011258A (ja) 2012-10-26 2016-01-21 株式会社ペルセウスプロテオミクス 抗ヒトcd40モノクローナル抗体及びその利用
CN104918957B (zh) 2012-10-30 2018-11-16 埃派斯进有限公司 抗-cd40抗体及其使用方法
US20150297623A1 (en) * 2012-11-06 2015-10-22 The Board Of Regents Of The University Of Texas System Methods for treatment of primary cancer and cancer metastasis
EA201590396A1 (ru) 2012-12-13 2015-12-30 Адуро Биотек, Инк. Композиция, содержащая циклические пуриновые динуклеотиды с определенной стереохимией, и способ ее получения и применения
US9556117B2 (en) 2012-12-18 2017-01-31 Actelion Pharmaceuticals Ltd. Indole carboxamide derivatives as P2X7 receptor antagonists
JP2016509582A (ja) 2012-12-19 2016-03-31 アンプリミューン, インコーポレイテッド 抗ヒトb7−h4抗体およびその使用
PT2934598T (pt) * 2012-12-19 2018-07-24 Univ Texas Focalização farmacêutica de uma trajetória de sinalização de dinucleótido cíclico de mamífero
AR093984A1 (es) 2012-12-21 2015-07-01 Merck Sharp & Dohme Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
KR102222220B1 (ko) 2013-01-22 2021-03-03 이도르시아 파마슈티컬스 리미티드 P2x7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
TWI599567B (zh) 2013-03-14 2017-09-21 健生藥品公司 P2x7調節劑
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
US9040534B2 (en) 2013-03-14 2015-05-26 Janssen Pharmaceutica Nv [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
TWI627174B (zh) 2013-03-14 2018-06-21 比利時商健生藥品公司 P2x7調控劑
EP3299391B1 (fr) 2013-03-14 2019-12-04 Genentech, Inc. Anticorps et immunoconjugués anti-b7-h4
EP2970271B1 (fr) 2013-03-14 2017-11-08 Janssen Pharmaceutica NV Modulateurs de p2x7
US20140322236A1 (en) 2013-03-15 2014-10-30 Sdix, Llc Anti-human adora2a antibodies
WO2014140374A2 (fr) 2013-03-15 2014-09-18 Novo Nordisk A/S Anticorps monovalents anti-cd27
MD20180107A2 (ro) 2013-03-18 2019-06-30 Biocerox Products B.V. Anticorpi anti-CD134 (OX40) umanizaţi şi utilizarea acestora
US20160084839A1 (en) 2013-04-02 2016-03-24 Marisa Dolled-Filhart Immunohistochemical assay for detecting expression of programmed death ligand 1 (pd-l1) in tumor tissue
ME03586B (fr) 2013-05-18 2020-07-20 Univ California Compositions et procédés d'activation de la signalisation dépendante de « stimulateur de gènes d'interféron »
MX376808B (es) 2013-05-24 2025-03-07 Medimmune Llc Anticuerpos anti-b7-h5 y sus usos.
US9676853B2 (en) 2013-05-31 2017-06-13 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-1
SG10201708143QA (en) 2013-06-06 2017-11-29 Pf Medicament Anti-c10orf54 antibodies and uses thereof
WO2014209168A1 (fr) 2013-06-24 2014-12-31 Kim Ruslan Zynsonovich Communicateur automobile
GB201311487D0 (en) 2013-06-27 2013-08-14 Alligator Bioscience Ab Bispecific molecules
RU2016107426A (ru) 2013-08-02 2017-09-07 Адуро Байотек Холдингс, Юроуп Б.В. Комбинирование агонистов cd27 и ингибирование иммунных контрольных точек для стимуляции иммунитета
TW201605896A (zh) 2013-08-30 2016-02-16 安美基股份有限公司 Gitr抗原結合蛋白
WO2015036394A1 (fr) 2013-09-10 2015-03-19 Medimmune Limited Anticorps contre pd-1 et leurs utilisations
EP3060056A4 (fr) * 2013-10-21 2017-10-18 Drexel University Utilisation d'agonistes de sting pour traiter une infection chronique par le virus de l'hépatite b
ES2707057T3 (es) 2013-11-06 2019-04-02 Bristol Myers Squibb Co Combinación de anticuerpos anti-KIR y anti-CS1 para tratar el mieloma múltiple
GB201322583D0 (en) 2013-12-19 2014-02-05 Alligator Bioscience Ab Antibodies
WO2015091655A1 (fr) 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Polythérapie avec un anticorps anti-ang 2 et un agoniste cd40
ES2783026T3 (es) 2014-02-04 2020-09-16 Pfizer Combinación de un antagonista de PD-1 y un agonista de 4-1BB para el tratamiento de cáncer
EP2905282A1 (fr) 2014-02-05 2015-08-12 AXXAM S.p.A. Thiazole ou oxazole substituée en tant qu'antagonistes du récepteur P2X7
WO2015134988A1 (fr) 2014-03-07 2015-09-11 Bristol-Myers Squibb Company Procédé d'utilisation de polypeptides d'anticorps qui sont des antagonistes de cd40 pour traiter une affection intestinale inflammatoire (aii)
MX2016015181A (es) 2014-05-21 2017-05-25 Pfizer Combinacion de un anticuerpo del receptor 4 de quimiocina anti-cc y un agonista de 4-1 bb para el tratamiento del cancer.
DK3148579T3 (da) 2014-05-28 2021-03-08 Agenus Inc Anti-gitr antistoffer og fremgangsmåder til anvendelse deraf
WO2015181267A1 (fr) 2014-05-29 2015-12-03 Spring Bioscience Corporation Anticorps anti-b7-h3 et leurs utilisations diagnostiques
AU2015271709B2 (en) 2014-06-06 2020-11-26 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
WO2015188047A1 (fr) 2014-06-06 2015-12-10 University Of Maryland, Baltimore Anticorps monoclonaux anti-cd-137 présentant des capacités de liaison distinctes au fcγr pour le traitement d'un cancer ou d'une auto-immunité
WO2015198147A1 (fr) 2014-06-23 2015-12-30 Theramab Llc Compositions et méthodes pour une immunothérapie efficace et sûre
CN106659852A (zh) 2014-07-09 2017-05-10 诺和诺德股份有限公司 机动化药物输送装置
CN105296433B (zh) 2014-08-01 2018-02-09 中山康方生物医药有限公司 一种ctla4抗体、其药物组合物及其用途
KR102443258B1 (ko) 2014-08-12 2022-09-14 엘리게이터 바이오사이언스 에이비 항 cd40 항체에 의한 병용 치료제
RU2017108173A (ru) 2014-08-14 2018-09-17 Ф.Хоффманн-Ля Рош Аг Комбинированная терапия на основе антител, активирующих человеческий cd40, и антител к человеческому pd-l1
US20170233485A1 (en) 2014-08-18 2017-08-17 Biogen Ma Inc. Anti-cd40 antibodies and uses thereof
US20170247455A1 (en) 2014-08-22 2017-08-31 Bristol-Myers Squibb Company Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody
AU2015306621B2 (en) 2014-08-27 2021-05-06 Memorial Sloan Kettering Cancer Center Antibodies, compositions, and uses
CA2951604A1 (fr) 2014-08-29 2016-03-03 Pablo Umana Therapie combinatoire d'immunocytokines a variant de l'il -2 ciblees therapie tumorale et d'anticorps anti-pd-l1 humaine
CN113698488A (zh) 2014-09-12 2021-11-26 基因泰克公司 抗-b7-h4抗体及免疫缀合物
RU2017115315A (ru) 2014-10-03 2018-11-08 Дана-Фарбер Кэнсер Инститьют, Инк. Антитела к рецептору глюкокортикоид-индуцированного фактора некроза опухоли (gitr) и способы их применения
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
AU2015340056A1 (en) 2014-10-27 2017-05-25 Agency For Science, Technology And Research Anti-TIM-3 antibodies
GB201419094D0 (en) 2014-10-27 2014-12-10 Agency Science Tech & Res Anti-TIM-3-antibodies
ES2772307T3 (es) 2014-10-28 2020-07-07 Childrens Univ Hospital Tuebingen Tratamiento de pacientes pediátricos con LLA-PCB con un anticuerpo anti-kir
HUE054075T2 (hu) 2014-10-29 2021-08-30 Seagen Inc CD40 elleni nem fukozilált antitestek adagolása és bevitele
WO2016070001A1 (fr) 2014-10-31 2016-05-06 Jounce Therapeutics, Inc. Méthodes de traitement d'états pathologiques avec des anticorps qui se lient à b7-h4
ES2763548T3 (es) 2014-11-06 2020-05-29 Hoffmann La Roche Anticuerpos anti-TIM3 y procedimientos de uso
WO2016094837A2 (fr) 2014-12-11 2016-06-16 Igenica Biotherapeutics, Inc. Anticorps anti-c10orf54 et leurs utilisations
ES2764178T3 (es) 2014-12-16 2020-06-02 Kayla Therapeutics Dinucleótidos cíclicos fluorados para inducción de citocinas
US20170340658A1 (en) 2014-12-16 2017-11-30 Invivogen Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment
WO2016106004A1 (fr) 2014-12-23 2016-06-30 Full Spectrum Genetics, Inc. Nouveaux composés de liaison anti-b7h3 et leurs utilisations
US20160200815A1 (en) 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
JO3746B1 (ar) 2015-03-10 2021-01-31 Aduro Biotech Inc تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون"
EP3685830A1 (fr) * 2015-05-20 2020-07-29 Institut National De La Sante Et De La Recherche Medicale - Inserm Procédés et composition pharmaceutique pour moduler la polarisation et l'activation de macrophages
MX2018001814A (es) 2015-08-13 2018-05-07 Merck Sharp & Dohme Compuestos dinucleotidos ciclicos como agonistas del estimulador de genes de interferon.
UY36969A (es) 2015-10-28 2017-05-31 Novartis Ag Composiciones y métodos para activar la señalización dependiente del estimulador del gen de interferon
EP3386536A4 (fr) 2015-12-07 2019-07-31 Opi Vi- IP Holdco LLC Composition de conjugués d'agonistes-constructions d'anticorps et leurs procédés d'utilisation
WO2017123657A1 (fr) 2016-01-11 2017-07-20 Gary Glick Dinucléotides cycliques pour traiter des affections associées à l'activité sting comme le cancer
US20190062272A1 (en) 2016-04-13 2019-02-28 Capten Therapeutics Inc. Small molecules for immunogenic treatment of cancer
EP3507367A4 (fr) 2016-07-05 2020-03-25 Aduro BioTech, Inc. Composés dinucléotidiques cycliques d'acide nucléique bloqué et leurs utilisations
WO2018045204A1 (fr) 2016-08-31 2018-03-08 Ifm Therapeutics, Inc Analogues de dinucléotides cycliques pour traiter des états associés à l'activité de la piqûre (stimulateur des gènes de l'interféron)
US10414747B2 (en) 2016-10-04 2019-09-17 Merck Sharp & Dohme Corp. Benzo[b]thiophene compounds as sting agonists
JOP20170188A1 (ar) 2016-11-25 2019-01-30 Janssen Biotech Inc ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
PT3512861T (pt) 2016-12-01 2021-04-29 Takeda Pharmaceuticals Co Dinucleotídeos cíclicos
AU2017378782A1 (en) 2016-12-20 2019-07-04 Merck Sharp & Dohme Corp. Combinations of PD-1 antagonists and cyclic dinucleotide sting agonists for cancer treatment
AU2017378783A1 (en) 2016-12-20 2019-07-04 Merck Sharp & Dohme Corp. Cyclic dinucleotide sting agonists for cancer treatment
US11492367B2 (en) 2017-01-27 2022-11-08 Janssen Biotech, Inc. Cyclic dinucleotides as sting agonists
JP7213188B2 (ja) 2017-01-27 2023-01-26 ヤンセン バイオテツク,インコーポレーテツド Stingアゴニストとしての環状ジヌクレオチド
JOP20190218A1 (ar) 2017-03-22 2019-09-22 Boehringer Ingelheim Int مركبات ثنائية النيوكليوتيدات حلقية معدلة
AR113224A1 (es) 2017-04-28 2020-02-19 Novartis Ag Conjugados de anticuerpo que comprenden un agonista de sting
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
WO2018208667A1 (fr) 2017-05-12 2018-11-15 Merck Sharp & Dohme Corp. Composés dinucléotidiques cycliques en tant qu'agonistes sting
JP2020524718A (ja) 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドCuradev Pharma Limited ヒトstingの複素環式小分子調節因子
JP2020524717A (ja) 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドCuradev Pharma Limited ヒトstingの小分子調節因子
CA3067257A1 (fr) 2017-06-22 2018-12-27 Curadev Pharma Limited Modulateurs a petites molecules de sting humain
JP2020530838A (ja) 2017-08-04 2020-10-29 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. がん治療のためのベンゾ[b]チオフェンSTINGアゴニスト
AU2018311965A1 (en) 2017-08-04 2020-02-13 Merck Sharp & Dohme Llc Combinations of PD-1 antagonists and benzo[b]thiophene sting antagonists for cancer treatment
CN107335049B (zh) * 2017-08-18 2019-10-18 中国药科大学 菊科类型环肽化合物作为cGAS-STING信号通路抑制剂的应用
US11638716B2 (en) 2017-08-31 2023-05-02 F-star Therapeutics, Inc. Compounds, compositions, and methods for the treatment of disease
WO2019051489A1 (fr) 2017-09-11 2019-03-14 Sperovie Biosciences, Inc. Composés, compositions et méthodes de traitement de maladie
WO2019055750A1 (fr) 2017-09-15 2019-03-21 Aduro Biotech, Inc. Composés de pyrazolopyrimidinone et leurs utilisations
EP3692033A1 (fr) 2017-10-05 2020-08-12 GlaxoSmithKline Intellectual Property Development Limited Modulateurs de stimulateur des gènes (sting) d'interféron utiles dans le traitement du vih
WO2019069275A1 (fr) 2017-10-05 2019-04-11 Glaxosmithkline Intellectual Property Development Limited Méthodes d'administration d'agonistes de sting

Also Published As

Publication number Publication date
WO2020227159A2 (fr) 2020-11-12
EP3962493A2 (fr) 2022-03-09
WO2020227159A3 (fr) 2020-12-10
US20210299155A1 (en) 2021-09-30
WO2020227159A8 (fr) 2021-01-07
US20220387470A1 (en) 2022-12-08
US11376272B2 (en) 2022-07-05

Similar Documents

Publication Publication Date Title
EP3768854A4 (fr) Modulation de l'expression de hsd17b13
IL271149A (en) Compounds for modulating s1p1 activity and methods of using the same
IL283128A (en) 2-formyl-3-hydroxyphenyloxymethyl compounds capable of modulating hemoglobin
EP3576737A4 (fr) Compositions et procédés de modulation de l'activité de la déshydrogénase à chaîne courte
MA54879A (fr) Inhibiteurs d'enpp1 et méthodes de modulation de réponse immunitaire
EP3781173A4 (fr) Modulation de la réponse immunitaire par ciblage de l'activité du récepteur olfactif
EP3781255A4 (fr) Implants utilisant une communication ultrasonore pour moduler l'activité du nerf splénique
EP3630975A4 (fr) Arn guides modifiés pour moduler l'activité cas9 et procédés d'utilisation
DK3906066T3 (da) Geneterapikonstruktioner til behandling af wilsons sygdom
MA55147A (fr) Compositions et procédés de modulation de l'activité de la déshydrogénase à chaîne courte
EP4045036C0 (fr) Amides hétéroaryle-biphényle pour le traitement de maladies associées à pd-l1
EA201890329A1 (ru) СОЕДИНЕНИЯ В КАЧЕСТВЕ МОДУЛЯТОРОВ RORγ
MA48579A (fr) Anticorps anti-pd1 et méthodes d'utilisation de ceux-ci
IL247714B (en) Compositions for modulating sod-1 expression
IL289829A (en) Immunomodulatory antibodies and methods of use thereof
EP3893931A4 (fr) Méthodes d'utilisation d'anticorps anti-trem2
EP3423429A4 (fr) Modulateurs de l'activité enzymatique de la lipoxygénase et de la cyclooxygénase
MA52889A (fr) Augmentation de l'activité immunitaire par modulation de facteurs de signalisation post-cellulaires
EP3443125A4 (fr) Méthodes d'évaluation de l'activité d'une sclérose en plaques
EP3873911A4 (fr) Composés, compositions et procédés de modulation de l'activité de cdk9
EP3359556A4 (fr) Modulation de l'activité des cytokines gamma-c
IL286681A (en) Compounds and methods for modulating ube3a-ats
EP3908179A4 (fr) Synchronisation de l'activité cérébrale
EP3510380A4 (fr) Composés sondes par activité, compositions et méthodes d'utilisation
MA52019A (fr) Schéma posologique de modulateur d'assemblage de capside