ATE378048T1 - Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonisten - Google Patents
Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonistenInfo
- Publication number
- ATE378048T1 ATE378048T1 AT03796701T AT03796701T ATE378048T1 AT E378048 T1 ATE378048 T1 AT E378048T1 AT 03796701 T AT03796701 T AT 03796701T AT 03796701 T AT03796701 T AT 03796701T AT E378048 T1 ATE378048 T1 AT E378048T1
- Authority
- AT
- Austria
- Prior art keywords
- macrophage
- methods
- cholinergic agonist
- release
- determining whether
- Prior art date
Links
- 239000000064 cholinergic agonist Substances 0.000 title abstract 9
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 210000002540 macrophage Anatomy 0.000 abstract 8
- 102000004127 Cytokines Human genes 0.000 abstract 6
- 108090000695 Cytokines Proteins 0.000 abstract 6
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 4
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 4
- 230000000770 proinflammatory effect Effects 0.000 abstract 4
- 108091034117 Oligonucleotide Proteins 0.000 abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 210000004962 mammalian cell Anatomy 0.000 abstract 2
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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| JP3699392B2 (ja) * | 2001-12-04 | 2005-09-28 | 本田技研工業株式会社 | 艇体の接着剤硬化促進装置 |
| DE10211415A1 (de) | 2002-03-15 | 2003-09-25 | Bayer Ag | Bicyclische N-Biarylamide |
| ATE378048T1 (de) * | 2002-12-06 | 2007-11-15 | The Feinstein Inst Medical Res | Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonisten |
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2003
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- 2003-12-05 JP JP2004559325A patent/JP4750421B2/ja not_active Expired - Fee Related
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- 2003-12-05 EP EP07020473.0A patent/EP1949901B1/de not_active Expired - Lifetime
- 2003-12-05 CN CNA2003801082615A patent/CN1735414A/zh active Pending
- 2003-12-05 WO PCT/US2003/038708 patent/WO2004052365A2/en not_active Ceased
- 2003-12-05 DE DE60317564T patent/DE60317564T2/de not_active Expired - Lifetime
- 2003-12-05 ES ES03796701T patent/ES2293086T3/es not_active Expired - Lifetime
- 2003-12-05 DK DK07020473.0T patent/DK1949901T3/da active
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- 2003-12-05 CN CN2012100243080A patent/CN102657651A/zh active Pending
- 2003-12-05 EP EP03796701.5A patent/EP1581223B2/de not_active Expired - Lifetime
- 2003-12-05 SI SI200332349T patent/SI1949901T1/sl unknown
- 2003-12-05 PT PT70204730T patent/PT1949901E/pt unknown
- 2003-12-05 EP EP09001425A patent/EP2062595A1/de not_active Withdrawn
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- 2011-01-26 JP JP2011014401A patent/JP2011105745A/ja not_active Withdrawn
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Also Published As
| Publication number | Publication date |
|---|---|
| US20040204355A1 (en) | 2004-10-14 |
| JP2014055178A (ja) | 2014-03-27 |
| PT1949901E (pt) | 2014-05-23 |
| JP2016084355A (ja) | 2016-05-19 |
| JP5925178B2 (ja) | 2016-05-25 |
| EP1581223B2 (de) | 2016-05-25 |
| EP1949901B1 (de) | 2014-02-12 |
| EP1949901A3 (de) | 2008-10-15 |
| JP4750421B2 (ja) | 2011-08-17 |
| ES2293086T3 (es) | 2008-03-16 |
| EP1949901A2 (de) | 2008-07-30 |
| EP1581223A2 (de) | 2005-10-05 |
| AU2003298939A1 (en) | 2004-06-30 |
| IL168787A (en) | 2010-11-30 |
| CA2507502C (en) | 2011-11-29 |
| WO2004052365A3 (en) | 2004-09-23 |
| DE60317564T2 (de) | 2008-10-23 |
| CN1735414A (zh) | 2006-02-15 |
| IL206855A (en) | 2015-11-30 |
| SI1949901T1 (sl) | 2014-06-30 |
| DK1949901T3 (da) | 2014-05-19 |
| JP2006514946A (ja) | 2006-05-18 |
| DE60317564D1 (de) | 2007-12-27 |
| EP2062595A1 (de) | 2009-05-27 |
| ES2462545T3 (es) | 2014-05-23 |
| JP2011105745A (ja) | 2011-06-02 |
| WO2004052365A2 (en) | 2004-06-24 |
| CN102657651A (zh) | 2012-09-12 |
| EP1581223B1 (de) | 2007-11-14 |
| AU2003298939C1 (en) | 2004-06-30 |
| CA2507502A1 (en) | 2004-06-24 |
| AU2003298939B2 (en) | 2007-03-15 |
| US7273872B2 (en) | 2007-09-25 |
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