EP1949901A3 - Hemmung von Entzündungen unter Verwendung von alpha-7-rezeptorbindenden cholinergen Agonisten - Google Patents
Hemmung von Entzündungen unter Verwendung von alpha-7-rezeptorbindenden cholinergen Agonisten Download PDFInfo
- Publication number
- EP1949901A3 EP1949901A3 EP07020473A EP07020473A EP1949901A3 EP 1949901 A3 EP1949901 A3 EP 1949901A3 EP 07020473 A EP07020473 A EP 07020473A EP 07020473 A EP07020473 A EP 07020473A EP 1949901 A3 EP1949901 A3 EP 1949901A3
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- Prior art keywords
- macrophage
- methods
- cholinergic agonist
- release
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200332349T SI1949901T1 (sl) | 2002-12-06 | 2003-12-05 | Postopek ugotavljanja holinergičnega agonista selektivnega za nikotinski receptor alfa 7 |
| EP09001425A EP2062595A1 (de) | 2002-12-06 | 2003-12-05 | Hemmung von Entzündungen unter Verwendung von alpha-7-rezeptorbindenden cholinergen Agonisten |
| CY20141100329T CY1115122T1 (el) | 2002-12-06 | 2014-05-09 | ΑΝΑΣΤΟΛΗ ΤΗΣ ΦΛΕΓΜΟΝΗΣ ΧΡΗΣΙΜΟΠΟΙΩΝΤΑΣ ΧΟΛΙΝΕΡΓΙΚΟΥΣ ΑΓΩΝΙΣΤΕΣ ΥΠΟΔΟΧΕΑ ΠΡΟΣΔΕΣΗΣ α-7 |
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| EP03796701.5A EP1581223B2 (de) | 2002-12-06 | 2003-12-05 | Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonisten |
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| EP03796701.5A Division-Into EP1581223B2 (de) | 2002-12-06 | 2003-12-05 | Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonisten |
| EP03796701.5A Division EP1581223B2 (de) | 2002-12-06 | 2003-12-05 | Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonisten |
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| EP09001425A Division-Into EP2062595A1 (de) | 2002-12-06 | 2003-12-05 | Hemmung von Entzündungen unter Verwendung von alpha-7-rezeptorbindenden cholinergen Agonisten |
| EP09001425A Division EP2062595A1 (de) | 2002-12-06 | 2003-12-05 | Hemmung von Entzündungen unter Verwendung von alpha-7-rezeptorbindenden cholinergen Agonisten |
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| EP1949901B1 EP1949901B1 (de) | 2014-02-12 |
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| EP07020473.0A Expired - Lifetime EP1949901B1 (de) | 2002-12-06 | 2003-12-05 | Ein Verfahren zum Bestimmen einer cholinergen Agonist selektiv für eines alpha 7 nikotinischen Rezeptors |
| EP03796701.5A Expired - Lifetime EP1581223B2 (de) | 2002-12-06 | 2003-12-05 | Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonisten |
| EP09001425A Withdrawn EP2062595A1 (de) | 2002-12-06 | 2003-12-05 | Hemmung von Entzündungen unter Verwendung von alpha-7-rezeptorbindenden cholinergen Agonisten |
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| EP09001425A Withdrawn EP2062595A1 (de) | 2002-12-06 | 2003-12-05 | Hemmung von Entzündungen unter Verwendung von alpha-7-rezeptorbindenden cholinergen Agonisten |
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| JP (4) | JP4750421B2 (de) |
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- 2003-12-05 ES ES07020473.0T patent/ES2462545T3/es not_active Expired - Lifetime
- 2003-12-05 CN CN2012100243080A patent/CN102657651A/zh active Pending
- 2003-12-05 EP EP03796701.5A patent/EP1581223B2/de not_active Expired - Lifetime
- 2003-12-05 SI SI200332349T patent/SI1949901T1/sl unknown
- 2003-12-05 PT PT70204730T patent/PT1949901E/pt unknown
- 2003-12-05 EP EP09001425A patent/EP2062595A1/de not_active Withdrawn
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999010338A2 (en) * | 1997-08-29 | 1999-03-04 | University Of Florida | Benzylidene- and cinnamylidene-anabaseines as neuronal nicotinic alpha-7 receptor agonists |
| WO2001073446A1 (en) * | 2000-03-29 | 2001-10-04 | Synaptica Limited | Alpha 7 nicotinic receptor screening assays |
| WO2001089526A1 (en) * | 2000-05-23 | 2001-11-29 | North Shore-Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US20020040035A1 (en) * | 2000-08-18 | 2002-04-04 | Myers Jason K. | Quinuclidine-substituted aryl compounds for treatment of disease |
Non-Patent Citations (1)
| Title |
|---|
| HONG WANG ET AL.: "NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7 SUBUNIT IS AN ESSENTIAL REGULATOR OF INFLAMMATION", NATURE, vol. 421, 23 January 2003 (2003-01-23), pages 384, XP002277770 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20040204355A1 (en) | 2004-10-14 |
| JP2014055178A (ja) | 2014-03-27 |
| PT1949901E (pt) | 2014-05-23 |
| JP2016084355A (ja) | 2016-05-19 |
| JP5925178B2 (ja) | 2016-05-25 |
| EP1581223B2 (de) | 2016-05-25 |
| EP1949901B1 (de) | 2014-02-12 |
| ATE378048T1 (de) | 2007-11-15 |
| JP4750421B2 (ja) | 2011-08-17 |
| ES2293086T3 (es) | 2008-03-16 |
| EP1949901A2 (de) | 2008-07-30 |
| EP1581223A2 (de) | 2005-10-05 |
| AU2003298939A1 (en) | 2004-06-30 |
| IL168787A (en) | 2010-11-30 |
| CA2507502C (en) | 2011-11-29 |
| WO2004052365A3 (en) | 2004-09-23 |
| DE60317564T2 (de) | 2008-10-23 |
| CN1735414A (zh) | 2006-02-15 |
| IL206855A (en) | 2015-11-30 |
| SI1949901T1 (sl) | 2014-06-30 |
| DK1949901T3 (da) | 2014-05-19 |
| JP2006514946A (ja) | 2006-05-18 |
| DE60317564D1 (de) | 2007-12-27 |
| EP2062595A1 (de) | 2009-05-27 |
| ES2462545T3 (es) | 2014-05-23 |
| JP2011105745A (ja) | 2011-06-02 |
| WO2004052365A2 (en) | 2004-06-24 |
| CN102657651A (zh) | 2012-09-12 |
| EP1581223B1 (de) | 2007-11-14 |
| AU2003298939C1 (en) | 2004-06-30 |
| CA2507502A1 (en) | 2004-06-24 |
| AU2003298939B2 (en) | 2007-03-15 |
| US7273872B2 (en) | 2007-09-25 |
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