ATE380817T1 - Verfahren zur katalytischen herstellung von hydrocodon und hydromorphon - Google Patents

Verfahren zur katalytischen herstellung von hydrocodon und hydromorphon

Info

Publication number: ATE380817T1
Authority: AT; Austria
Prior art keywords: hydromorphone; hydrocodone; catalytic production; analogs; catalytic
Prior art date: 2003-11-05

Application number

AT04796303T

Other languages

English (en)

Inventor

Peter Xianqi Wang

Carl Ray White

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-05

Filing date

2004-10-25

Publication date

2007-12-15

2003-11-05 Priority claimed from PCT/US2003/035462 external-priority patent/WO2005047291A1/en

2004-10-25 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

2007-12-15 Application granted granted Critical

2007-12-15 Publication of ATE380817T1 publication Critical patent/ATE380817T1/de

Links

OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 title abstract 3
230000003197 catalytic effect Effects 0.000 title abstract 2
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 title abstract 2
LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 title abstract 2
229960000240 hydrocodone Drugs 0.000 title abstract 2
WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 title abstract 2
229960001410 hydromorphone Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 title abstract 2
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 2
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
229960004126 codeine Drugs 0.000 abstract 1
229960005181 morphine Drugs 0.000 abstract 1
-1 phosphine halide Chemical group 0.000 abstract 1
229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
229910052723 transition metal Inorganic materials 0.000 abstract 1
150000003624 transition metals Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT04796303T 2003-11-05 2004-10-25 Verfahren zur katalytischen herstellung von hydrocodon und hydromorphon ATE380817T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10/495,503 US7323565B2 (en)	2002-11-11	2003-11-05	Method for the catalytic production of hydrocodone and hydromorphone
PCT/US2003/035462 WO2005047291A1 (en)	2002-11-11	2003-11-05	Method for the catalytic production of hydrocodone and hydromorphone

Publications (1)

Publication Number	Publication Date
ATE380817T1 true ATE380817T1 (de)	2007-12-15

Family

ID=36423513

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04796303T ATE380817T1 (de)	2003-11-05	2004-10-25	Verfahren zur katalytischen herstellung von hydrocodon und hydromorphon

Country Status (7)

Country	Link
US (1)	US7323565B2 (de)
EP (1)	EP1687310B1 (de)
AT (1)	ATE380817T1 (de)
CA (1)	CA2544950A1 (de)
DE (1)	DE602004010711T2 (de)
ES (1)	ES2295946T3 (de)
WO (1)	WO2005113557A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2008538746A (ja)	2005-03-28	2008-11-06	マリンクロッド・インコーポレイテッド	ヒドロコドン、ヒドロモルホンおよびその誘導体の触媒的製造方法
ES2357216T3 (es) *	2005-06-16	2011-04-20	Mallinckrodt, Inc.	Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
US7399859B1 (en) *	2007-02-06	2008-07-15	Cody Laboratories Inc.	Method for catalytic preparation of hydromorphone and hydrocodone
US8962841B2 (en)	2007-06-29	2015-02-24	Brock University	Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US7999104B2 (en)	2007-06-29	2011-08-16	Brock University	Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
WO2010118271A1 (en) *	2009-04-09	2010-10-14	Mallinckrodt Inc.	Preparation of saturated ketone morphinan compounds by catalytic isomerization
US9040705B2 (en) *	2009-04-09	2015-05-26	Mallinckrodt Llc	Preparation of saturated ketone morphinan compounds
US20100261906A1 (en) *	2009-04-09	2010-10-14	Mallinckrodt Inc.	Preparation of 6-Keto, 3-Alkoxy Morphinans
WO2011137086A1 (en)	2010-04-29	2011-11-03	Mallinckrodt Llc	Preparation of saturated ketone morphinan compounds having low metal content
WO2012003468A1 (en)	2010-07-02	2012-01-05	Johnson Matthey Public Limited Company	Process for the synthesis and purification of oxycodone
AU2012253188B2 (en)	2011-05-06	2016-12-22	Brock University	Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
US9556108B2 (en)	2014-07-10	2017-01-31	Mallinckrodt Llc	Process for preparing substituted phenylalkanes
DK3319941T3 (da)	2015-07-10	2022-03-14	SpecGx LLC	Totrinsfremgangsmåde til fremstilling af 3-substituerede phenylalkylaminer
EP3255051A1 (de)	2016-06-09	2017-12-13	Siegfried AG	Trägerbasierter metallkatalysator für die herstellung von hydrocodon und hydromorphon
US10081636B2 (en)	2016-07-08	2018-09-25	Cody Laboratories, Inc.	Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates
WO2022101408A1 (en)	2020-11-13	2022-05-19	Ferrer Internacional, S.A.	Synthesis of hydromorphone base

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US2577947A (en) *		1951-12-11		Manufacture of dihydrocodeinone
DE365683C (de)	1921-03-22	1922-12-22	Knoll & Co Chem Fab	Verfahren zur Darstellung von Ketoderivaten der Morphinreihe
DE415097C (de)	1923-10-19	1925-06-13	Chem Fab	Verfahren zur Darstellung von Dihydrokodeinon
DE607931C (de)	1934-01-26	1935-01-11	Chemische Fabriken	Verfahren zur Darstellung von Dihydromorphinonen
US2577847A (en) *	1948-10-16	1951-12-11	Allied Chem & Dye Corp	Purification of chlorocarbons
US2544291A (en) *	1949-04-05	1951-03-06	New York Quinine And Chemical	Alkaloid manufacture
US2654756A (en) *	1949-10-20	1953-10-06	Mallinckrodt Chemical Works	Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2628962A (en) *	1949-10-20	1953-02-17	Mallinckrodt Chemical Works	Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2715626A (en) *	1950-07-05	1955-08-16	Merck & Co Inc	Process of preparing dihydrocodeinone
US2649454A (en) *	1951-08-20	1953-08-18	Univ California	Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
US4003903A (en) *	1975-02-12	1977-01-18	Florida Board Of Regents	N-acyl-N-norsalutaridines and process for making them
US4322426A (en) *	1980-04-28	1982-03-30	E. I. Du Pont De Nemours And Company	17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists
US4368326A (en) *	1980-07-03	1983-01-11	Rice Kenner C	Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4478840A (en) *	1983-10-11	1984-10-23	E. I. Du Pont De Nemours And Company	Appetite suppressing compositions and methods
US4535157A (en) *	1983-11-01	1985-08-13	Key Pharmaceuticals, Inc.	Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
US4613668A (en) *	1983-12-22	1986-09-23	The United States Of America As Represented By The Department Of Health And Human Services	Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
GB9213524D0 (en) *	1992-06-25	1992-08-12	Macfarlan Smith Ltd	Biocatalysis in the synthesis of analgesic and antitussive compounds
GB9616253D0 (en)	1996-08-01	1996-09-11	Johnson Matthey Plc	Preparation of narcotic analgesics
GB9805516D0 (en) *	1998-03-17	1998-05-13	Johnson Matthey Plc	Preparation of opiates
US6177567B1 (en) *	1999-10-15	2001-01-23	Boehringer Ingelheim Chemicals, Inc.	Method for preparing oxycodone
US6512117B1 (en)	1999-11-09	2003-01-28	Abbott Laboratories	Hydromorphone and hydrocodone compositions and methods for their synthesis

2003
- 2003-11-05 US US10/495,503 patent/US7323565B2/en not_active Expired - Fee Related
2004
- 2004-10-25 CA CA002544950A patent/CA2544950A1/en not_active Abandoned
- 2004-10-25 DE DE602004010711T patent/DE602004010711T2/de not_active Expired - Fee Related
- 2004-10-25 ES ES04796303T patent/ES2295946T3/es not_active Expired - Lifetime
- 2004-10-25 WO PCT/US2004/035292 patent/WO2005113557A1/en not_active Ceased
- 2004-10-25 EP EP04796303A patent/EP1687310B1/de not_active Expired - Lifetime
- 2004-10-25 AT AT04796303T patent/ATE380817T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE602004010711T2 (de)	2008-12-04
WO2005113557A1 (en)	2005-12-01
US20060074239A1 (en)	2006-04-06
EP1687310B1 (de)	2007-12-12
EP1687310A1 (de)	2006-08-09
DE602004010711D1 (de)	2008-01-24
CA2544950A1 (en)	2005-12-01
ES2295946T3 (es)	2008-04-16
WO2005113557A8 (en)	2006-05-26
US7323565B2 (en)	2008-01-29

Legal Events

Date	Code	Title	Description
2008-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE380817T1 (de)	2007-12-15	Verfahren zur katalytischen herstellung von hydrocodon und hydromorphon
ATE376550T1 (de)	2007-11-15	Katalytisches verfahren zur herstellung von hydromorphone und hydrocodone
DE60328492D1 (de)	2009-09-03	Verfahren zur erzeugung von nanoteilchen
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DE602004020895D1 (de)	2009-06-10	Verfahren zur herstellung von kohlenstoffnanospulen
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