ATE381318T1 - Herstellungsverfahren einer interaktionverbindung von wirkstoffen mit einem porösen träger durch ein überkritisches fluidum - Google Patents
Herstellungsverfahren einer interaktionverbindung von wirkstoffen mit einem porösen träger durch ein überkritisches fluidumInfo
- Publication number
- ATE381318T1 ATE381318T1 AT02796803T AT02796803T ATE381318T1 AT E381318 T1 ATE381318 T1 AT E381318T1 AT 02796803 T AT02796803 T AT 02796803T AT 02796803 T AT02796803 T AT 02796803T AT E381318 T1 ATE381318 T1 AT E381318T1
- Authority
- AT
- Austria
- Prior art keywords
- porous support
- supercritical
- fluidum
- production
- supercritical fluid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 230000003993 interaction Effects 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 239000012530 fluid Substances 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 230000002452 interceptive effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000009792 diffusion process Methods 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000003068 static effect Effects 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Saccharide Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0113178A FR2830760B1 (fr) | 2001-10-12 | 2001-10-12 | Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE381318T1 true ATE381318T1 (de) | 2008-01-15 |
Family
ID=8868228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02796803T ATE381318T1 (de) | 2001-10-12 | 2002-10-11 | Herstellungsverfahren einer interaktionverbindung von wirkstoffen mit einem porösen träger durch ein überkritisches fluidum |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7390411B2 (de) |
| EP (1) | EP1434567B1 (de) |
| JP (1) | JP4401778B2 (de) |
| CN (1) | CN100396277C (de) |
| AT (1) | ATE381318T1 (de) |
| AU (1) | AU2002361279B2 (de) |
| BR (2) | BR0213220A (de) |
| CA (1) | CA2462537C (de) |
| CY (1) | CY1107306T1 (de) |
| DE (1) | DE60224215T2 (de) |
| DK (1) | DK1434567T3 (de) |
| ES (1) | ES2295446T3 (de) |
| FR (1) | FR2830760B1 (de) |
| MX (1) | MXPA04003300A (de) |
| PT (1) | PT1434567E (de) |
| WO (1) | WO2003043604A1 (de) |
| ZA (1) | ZA200402580B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2854079B1 (fr) | 2003-04-25 | 2007-11-30 | Pf Medicament | Procede de preparation de complexes moleculaires |
| FR2868315B1 (fr) * | 2004-04-01 | 2006-07-14 | Pierre Fabre Medicament Sa | Procede de preparation d'un compose d'inclusion soluble de substances actives dans une molecule hote avec l'aide d'un agent d'interaction par fluide supercritique |
| RU2382654C2 (ru) * | 2004-04-01 | 2010-02-27 | Пьер Фабр Медикаман | Комплексы включения, полученные способом с использованием co2 в сверхкритическом состоянии и агента взаимодействия с комплексом |
| FR2876914A1 (fr) * | 2004-10-21 | 2006-04-28 | Pierre Fabre Medicament Sa | Complexe comprenant un antibiotique, une cyclodextrine et un agent d'interaction |
| FR2876910B1 (fr) * | 2004-10-21 | 2007-04-13 | Pierre Fabre Medicament Sa | Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction |
| ITSA20050008A1 (it) * | 2005-03-10 | 2006-09-11 | Univ Degli Studi Salerno | Processo per la produzione di membrane caricate con uno o piu' principi attivi |
| DE602006013933D1 (de) * | 2006-02-10 | 2010-06-10 | Carotech Sdn Bhd Chemor | Verfahren zur Gewinnung hochangereicherter Naturstoff-fraktionen aus Palmöl unter Verwendung von superkritischen und beinahe superkritischen Flüssigmedien |
| FR2944280B1 (fr) | 2009-04-09 | 2012-08-03 | Galderma Res & Dev | Procede de preparation de complexes moleculaires entre adapalene et des cyclodextrines |
| FR2944207B1 (fr) * | 2009-04-09 | 2011-05-06 | Galderma Res & Dev | Compositions comprenant au moins un complexe compose d'un derive d'acide naphtoique et d'au moins une cyclodestrine et leurs utilisations |
| PL2699114T3 (pl) * | 2011-04-22 | 2018-11-30 | Pepsico, Inc. | Kapsułkowanie ekstraktu w porowatych cząstkach |
| EP2884523B1 (de) * | 2013-12-16 | 2020-02-05 | IMEC vzw | Verfahren zum Aktivieren einer porösen Schichtoberfläche |
| CN105343893B (zh) * | 2015-12-11 | 2018-07-20 | 中国药科大学 | 对乙酰氨基酚-2-羟丙基-β-环糊精包合物制备方法 |
| KR102096724B1 (ko) * | 2016-01-08 | 2020-04-03 | 아크로 바이오메디컬 컴퍼니 엘티디 | 무세포 각막, 무세포 각막의 제조 방법 및 그의 용도 |
| CN116688155A (zh) * | 2023-07-20 | 2023-09-05 | 内蒙古工业大学 | 一种木犀草素/γ-环糊精包合物、制备方法及应用 |
| CN118697820A (zh) * | 2024-05-31 | 2024-09-27 | 广州新征程生物科技有限公司 | 一种治疗心脑血管病的中药及制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US189454A (en) * | 1877-04-10 | Improvement in paper boxes | ||
| GB2191715B (en) | 1986-06-17 | 1990-07-25 | Midrex Int Bv | Method and apparatus for dedusting and desulfurizing gases |
| JPH0677511B2 (ja) * | 1986-12-05 | 1994-10-05 | 金印わさび株式会社 | 香辛成分の包接化合物の製造方法 |
| US4822497A (en) * | 1987-09-22 | 1989-04-18 | Modar, Inc. | Method for solids separation in a wet oxidation type process |
| DE3744329A1 (de) * | 1987-12-28 | 1989-07-06 | Schwarz Pharma Gmbh | Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung |
| FR2629735B1 (fr) * | 1988-04-11 | 1991-03-22 | Agronomique Inst Nat Rech | Procede d'extraction au dioxyde de carbone supercritique de composes volatils, et composes obtenus |
| GB9100643D0 (en) | 1991-01-11 | 1991-02-27 | Shaffery Michael J | Filter system |
| US5389263A (en) * | 1992-05-20 | 1995-02-14 | Phasex Corporation | Gas anti-solvent recrystallization and application for the separation and subsequent processing of RDX and HMX |
| ATE166573T1 (de) * | 1993-03-24 | 1998-06-15 | Ciba Geigy Ag | Verfahren zur herstellung einer liposomendispersion im hochdruckbereich |
| GB9313642D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| EP0706821A1 (de) | 1994-10-06 | 1996-04-17 | Centre De Microencapsulation | Verfahren zum Beschichten von Partikeln |
| FR2725990B1 (fr) * | 1994-10-21 | 1997-01-10 | Pf Medicament | Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux |
| FR2741619B1 (fr) * | 1995-11-28 | 1998-02-13 | Pf Medicament | Nouveaux derives de 2,3,5-trimethyl-4-hydroxy-anilides, leur preparation et leur application en therapeutique |
| JP3986086B2 (ja) | 1996-03-01 | 2007-10-03 | ザ ユニバーシティ オブ カンザス | 近臨界および超臨界反溶媒を用いる粒子析出方法および被覆方法 |
| FR2753639B1 (fr) * | 1996-09-25 | 1998-12-11 | Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede | |
| US5766637A (en) | 1996-10-08 | 1998-06-16 | University Of Delaware | Microencapsulation process using supercritical fluids |
| DE19711393C1 (de) | 1997-03-19 | 1998-08-13 | Fraunhofer Ges Forschung | Verfahren zum Mikroverkapseln von Partikeln |
| IT1296464B1 (it) | 1997-11-19 | 1999-06-25 | Vectorpharma Int | Composizioni farmaceutiche in forma di polveri di polimeri reticolati caricati con farmaci e relativo processo di preparazione mediante |
| GB9810559D0 (en) | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
| GB9824298D0 (en) | 1998-11-05 | 1998-12-30 | Smithkline Beecham Plc | Novel process |
| SE9804001D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New process |
| US6555139B2 (en) * | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
| CN1280875A (zh) * | 1999-06-30 | 2001-01-24 | 刘士群 | 用超临界反萃剂制造微粒的方法和装置 |
| FR2798863B1 (fr) * | 1999-09-27 | 2001-12-28 | Separex Sa | Procede et installation de mise a l'etat adsorbe sur un support poreux de composes actifs contenus dans un produit |
| FR2799984B1 (fr) | 1999-10-21 | 2002-05-03 | Lavipharm | Procede de fractionnement d'une matiere composee de plusieurs constituants a l'aide d'un solvant a pression supercritique |
| FR2803538B1 (fr) | 1999-12-15 | 2002-06-07 | Separex Sa | Procede et dispositif de captage de fines particules par percolation dans un lit de granules |
| FR2815540B1 (fr) * | 2000-10-19 | 2005-06-10 | Separex Sa | Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote |
| US6896905B2 (en) * | 2001-02-15 | 2005-05-24 | Rohm And Haas Company | Porous particles, their aqueous dispersions, and method of preparation |
| WO2002089851A1 (fr) | 2001-03-06 | 2002-11-14 | Separex (Societe Anonyme) | Procede de fabrication de complexes hote-client |
-
2001
- 2001-10-12 FR FR0113178A patent/FR2830760B1/fr not_active Expired - Fee Related
-
2002
- 2002-10-11 EP EP02796803A patent/EP1434567B1/de not_active Expired - Lifetime
- 2002-10-11 AU AU2002361279A patent/AU2002361279B2/en not_active Ceased
- 2002-10-11 BR BR0213220-6A patent/BR0213220A/pt not_active IP Right Cessation
- 2002-10-11 DE DE60224215T patent/DE60224215T2/de not_active Expired - Lifetime
- 2002-10-11 ES ES02796803T patent/ES2295446T3/es not_active Expired - Lifetime
- 2002-10-11 US US10/492,346 patent/US7390411B2/en not_active Expired - Lifetime
- 2002-10-11 AT AT02796803T patent/ATE381318T1/de active
- 2002-10-11 MX MXPA04003300A patent/MXPA04003300A/es active IP Right Grant
- 2002-10-11 WO PCT/FR2002/003474 patent/WO2003043604A1/fr not_active Ceased
- 2002-10-11 CA CA2462537A patent/CA2462537C/fr not_active Expired - Fee Related
- 2002-10-11 BR BRPI0213220A patent/BRPI0213220B1/pt unknown
- 2002-10-11 JP JP2003545285A patent/JP4401778B2/ja not_active Expired - Fee Related
- 2002-10-11 CN CNB028202031A patent/CN100396277C/zh not_active Expired - Fee Related
- 2002-10-11 PT PT02796803T patent/PT1434567E/pt unknown
- 2002-10-11 DK DK02796803T patent/DK1434567T3/da active
-
2004
- 2004-04-01 ZA ZA200402580A patent/ZA200402580B/en unknown
-
2008
- 2008-03-13 CY CY20081100290T patent/CY1107306T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1434567T3 (da) | 2008-05-05 |
| FR2830760A1 (fr) | 2003-04-18 |
| JP4401778B2 (ja) | 2010-01-20 |
| FR2830760B1 (fr) | 2004-06-04 |
| HK1087019A1 (zh) | 2006-10-06 |
| CA2462537C (fr) | 2011-06-21 |
| AU2002361279B2 (en) | 2007-02-08 |
| JP2005512621A (ja) | 2005-05-12 |
| DE60224215D1 (de) | 2008-01-31 |
| PT1434567E (pt) | 2008-02-08 |
| CN100396277C (zh) | 2008-06-25 |
| BRPI0213220B1 (pt) | 2018-09-18 |
| DE60224215T2 (de) | 2008-12-04 |
| EP1434567B1 (de) | 2007-12-19 |
| US7390411B2 (en) | 2008-06-24 |
| MXPA04003300A (es) | 2004-07-23 |
| CY1107306T1 (el) | 2012-11-21 |
| US20050274671A1 (en) | 2005-12-15 |
| WO2003043604A1 (fr) | 2003-05-30 |
| EP1434567A1 (de) | 2004-07-07 |
| BR0213220A (pt) | 2004-08-31 |
| CN1713894A (zh) | 2005-12-28 |
| CA2462537A1 (fr) | 2003-05-30 |
| AU2002361279A1 (en) | 2003-06-10 |
| ZA200402580B (en) | 2004-11-04 |
| ES2295446T3 (es) | 2008-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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