DK1434567T3 - Fremgangsmåde til fremstilling af en forbindelse til aktive stoffers interaktion med en porös bærer ved hjælp af en superkritisk væske - Google Patents

Fremgangsmåde til fremstilling af en forbindelse til aktive stoffers interaktion med en porös bærer ved hjælp af en superkritisk væske

Info

Publication number
DK1434567T3
DK1434567T3 DK02796803T DK02796803T DK1434567T3 DK 1434567 T3 DK1434567 T3 DK 1434567T3 DK 02796803 T DK02796803 T DK 02796803T DK 02796803 T DK02796803 T DK 02796803T DK 1434567 T3 DK1434567 T3 DK 1434567T3
Authority
DK
Denmark
Prior art keywords
supercritical fluid
compound
interaction
preparing
active substances
Prior art date
Application number
DK02796803T
Other languages
English (en)
Inventor
Bernard Freiss
Florence Marciacq
Jacques Fages
Martial Sauceau
Hubert Lochard
Jean-Jacques Letourneau
Christophe Joussot-Dubien
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Application granted granted Critical
Publication of DK1434567T3 publication Critical patent/DK1434567T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
DK02796803T 2001-10-12 2002-10-11 Fremgangsmåde til fremstilling af en forbindelse til aktive stoffers interaktion med en porös bærer ved hjælp af en superkritisk væske DK1434567T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0113178A FR2830760B1 (fr) 2001-10-12 2001-10-12 Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique
PCT/FR2002/003474 WO2003043604A1 (fr) 2001-10-12 2002-10-11 Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique

Publications (1)

Publication Number Publication Date
DK1434567T3 true DK1434567T3 (da) 2008-05-05

Family

ID=8868228

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02796803T DK1434567T3 (da) 2001-10-12 2002-10-11 Fremgangsmåde til fremstilling af en forbindelse til aktive stoffers interaktion med en porös bærer ved hjælp af en superkritisk væske

Country Status (17)

Country Link
US (1) US7390411B2 (da)
EP (1) EP1434567B1 (da)
JP (1) JP4401778B2 (da)
CN (1) CN100396277C (da)
AT (1) ATE381318T1 (da)
AU (1) AU2002361279B2 (da)
BR (2) BRPI0213220B1 (da)
CA (1) CA2462537C (da)
CY (1) CY1107306T1 (da)
DE (1) DE60224215T2 (da)
DK (1) DK1434567T3 (da)
ES (1) ES2295446T3 (da)
FR (1) FR2830760B1 (da)
MX (1) MXPA04003300A (da)
PT (1) PT1434567E (da)
WO (1) WO2003043604A1 (da)
ZA (1) ZA200402580B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854079B1 (fr) * 2003-04-25 2007-11-30 Pf Medicament Procede de preparation de complexes moleculaires
FR2868315B1 (fr) * 2004-04-01 2006-07-14 Pierre Fabre Medicament Sa Procede de preparation d'un compose d'inclusion soluble de substances actives dans une molecule hote avec l'aide d'un agent d'interaction par fluide supercritique
DK2260871T3 (da) * 2004-04-01 2013-08-26 Pf Medicament Inklusionskomplekser omfattende piroxicam, en cyklodextrin og arginin
FR2876914A1 (fr) * 2004-10-21 2006-04-28 Pierre Fabre Medicament Sa Complexe comprenant un antibiotique, une cyclodextrine et un agent d'interaction
FR2876910B1 (fr) 2004-10-21 2007-04-13 Pierre Fabre Medicament Sa Complexe comprenant la mequitazine, une cyclodextrine et un agent d'interaction
ITSA20050008A1 (it) * 2005-03-10 2006-09-11 Univ Degli Studi Salerno Processo per la produzione di membrane caricate con uno o piu' principi attivi
ES2345396T3 (es) * 2006-02-10 2010-09-22 Carotech Sdn. Bhd Proceso para la produccion de fracciones altamente enriquecidas de compuestos naturales de aceite de palma con fluidos supercriticos y proximos al estado critico.
FR2944280B1 (fr) * 2009-04-09 2012-08-03 Galderma Res & Dev Procede de preparation de complexes moleculaires entre adapalene et des cyclodextrines
FR2944207B1 (fr) * 2009-04-09 2011-05-06 Galderma Res & Dev Compositions comprenant au moins un complexe compose d'un derive d'acide naphtoique et d'au moins une cyclodestrine et leurs utilisations
RU2549780C1 (ru) * 2011-04-22 2015-04-27 Пепсико, Инк. Инкапсуляция экстракта в пористые частицы
EP2884523B1 (en) * 2013-12-16 2020-02-05 IMEC vzw Method for activating a porous layer surface
CN105343893B (zh) * 2015-12-11 2018-07-20 中国药科大学 对乙酰氨基酚-2-羟丙基-β-环糊精包合物制备方法
WO2017118266A1 (en) * 2016-01-08 2017-07-13 Chen Shing-Jye Acellular corneas, methods of producing the same and uses thereof
CN116688155A (zh) * 2023-07-20 2023-09-05 内蒙古工业大学 一种木犀草素/γ-环糊精包合物、制备方法及应用
CN118697820A (zh) * 2024-05-31 2024-09-27 广州新征程生物科技有限公司 一种治疗心脑血管病的中药及制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US189454A (en) * 1877-04-10 Improvement in paper boxes
GB2191715B (en) 1986-06-17 1990-07-25 Midrex Int Bv Method and apparatus for dedusting and desulfurizing gases
JPH0677511B2 (ja) * 1986-12-05 1994-10-05 金印わさび株式会社 香辛成分の包接化合物の製造方法
US4822497A (en) 1987-09-22 1989-04-18 Modar, Inc. Method for solids separation in a wet oxidation type process
DE3744329A1 (de) 1987-12-28 1989-07-06 Schwarz Pharma Gmbh Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung
FR2629735B1 (fr) * 1988-04-11 1991-03-22 Agronomique Inst Nat Rech Procede d'extraction au dioxyde de carbone supercritique de composes volatils, et composes obtenus
GB9100643D0 (en) 1991-01-11 1991-02-27 Shaffery Michael J Filter system
US5389263A (en) 1992-05-20 1995-02-14 Phasex Corporation Gas anti-solvent recrystallization and application for the separation and subsequent processing of RDX and HMX
ATE166573T1 (de) 1993-03-24 1998-06-15 Ciba Geigy Ag Verfahren zur herstellung einer liposomendispersion im hochdruckbereich
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
EP0706821A1 (en) 1994-10-06 1996-04-17 Centre De Microencapsulation Method of coating particles
FR2725990B1 (fr) 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
FR2741619B1 (fr) 1995-11-28 1998-02-13 Pf Medicament Nouveaux derives de 2,3,5-trimethyl-4-hydroxy-anilides, leur preparation et leur application en therapeutique
WO1997031691A1 (en) 1996-03-01 1997-09-04 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
FR2753639B1 (fr) 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
US5766637A (en) 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
DE19711393C1 (de) 1997-03-19 1998-08-13 Fraunhofer Ges Forschung Verfahren zum Mikroverkapseln von Partikeln
IT1296464B1 (it) 1997-11-19 1999-06-25 Vectorpharma Int Composizioni farmaceutiche in forma di polveri di polimeri reticolati caricati con farmaci e relativo processo di preparazione mediante
GB9810559D0 (en) 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
GB9824298D0 (en) 1998-11-05 1998-12-30 Smithkline Beecham Plc Novel process
SE9804001D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New process
US6555139B2 (en) * 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
CN1280875A (zh) * 1999-06-30 2001-01-24 刘士群 用超临界反萃剂制造微粒的方法和装置
FR2798863B1 (fr) 1999-09-27 2001-12-28 Separex Sa Procede et installation de mise a l'etat adsorbe sur un support poreux de composes actifs contenus dans un produit
FR2799984B1 (fr) 1999-10-21 2002-05-03 Lavipharm Procede de fractionnement d'une matiere composee de plusieurs constituants a l'aide d'un solvant a pression supercritique
FR2803538B1 (fr) 1999-12-15 2002-06-07 Separex Sa Procede et dispositif de captage de fines particules par percolation dans un lit de granules
FR2815540B1 (fr) * 2000-10-19 2005-06-10 Separex Sa Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote
US6896905B2 (en) * 2001-02-15 2005-05-24 Rohm And Haas Company Porous particles, their aqueous dispersions, and method of preparation
WO2002089851A1 (fr) 2001-03-06 2002-11-14 Separex (Societe Anonyme) Procede de fabrication de complexes hote-client

Also Published As

Publication number Publication date
CY1107306T1 (el) 2012-11-21
CA2462537C (fr) 2011-06-21
FR2830760A1 (fr) 2003-04-18
MXPA04003300A (es) 2004-07-23
WO2003043604A1 (fr) 2003-05-30
CN100396277C (zh) 2008-06-25
JP2005512621A (ja) 2005-05-12
ATE381318T1 (de) 2008-01-15
BRPI0213220B1 (pt) 2018-09-18
FR2830760B1 (fr) 2004-06-04
ES2295446T3 (es) 2008-04-16
EP1434567A1 (fr) 2004-07-07
BR0213220A (pt) 2004-08-31
CA2462537A1 (fr) 2003-05-30
AU2002361279B2 (en) 2007-02-08
DE60224215D1 (de) 2008-01-31
PT1434567E (pt) 2008-02-08
HK1087019A1 (zh) 2006-10-06
EP1434567B1 (fr) 2007-12-19
DE60224215T2 (de) 2008-12-04
US7390411B2 (en) 2008-06-24
AU2002361279A1 (en) 2003-06-10
JP4401778B2 (ja) 2010-01-20
ZA200402580B (en) 2004-11-04
CN1713894A (zh) 2005-12-28
US20050274671A1 (en) 2005-12-15

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