ATE381554T1 - Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen - Google Patents

Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen

Info

Publication number: ATE381554T1
Authority: AT; Austria
Prior art keywords: compounds; treatment; formula; aroylthiophenes; aroylfurans
Prior art date: 2003-12-22

Application number

AT04804957T

Other languages

English (en)

Inventor

Martin Eberle

Felix Bachmann

Alessandro Strebel

Subho Roy

Goutam Saha

Subir Kumar Sadhukhan

Rohit Saxena

Sudhir Srivastava

Original Assignee

Basilea Pharmaceutica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-22

Filing date

2004-12-21

Publication date

2008-01-15

2004-12-21 Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag

2008-01-15 Application granted granted Critical

2008-01-15 Publication of ATE381554T1 publication Critical patent/ATE381554T1/de

Links

206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
239000008194 pharmaceutical composition Substances 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
230000001613 neoplastic effect Effects 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Hematology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Transplantation (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT04804957T 2003-12-22 2004-12-21 Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen ATE381554T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP03405912		2003-12-22
EP03405911		2003-12-22
EP04405517		2004-08-19

Publications (1)

Publication Number	Publication Date
ATE381554T1 true ATE381554T1 (de)	2008-01-15

Family

ID=34714028

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT07118973T ATE455765T1 (de)	2003-12-22	2004-12-21	Aryloxy- und arylthioxyacetophenon-verbindungen zur behandlung von krebs
AT04804957T ATE381554T1 (de)	2003-12-22	2004-12-21	Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT07118973T ATE455765T1 (de)	2003-12-22	2004-12-21	Aryloxy- und arylthioxyacetophenon-verbindungen zur behandlung von krebs

Country Status (9)

Country	Link
US (1)	US8486996B2 (de)
EP (2)	EP1697336B1 (de)
JP (1)	JP4805166B2 (de)
CN (1)	CN101061101B (de)
AT (2)	ATE455765T1 (de)
CA (1)	CA2545821C (de)
DE (2)	DE602004010845T2 (de)
ES (2)	ES2298853T3 (de)
WO (1)	WO2005061476A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1909910A1 (de)	2005-08-04	2008-04-16	Sirtris Pharmaceuticals, Inc.	Benzimidazol-derivative als sirtuin-modulatoren
MX2008011220A (es)	2006-03-07	2008-09-11	Array Biopharma Inc	Compuestos de pirazol heterobiciclicos y metodos de uso.
EP2069359B1 (de)	2006-08-21	2014-11-12	Genentech, Inc.	Aza-benzothiophenylverbindungen und anwendungsverfahren dafür
ZA200900896B (en) *	2006-08-21	2010-06-30	Genentech Inc	Aza-benzofuranyl compounds and methods of use
RU2448111C2 (ru) *	2006-08-21	2012-04-20	Дженентек, Инк.	Соединения азабензофуранила и способ их применения
WO2008024725A1 (en) *	2006-08-21	2008-02-28	Genentech, Inc.	Aza-benzofuranyl compounds and methods of use
AU2008210455A1 (en) *	2007-01-31	2008-08-07	Vertex Pharmaceuticals Incorporated	2-aminopyridine derivatives useful as kinase inhibitors
US8173635B2 (en)	2007-11-02	2012-05-08	Vertex Pharmaceuticals Incorporated	Kinase inhibitors
WO2010003025A1 (en)	2008-07-01	2010-01-07	Genentech, Inc.	Bicyclic heterocycles as mek kinase inhibitors
JP5615274B2 (ja)	2008-07-01	2014-10-29	ジェネンテック，インコーポレイテッド	Ｍｅｋキナーゼインヒビターとしてのイソインドロン誘導体及びその使用方法
US8569337B2 (en)	2008-07-23	2013-10-29	Vertex Pharmaceuticals Incorporated	Tri-cyclic pyrazolopyridine kinase inhibitors
CN102131809A (zh)	2008-07-23	2011-07-20	沃泰克斯药物股份有限公司	三环吡唑并吡啶激酶抑制剂
AU2009274011B2 (en)	2008-07-23	2014-12-18	Vertex Pharmaceuticals Incorporated	Pyrazolopyridine kinase inhibitors
JP2011530527A (ja) *	2008-08-06	2011-12-22	バーテックスファーマシューティカルズインコーポレイテッド	アミノピリジンキナーゼ阻害剤
MX2011011653A (es)	2009-05-06	2012-01-20	Vertex Pharma	Pirazolopiridinas.
AU2011209649A1 (en)	2010-01-27	2012-08-09	Vertex Pharmaceuticals Incorporated	Pyrazolopyrazine kinase inhibitors
JP2013518114A (ja)	2010-01-27	2013-05-20	バーテックスファーマシューティカルズインコーポレイテッド	ピラゾロピリミジンキナーゼ阻害剤
CN102858769A (zh)	2010-01-27	2013-01-02	沃泰克斯药物股份有限公司	吡唑并吡啶激酶抑制剂
EA202190832A1 (ru)	2018-09-22	2021-08-18	Торрент Фармасьютикалс Лимитед	Способы получения соединений пиразола

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2350109A (en) *	1999-05-17	2000-11-22	Bayer Ag	Pharmaceutically active benzofuranyl sulfonates
WO2001007031A1 (en)	1999-07-26	2001-02-01	Shionogi & Co., Ltd.	Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same
GB9920872D0 (en) *	1999-09-04	1999-11-10	Glaxo Group Ltd	Benzophenones as inhibitors of reverse transcriptase
DE19947154A1 (de) *	1999-10-01	2001-10-04	Bayer Ag	Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
WO2002083648A1 (fr) *	2001-04-16	2002-10-24	Eisai Co., Ltd.	Nouveau compose a base de 1h-indazole
AU2003215380B2 (en) *	2002-02-22	2008-10-02	Bayer Pharmaceuticals Corporation	Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
US7144885B2 (en) *	2002-02-22	2006-12-05	Bayer Pharmaceuticals Corporation	Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
EP1534715B1 (de) *	2002-07-11	2007-08-15	Bayer Pharmaceuticals Corporation	Furopyridin- und furopyrimidinderivate zur behandlung von hyperproliferativen erkrankungen

2004
- 2004-12-21 CA CA2545821A patent/CA2545821C/en not_active Expired - Fee Related
- 2004-12-21 ES ES04804957T patent/ES2298853T3/es not_active Expired - Lifetime
- 2004-12-21 DE DE602004010845T patent/DE602004010845T2/de not_active Expired - Lifetime
- 2004-12-21 CN CN2004800386105A patent/CN101061101B/zh not_active Expired - Fee Related
- 2004-12-21 AT AT07118973T patent/ATE455765T1/de active
- 2004-12-21 ES ES07118973T patent/ES2338060T3/es not_active Expired - Lifetime
- 2004-12-21 AT AT04804957T patent/ATE381554T1/de active
- 2004-12-21 EP EP04804957A patent/EP1697336B1/de not_active Expired - Lifetime
- 2004-12-21 EP EP07118973A patent/EP1894917B1/de not_active Expired - Lifetime
- 2004-12-21 WO PCT/EP2004/053622 patent/WO2005061476A2/en not_active Ceased
- 2004-12-21 DE DE602004025302T patent/DE602004025302D1/de not_active Expired - Lifetime
- 2004-12-21 JP JP2006546171A patent/JP4805166B2/ja not_active Expired - Fee Related
2006
- 2006-05-12 US US11/433,511 patent/US8486996B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE602004025302D1 (de)	2010-03-11
ATE455765T1 (de)	2010-02-15
WO2005061476A3 (en)	2006-01-26
ES2298853T3 (es)	2008-05-16
JP2007517787A (ja)	2007-07-05
CA2545821A1 (en)	2005-07-07
JP4805166B2 (ja)	2011-11-02
EP1894917B1 (de)	2010-01-20
EP1894917A1 (de)	2008-03-05
US8486996B2 (en)	2013-07-16
CA2545821C (en)	2010-09-21
EP1697336B1 (de)	2007-12-19
ES2338060T3 (es)	2010-05-03
US20060205739A1 (en)	2006-09-14
EP1697336A2 (de)	2006-09-06
DE602004010845T2 (de)	2008-12-04
CN101061101B (zh)	2011-09-07
WO2005061476A2 (en)	2005-07-07
DE602004010845D1 (de)	2008-01-31
CN101061101A (zh)	2007-10-24

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2008-06-15

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CY1107422T1 (el)	2012-12-19	Φουραζανοβενζιμιδαζoλες
SE0300119D0 (sv)	2003-01-17	Novel compounds
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GB0129476D0 (en)	2002-01-30	Organic compounds
SE0300480D0 (sv)	2003-02-21	Novel compounds
SE0302139D0 (sv)	2003-07-28	Novel compounds
TW200833670A (en)	2008-08-16	Novel compounds 569
TW200604197A (en)	2006-02-01	New compounds
DE602004029355D1 (de)	2010-11-11	Sulfopyrrolderivate
SE0101038D0 (sv)	2001-03-23	Novel compounds
SE0300456D0 (sv)	2003-02-19	Novel compounds
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GB0120461D0 (en)	2001-10-17	Novel compounds
SE0303280D0 (sv)	2003-12-05	Novel compounds
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SE0401763D0 (sv)	2004-07-05	Compounds
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