ATE382426T1 - Verfahren zum mikropipettieren einer flüssigprobe - Google Patents

Verfahren zum mikropipettieren einer flüssigprobe

Info

Publication number
ATE382426T1
ATE382426T1 AT00309286T AT00309286T ATE382426T1 AT E382426 T1 ATE382426 T1 AT E382426T1 AT 00309286 T AT00309286 T AT 00309286T AT 00309286 T AT00309286 T AT 00309286T AT E382426 T1 ATE382426 T1 AT E382426T1
Authority
AT
Austria
Prior art keywords
base plate
micropipetting
liquid sample
spots
sample solution
Prior art date
Application number
AT00309286T
Other languages
English (en)
Inventor
Toshikazu Hirota
Takahashi Nobuo
Takeuchi Yukihisa
Original Assignee
Ngk Insulators Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ngk Insulators Ltd filed Critical Ngk Insulators Ltd
Application granted granted Critical
Publication of ATE382426T1 publication Critical patent/ATE382426T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5088—Rigid containers without fluid transport within confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/02—Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/027—Drop detachment mechanisms of single droplets from nozzles or pins electrostatic forces between substrate and tip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/54—Supports specially adapted for pipettes and burettes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1039—Micropipettes, e.g. microcapillary tubes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Saccharide Compounds (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
AT00309286T 1999-10-22 2000-10-20 Verfahren zum mikropipettieren einer flüssigprobe ATE382426T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30162799 1999-10-22

Publications (1)

Publication Number Publication Date
ATE382426T1 true ATE382426T1 (de) 2008-01-15

Family

ID=17899231

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00309286T ATE382426T1 (de) 1999-10-22 2000-10-20 Verfahren zum mikropipettieren einer flüssigprobe

Country Status (6)

Country Link
US (6) US6656432B1 (de)
EP (3) EP2027914A3 (de)
JP (2) JP3599329B2 (de)
AT (1) ATE382426T1 (de)
DE (2) DE60042262D1 (de)
WO (1) WO2001029561A1 (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3492570B2 (ja) * 1999-10-22 2004-02-03 日本碍子株式会社 マイクロピペット及び分注装置
US6656432B1 (en) * 1999-10-22 2003-12-02 Ngk Insulators, Ltd. Micropipette and dividedly injectable apparatus
EP1274508B1 (de) * 2000-04-03 2007-12-05 Parabol Technologies S.A. Vorrichtung zur abgabe von genau kontrollierten kleinen flüssigkeitsmengen
WO2001077640A2 (en) * 2000-04-05 2001-10-18 Alexion Pharmaceuticals, Inc. Methods and devices for storing and dispensing liquids
JP3532829B2 (ja) 2000-05-17 2004-05-31 日立ソフトウエアエンジニアリング株式会社 バイオチップ作成溶液及びバイオチップ作成方法
US7731904B2 (en) * 2000-09-19 2010-06-08 Canon Kabushiki Kaisha Method for making probe support and apparatus used for the method
US6875402B2 (en) * 2000-10-16 2005-04-05 Ngk Insulators, Ltd. Micropipette, dispenser and method for producing biochip
US6503454B1 (en) * 2000-11-22 2003-01-07 Xerox Corporation Multi-ejector system for ejecting biofluids
US6861034B1 (en) 2000-11-22 2005-03-01 Xerox Corporation Priming mechanisms for drop ejection devices
US6713022B1 (en) * 2000-11-22 2004-03-30 Xerox Corporation Devices for biofluid drop ejection
US6740530B1 (en) 2000-11-22 2004-05-25 Xerox Corporation Testing method and configurations for multi-ejector system
EP1256809A1 (de) * 2000-12-18 2002-11-13 Ngk Insulators, Ltd. Verfahren zur formung von detektionspunkten in einem chip zur subjektdetektion
US20020106308A1 (en) * 2001-02-02 2002-08-08 Zweifel Ronald A. Microdrop dispensing apparatus
US7407746B2 (en) 2001-02-08 2008-08-05 Ngk Insulators, Ltd. Biochip and method for producing the same
JP2002286735A (ja) * 2001-03-28 2002-10-03 Canon Inc プローブ担体製造用の液体吐出装置、プローブ担体の製造装置及びプローブ担体の製造方法
JP3927125B2 (ja) * 2001-05-01 2007-06-06 日本碍子株式会社 バイオチップの製造方法
JP3600198B2 (ja) * 2001-08-31 2004-12-08 日本碍子株式会社 液滴吐出装置
JP3701594B2 (ja) * 2001-09-25 2005-09-28 日本碍子株式会社 液滴吐出方法
JP4326334B2 (ja) * 2001-11-02 2009-09-02 日本碍子株式会社 プローブ溶液組成物と、これを用いた反応性チップおよびその製造方法
WO2003049209A1 (en) * 2001-11-21 2003-06-12 Apogent Robotics Limited Actuator structure
US7005293B2 (en) 2001-12-18 2006-02-28 Agilent Technologies, Inc. Multiple axis printhead adjuster for non-contact fluid deposition devices
US6846454B2 (en) * 2001-12-24 2005-01-25 Agilent Technologies, Inc. Fluid exit in reaction chambers
DE10202996A1 (de) * 2002-01-26 2003-08-14 Eppendorf Ag Piezoelektrisch steuerbare Mikrofluidaktorik
US7504364B2 (en) 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
US6858464B2 (en) 2002-06-19 2005-02-22 Semiconductor Energy Laboratory Co., Ltd. Method of manufacturing light emitting device
WO2005003326A2 (en) 2003-03-28 2005-01-13 Receptors Llc. Artificial receptors including reversibly immobilized building blocks and methods
US7125727B2 (en) * 2003-01-29 2006-10-24 Protedyne Corporation Sample handling tool with piezoelectric actuator
US20040185169A1 (en) * 2003-03-21 2004-09-23 Peck Bill J. Methods for fabricating biopolymer arrays
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
EP1655604A4 (de) * 2003-06-24 2007-10-24 Ngk Insulators Ltd Analyseteststück und verfahren zur herstellung davon
JP4458327B2 (ja) * 2003-08-28 2010-04-28 キヤノン株式会社 標的物質の定量方法および該方法に用いるプローブ担体
US20050084981A1 (en) * 2003-10-16 2005-04-21 Magdalena Ostrowski Method of depositing a bioactive material on a substrate
CA2544614A1 (en) * 2003-12-02 2005-06-16 Receptors Llc Artificial receptors including gradients
JP4711326B2 (ja) * 2003-12-22 2011-06-29 キヤノン株式会社 検定試料および検量線の作製方法
US20050233337A1 (en) * 2004-04-19 2005-10-20 Peck Bill J Chemical arrays and methods of producing the same
WO2005121367A1 (en) * 2004-06-10 2005-12-22 Agency For Science, Technology And Research Diagnostic primers and method for detecting avian influenza virus subtype h5 and h5n1
CH701163B1 (de) * 2004-06-24 2010-12-15 Tecan Trading Ag System zum Manipulieren von Flüssigkeitsproben sowie Vorrichtung und Verfahren zum Anordnen von Pipetten- oder Dispenserspitzen in einem solchen System.
US20060024206A1 (en) * 2004-07-29 2006-02-02 Sinha Naveen N Non-invasive acoustic technique for mixing and segregation of fluid suspensions in microfluidic applications
WO2006029234A1 (en) 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks
WO2006029383A2 (en) 2004-09-11 2006-03-16 Receptors Llc Combinatorial artificial receptors including peptide building blocks
CN101022955A (zh) 2004-09-16 2007-08-22 皇家飞利浦电子股份有限公司 打印头、打印头组件、打印盒以及打印机
DE102004062923A1 (de) * 2004-12-28 2006-07-06 Hirschmann Laborgeräte GmbH & Co. KG Vorrichtung zur Förderung von Fluiden, Verfahren zur Herstellung derselben und Pipette mit einer solchen Vorrichtung
DE102005012567B4 (de) * 2005-03-04 2008-09-04 Identif Gmbh Markierungslösung, deren Verwendung und Verfahren zu ihrer Herstellung
JP4103009B2 (ja) * 2005-03-23 2008-06-18 セイコーエプソン株式会社 液滴吐出装置、およびマイクロアレイ製造方法
EP1874950B1 (de) 2005-04-05 2015-06-03 Corning Incorporated Markierungsfreie biosensoren
US20060246599A1 (en) * 2005-04-29 2006-11-02 Sarah Rosenstein Lateral flow device
US20060246574A1 (en) * 2005-04-29 2006-11-02 Sarah Rosenstein Dispenser for making a lateral flow device
US8263414B2 (en) * 2005-05-23 2012-09-11 Siemens Healthcare Diagnostics Inc. Dispensing of a diagnostic liquid onto a diagnostic reagent
JP4654795B2 (ja) * 2005-06-28 2011-03-23 パナソニック株式会社 生体分子検出方法
WO2007071613A1 (de) * 2005-12-20 2007-06-28 Tecan Trading Ag Konditionier-vorrichtung für liquidhandling-systemflüssigkeiten
KR100738087B1 (ko) * 2005-12-22 2007-07-12 삼성전자주식회사 액적 조작을 이용한 세포 정량 분배장치
JP4735833B2 (ja) * 2006-01-13 2011-07-27 セイコーエプソン株式会社 バイオチップ及びバイオセンサ
EP1987358A4 (de) * 2006-01-26 2013-12-04 California Inst Of Techn Mechanisch herbeigeführtes trapping molekularer interaktionen
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
WO2008115185A2 (en) * 2006-04-24 2008-09-25 Nimblegen Systems, Inc. Use of microarrays for genomic representation selection
US7918366B2 (en) * 2006-09-12 2011-04-05 Hewlett-Packard Development Company, L.P. Multiple drop weight printhead and methods of fabrication and use
JP2008145243A (ja) * 2006-12-08 2008-06-26 Canon Inc プローブ・アレイ作製装置用の液体吐出ユニットとその製造方法
US9304141B2 (en) 2007-04-18 2016-04-05 Becton, Dickinson And Company Method and apparatus for determing dispense volume
DK2140275T3 (en) * 2007-05-02 2018-04-09 Siemens Healthcare Diagnostics Inc Piezo Dispensing of a Diagnostic Fluid in Microfluidic Devices
US8304254B2 (en) * 2007-05-02 2012-11-06 Siemens Healthcare Diagnostics Inc. Piezo dispensing of a diagnostic liquid onto a reagent surface
WO2009106294A1 (en) * 2008-02-29 2009-09-03 Roche Diagnostics Gmbh Methods and systems for uniform enrichment of genomic regions
JP5345347B2 (ja) * 2008-07-15 2013-11-20 日立アロカメディカル株式会社 検体処理装置及び方法
CH700127A1 (de) * 2008-12-17 2010-06-30 Tecan Trading Ag System und Vorrichtung zur Aufarbeitung biologischer Proben und zur Manipulation von Flüssigkeiten mit biologischen Proben.
FI20095501A0 (fi) * 2009-05-04 2009-05-04 Pekka Haenninen Menetelmä näytteiden karakterisoimiseksi ja/tai määrittämiseksi
US8695639B2 (en) 2009-05-07 2014-04-15 International Business Machines Corporation Multilayer microfluidic probe head and method of fabrication thereof
US8753813B2 (en) * 2009-12-07 2014-06-17 Northwestern University Generation of combinatorial patterns by deliberate tilting of a polymer-pen array
US20120000595A1 (en) * 2010-06-04 2012-01-05 Ngk Insulators, Ltd. Method for manufacturing a droplet discharge head
TWI532530B (zh) 2010-10-29 2016-05-11 萬國商業機器公司 具有浸入通道之多層微流體探針頭及其製造方法
JP5765081B2 (ja) * 2011-06-22 2015-08-19 ソニー株式会社 撮像素子、電子機器、製造方法、および検査装置
DE102012108158B4 (de) 2012-09-03 2016-03-17 Johann Wolfgang Goethe-Universität Kapillarzelle, Anordnung und Verfahren zur Aufnahme, zur Positionierung und zur Untersuchung einer mikroskopischen Probe
US11371951B2 (en) 2012-09-27 2022-06-28 Sensirion Ag Gas sensor comprising a set of one or more sensor cells
US8802568B2 (en) 2012-09-27 2014-08-12 Sensirion Ag Method for manufacturing chemical sensor with multiple sensor cells
WO2016133783A1 (en) * 2015-02-17 2016-08-25 Zalous, Inc. Microdroplet digital pcr system
JP6589547B2 (ja) * 2015-10-20 2019-10-16 株式会社リコー 液滴形成装置
CN112175787B (zh) * 2019-07-01 2022-05-06 申翌生物科技(杭州)有限公司 利用pcr反应系统进行pcr反应的方法
EP3995563A4 (de) 2019-07-01 2022-10-05 Shenyi Biotech (Hangzhou) Co., Ltd. Neues verfahren zur durchführung einer pcr-reaktion unter verwendung eines umfassenden pcr-reaktionssystems
CN113996354B (zh) * 2021-10-25 2023-03-24 苏州缔因安生物科技有限公司 一种控制微液滴生成装置、生成方法及用途
CN113996353A (zh) * 2021-10-25 2022-02-01 苏州缔因安生物科技有限公司 一种微滴生成装置、生成方法及用途
WO2024087107A1 (zh) * 2022-10-27 2024-05-02 深圳华大生命科学研究院 生物芯片容器及其制备和使用方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE349676B (de) * 1971-01-11 1972-10-02 N Stemme
US4216483A (en) 1977-11-16 1980-08-05 Silonics, Inc. Linear array ink jet assembly
US4245279A (en) * 1979-09-04 1981-01-13 Gte Products Corporation Photoflash unit with inverted flashlamps
US4450454A (en) * 1980-11-20 1984-05-22 Epson Corporation Small size ink jet printer
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
CA1244714A (en) * 1984-04-16 1988-11-15 William J. Debonte Method for selective multi-cycle resonant operation of an ink jet apparatus for controlling dot size
US4730197A (en) * 1985-11-06 1988-03-08 Pitney Bowes Inc. Impulse ink jet system
US4727378A (en) * 1986-07-11 1988-02-23 Tektronix, Inc. Method and apparatus for purging an ink jet head
US4786327A (en) * 1986-09-29 1988-11-22 Hewlett-Packard Company Dye preparation for thermal ink-jet printheads using ion exchange
JPH02269058A (ja) * 1989-03-14 1990-11-02 Seiko Epson Corp レーリーモード弾性表面波による液滴ジェット装置
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5374521A (en) * 1991-09-17 1994-12-20 Kipling; Arlin L. Acoustic reflection process for molecular sensing using a bulk acoustic wave quartz sensor
US5223853A (en) * 1992-02-24 1993-06-29 Xerox Corporation Electronic spot size control in a thermal ink jet printer
JP3144948B2 (ja) 1992-05-27 2001-03-12 日本碍子株式会社 インクジェットプリントヘッド
JP3144949B2 (ja) * 1992-05-27 2001-03-12 日本碍子株式会社 圧電／電歪アクチュエータ
JP3339724B2 (ja) * 1992-09-29 2002-10-28 株式会社リコー インクジェット記録方法及びその装置
JP3106026B2 (ja) * 1993-02-23 2000-11-06 日本碍子株式会社 圧電／電歪アクチュエータ
JP3363524B2 (ja) * 1993-06-30 2003-01-08 キヤノン株式会社 プリントヘッドとそのヒータボード及びプリント装置とその方法
CH686368A5 (de) * 1993-07-19 1996-03-15 Sika Ag Zusatzmittel zur Verhinderung der Korrosion von Metallen in Baustoffen, Verfahren zur Herstellung von Baustoffen unter Verwendung des Korrosionsinhibitors.
US5689291A (en) * 1993-07-30 1997-11-18 Tektronix, Inc. Method and apparatus for producing dot size modulated ink jet printing
DE4336416A1 (de) * 1993-10-19 1995-08-24 Francotyp Postalia Gmbh Face-Shooter-Tintenstrahldruckkopf und Verfahren zu seiner Herstellung
DK1157743T3 (da) * 1993-10-28 2009-07-06 Houston Advanced Res Ct Mikrofremstillet poröst gennemströmningsapparat til diskret påvisning af bindingsreaktioner
JPH07309013A (ja) * 1994-05-11 1995-11-28 Xerox Corp インクジェットプリンタのスポットサイズのチップレベル制御
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6558633B1 (en) * 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
JP3388060B2 (ja) 1994-11-25 2003-03-17 日本碍子株式会社 流体の特性測定用素子及び流体の特性測定装置
US5843662A (en) * 1995-01-10 1998-12-01 Geno Technology, Inc. Method, device, and kit for total nucleic acid assay
US5922534A (en) * 1995-03-28 1999-07-13 Hewlett-Packard Company Dry biochemical assay plate and method for making the same
JPH0970989A (ja) * 1995-06-29 1997-03-18 Canon Inc インクジェット記録方法およびインクジェット記録装置
JPH09156102A (ja) * 1995-12-01 1997-06-17 Canon Inc 画像形成装置および方法
US5958342A (en) * 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US5916524A (en) 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5877580A (en) 1996-12-23 1999-03-02 Regents Of The University Of California Micromachined chemical jet dispenser
US6458584B1 (en) * 1996-12-23 2002-10-01 University Of Chicago Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable
US5858801A (en) * 1997-03-13 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Patterning antibodies on a surface
EP0865824B1 (de) 1997-03-20 2004-05-19 F. Hoffmann-La Roche Ag Mikromechanische Pipettiervorrichtung
JPH10323974A (ja) * 1997-03-25 1998-12-08 Canon Inc インクジェット記録方法と装置、及び該装置に用いられる定着発熱体
JP3554184B2 (ja) * 1997-04-04 2004-08-18 キヤノン株式会社 プリント装置およびプリント位置合わせ方法
DE19715484A1 (de) * 1997-04-14 1998-10-15 Boehringer Mannheim Gmbh Verfahren zum Aufbringen von Reagenzspots
ATE199663T1 (de) * 1997-07-11 2001-03-15 Akzo Nobel Nv Vorrichtung zur durchführung eines tests, verwendung einer membran zur herstellung dieser vorrichtung, kit mit dieser vorrichtung und analyseverfahren unter verwendung dieses gerätes.
JP2001510727A (ja) * 1997-07-22 2001-08-07 ラピジーン，インコーポレイテッド ポリエチレンイミンベースの生体分子アレイ
JP3610231B2 (ja) * 1997-08-01 2005-01-12 キヤノン株式会社 反応場アレー、反応場アレーの製造方法、反応場アレーを用いた反応方法及び反応場アレーを用いた試料溶液中の物質の定量方法
JP4313861B2 (ja) 1997-08-01 2009-08-12 キヤノン株式会社 プローブアレイの製造方法
JP2001517789A (ja) * 1997-09-19 2001-10-09 アクレイラ バイオサイエンシズ，インコーポレイティド 液体移送装置および液体移送方法
JPH11207960A (ja) * 1997-11-18 1999-08-03 Canon Inc 液体吐出ヘッドおよびカートリッジならびにこれを用いた画像形成装置
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
JPH11181344A (ja) * 1997-12-22 1999-07-06 Brother Ind Ltd 水性インク及びその製造方法
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6269846B1 (en) * 1998-01-13 2001-08-07 Genetic Microsystems, Inc. Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays
JPH11277725A (ja) * 1998-03-30 1999-10-12 Seiko Epson Corp 印刷物品の製造方法および印刷装置
US6280946B2 (en) * 1998-08-07 2001-08-28 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the universal detection of bacteria and eucarya
US6461812B2 (en) 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
US6689323B2 (en) * 1998-10-30 2004-02-10 Agilent Technologies Method and apparatus for liquid transfer
US6627157B1 (en) 1999-03-04 2003-09-30 Ut-Battelle, Llc Dual manifold system and method for fluid transfer
US6245297B1 (en) * 1999-04-16 2001-06-12 Pe Corporation (Ny) Apparatus and method for transferring small volumes of substances
US6221653B1 (en) * 1999-04-27 2001-04-24 Agilent Technologies, Inc. Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids
US6232072B1 (en) * 1999-10-15 2001-05-15 Agilent Technologies, Inc. Biopolymer array inspection
US6656432B1 (en) * 1999-10-22 2003-12-02 Ngk Insulators, Ltd. Micropipette and dividedly injectable apparatus
JP4222756B2 (ja) * 2000-05-04 2009-02-12 センター フォア ブラッド リサーチ インコーポレイテッド 固相生体分子分析調製同定システム用コロイド組成物
US20020037359A1 (en) * 2000-09-25 2002-03-28 Mutz Mitchell W. Focused acoustic energy in the preparation of peptide arrays

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US6852545B2 (en) 2005-02-08
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US20040037743A1 (en) 2004-02-26
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