ATE382681T1 - Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen - Google Patents

Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen

Info

Publication number
ATE382681T1
ATE382681T1 AT99941984T AT99941984T ATE382681T1 AT E382681 T1 ATE382681 T1 AT E382681T1 AT 99941984 T AT99941984 T AT 99941984T AT 99941984 T AT99941984 T AT 99941984T AT E382681 T1 ATE382681 T1 AT E382681T1
Authority
AT
Austria
Prior art keywords
stem cells
mesenchymal stem
transplantation
heart function
improved heart
Prior art date
Application number
AT99941984T
Other languages
English (en)
Inventor
Donald Mickle
Ren-Ke Le
Richard Weisel
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ATE382681T1 publication Critical patent/ATE382681T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1329—Cardiomyocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
AT99941984T 1998-07-31 1999-07-29 Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen ATE382681T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9479498P 1998-07-31 1998-07-31
US12915299P 1999-04-14 1999-04-14

Publications (1)

Publication Number Publication Date
ATE382681T1 true ATE382681T1 (de) 2008-01-15

Family

ID=26789238

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99941984T ATE382681T1 (de) 1998-07-31 1999-07-29 Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen

Country Status (9)

Country Link
US (1) US20050031600A1 (de)
EP (1) EP1100870B1 (de)
JP (1) JP2002521493A (de)
AT (1) ATE382681T1 (de)
AU (1) AU5545499A (de)
BR (1) BR9912662A (de)
CA (1) CA2339182C (de)
DE (1) DE69937888T2 (de)
WO (1) WO2000006701A1 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030103951A1 (en) * 1997-07-14 2003-06-05 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US7514074B2 (en) 1997-07-14 2009-04-07 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US20040131601A1 (en) * 2000-03-30 2004-07-08 Foundry Networks, Inc., A Delaward Corporation Injection of bone marrow-derived cells and medium for angiogenesis
US7097832B1 (en) * 1999-03-30 2006-08-29 Myocardial Therapeutics, Inc. Intramyocardial injection of autologous bone marrow
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US8062675B2 (en) 1999-07-07 2011-11-22 Angioblast Systems, Inc. Mesenchymal precursor cell
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
WO2001048149A1 (en) * 1999-12-28 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Adult bone marrow-origin cell capable of differentiating into heart muscle cell
WO2001048150A1 (en) * 1999-12-28 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Cells capable of differentiating into heart muscle cells
CA2429502A1 (en) * 2000-07-26 2002-01-31 Scimed Life Systems, Inc. Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
EP1315510A4 (de) * 2000-07-31 2005-08-03 New York Medical College Verfahren und zusammensetzungen zur reparatur und/oder regeneration des beschädigten herzmuskels
US7547674B2 (en) 2001-06-06 2009-06-16 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
EP1412479A4 (de) 2001-07-12 2004-07-28 Geron Corp Aus menschlichen pluripotenten stammzellen produzierte zellen mit kardiomyozytenabstammung
US20030082153A1 (en) 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
US7998062B2 (en) 2004-03-29 2011-08-16 Superdimension, Ltd. Endoscope structures and techniques for navigating to a target in branched structure
WO2004009758A2 (en) * 2002-07-23 2004-01-29 Nanodiagnostics, Inc. Embryonic stem cell markers and uses thereof
WO2007116408A2 (en) * 2006-04-11 2007-10-18 Nanodiagnostics Israel Ltd. Pluripotent stem cells characterized by expression of germline specific genes
AR047712A1 (es) * 2002-09-07 2006-02-15 Royal Veterinary College Metodo de tratamiento de una lesion de tejido esqueletico blando natural administrando una composicion de celulas madre mesenquimatosas
AU2003280824A1 (en) * 2002-11-15 2004-06-15 Fumihiko Ishikawa Method of organ regeneration
US7599730B2 (en) 2002-11-19 2009-10-06 Medtronic Navigation, Inc. Navigation system for cardiac therapies
EP1638460A4 (de) * 2003-06-12 2010-05-05 Univ Minnesota Richten von zellen auf zielgewebe oder organe
EP2316328B1 (de) 2003-09-15 2012-05-09 Super Dimension Ltd. Umhüllungsvorrichtung zur Fixierung von Bronchoskopen
ATE438335T1 (de) 2003-09-15 2009-08-15 Super Dimension Ltd System aus zubehör zur verwendung mit bronchoskopen
US7416525B2 (en) 2003-09-18 2008-08-26 Myrakelle, Llc Rotary blood pump
WO2005054448A1 (en) * 2003-12-04 2005-06-16 Guhathakurta Dr Soma A novel process and method for deriving cardiomyocyte precursors from bone-marrow stem cells
EP1544290A1 (de) * 2003-12-19 2005-06-22 Yu-Show Fu System zur Herstellung somatischer Zellen
US8764725B2 (en) 2004-02-09 2014-07-01 Covidien Lp Directional anchoring mechanism, method and applications thereof
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
CA2564679C (en) * 2004-03-22 2015-06-23 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
WO2005097147A1 (en) * 2004-03-30 2005-10-20 Boston Scientific Limited (Incorporated In Ireland) Restenosis therapy using mesenchymal stem cells
CA2567692A1 (en) * 2004-06-08 2005-12-29 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20050277124A1 (en) * 2004-06-10 2005-12-15 White Steven M Cardiac conduction system cells and uses thereof
RU2250772C1 (ru) * 2004-07-16 2005-04-27 Центральный научно-исследовательский рентгено-радиологический институт МЗ РФ (ЦНИРРИ) Способ лечения неоперабельных кардиологических больных
CN101103101B (zh) 2004-09-24 2012-10-10 成血管细胞系统公司 增强间充质前体细胞（mpc）的增生和/或存活的方法
US8889742B2 (en) * 2004-11-30 2014-11-18 The Trustees Of The University Of Pennsylvania Use of HDAC and/or DNMT inhibitors for treatment of ischemic injury
KR20130099253A (ko) 2005-06-22 2013-09-05 제론 코포레이션 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
AU2007233078B2 (en) 2006-03-31 2011-11-24 Thoratec Corporation Rotary blood pump
WO2008125279A2 (en) * 2007-04-11 2008-10-23 Universitätsklinikum Heidelberg Atrial-radiofrequency catheter ablation mediated targeting of mesenchymal stromal cells
CN101668848B (zh) * 2007-04-26 2014-10-22 雷蒙特亚特特拉维夫大学有限公司 来自口腔粘膜的多能自体干细胞和使用方法
US8905920B2 (en) 2007-09-27 2014-12-09 Covidien Lp Bronchoscope adapter and method
WO2009046058A1 (en) * 2007-10-01 2009-04-09 University Of Miami A method to amplify cardiac stem cells in vitro and in vivo
US9962409B2 (en) 2007-10-01 2018-05-08 Vestion, Inc. Therapy using cardiac stem cells and mesenchymal stem cells
AU2008323719B2 (en) 2007-11-09 2013-04-04 New York Medical College Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor
CN101939418A (zh) 2008-01-30 2011-01-05 杰龙公司 用于培养干细胞衍生的心肌细胞的合成表面
WO2009122273A2 (en) 2008-04-03 2009-10-08 Superdimension, Ltd. Magnetic interference detection system and method
EP2297673B1 (de) 2008-06-03 2020-04-22 Covidien LP Registrationsverfahren auf merkmalbasis
US8218847B2 (en) 2008-06-06 2012-07-10 Superdimension, Ltd. Hybrid registration method
US8932207B2 (en) 2008-07-10 2015-01-13 Covidien Lp Integrated multi-functional endoscopic tool
US8611984B2 (en) 2009-04-08 2013-12-17 Covidien Lp Locatable catheter
US10582834B2 (en) 2010-06-15 2020-03-10 Covidien Lp Locatable expandable working channel and method
WO2012048093A2 (en) 2010-10-08 2012-04-12 Osiris Therapeutics, Inc. Enhanced msc preparations
EP3235892B1 (de) 2012-02-14 2019-02-27 Merck Patent GmbH Materialien für organische elektrolumineszenzvorrichtungen
WO2014027474A1 (ja) * 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
WO2014093051A2 (en) 2012-11-30 2014-06-19 Vestion, Inc. Cardiac stem cells and methods of identifying and using the same
JP2016537414A (ja) 2013-10-29 2016-12-01 ベスティオン、インク． 心臓神経堤細胞、及びその使用方法
US9402549B2 (en) 2013-11-27 2016-08-02 General Electric Company Methods and apparatus to estimate ventricular volumes
NZ759969A (en) 2013-12-20 2022-12-23 Fred Hutchinson Cancer Center Tagged chimeric effector molecules and receptors thereof
US10952593B2 (en) 2014-06-10 2021-03-23 Covidien Lp Bronchoscope adapter
EP3209768A1 (de) 2014-07-25 2017-08-30 Recellerate Inc. Verfahren zur behandlung von körpertrainingsinduzierter pulmonaler hämorrhagie
EP3288570A4 (de) 2015-04-29 2018-11-21 Fred Hutchinson Cancer Research Center Modifizierte stammzellen und verwendungen davon
US10426555B2 (en) 2015-06-03 2019-10-01 Covidien Lp Medical instrument with sensor for use in a system and method for electromagnetic navigation
US10478254B2 (en) 2016-05-16 2019-11-19 Covidien Lp System and method to access lung tissue
CN106038597B (zh) * 2016-05-27 2020-01-31 遵义医学院附属医院 间充质干细胞在制备治疗急性肺损伤制剂中的应用
US10722311B2 (en) 2016-10-28 2020-07-28 Covidien Lp System and method for identifying a location and/or an orientation of an electromagnetic sensor based on a map
US10751126B2 (en) 2016-10-28 2020-08-25 Covidien Lp System and method for generating a map for electromagnetic navigation
US10517505B2 (en) 2016-10-28 2019-12-31 Covidien Lp Systems, methods, and computer-readable media for optimizing an electromagnetic navigation system
US10615500B2 (en) 2016-10-28 2020-04-07 Covidien Lp System and method for designing electromagnetic navigation antenna assemblies
US10638952B2 (en) 2016-10-28 2020-05-05 Covidien Lp Methods, systems, and computer-readable media for calibrating an electromagnetic navigation system
US10418705B2 (en) 2016-10-28 2019-09-17 Covidien Lp Electromagnetic navigation antenna assembly and electromagnetic navigation system including the same
US10446931B2 (en) 2016-10-28 2019-10-15 Covidien Lp Electromagnetic navigation antenna assembly and electromagnetic navigation system including the same
US10792106B2 (en) 2016-10-28 2020-10-06 Covidien Lp System for calibrating an electromagnetic navigation system
US11219489B2 (en) 2017-10-31 2022-01-11 Covidien Lp Devices and systems for providing sensors in parallel with medical tools
WO2019102268A1 (en) 2017-11-22 2019-05-31 Mesoblast International Sarl Cellular compositions and methods of treatment i

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5202120A (en) * 1987-09-11 1993-04-13 Case Western Reserve University Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
EP0590066A4 (de) * 1991-06-12 1994-12-07 David A Smith Methode zur induktion humaner myokardialer zellproliferation.
US5543318A (en) * 1991-06-12 1996-08-06 Smith; David A. Method of isolation, culture and proliferation of human atrial myocytes
AU4543193A (en) * 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5602301A (en) * 1993-11-16 1997-02-11 Indiana University Foundation Non-human mammal having a graft and methods of delivering protein to myocardial tissue
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
EP0852463B1 (de) * 1995-06-06 2008-09-03 Case Western Reserve University Myogene differenzierung menschlicher mesenchymaler stammzellen
CA2237890C (en) * 1995-11-16 2011-03-29 Case Western Reserve University In vitro chondrogenic induction of human mesenchymal stem cells
JP2000508922A (ja) * 1996-04-26 2000-07-18 ケース ウエスターン リザーブ ユニバーシティ 間葉幹細胞を用いる皮膚再生
US6110459A (en) * 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
US6099832A (en) * 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
WO1999003973A1 (en) * 1997-07-14 1999-01-28 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
EP1064356A2 (de) * 1998-03-23 2001-01-03 ZymoGenetics, Inc. Herz-derivierte stammzellen
AU770889B2 (en) * 1999-07-23 2004-03-04 Genvec, Inc. Muscle cells and their use in cardiac repair

Also Published As

Publication number Publication date
BR9912662A (pt) 2001-06-05
EP1100870B1 (de) 2008-01-02
AU5545499A (en) 2000-02-21
CA2339182A1 (en) 2000-02-10
US20050031600A1 (en) 2005-02-10
CA2339182C (en) 2010-04-06
DE69937888D1 (de) 2008-02-14
WO2000006701A1 (en) 2000-02-10
JP2002521493A (ja) 2002-07-16
EP1100870A4 (de) 2004-10-13
EP1100870A1 (de) 2001-05-23
DE69937888T2 (de) 2009-01-02
WO2000006701A9 (en) 2000-06-15

Similar Documents

Publication Publication Date Title
DE69937888D1 (de) Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
DE60043229D1 (de) Zusammensetzung zur gefässbeschichtung
DE60120151D1 (de) Isolierung von mesenchymalen stammzellen und deren verwendung
ATE348148T1 (de) Leberstammzellen
ATE489101T1 (de) Wiederherstellung der gelenken mit mesenchymalen stammzellen
EA200300738A1 (ru) Защита, восстановление и усиление эритропоэтинреактивных клеток, тканей и органов
NO20003600L (no) Kalium kanal inhibitorer
WO2000001231A8 (en) Improved methods for storing neural cells
MXPA02007137A (es) Fuente de tejido hepatico.
IS2631B (is) Aðferðir þar sem integrín-mótlyf eru notuð til að meðhöndla margföld mergæxli og uppsog í bein af völdum mergæxla
DK1123414T3 (da) Antisense-modulering af integrin alpha 4.ekspression
DK1178726T3 (da) Vandig opløsning til konservering af væv og organer
NO2019032I1 (no) Treosulfan
ATE305785T1 (de) Cd45 hemmer
AU4643501A (en) Use of vascular endothelial growth factor, placenta growth factor or both for preventing or treating ischemic diseases or stroke
DK1664307T3 (da) Ny endospermspecifik plantepromotor til afgröder
MXPA02002444A (es) Metodo para generar celulas y tejidos inmunocompatibles, utilizando tecnicas de transferencia nuclear.
DK1194158T3 (da) Anvendelse af UK 114-proteiner til hæmning af organtransplantatafstödning
DK1261325T3 (da) Tumorinhiberende sammensætninger, der indeholder nitroacridiner
ATE389014T1 (de) Phosphorylierte glyoxalase i und deren verwendung
UA39614A (uk) Спосіб корекції функціонального стану міокарда у лабораторних тварин пізнього онтогенезу
UA33888A (uk) Спосіб зменшення імунореактивності алогенного кісткового мозку експериментальних тварин
BG102613A (en) New substituted imidazoles

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties