ATE383370T1 - Verbindungen die p-selectin binden - Google Patents

Verbindungen die p-selectin binden

Info

Publication number: ATE383370T1
Authority: AT; Austria
Prior art keywords: compounds; selectin; binding; bind; derivatives
Prior art date: 2002-08-09

Application number

AT03792179T

Other languages

English (en)

Inventor

Chantal Appeldoorn

Erik Biessen

Thomas Molenaar

Johan Lacdr Kuiper

Berkel Theodorus Van

Original Assignee

Astellas Pharma Europ B V

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-09

Filing date

2003-07-04

Publication date

2008-01-15

2003-07-04 Application filed by Astellas Pharma Europ B V filed Critical Astellas Pharma Europ B V

2008-01-15 Application granted granted Critical

2008-01-15 Publication of ATE383370T1 publication Critical patent/ATE383370T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 6
238000000034 method Methods 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
101000622137 Homo sapiens P-selectin Proteins 0.000 abstract 1
108010035766 P-Selectin Proteins 0.000 abstract 1
102000008212 P-Selectin Human genes 0.000 abstract 1
238000002405 diagnostic procedure Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Oncology (AREA)
Hematology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Peptides Or Proteins (AREA)

AT03792179T 2002-08-09 2003-07-04 Verbindungen die p-selectin binden ATE383370T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02078308		2002-08-09

Publications (1)

Publication Number	Publication Date
ATE383370T1 true ATE383370T1 (de)	2008-01-15

Family

ID=31896910

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03792179T ATE383370T1 (de)	2002-08-09	2003-07-04	Verbindungen die p-selectin binden

Country Status (11)

Country	Link
US (3)	US20060217294A1 (de)
EP (1)	EP1527086B1 (de)
JP (2)	JP4563806B2 (de)
AT (1)	ATE383370T1 (de)
AU (1)	AU2003250899A1 (de)
BR (1)	BR0313019A (de)
CA (1)	CA2493471C (de)
DE (1)	DE60318585T2 (de)
ES (1)	ES2299749T3 (de)
MX (1)	MXPA05001599A (de)
WO (1)	WO2004018502A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003250899A1 (en) *	2002-08-09	2004-03-11	Astellas Pharma Europe B.V.	Compounds binding to p-selectin
WO2004033473A1 (en)	2002-10-11	2004-04-22	Yamanouchi Europe B.V.	Glucose-based compounds with affinity to p-selectin
EP1577289A1 (de)	2004-03-18	2005-09-21	Revotar Biopharmaceuticals AG	Nicht-glykosylierte/-glykosidische/-peptidische keine Moleküle als Selektininhibitoren für die Behandlung entzündlicher Erkrankungen.
EP1764096A1 (de)	2005-09-20	2007-03-21	Revotar Biopharmaceuticals AG	Neue Phloroglucinolderivate mit Selectin-Ligand-Aktivität
EP1764095A1 (de) *	2005-09-20	2007-03-21	Revotar Biopharmaceuticals AG	Neue Nitrocatecholderivate mit Selectin-Ligand-Activität
EP1764093A1 (de)	2005-09-20	2007-03-21	Revotar Biopharmaceuticals AG	Neue aromatische Verbindungen und deren medizinische Verwendung
CA2662449A1 (en) *	2006-09-08	2008-03-13	Bayer Schering Pharma Aktiengesellschaft	Compounds and methods for 18f labeled agents
HUE034308T2 (en)	2013-03-21	2018-02-28	Sanofi Aventis Deutschland	Preparation of hydantoin-containing peptide products
CN105102427B (zh)	2013-03-21	2018-09-07	赛诺菲-安万特德国有限公司	含有环状酰亚胺的肽产物的合成
EP4090358A4 (de) *	2020-01-16	2024-02-14	Case Western Reserve University	Neutrophile elastase-bindende peptide und zusammensetzungen davon
CN115039782A (zh) *	2022-07-20	2022-09-13	中国农业科学院植物保护研究所	一种化合物在大豆孢囊线虫几丁质酶抑制剂中的应用
WO2025168211A1 (en)	2023-02-10	2025-08-14	Novo Nordisk A/S	P-selectin peptide ligands

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994005314A1 (en) *	1992-09-08	1994-03-17	Centocor, Inc.	Peptide inhibitors of leukocyte adhesion
JPH10502349A (ja) *	1994-06-29	1998-03-03	テキサス・バイオテクノロジー・コーポレイシヨン	インテグリンα▲下４▼β▲下１▼のＶＣＡＭ−１またはフィブロネクチンへの結合を阻害する方法
WO2000027420A1 (en) *	1998-11-06	2000-05-18	The Wistar Institute Of Anatomy And Biology	Compositions and methods for treatment of cancer
EP1288222A1 (de) *	2001-09-03	2003-03-05	Yamanouchi Europe B.V.	Selektiv P-Selectin bindende peptidische Verbindungen
AU2003250899A1 (en) *	2002-08-09	2004-03-11	Astellas Pharma Europe B.V.	Compounds binding to p-selectin

2003
- 2003-07-04 AU AU2003250899A patent/AU2003250899A1/en not_active Abandoned
- 2003-07-04 US US10/524,172 patent/US20060217294A1/en not_active Abandoned
- 2003-07-04 JP JP2004530000A patent/JP4563806B2/ja not_active Expired - Fee Related
- 2003-07-04 EP EP03792179A patent/EP1527086B1/de not_active Expired - Lifetime
- 2003-07-04 ES ES03792179T patent/ES2299749T3/es not_active Expired - Lifetime
- 2003-07-04 AT AT03792179T patent/ATE383370T1/de not_active IP Right Cessation
- 2003-07-04 CA CA2493471A patent/CA2493471C/en not_active Expired - Fee Related
- 2003-07-04 DE DE60318585T patent/DE60318585T2/de not_active Expired - Lifetime
- 2003-07-04 MX MXPA05001599A patent/MXPA05001599A/es unknown
- 2003-07-04 WO PCT/EP2003/007260 patent/WO2004018502A1/en not_active Ceased
- 2003-07-04 BR BR0313019-3A patent/BR0313019A/pt not_active Application Discontinuation
2008
- 2008-06-25 US US12/146,302 patent/US20090062186A1/en not_active Abandoned
2010
- 2010-03-16 US US12/725,199 patent/US20100323969A1/en not_active Abandoned
- 2010-04-21 JP JP2010098138A patent/JP2010209088A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
JP4563806B2 (ja)	2010-10-13
MXPA05001599A (es)	2005-08-19
JP2006513141A (ja)	2006-04-20
CA2493471A1 (en)	2004-03-04
WO2004018502A1 (en)	2004-03-04
BR0313019A (pt)	2005-07-12
EP1527086A1 (de)	2005-05-04
DE60318585T2 (de)	2009-01-08
EP1527086B1 (de)	2008-01-09
JP2010209088A (ja)	2010-09-24
US20100323969A1 (en)	2010-12-23
DE60318585D1 (de)	2008-02-21
US20060217294A1 (en)	2006-09-28
US20090062186A1 (en)	2009-03-05
ES2299749T3 (es)	2008-06-01
WO2004018502A8 (en)	2005-05-12
AU2003250899A1 (en)	2004-03-11
CA2493471C (en)	2013-02-12

Legal Events

Date	Code	Title	Description
2008-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
IS2376B (is)	2008-07-15	Þíenópýrimidíndíón og notkun þeirra í breytingu ásjálfsnæmissjúkdómi
DE602004025101D1 (de)	2010-03-04	Humane anti-humane cd3-bindungsmoleküle
SG144925A1 (en)	2008-08-28	Methods for treating cardiovascular disease using a soluble ctla4 molecule
ATE383370T1 (de)	2008-01-15	Verbindungen die p-selectin binden
BRPI0513681A (pt)	2008-05-13	composição que compreendem anticorpo her2, método, formulações farmacêuticas, polipeptìdeo, anticorpo e método de tratamento de cáncer
CA2413190A1 (en)	2002-01-10	Methods for treating rheumatic diseases using a soluble ctla4 molecule
EA200602196A1 (ru)	2007-06-29	Производные пиразола, композиции, содержащие эти соединения, и способы применения
CY1106386T1 (el)	2011-10-12	Υποκατεστημενα παραγωγα 3-πυρρολιδιν-ινδολης
UA117216C2 (uk)	2018-07-10	Пухлиноасоційований пептид та його застосування
CY1109168T1 (el)	2014-07-02	Συνθεση νατριουχου φονταπαρινοξης υψηλης καθαροτητας
CY1112889T1 (el)	2016-04-13	Αναλογα αζετιδινης αναστολεων νουκλεοσιδασης και φωσφορυλασης
BRPI0413728A (pt)	2006-10-24	muteìnas de lipocalina da lágrima
WO2004010957A3 (en)	2004-06-10	Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
DE602007009995D1 (de)	2010-12-02	Muteine von tearlipocalin und verfahren zu deren gewinnung
ATE330967T1 (de)	2006-07-15	An her2 bindende peptidverbindungen
NZ543467A (en)	2008-07-31	The severe acute respiratory syndrome coronavirus
AU2006226733A8 (en)	2013-01-10	Antibodies against CD38 for treatment of multiple myeloma
WO2004094473A3 (en)	2005-06-02	Humanized antibodies to interferon alpha receptor-1 (ifnar-1)
DE60336225D1 (de)	2011-04-14	Neue pharmazeutische zusammenstezungen, flibanserin polymorph a enthaltend
ATE371724T1 (de)	2007-09-15	Behandlung neurodegenerativer krankheiten
ATE482933T1 (de)	2010-10-15	Sulfopyrrolderivate
BR0311491A (pt)	2005-04-26	Composto, composição farmacêutica, uso de um composto, e, método terapêutico para tratar câncer em um mamìfero
NO20075637L (no)	2008-01-29	4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater som medikamenter for behandling av infertilitet
BRPI0407031A (pt)	2006-01-17	Composições e métodos para tratamento de câncer empregando igsf9 e liv-1
EA200702375A1 (ru)	2008-06-30	Производные мочевины, способы их получения и применения