ATE384124T1 - Pluripotente stammzellen erzeugt aus stromalzellen aus dem fettgewebe und deren verwendungen - Google Patents

Pluripotente stammzellen erzeugt aus stromalzellen aus dem fettgewebe und deren verwendungen

Info

Publication number
ATE384124T1
ATE384124T1 AT01911175T AT01911175T ATE384124T1 AT E384124 T1 ATE384124 T1 AT E384124T1 AT 01911175 T AT01911175 T AT 01911175T AT 01911175 T AT01911175 T AT 01911175T AT E384124 T1 ATE384124 T1 AT E384124T1
Authority
AT
Austria
Prior art keywords
adiative
pluripotent stem
stem cells
stromal cells
cells
Prior art date
Application number
AT01911175T
Other languages
English (en)
Inventor
William Wilkison
Jeffrey Gimble
Original Assignee
Artecel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artecel Inc filed Critical Artecel Inc
Application granted granted Critical
Publication of ATE384124T1 publication Critical patent/ATE384124T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0667Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/44Thiols, e.g. mercaptoethanol
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01911175T 2000-02-26 2001-02-26 Pluripotente stammzellen erzeugt aus stromalzellen aus dem fettgewebe und deren verwendungen ATE384124T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18533800P 2000-02-26 2000-02-26

Publications (1)

Publication Number Publication Date
ATE384124T1 true ATE384124T1 (de) 2008-02-15

Family

ID=22680577

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01911175T ATE384124T1 (de) 2000-02-26 2001-02-26 Pluripotente stammzellen erzeugt aus stromalzellen aus dem fettgewebe und deren verwendungen

Country Status (13)

Country Link
US (2) US7078230B2 (de)
EP (1) EP1261694B1 (de)
JP (1) JP2003523767A (de)
AT (1) ATE384124T1 (de)
AU (2) AU2001238695B2 (de)
CA (1) CA2400485C (de)
DE (1) DE60132429T2 (de)
DK (1) DK1261694T3 (de)
ES (1) ES2300320T3 (de)
IL (1) IL151228A (de)
PT (1) PT1261694E (de)
SG (1) SG134168A1 (de)
WO (1) WO2001062901A2 (de)

Families Citing this family (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1166773C (zh) * 1997-12-02 2004-09-15 泽恩比奥公司 分离的人脂肪组织衍生的基质细胞
US20050076396A1 (en) * 1999-03-10 2005-04-07 Katz Adam J. Adipose-derived stem cells and lattices
KR100979664B1 (ko) * 1999-03-10 2010-09-02 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 지방 유래 간세포 및 격자
US20050153442A1 (en) * 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US8075881B2 (en) 1999-08-05 2011-12-13 Regents Of The University Of Minnesota Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
WO2001011011A2 (en) 1999-08-05 2001-02-15 Mcl Llc Multipotent adult stem cells and methods for isolation
US8609412B2 (en) * 1999-08-05 2013-12-17 Regents Of The University Of Minnesota Mapc generation of lung tissue
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
WO2002064748A2 (en) * 2001-02-14 2002-08-22 Furcht Leo T Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US7582292B2 (en) * 2000-02-26 2009-09-01 Artecel, Inc. Adipose tissue derived stromal cells for the treatment of neurological disorders
EP1261694B1 (de) * 2000-02-26 2008-01-16 Artecel, Inc. Pluripotente stammzellen erzeugt aus stromalzellen aus dem fettgewebe und deren verwendungen
US6673606B1 (en) * 2000-04-12 2004-01-06 The Children's Hospital Of Philadelphia Therapeutic uses for mesenchymal stromal cells
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
US7282366B2 (en) 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
US6458589B1 (en) * 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7473555B2 (en) 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
FR2819265B1 (fr) * 2001-01-10 2004-01-02 Centre Nat Rech Scient Cellules du tissu adipeux extramedullaire et leurs applications dans la reconstitution des lignees hematopoietiques
DE10144326B4 (de) * 2001-09-10 2005-09-22 Siemens Ag Verfahren und System zur Überwachung eines Reifenluftdrucks
JP2005508393A (ja) * 2001-11-09 2005-03-31 アーテセル・サイエンシズ・インコーポレーテツド 胚および成人幹細胞をサポートするための間質細胞の使用の方法および組成物
CN100516200C (zh) * 2001-11-09 2009-07-22 阿特塞尔科学公司 用于角膜和眶内缺损修复的脂肪组织来源的基质细胞及其应用
KR20090115984A (ko) * 2001-11-09 2009-11-10 아르테셀 사이언스, 인크. 지방 조직에서 유래된 기질세포의 내분비 췌장 분화 및 이의 용도
KR100930139B1 (ko) * 2001-12-07 2009-12-07 사이토리 테라퓨틱스, 인크. 처리된 리포애스퍼레이트 세포로 환자를 치료하기 위한시스템 및 방법
US7651684B2 (en) 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
WO2006075986A1 (en) * 2005-01-10 2006-07-20 Macropore Biosurgery, Inc. Devices and methods for monitoring, managing, and servicing medical devices
US20050048035A1 (en) 2001-12-07 2005-03-03 Fraser John K. Methods of using regenerative cells in the treatment of stroke and related diseases and disorders
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US7514075B2 (en) 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
US8404229B2 (en) 2001-12-07 2013-03-26 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to treat acute tubular necrosis
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US20050250202A1 (en) * 2002-03-19 2005-11-10 March Keith L Adipose stromal stem cells for tissue and vascular modification
KR20040094910A (ko) * 2002-04-03 2004-11-10 아르테셀 사이언스, 인크. 개선된 지방세포 분화된 지방 유래 성체 줄기세포 및 이의용도
CN1656214A (zh) * 2002-05-24 2005-08-17 基质细胞有限责任公司 祖细胞在没有细胞因子存在条件下的生长和维持
US20060228798A1 (en) 2002-11-27 2006-10-12 Catherine Verfaillie Homologous recombination in multipotent adult progenitor cells
FR2850009B1 (fr) * 2003-01-20 2005-12-23 Spine Next Sa Ensemble de traitement de la degenerescence d'un disque intervertebral
US20040193274A1 (en) * 2003-03-28 2004-09-30 Trieu Hai H. Materials and methods for augmenting and/or repairing intervertebral discs
WO2005035738A1 (en) 2003-10-07 2005-04-21 Biomaster Inc. Cell differentiation of adipose-derived precursor cells
JP2007508018A (ja) 2003-10-08 2007-04-05 べト−ステム インコーポレイテッド 新規の幹細胞組成物の調製法および使用法、ならびにこの組成物を含有するキット
WO2005042048A2 (en) * 2003-10-22 2005-05-12 Encelle, Inc. Bioactive hydrogel compositions for regenerating connective tissue
US9631176B2 (en) 2003-11-04 2017-04-25 Biomaster, Inc. Method for preparing stem cells from fat tissue
EP3461884B1 (de) 2004-03-22 2025-05-28 Mesoblast International Sàrl Mesenchymale stammzellen und verwendungen davon
JPWO2005093083A1 (ja) * 2004-03-29 2008-02-14 和久 前田 疾病予測方法、及びその利用方法
JP2007252393A (ja) * 2004-04-28 2007-10-04 Nippon Medical School 脂肪組織由来幹細胞から骨髄を形成するための組成物およびその方法
JP4731556B2 (ja) * 2004-07-02 2011-07-27 サイトリ セラピューティクス インコーポレイテッド 臨床的に安全な脂肪組織由来再生細胞を単離し、使用するためのシステムおよび方法
ES2313805B1 (es) * 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
US20060051865A1 (en) * 2004-08-31 2006-03-09 Higgins Joel C Systems and methods for isolating stromal cells from adipose tissue and uses thereof
WO2006046583A1 (ja) * 2004-10-26 2006-05-04 Santen Pharmaceutical Co., Ltd. 視細胞またはその機能を再生させるための材料
JP2008528041A (ja) * 2005-01-31 2008-07-31 コグネート セラピューティクス,インコーポレーテッド 内皮細胞の性質を示す脂肪由来成体間質細胞
EP1859028B1 (de) * 2005-02-10 2015-12-02 Regents Of The University Of Minnesota Vaskuläre Endothelzellen
CA2607218C (en) * 2005-05-05 2016-08-23 Regents Of The University Of Minnesota Use of mapc or progeny therefrom to populate lymphohematopoietic tissues
US20080187518A1 (en) * 2005-05-25 2008-08-07 University Of Virginia Patent Foundation Production of Osteoclasts from Adipose Tissues
US7531355B2 (en) 2005-07-29 2009-05-12 The Regents Of The University Of California Methods and compositions for smooth muscle reconstruction
WO2007117262A2 (en) * 2005-07-29 2007-10-18 Athersys, Inc. Culture of non-embryonic cells at high cell density
US20070077649A1 (en) * 2005-09-06 2007-04-05 Sammak Paul J Transplantable cell growth niche and related compositions and methods
CN101310012B (zh) * 2005-10-14 2012-05-09 明尼苏达大学董事会 非胚胎干细胞分化成具有胰腺表型的细胞
WO2007055882A2 (en) * 2005-11-07 2007-05-18 Hosheng Tu Breast augmentation and reconstruction system
US20070104693A1 (en) * 2005-11-07 2007-05-10 Quijano Rodolfo C Breast augmentation system
US20070104692A1 (en) * 2005-11-07 2007-05-10 Quijano Rodolfo C Breast tissue regeneration
KR100679642B1 (ko) 2005-11-16 2007-02-06 주식회사 알앤엘바이오 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제
FR2896511B1 (fr) * 2006-01-26 2012-10-26 Centre Nat Rech Scient Procede de culture de cellules issues du tissu adipeux et leurs applications.
US8592209B2 (en) * 2006-01-30 2013-11-26 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
US20090175835A1 (en) * 2006-02-07 2009-07-09 Korea Institute Of Radiological & Medical Sciences Composition for treating damage of central or peripheral nerve system
EP2366775B1 (de) 2006-03-23 2015-04-22 Pluristem Ltd. Verfahren zur Zellexpansion sowie Verwendungen von damit produzierten Zellen und konditionierten Medien für die Therapie
EP2019859A4 (de) * 2006-04-25 2009-11-25 Univ Louisiana State Erwachsene stammzellen aus fettgewebe für leberregenerierung
WO2007136424A2 (en) * 2006-05-17 2007-11-29 Cognate Therapeutics, Inc. Isolation and purification of hematopoietic stem cells from post-liposuction lipoaspirates
FR2901136B1 (fr) * 2006-05-18 2010-10-01 Centre Nat Rech Scient Utilisation de cellules derivees du tissu adipeux pour la preparation d'un medicament anti-tumoral
WO2007139551A1 (en) * 2006-05-30 2007-12-06 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells from adipose tissue
US8148151B2 (en) 2006-06-02 2012-04-03 Geron Corporation Differentiation of primate pluripotent cells to hepatocyte-lineage cells
FR2902011B1 (fr) * 2006-06-12 2008-12-26 Inst Radioprot Et De Surete Nu Utilisation de fractions cellulaires du tissu adipeux pour la regeneration tissulaire post irradiation
KR100788632B1 (ko) * 2006-06-15 2007-12-26 주식회사 알앤엘바이오 인간 지방조직 유래 다분화능 줄기세포, 섬유아세포 및지방 또는 지방세포를 함유한 피부미용 또는 성형용조성물의 제조방법
WO2008013863A2 (en) * 2006-07-26 2008-01-31 Cytori Therapeutics, Inc. Generation of adipose tissue and adipocytes
JP2010505849A (ja) * 2006-10-06 2010-02-25 ユニバーシティ オブ バージニア パテント ファウンデーション 糖尿病性創傷治癒に有用な方法および組成物
PT2578081E (pt) * 2006-10-11 2016-06-17 Massachusetts Inst Technology Composições, métodos e dispositivos para o tratamento de doenças hepáticas
WO2008063675A2 (en) * 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
WO2008103807A2 (en) * 2007-02-21 2008-08-28 Cedars-Sinai Medical Center Methods of producing preadipocytes and increasing the proliferation of adult adipose stem/progenitor cells
CN101668848B (zh) * 2007-04-26 2014-10-22 雷蒙特亚特特拉维夫大学有限公司 来自口腔粘膜的多能自体干细胞和使用方法
MX2010003019A (es) 2007-09-19 2010-04-30 Pluristem Ltd Celulas adherentes de los tejidos adiposo y de placenta y uso de las mismas en la terapia.
US8273091B2 (en) * 2007-10-04 2012-09-25 Ebi, Llc Alignment device for locking nail
KR101046188B1 (ko) * 2007-11-30 2011-07-04 주식회사 알앤엘바이오 탈락막 또는 지방 유래 줄기세포를 함유하는 요실금의 세포치료제
RU2368378C1 (ru) * 2007-12-26 2009-09-27 Государственное Учреждение Научный Центр Неврологии Российской Академии Медицинских Наук Способ коррекции функциональных нарушений организма, вызванных повреждением нервных клеток мозга
AU2009205886B2 (en) * 2008-01-18 2015-08-27 Katholieke Universiteit Leuven Stem cell aggregates and methods for making and using
EP2250254A4 (de) 2008-02-05 2011-09-07 Regenertech Pty Ltd Verfahren zur herstellung von vorläuferzellen aus differenzierten zellen
BRPI0909541A2 (pt) 2008-05-27 2016-10-11 Pluristem Ltd ''método para tratamento de doenças inflamatórias do cólon''
WO2010021993A1 (en) * 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
CN105708862B (zh) 2008-09-02 2020-11-06 普拉里斯坦有限公司 来自胎盘组织的粘附细胞及其在治疗中的用途
WO2010049752A1 (en) 2008-10-31 2010-05-06 Katholieke Universiteit Leuven Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells
RU2396345C1 (ru) * 2008-12-15 2010-08-10 Государственное Учебно-Научное Учреждение Факультет Фундаментальной Медицины Московского Государственного Университета Имени М.В. Ломоносова Способ получения популяции стромальных клеток жировой ткани, индуцированных к нейральной дифференцировке
AU2010242780B2 (en) 2009-05-01 2016-04-21 Puregraft Llc Systems, methods and compositions for optimizing tissue and cell enriched grafts
WO2011006205A1 (en) * 2009-07-15 2011-01-20 Regenertech Pty Limited Method of producing progenitor cells from differentiated cells
WO2011011477A1 (en) * 2009-07-21 2011-01-27 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
WO2011011500A1 (en) * 2009-07-21 2011-01-27 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
US20110027239A1 (en) * 2009-07-29 2011-02-03 Tissue Genesis, Inc. Adipose-derived stromal cells (asc) as delivery tool for treatment of cancer
WO2011022045A2 (en) * 2009-08-17 2011-02-24 Singh Ashok K Apparatus and process for generating and harvesting adult stem cells and fluid associated with it from skin and omentum for medical, cosmetic, and veterinary use
EP2977445B1 (de) 2009-11-30 2018-07-25 Pluristem Ltd. Adhärente zellen aus der plazenta und ihre verwendung bei der behandlung von erkrankungen
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
US20110206647A1 (en) * 2010-02-25 2011-08-25 Abt Holding Company Modulation of Angiogenesis
WO2011106476A1 (en) * 2010-02-25 2011-09-01 Abt Holding Company Modulation of microglia activation
US9447379B2 (en) 2010-02-27 2016-09-20 Reza Izadpanah Derivation of hematopoietic cells from adult mesenchymal stem cells
SG185526A1 (en) 2010-05-12 2012-12-28 Abt Holding Co Modulation of splenocytes in cell therapy
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
WO2011158125A2 (en) 2010-06-17 2011-12-22 Katholieke Universiteit Leuven Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells
US9296984B2 (en) 2010-07-09 2016-03-29 The Gid Group, Inc. Tissue processing apparatus and method for processing adipose tissue
WO2013106655A1 (en) 2012-01-11 2013-07-18 The Gid Group, Inc. Method for processing adipose tissue and processing apparatus
EP3366327B1 (de) 2010-07-09 2022-09-21 GID BIO, Inc. Vorrichtung und verfahren zur erhebung und verarbeitung von menschlichem biologischem material mit fettgewebe
US9206387B2 (en) 2010-07-09 2015-12-08 The Gid Group, Inc. Method and apparatus for processing adipose tissue
EP2573168A4 (de) * 2010-07-22 2014-04-02 Affiliated Hospital Of Ningxia Medical University Verfahren zur erzeugung von nervenzellen aus stammzellen, nervenzellen und verwendungen dafür
EP2609191B1 (de) 2010-08-24 2017-11-22 Regents Of The University Of Minnesota Nichtstatische suspensionskultur aus zellverbänden
JP5804342B2 (ja) * 2010-09-11 2015-11-04 国立大学法人金沢大学 脂肪組織由来間質細胞群を含む肝炎治療剤
WO2012048276A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US20120087868A1 (en) 2010-10-08 2012-04-12 Gabriele Todd Nanoparticle-loaded cells
AU2011352928B2 (en) 2010-12-27 2017-02-02 Stroma Cell Therapeutics, Llc Ultrasonic cavitation derived stromal or mesenchymal vascular extracts and cells derived therefrom obtained from adipose tissue and use thereof
EP3260533B1 (de) 2011-03-22 2019-09-11 Pluristem Ltd. Verfahren zur behandlung von strahlungs- oder chemischen verletzungen
CN103476924A (zh) 2011-04-15 2013-12-25 普拉里斯坦有限公司 收获细胞的方法和系统
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
CN102433299B (zh) * 2011-11-17 2013-01-23 安徽农业大学 小鼠脂肪干细胞的分离、培养及纯化方法
US9512405B2 (en) 2011-12-14 2016-12-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Non-enzymatic method for isolating human adipose-derived stromal stem cells
CA2860227C (en) 2011-12-23 2020-03-24 Pioneer Surgical Technology Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith
WO2014037863A1 (en) 2012-09-04 2014-03-13 Pluristem Ltd. Methods for prevention and treatment of preeclampsia
EP3075841B1 (de) 2012-09-06 2021-03-10 GID BIO, Inc. Gewebeverarbeitungsvorrichtung und verfahren zur verarbeitung von fettgewebe
WO2014089554A1 (en) * 2012-12-07 2014-06-12 Antria, Inc. Formulations containing and kit for using adipose-derived stem cells and use thereof
US9650608B2 (en) 2013-02-22 2017-05-16 Medivet America, Llc Activating adipose-derived stem cells for transplantation
IL289870B2 (en) 2013-04-12 2023-03-01 Lafrancesca Saverio Improving organs for transplantation
JP2016519939A (ja) 2013-05-22 2016-07-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California 多能性ヒト脂肪成体幹細胞:単離、キャラクタリゼーションおよび臨床的意味
US20150037436A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US20150037303A1 (en) * 2013-08-01 2015-02-05 Regen Biopharma, Inc Cells, compositions, and treatment methods for stimulation of hematopoiesis
US10336980B2 (en) 2013-09-05 2019-07-02 The Gid Group, Inc. Tissue processing apparatus and method for processing adipose tissue
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
EP3198006B1 (de) 2014-09-26 2021-03-24 Terumo BCT, Inc. Geplante fütterung
US10258652B2 (en) 2014-12-18 2019-04-16 Pluristem Ltd. Methods and compositions for treating and preventing muscle wasting disorders
US20180015125A1 (en) 2015-03-23 2018-01-18 Pluristem Ltd. Use of adherent stromal cells for enhancing hematopoiesis in a subject in need thereof
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
NZ745530A (en) 2016-01-21 2023-03-31 Abt Holding Co Stem cells for wound healing
AU2017220148A1 (en) 2016-02-18 2018-07-19 Pluristem Ltd. Methods and compositions for treating cancers and neoplasms
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
BR112019003871A2 (pt) 2016-08-30 2019-07-16 Lifecell Corp sistemas e métodos para controle de dispositivo médico
USD851777S1 (en) 2017-01-30 2019-06-18 Lifecell Corporation Canister-type device for tissue processing
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
CN106834259A (zh) * 2017-04-14 2017-06-13 青岛青春派生物科技有限公司 一种人脂肪组织消化酶及其制备方法
US20200246386A1 (en) 2017-04-24 2020-08-06 Pluristem Ltd. Methods and compositions for treating neurological disorders
US11732233B2 (en) 2017-07-18 2023-08-22 Gid Bio, Inc. Adipose tissue digestion system and tissue processing method
SG11202004680UA (en) 2017-11-22 2020-06-29 Mesoblast Int Sarl Cellular compositions and methods of treatment i
US11674131B2 (en) 2018-12-03 2023-06-13 Ross Ward Indirect ultrasonic cavitation-derived perivascular cells and methods of use thereof
EP4314244B1 (de) 2021-03-23 2025-07-23 Terumo BCT, Inc. Zellerfassung und -erweiterung
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5863531A (en) 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US5804178A (en) 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
NO171069C (no) 1990-05-29 1993-01-20 Protan Biopolymer As Kovalent tverrbundne, sterkt svellende alkalimetall- og ammonium-alginatgeler, samt fremgangsmaate for fremstilling derav
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US6176874B1 (en) 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5723331A (en) 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US6103522A (en) 1994-07-20 2000-08-15 Fred Hutchinson Cancer Research Center Human marrow stromal cell lines which sustain hematopoiesis
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US6653134B2 (en) 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US6123727A (en) 1995-05-01 2000-09-26 Massachusetts Institute Of Technology Tissue engineered tendons and ligaments
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5741685A (en) 1995-06-07 1998-04-21 Children's Medical Center Corporation Parenchymal cells packaged in immunoprotective tissue for implantation
JP3452366B2 (ja) 1995-10-20 2003-09-29 トランスティッシュウ テクノロジーズ ゲーエムベーハー 新規人工組織、その製法およびその使用
WO1997017038A1 (en) 1995-11-09 1997-05-15 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
CA2237890C (en) 1995-11-16 2011-03-29 Case Western Reserve University In vitro chondrogenic induction of human mesenchymal stem cells
US6200606B1 (en) 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
CA2271758A1 (en) 1996-11-15 1998-05-22 Osiris Therapeutics, Inc. Msc-megakaryocyte precursor composition and method of isolating mscs associated with isolated megakaryocytes by isolating megakaryocytes
US5786207A (en) 1997-05-28 1998-07-28 University Of Pittsburgh Tissue dissociating system and method
CN1166773C (zh) * 1997-12-02 2004-09-15 泽恩比奥公司 分离的人脂肪组织衍生的基质细胞
US6027744A (en) 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
DE69940731D1 (de) * 1998-05-26 2009-05-28 Genitrix Llc Zusammensetzungen und verfahren zur modulation einer immunantwort auf ein antigen durch verabreichung von zytokine-beladenen zellen
AU4221399A (en) 1998-05-29 1999-12-13 Osiris Therapeutics, Inc. Human cd45+ and/or fibroblast + mesenchymal stem cells
EP1108011A2 (de) 1998-06-08 2001-06-20 Osiris Therapeutics, Inc. In vitro-erhaltung von hämatopoietischenstammzellen.
US6153432A (en) 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
KR100979664B1 (ko) * 1999-03-10 2010-09-02 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 지방 유래 간세포 및 격자
US6429013B1 (en) 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US6555374B1 (en) * 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
WO2001021767A2 (en) 1999-09-24 2001-03-29 Morphogen Pharmaceuticals, Inc. Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
EP1261694B1 (de) * 2000-02-26 2008-01-16 Artecel, Inc. Pluripotente stammzellen erzeugt aus stromalzellen aus dem fettgewebe und deren verwendungen
EP1152058A1 (de) * 2000-05-03 2001-11-07 Institut Curie Methoden und Zusammensetzungen zur effizienten homologen Rekombination

Also Published As

Publication number Publication date
IL151228A (en) 2013-05-30
PT1261694E (pt) 2008-04-03
EP1261694B1 (de) 2008-01-16
DE60132429T2 (de) 2009-01-08
SG134168A1 (en) 2007-08-29
US20010033834A1 (en) 2001-10-25
AU2001238695B2 (en) 2005-11-24
JP2003523767A (ja) 2003-08-12
US20060228341A1 (en) 2006-10-12
WO2001062901A2 (en) 2001-08-30
DK1261694T3 (da) 2008-05-26
WO2001062901A3 (en) 2002-02-21
AU3869501A (en) 2001-09-03
ES2300320T3 (es) 2008-06-16
CA2400485A1 (en) 2001-08-30
US7078230B2 (en) 2006-07-18
EP1261694A2 (de) 2002-12-04
CA2400485C (en) 2014-04-29
DE60132429D1 (de) 2008-03-06

Similar Documents

Publication Publication Date Title
ATE384124T1 (de) Pluripotente stammzellen erzeugt aus stromalzellen aus dem fettgewebe und deren verwendungen
EP1200555A4 (de) Identifizierung pluripotenter prämesenchymaler, prähämotopoietischer vorläuferzellen
WO2004069172A3 (en) Multilineage-inducible cells and uses thereof
ATE439429T1 (de) Multipotente neurale stammzellen aus hautgewebe und deren verwendungen
WO2005047524A3 (en) Compositions and methods for inducing cell dedifferentiation
ES2571355T3 (es) Sistema de cultivo sin células alimentadoras ni xenocontaminantes para células madre embrionarias humanas
WO1999064566A8 (en) In vitro maintenance of hematopoietic stem cells
PA8513601A1 (es) Composiciones farmaceuticas de inhibidores de la glucogenofosforilasa
AR059155A1 (es) Composiciones que comprenden enzimas y fotoblanqueadores
GB2392674A (en) Mesenchymal cells and osteoblasts from human embryonic stem cell
PH12020551584A1 (en) Stem/progenitor cells from duodenal brunner's glands and methods of isolating and using them
SG163588A1 (en) Methods for identifying agents and conditions that modulate neurogenesis
BR9703386A (pt) Células aviárias imortalizadas
EP1503776A4 (de) Verfahren zur verbesserung der biologischen aktivität von pflanzenextrakten
HUP0101393A1 (hu) Redukáló körülményekre érzékeny transzfektáló kompozíciók, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
DK1289513T3 (da) Anvendelse af aloe-emodin i behandlingen af neuroektodermale tumorer
ATE392644T1 (de) Alpha-(1' -hydroxyalkyl)acrylate enthaltende beschichtungsmassen
ES2185472A1 (es) Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o tratamiento de celulas cancerosas.
ES2186963T3 (es) Aislados de rizobacterias para su utilizacion contra hongos del suelo fitopatogenos y procedimiento para la utilizacion de aislados de rizobacterias.
WO2002033043A3 (en) Method and marker for the isolation of human multipotent hematopoietic stem cells
DE69922379D1 (de) Faulanlage
ATE352609T1 (de) Mastzellkulturen aus dem schwein und deren verwendungen
DE69934399D1 (de) Komplex aus peptid und mhc-peptid auf oberfläche von phagen
TW200643169A (en) The preparation of multipotent stem cells and the use thereof
ATE319811T1 (de) Auf eine zellinie beschränkte vorläuferzellen aus dem neuralrohr der maus und aus embryonalen stammzellen der maus

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1261694

Country of ref document: EP