ATE384727T1 - Pyrimdobenzimidazolderivate und verwendung damit als agonisten oder antagonisten von melanocortinrezeptoren - Google Patents

Pyrimdobenzimidazolderivate und verwendung damit als agonisten oder antagonisten von melanocortinrezeptoren

Info

Publication number: ATE384727T1
Authority: AT; Austria
Prior art keywords: derivatives; pyrimdobenzimidazole; agonists; antagonists; products
Prior art date: 2004-06-24

Application number

AT05778708T

Other languages

English (en)

Inventor

Lydie Poitout

Carole Sackur

Valerie Brault

Pierre Roubert

Pascale Plas

Original Assignee

Sod Conseils Rech Applic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-24

Filing date

2005-06-22

Publication date

2008-02-15

2005-06-22 Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic

2008-02-15 Application granted granted Critical

2008-02-15 Publication of ATE384727T1 publication Critical patent/ATE384727T1/de

Links

102000004378 Melanocortin Receptors Human genes 0.000 title abstract 3
108090000950 Melanocortin Receptors Proteins 0.000 title abstract 3
239000000556 agonist Substances 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
SVDBONWIXMGDMM-UHFFFAOYSA-N 3h-imidazo[4,5-f]quinazoline Chemical class N1=CN=CC2=C(NC=N3)C3=CC=C21 SVDBONWIXMGDMM-UHFFFAOYSA-N 0.000 abstract 1
102000008316 Type 4 Melanocortin Receptor Human genes 0.000 abstract 1
108010021436 Type 4 Melanocortin Receptor Proteins 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Virology (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Child & Adolescent Psychology (AREA)
Communicable Diseases (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)

AT05778708T 2004-06-24 2005-06-22 Pyrimdobenzimidazolderivate und verwendung damit als agonisten oder antagonisten von melanocortinrezeptoren ATE384727T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0406903A FR2872165B1 (fr)	2004-06-24	2004-06-24	Nouveaux derives de pyrimido-benzimidazole

Publications (1)

Publication Number	Publication Date
ATE384727T1 true ATE384727T1 (de)	2008-02-15

Family

ID=34948173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05778708T ATE384727T1 (de)	2004-06-24	2005-06-22	Pyrimdobenzimidazolderivate und verwendung damit als agonisten oder antagonisten von melanocortinrezeptoren

Country Status (12)

Country	Link
US (2)	US7763725B2 (de)
EP (1)	EP1768985B1 (de)
JP (1)	JP5033622B2 (de)
CN (1)	CN1968955B (de)
AT (1)	ATE384727T1 (de)
CA (1)	CA2572121C (de)
DE (1)	DE602005004547T2 (de)
ES (1)	ES2301045T3 (de)
FR (1)	FR2872165B1 (de)
PT (1)	PT1768985E (de)
RU (1)	RU2392279C2 (de)
WO (1)	WO2006010811A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2872165B1 (fr)	2004-06-24	2006-09-22	Sod Conseils Rech Applic	Nouveaux derives de pyrimido-benzimidazole
US8314119B2 (en) *	2006-11-06	2012-11-20	Abbvie Inc.	Azaadamantane derivatives and methods of use
EP2072050A1 (de)	2007-12-21	2009-06-24	Santhera Pharmaceuticals (Schweiz) AG	Komponenten mit anti-emetischer Wirkung
CN101333214A (zh) *	2008-08-05	2008-12-31	徐州师范大学	一种全氟烷基化的苯并［4,5］咪唑并［1,2-а］嘧啶类衍生物的合成方法
CN101717397B (zh) *	2008-10-09	2012-11-28	中国科学院上海药物研究所	一类取代吡啶并[2',1':2,3]咪唑并[4,5-c]异喹啉酮类化合物及其合成方法和用途,以及包含该类化合物的药物组合物
PE20131394A1 (es)	2010-09-23	2014-01-11	Abbvie Inc	Monohidrato de derivados de aza-adamantano
WO2012100342A1 (en)	2011-01-27	2012-08-02	Université de Montréal	Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
LT3539551T (lt)	2011-12-29	2022-01-10	Rhythm Pharmaceuticals, Inc.	Su melanokortino-4 receptoriumi susijusių sutrikimų gydymo būdas heterozigotiniuose nešiotojuose
CN102702056B (zh) *	2012-05-31	2014-09-24	北京师范大学	一种一锅法合成取代间苯二异硫氰酸酯的方法、合成的取代间苯二异硫氰酸酯化合物
EP2970388B1 (de)	2013-03-15	2018-07-25	Rhythm Pharmaceuticals, Inc.	Peptidzusammensetzungen
CN115957297A (zh)	2013-03-15	2023-04-14	节奏制药公司	药物组合物
WO2016042775A1 (en) *	2014-09-18	2016-03-24	Sunovion Pharmaceuticals Inc.	Tricyclic derivative
GB2548839B (en) *	2016-03-29	2021-02-24	Great Matter Pharma Ab	New uses and methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR406903A (fr)	1909-09-10	1910-02-15	Edwin Russell	Perfectionnements aux protecteurs de bandages pneumatiques
ZW11781A1 (en) *	1980-06-27	1982-01-20	Hoffmann La Roche	Pyrimidine derivatives
DK522187D0 (da) *	1987-10-06	1987-10-06	Ferrosan As	Imidozothienopyrimidiner, deres fremstilling og anvendelse
US5212310A (en) *	1991-12-19	1993-05-18	Neurogen Corporation	Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
ES2199224T3 (es) *	1992-12-04	2004-02-16	Janssen Pharmaceutica N.V.	Derivados de imidazo(1,2-a)tieno(2,3-d)azepina antialergicos.
JP2003534377A (ja) *	2000-05-30	2003-11-18	メルクエンドカムパニーインコーポレーテッド	メラノコルチン受容体作働薬
FR2872165B1 (fr)	2004-06-24	2006-09-22	Sod Conseils Rech Applic	Nouveaux derives de pyrimido-benzimidazole

2004
- 2004-06-24 FR FR0406903A patent/FR2872165B1/fr not_active Expired - Fee Related
2005
- 2005-06-22 ES ES05778708T patent/ES2301045T3/es not_active Expired - Lifetime
- 2005-06-22 CN CN2005800201315A patent/CN1968955B/zh not_active Expired - Fee Related
- 2005-06-22 AT AT05778708T patent/ATE384727T1/de active
- 2005-06-22 CA CA2572121A patent/CA2572121C/fr not_active Expired - Fee Related
- 2005-06-22 RU RU2007102574/04A patent/RU2392279C2/ru not_active IP Right Cessation
- 2005-06-22 PT PT05778708T patent/PT1768985E/pt unknown
- 2005-06-22 EP EP05778708A patent/EP1768985B1/de not_active Expired - Lifetime
- 2005-06-22 US US11/571,230 patent/US7763725B2/en not_active Expired - Fee Related
- 2005-06-22 JP JP2007517359A patent/JP5033622B2/ja not_active Expired - Fee Related
- 2005-06-22 DE DE602005004547T patent/DE602005004547T2/de not_active Expired - Lifetime
- 2005-06-22 WO PCT/FR2005/001563 patent/WO2006010811A1/fr not_active Ceased
2010
- 2010-06-17 US US12/817,929 patent/US8288395B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FR2872165A1 (fr)	2005-12-30
EP1768985B1 (de)	2008-01-23
CN1968955A (zh)	2007-05-23
JP5033622B2 (ja)	2012-09-26
RU2392279C2 (ru)	2010-06-20
US20090209531A1 (en)	2009-08-20
ES2301045T3 (es)	2008-06-16
US8288395B2 (en)	2012-10-16
PT1768985E (pt)	2008-04-18
CA2572121C (fr)	2014-02-11
HK1105197A1 (zh)	2008-02-06
CA2572121A1 (fr)	2006-02-02
DE602005004547T2 (de)	2009-02-19
US20100256135A1 (en)	2010-10-07
FR2872165B1 (fr)	2006-09-22
DE602005004547D1 (de)	2008-03-13
JP2008503554A (ja)	2008-02-07
EP1768985A1 (de)	2007-04-04
WO2006010811A1 (fr)	2006-02-02
RU2007102574A (ru)	2008-07-27
US7763725B2 (en)	2010-07-27
CN1968955B (zh)	2012-06-13

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2008-08-15

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Publication	Publication Date	Title
BRPI0410454A (pt)	2006-06-13	composições e compostos imunossupressores
EA200800100A1 (ru)	2008-06-30	Соединения азаиндазола и способы применения
NO20050749L (no)	2005-05-23	Nye alkyn-forbindelser med MCH-antagonistisk effekt og medikamenter inneholdende disse forbindelsene
MA29088B1 (fr)	2007-12-03	Composes d'indazole-carboxamide.
ATE432280T1 (de)	2009-06-15	Imidazopyridinderivate als melanocortinrezeptoragonisten
NO341523B1 (no)	2017-11-27	Benzoimidazol-2-ylpyrimidiner og -pyraziner som modulatorer av histamin H4-reseptoren, farmasøytisk sammensetning samt anvendelse
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ATE469895T1 (de)	2010-06-15	Cgrp-rezeptorantagonisten
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EA200602062A1 (ru)	2007-04-27	Амидосоединения и их применение в качестве фармацевтических средств
EA200602243A1 (ru)	2007-04-27	3-аминоциклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов
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BRPI0510170B8 (pt)	2021-05-25	composto, composição farmacêutica para o tratamento de doenças mediadas pelo receptor muscarínico de acetilcolina e uso do composto
TW200505428A (en)	2005-02-16	Immunosuppressant compounds and compositions
MXPA05012461A (es)	2006-02-22	Compuestos y composiciones inmunosupresores.
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MX2007010769A (es)	2008-03-07	Compuestos de quinolina como agonistas de receptor 5-ht4.
DE602008003788D1 (de)	2011-01-13	Neuartige rar-rezeptoragonisten-liganden und deren verwendung in der humanmedizin und kosmetik
ATE524463T1 (de)	2011-09-15	4-chromenonyl-1,4-dihydropyridincarbonitrile und ihre verwendung
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