ATE384743T1 - Aminoterminal modifizierte parathyroidhormon (pth) analoge - Google Patents

Aminoterminal modifizierte parathyroidhormon (pth) analoge

Info

Publication number: ATE384743T1
Authority: AT; Austria
Prior art keywords: pth; desamino; aminoterminal; analogue; parathyroid hormone
Prior art date: 1998-11-25

Application number

AT99962819T

Other languages

English (en)

Inventor

F Richard Bringhurst

Hisashi Takasu

Thomas J Gardella

Original Assignee

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-25

Filing date

1999-11-23

Publication date

2008-02-15

1999-11-23 Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp

2008-02-15 Application granted granted Critical

2008-02-15 Publication of ATE384743T1 publication Critical patent/ATE384743T1/de

Links

108090000445 Parathyroid hormone Proteins 0.000 title abstract 3
102000003982 Parathyroid hormone Human genes 0.000 title 2
239000000199 parathyroid hormone Substances 0.000 title 2
229960001319 parathyroid hormone Drugs 0.000 title 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
150000001413 amino acids Chemical group 0.000 abstract 2
102100030869 Parathyroid hormone 2 receptor Human genes 0.000 abstract 1
101710149426 Parathyroid hormone 2 receptor Proteins 0.000 abstract 1
102100032256 Parathyroid hormone/parathyroid hormone-related peptide receptor Human genes 0.000 abstract 1
101710180613 Parathyroid hormone/parathyroid hormone-related peptide receptor Proteins 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
108091002540 human parathyroid hormone (1-31)amide Proteins 0.000 abstract 1
102000032129 human parathyroid hormone (1-31)amide Human genes 0.000 abstract 1
OXZNHYPGOAWYLT-FISSOZIDSA-N ostabolin Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)OC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCC(O)=O)C(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1C=NC=N1 OXZNHYPGOAWYLT-FISSOZIDSA-N 0.000 abstract 1
108010067557 parathyroid hormone (1-34)amide Proteins 0.000 abstract 1
RRBCHMCWWOHRQL-UMXFMPSGSA-N parathyroid hormone (1-34)amide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C1=CN=CN1 RRBCHMCWWOHRQL-UMXFMPSGSA-N 0.000 abstract 1
239000000018 receptor agonist Substances 0.000 abstract 1
229940044601 receptor agonist Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Physical Education & Sports Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Orthopedic Medicine & Surgery (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT99962819T 1998-11-25 1999-11-23 Aminoterminal modifizierte parathyroidhormon (pth) analoge ATE384743T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11015298P	1998-11-25	1998-11-25

Publications (1)

Publication Number	Publication Date
ATE384743T1 true ATE384743T1 (de)	2008-02-15

Family

ID=22331485

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99962819T ATE384743T1 (de)	1998-11-25	1999-11-23	Aminoterminal modifizierte parathyroidhormon (pth) analoge

Country Status (7)

Country	Link
US (2)	US6537965B1 (de)
EP (1)	EP1175444B1 (de)
JP (1)	JP2003533167A (de)
AT (1)	ATE384743T1 (de)
AU (1)	AU1918300A (de)
DE (1)	DE69938064T2 (de)
WO (1)	WO2000031137A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000023594A1 (en) *	1998-10-22	2000-04-27	The General Hospital Corporation	BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
JP4486258B2 (ja) *	1998-11-25	2010-06-23	ザ・ジェネラル・ホスピタル・コーポレイション	ヒト副甲状腺ホルモンの改変、調製および使用
WO2000032771A1 (en) *	1998-11-30	2000-06-08	The General Hospital Corporation	Pth1r and pth3r receptors, methods and uses thereof
WO2000039278A2 (en) *	1998-12-31	2000-07-06	The General Hospital Corporation	Pth functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
ATE308609T1 (de)	1998-12-31	2005-11-15	Gen Hospital Corp	Pth rezeptor und testverfahren unter verwendung desselben
US7057012B1 (en) *	1998-12-31	2006-06-06	The General Hospital Corporation	PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
WO2001023521A2 (en) *	1999-09-29	2001-04-05	The General Hospital Corporation	Polypeptide derivatives of parathyroid hormone (pth)
US6756480B2 (en)	2000-04-27	2004-06-29	Amgen Inc.	Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
AU2001292905A1 (en) *	2000-09-19	2002-04-02	Curagen Corporation	Method of identifying osteoregenerative agents using differential gene expression
KR100491737B1 (ko) *	2001-07-20	2005-05-27	주식회사 한국아이템개발	공기 정화 기능의 모기 퇴치기
WO2003009804A2 (en)	2001-07-23	2003-02-06	The General Hospital Corporation	Conformationally constrained parathyroid hormone (pth) analogs
MXPA04001418A (es) *	2001-08-17	2004-05-27	Novartis Ag	Acido n-(5-clorosalociloil)-8-aminocaprilico como agente de suministro oral para fragmentos de hormona paratiroides.
EP1513547A4 (de)	2002-05-23	2009-11-04	Michael F Holick	Verwendung von parathormone-peptid-analoga zur behandlung von scheidenatrophie
US7799757B2 (en) *	2002-06-13	2010-09-21	Michael Chorev	Analogs of parathyroid hormone and PTH-related protein as bone anabolic agents
AU2002951372A0 (en) *	2002-09-13	2002-09-26	St Vincent's Institute Of Medical Research	Parathyroid hormone-like polypeptides
US8088734B2 (en)	2003-01-21	2012-01-03	Unigene Laboratories Inc.	Oral delivery of peptides
WO2004093902A1 (en) *	2003-03-19	2004-11-04	The General Hospital Corporation	CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH α-HELIX STABILIZERS
CN1822853A (zh) *	2003-07-15	2006-08-23	加拿大国家研究委员会	用于治疗特征在于过度增殖皮肤细胞的疾病的人类甲状旁腺激素环状类似物
US7910544B2 (en) *	2003-07-17	2011-03-22	The General Hospital Corporation	Conformationally constrained parthyroid hormone (PTH) analogs
CN100566669C (zh) *	2004-05-13	2009-12-09	阿尔扎公司	甲状旁腺激素药物的透皮释放装置
JP5007427B2 (ja) *	2004-05-13	2012-08-22	アルザコーポレイション	副甲状腺ホルモン剤の経皮送達のための装置および方法
JP2009545320A (ja) *	2006-08-04	2009-12-24	ザジェネラルホスピタルコーポレイション	副甲状腺ホルモン（ｐｔｈ）のポリペプチド誘導体
EP1961765A1 (de) *	2006-12-08	2008-08-27	Zealand Pharma A/S	Verkürzte PTH-Peptide mit zyklischer Konformation
US20090023655A1 (en) *	2007-04-02	2009-01-22	Louis Luttrell	Biased Ligands for Receptors Such as the PTH Receptor
CN101784281B (zh)	2007-08-01	2014-07-02	总医院有限公司	确定g蛋白偶联受体激动剂的方法
EP2411038B1 (de)	2009-03-27	2016-12-28	Van Andel Research Institute	Parathryoidhormonpeptide und parathyroidhormonbezogene proteinpeptide sowie anwendungsverfahren dafür
US9492508B2 (en)	2010-05-13	2016-11-15	The General Hospital Corporation	Parathyroid hormone analogs and uses thereof
WO2019178462A1 (en)	2018-03-16	2019-09-19	The General Hospital Corporation	Parathyroid hormone polypeptide conjugates and methods of their use

Family Cites Families (12)

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Publication number	Priority date	Publication date	Assignee	Title
JPS5896052A (ja) *	1981-11-30	1983-06-07	Toyo Jozo Co Ltd	高活性ｈ−ＰＴＨ（１−３４）アミドの製造法
US4423037A (en) *	1982-05-13	1983-12-27	The General Hospital Corporation	Inhibitors of peptide hormone action
JPS59204159A (ja) *	1983-04-28	1984-11-19	Toyo Jozo Co Ltd	〔Ｍｅｔ（Ｏ）↑８’↑１↑８〕ｈＰＴＨ−（１−３４）ペプチド
IL78342A (en) *	1985-04-04	1991-06-10	Gen Hospital Corp	Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
US5527772A (en)	1987-10-20	1996-06-18	Holick; Michael F.	Regulation of cell proliferation and differentiation using peptides
US5605815A (en) *	1988-03-14	1997-02-25	Yale University	Nucleic acids encoding and expression of parathyroid hormone-like peptide
US5350836A (en) *	1989-10-12	1994-09-27	Ohio University	Growth hormone antagonists
US5814603A (en) *	1992-06-12	1998-09-29	Affymax Technologies N.V.	Compounds with PTH activity
US5589452A (en) *	1992-07-14	1996-12-31	Syntex (U.S.A.) Inc.	Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
WO2000023594A1 (en) *	1998-10-22	2000-04-27	The General Hospital Corporation	BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
JP4486258B2 (ja) *	1998-11-25	2010-06-23	ザ・ジェネラル・ホスピタル・コーポレイション	ヒト副甲状腺ホルモンの改変、調製および使用
WO2000032771A1 (en) *	1998-11-30	2000-06-08	The General Hospital Corporation	Pth1r and pth3r receptors, methods and uses thereof

1999
- 1999-11-23 AT AT99962819T patent/ATE384743T1/de not_active IP Right Cessation
- 1999-11-23 DE DE69938064T patent/DE69938064T2/de not_active Expired - Lifetime
- 1999-11-23 JP JP2000583963A patent/JP2003533167A/ja active Pending
- 1999-11-23 EP EP99962819A patent/EP1175444B1/de not_active Expired - Lifetime
- 1999-11-23 US US09/447,800 patent/US6537965B1/en not_active Expired - Fee Related
- 1999-11-23 WO PCT/US1999/027656 patent/WO2000031137A1/en not_active Ceased
- 1999-11-23 AU AU19183/00A patent/AU1918300A/en not_active Abandoned
2003
- 2003-02-11 US US10/361,928 patent/US20030144209A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US6537965B1 (en)	2003-03-25
EP1175444A1 (de)	2002-01-30
AU1918300A (en)	2000-06-13
US20030144209A1 (en)	2003-07-31
EP1175444B1 (de)	2008-01-23
DE69938064D1 (de)	2008-03-13
DE69938064T2 (de)	2009-01-15
JP2003533167A (ja)	2003-11-11
WO2000031137A1 (en)	2000-06-02

Legal Events

Date	Code	Title	Description
2008-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69938064D1 (de)	2008-03-13	Aminoterminal modifizierte parathyroidhormon (pth) analoge
ATE458054T1 (de)	2010-03-15	Menschliches parathyroidhormon, modifikationen, herstellung und verwendung
KR100699422B1 (ko)	2007-03-28	부갑상선 호르몬의 동족체
ES2329233T3 (es)	2009-11-24	Analogos de la hormona paratiroidea.
Abou-Samra et al.	1989	Non-Homologous Sequences of Parathyroid Hormone and the Parathyroid Hormone Related Peptide Bind to a CommonReceptor on ROS 17/2.8 Cells
US6921750B2 (en)	2005-07-26	Analogs of parathyroid hormone
ATE304020T1 (de)	2005-09-15	Parathyroidhormon-verwandthe peptidanaloge
MX337038B (es)	2016-02-10	Co-antagonistas de receptor de glucagon/glp-1.
EA200901108A1 (ru)	2010-02-26	Соагонисты глюкагоновых/glp-1-рецепторов
HUP0004560A2 (hu)	2001-04-28	Törést gyógyító PTHrP analógok
EA199901025A1 (ru)	2000-06-26	Пептидные аналоги паратиреоидного гормона
WO2000023594A9 (en)	2000-10-12	BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
RU2000109305A (ru)	2002-02-10	ЗАЖИВЛЕНИЕ ПЕРЕЛОМОВ С ПОМОЩЬЮ АНАЛОГОВ ПЕПТИДА, ПОДОБНОГО ПАРАТИРЕОИДНОМУ ГОРМОНУ (РТНrР)
EP0965637A4 (de)	2002-09-25	Fas ANTIGEN-DERIVATE
EP1592434A1 (de)	2005-11-09	Konformationseingeschränkte parathormon (pth)-analoga mit lactam-brücken
WO2004093902A1 (en)	2004-11-04	CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH α-HELIX STABILIZERS
CO5560586A2 (es)	2005-09-30	Acido n-(5-clorosaliciloil)-8-aminocaprilico como agente de suministro oral para fragmentos de hormona paratiroides
ES2095255T3 (es)	1997-02-16	Analogos de sustitucion de peptidos magainina.
JP2020519250A5 (de)	2021-06-10
NO20012232L (no)	2001-05-04	Enzymatisk amidering av peptider
GB0001712D0 (en)	2000-03-15	Therapeutic peptides
EP1096008A3 (de)	2001-05-23	Menschlicher G-Protein-gekoppelter Rezeptor, PFI-014
EP1295943A4 (de)	2005-11-16	Polypeptide mit aktivität der stimulierung von neutrophilen
COLI	1989	Bernard N. Violand, Ned R. Siegel, Gregg Bogosian, Wesley E. Workman and James F. Kane Monsanto Agricultural Co., Animal Sciences Division
UA104842C2 (uk)	2014-03-25	Ненативний глюкагоновий пептид