ATE386104T1 - Substanzen zur vorbeugung und behandlung von autoimmunkrankheiten - Google Patents

Substanzen zur vorbeugung und behandlung von autoimmunkrankheiten

Info

Publication number
ATE386104T1
ATE386104T1 AT03808948T AT03808948T ATE386104T1 AT E386104 T1 ATE386104 T1 AT E386104T1 AT 03808948 T AT03808948 T AT 03808948T AT 03808948 T AT03808948 T AT 03808948T AT E386104 T1 ATE386104 T1 AT E386104T1
Authority
AT
Austria
Prior art keywords
prevention
substances
treatment
autoimmune disease
autoimmune diseases
Prior art date
Application number
AT03808948T
Other languages
English (en)
Inventor
Alan Escher
Fengchun Li
Original Assignee
Univ Loma Linda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Loma Linda filed Critical Univ Loma Linda
Application granted granted Critical
Publication of ATE386104T1 publication Critical patent/ATE386104T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Rehabilitation Therapy (AREA)
AT03808948T 2002-08-06 2003-08-06 Substanzen zur vorbeugung und behandlung von autoimmunkrankheiten ATE386104T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40165202P 2002-08-06 2002-08-06

Publications (1)

Publication Number Publication Date
ATE386104T1 true ATE386104T1 (de) 2008-03-15

Family

ID=32107846

Family Applications (3)

Application Number Title Priority Date Filing Date
AT05021002T ATE344317T1 (de) 2002-08-06 2003-08-06 Substanzen zur vorbeugung und behandlung von autoimmunkrankheiten
AT03808948T ATE386104T1 (de) 2002-08-06 2003-08-06 Substanzen zur vorbeugung und behandlung von autoimmunkrankheiten
AT05021001T ATE344316T1 (de) 2002-08-06 2003-08-06 Substanzen zur vorbeugung und behandlung von autoimmunkrankheiten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05021002T ATE344317T1 (de) 2002-08-06 2003-08-06 Substanzen zur vorbeugung und behandlung von autoimmunkrankheiten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT05021001T ATE344316T1 (de) 2002-08-06 2003-08-06 Substanzen zur vorbeugung und behandlung von autoimmunkrankheiten

Country Status (10)

Country Link
US (3) US7381711B2 (de)
EP (3) EP1626083B1 (de)
JP (3) JP4301567B2 (de)
CN (3) CN100389192C (de)
AT (3) ATE344317T1 (de)
AU (1) AU2003296892B2 (de)
CA (3) CA2494888C (de)
DE (3) DE60319103T2 (de)
ES (3) ES2275253T3 (de)
WO (1) WO2004034966A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1626083B1 (de) * 2002-08-06 2006-11-02 Loma Linda University Substanzen zur Vorbeugung und Behandlung von Autoimmunkrankheiten
WO2006047954A1 (en) * 2004-11-04 2006-05-11 Ziyi Cheng The method of obtaining and applying the materials for autoantigen immunological recognition
WO2006124375A2 (en) 2005-05-11 2006-11-23 Loma Linda University Substances, compositions and methods for preventing and treating immune-mediated inflammatory disorders
US20090191218A1 (en) 2005-05-11 2009-07-30 Fengchun Li DNA Vaccines And Methods For The Prevention Of Transplantation Rejection
WO2008039980A2 (en) 2006-09-28 2008-04-03 Loma Linda University Apoptotic cell-mediated transfection of mammalian cells with interfering rna
US8722915B2 (en) 2010-05-28 2014-05-13 Dow Corning Corporation Preparation of organohalosilanes
KR101839585B1 (ko) 2010-05-28 2018-03-16 다우 코닝 코포레이션 디오가노디할로실란의 제조 방법
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
AU2011289579B2 (en) 2010-08-10 2016-11-17 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
EP2614035A1 (de) 2010-09-08 2013-07-17 Dow Corning Corporation Verfahren zur herstellung eines trihalosilans
JP5792828B2 (ja) 2010-12-17 2015-10-14 ダウ コーニング コーポレーションＤｏｗ Ｃｏｒｎｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ トリハロシランを作製する方法
WO2013044177A2 (en) 2011-09-23 2013-03-28 Loma Linda University Bacterial strains expressing methylase genes and uses thereof
US11680273B2 (en) 2011-09-23 2023-06-20 Loma Linda University Treatment of autoimmune diseases
US9296765B2 (en) 2012-08-13 2016-03-29 Dow Corning Corporation Method of preparing an organohalosilane
CN103116030A (zh) * 2013-01-30 2013-05-22 山东东兴生物科技股份有限公司 一种检测i型糖尿病自身免疫抗体试剂盒及其检测方法
KR102299593B1 (ko) 2013-11-12 2021-09-09 다우 실리콘즈 코포레이션 할로실란의 제조 방법
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
CA2946064C (en) 2014-02-21 2023-09-26 Ecole Polytechnique Federale De Lausanne (Epfl) Glycotargeting therapeutics
US10081643B2 (en) 2014-12-18 2018-09-25 Dow Silicones Corporation Method for producing aryl-functional silanes
EP3638296A1 (de) 2017-06-16 2020-04-22 The University Of Chicago Zusammensetzungen und verfahren zur herbeiführung einer immuntoleranz
US11806386B2 (en) 2017-08-07 2023-11-07 St. Vincent's Institute Of Medical Research Type I diabetes therapy
EP3790577A4 (de) 2018-05-09 2022-04-27 The University of Chicago Zusammensetzungen und verfahren im zusammenhang mit immuntoleranz
US20240016905A1 (en) * 2020-03-03 2024-01-18 Aditxt, Inc. Methods of treating hyperglycemia and suppressing onset of type 1 diabetes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700638A (en) * 1993-08-26 1997-12-23 Washington University Cell death regulator
US5691179A (en) * 1993-08-26 1997-11-25 Washington University Cell death regulators
CN1056380C (zh) * 1998-02-27 2000-09-13 中科院成都地奥制药公司 抑制人体恶性肿瘤生长的反义寡核苷酸
US6645490B2 (en) * 1998-03-02 2003-11-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities
JP2000236100A (ja) * 1999-02-17 2000-08-29 Sanyo Electric Co Ltd 半導体素子
DE60024791T2 (de) * 1999-04-08 2006-07-06 The Johns Hopkins University Antigen-spezifische induktion der peripheren immuntoleranz
CN1117098C (zh) * 1999-06-25 2003-08-06 北京金赛狮生物制药技术开发有限责任公司 针对囊依赖的淋巴细胞白血病基因的反义核酸的抑癌作用
EP1626083B1 (de) * 2002-08-06 2006-11-02 Loma Linda University Substanzen zur Vorbeugung und Behandlung von Autoimmunkrankheiten

Also Published As

Publication number Publication date
WO2004034966A2 (en) 2004-04-29
JP5123226B2 (ja) 2013-01-23
DE60309514T2 (de) 2007-05-10
ES2275253T3 (es) 2007-06-01
EP1543109A2 (de) 2005-06-22
EP1543109B1 (de) 2008-02-13
US7638498B2 (en) 2009-12-29
EP1626083B1 (de) 2006-11-02
DE60319103D1 (de) 2008-03-27
JP2006513993A (ja) 2006-04-27
CN101147807B (zh) 2010-05-26
US20080171713A1 (en) 2008-07-17
JP2009149664A (ja) 2009-07-09
ES2275254T3 (es) 2007-06-01
AU2003296892A1 (en) 2004-05-04
CN101057976A (zh) 2007-10-24
DE60309514D1 (de) 2006-12-14
WO2004034966A3 (en) 2004-07-08
ATE344317T1 (de) 2006-11-15
US20080171714A1 (en) 2008-07-17
US20050239729A1 (en) 2005-10-27
CA2653201A1 (en) 2004-04-29
DE60319103T2 (de) 2009-02-05
CA2649821A1 (en) 2004-04-29
CA2494888C (en) 2009-03-31
EP1626083A1 (de) 2006-02-15
CA2649821C (en) 2016-09-20
DE60309513D1 (de) 2006-12-14
ES2300652T3 (es) 2008-06-16
JP4301567B2 (ja) 2009-07-22
JP5555431B2 (ja) 2014-07-23
EP1543109A4 (de) 2005-10-19
EP1624053B1 (de) 2006-11-02
US7381711B2 (en) 2008-06-03
CN101057976B (zh) 2010-05-26
AU2003296892B2 (en) 2006-01-05
EP1624053A1 (de) 2006-02-08
CA2494888A1 (en) 2004-04-29
CA2653201C (en) 2011-11-08
CN101147807A (zh) 2008-03-26
JP2009143945A (ja) 2009-07-02
CN1675353A (zh) 2005-09-28
DE60309513T2 (de) 2007-05-03
CN100389192C (zh) 2008-05-21
ATE344316T1 (de) 2006-11-15

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