ATE387187T1 - Mikrogranulat auf wirkstoffbasis und verfahren zu seiner herstellung - Google Patents

Mikrogranulat auf wirkstoffbasis und verfahren zu seiner herstellung

Info

Publication number
ATE387187T1
ATE387187T1 AT01996363T AT01996363T ATE387187T1 AT E387187 T1 ATE387187 T1 AT E387187T1 AT 01996363 T AT01996363 T AT 01996363T AT 01996363 T AT01996363 T AT 01996363T AT E387187 T1 ATE387187 T1 AT E387187T1
Authority
AT
Austria
Prior art keywords
production
active ingredients
core
microgranules
coated
Prior art date
Application number
AT01996363T
Other languages
English (en)
Inventor
Etienne Bruna
Edouard Gendrot
Gerard Cousin
Original Assignee
Ethypharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Sa filed Critical Ethypharm Sa
Application granted granted Critical
Publication of ATE387187T1 publication Critical patent/ATE387187T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micromachines (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Catalysts (AREA)
  • Medicines Containing Plant Substances (AREA)
AT01996363T 2000-11-16 2001-11-15 Mikrogranulat auf wirkstoffbasis und verfahren zu seiner herstellung ATE387187T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0014803A FR2816507B1 (fr) 2000-11-16 2000-11-16 Microgranules a base de principe actif, procede de fabrication et compositons pharmaceutiques integrant lesdits microgranules

Publications (1)

Publication Number Publication Date
ATE387187T1 true ATE387187T1 (de) 2008-03-15

Family

ID=8856551

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01996363T ATE387187T1 (de) 2000-11-16 2001-11-15 Mikrogranulat auf wirkstoffbasis und verfahren zu seiner herstellung

Country Status (15)

Country Link
US (1) US7829122B2 (de)
EP (1) EP1333812B1 (de)
JP (1) JP4234427B2 (de)
CN (1) CN1222277C (de)
AT (1) ATE387187T1 (de)
AU (2) AU2002223074B2 (de)
CA (1) CA2427899C (de)
DE (1) DE60133028T2 (de)
DK (1) DK1333812T3 (de)
ES (1) ES2300384T3 (de)
FR (1) FR2816507B1 (de)
HK (1) HK1063017A1 (de)
MX (1) MXPA03004300A (de)
PT (1) PT1333812E (de)
WO (1) WO2002039981A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796840B1 (fr) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques Comprimes faiblement doses et procede de preparation
DE60124895D1 (de) * 2001-07-26 2007-01-11 Ethypharm Sa Umgehüllte Allylamine oder Benzylamine enthaltende Granulate, Verfahren zur Herstellung und in der Mundhöhle dispergierbare Tabletten enthaltend die umgehüllten Granulate
FR2831820B1 (fr) * 2001-11-05 2004-08-20 Ethypharm Sa Comprime orodispersible presentant une grande homogeneite et son procede de preparation
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
FR2850576B1 (fr) * 2003-02-05 2007-03-23 Ethypharm Sa Composition comprenant un melange de principes actifs, et procede de preparation
NZ544826A (en) * 2003-07-25 2008-07-31 Warner Chilcott Co Inc A doxycycline metal complex in a solid dosage form
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
PL2486942T3 (pl) 2004-11-24 2019-05-31 Meda Pharmaceuticals Inc Kompozycje zawierające azelastynę oraz sposoby ich stosowania
AU2006206359B2 (en) * 2005-01-21 2011-03-31 Allergan Pharmaceuticals International Limited A tetracycline metal complex in a solid dosage form
CN101912360A (zh) * 2010-07-13 2010-12-15 山东达因海洋生物制药股份有限公司 布洛芬混悬液及其制备方法
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
JP6025755B2 (ja) 2011-02-11 2016-11-16 ズィーエックス ファーマ，エルエルシー 多粒子ｌ−メントール製剤及びその関連する方法
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
DE102012007671A1 (de) * 2012-04-16 2013-10-17 Acino Pharma Ag Pellets mit hohem Wirkstoffgehalt
FR2999432B1 (fr) 2012-12-17 2014-12-12 Ethypharm Sa Comprimes orodispersibles obtenus par compression moulage
BR112015006499A2 (pt) 2013-04-23 2017-07-04 Zx Pharma Llc composição de óleo de horlelã-pimenta de liberação controlada microparticulada com revestimento entérico e métodos relacionados
KR102019645B1 (ko) * 2019-02-21 2019-09-09 한국화학연구원 염기성오염물질 제거용 비드 및 이의 제조방법
CN111184694A (zh) * 2020-01-19 2020-05-22 广东青云山药业有限公司 一种口腔速溶颗粒的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558768A (en) * 1969-12-19 1971-01-26 Sterling Drug Inc Sustained release pharmaceutical compositions
IT1115596B (it) 1978-03-13 1986-02-03 Bayer Italia Spa Metodo per la preparazione di microgranuli gastoresistenti ed enterosolubili di sostanze farmaceutiche,in particolare di sostanze proteiche e microgranuli preparati con detto metodo
US4248858A (en) * 1979-08-09 1981-02-03 American Home Products Corporation Sustained release pharmaceutical compositions
IT1180507B (it) * 1984-06-29 1987-09-23 Roberto Valducci Procedimento per la preparazione di etofibrato o sostanze di pari o simili caratteristiche, in microgunuli-ritardo e prodotto ottenuto con tale procedimento
JPS63188621A (ja) * 1987-01-30 1988-08-04 Taisho Pharmaceut Co Ltd 矯味経口製剤
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
US4853229A (en) * 1987-10-26 1989-08-01 Alza Corporation Method for adminstering tiny pills
US5344657A (en) * 1988-04-27 1994-09-06 Elf Sanofi Microbeads of diltiazem, a process for their manufacture and a substained-release pharmaceutical composition containing them
JP3078859B2 (ja) 1990-02-23 2000-08-21 武田薬品工業株式会社 安定な放出制御性製剤用コーティング剤
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
DE69530973T2 (de) 1994-02-16 2004-05-19 Abbott Laboratories, Abbott Park Verfahren zur herstellung feinteiliger pharmazeutischer formulierungen
US5837292A (en) * 1996-07-03 1998-11-17 Yamanouchi Europe B.V. Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug

Also Published As

Publication number Publication date
CN1222277C (zh) 2005-10-12
PT1333812E (pt) 2008-03-17
DE60133028T2 (de) 2009-03-12
HK1063017A1 (en) 2004-12-10
EP1333812A1 (de) 2003-08-13
ES2300384T3 (es) 2008-06-16
JP2004517064A (ja) 2004-06-10
CA2427899A1 (fr) 2002-05-23
JP4234427B2 (ja) 2009-03-04
CA2427899C (fr) 2011-05-10
EP1333812B1 (de) 2008-02-27
US7829122B2 (en) 2010-11-09
CN1481235A (zh) 2004-03-10
AU2002223074B2 (en) 2005-03-10
DE60133028D1 (de) 2008-04-10
FR2816507A1 (fr) 2002-05-17
DK1333812T3 (da) 2008-03-31
US20040101568A1 (en) 2004-05-27
MXPA03004300A (es) 2004-09-10
FR2816507B1 (fr) 2003-02-28
AU2307402A (en) 2002-05-27
WO2002039981A1 (fr) 2002-05-23

Similar Documents

Publication Publication Date Title
DE60133028D1 (de) Mikrogranulat auf wirkstoffbasis und verfahren zu seiner herstellung
DE69308849D1 (de) Im magen stabile zusammensetzungen aus omeprazole mikrogranulaten und verfahren zu ihrer herstellung
IL151150A0 (en) Multiparticulate drug form comprising at least two differently coated pellet forms
WO2004030652A3 (en) Dosage form having an inner core and at least two coating layers
FR2767070B1 (fr) Composition visqueuses aqueuses, limpides ou non, pour la fabrication de capsules molles et de capsules dures, et procede de fabrication de films pour de telles capsules
BG105282A (en) Pharmaceutical oral preparation of a compound having an antifugic activity, and preparation method
DE69510333D1 (de) Synergetische termitizide zusammensetzung aus pyrethroid und n-phenyl-pyrazol
WO2002051363A3 (en) Absorbent articles with simplified compositions having good stability
DE59801636D1 (de) Tantalpulver, verfahren zu seiner herstellung, sowie daraus erhältliche sinteranoden
DE59801634D1 (de) Tantal-pulver, verfahren zu seiner herstellung, sowie daraus erhältliche sinteranoden
DE59903878D1 (de) Aus mindestens drei komponenten bestehendes beschichtungsmittel, verfahren zu seiner herstellung sowie seine verwendung
WO2003035044A3 (de) Herstellung von formkörpern auf basis von stärke-gel
DE3877256D1 (de) Beschichteter gegenstand und verfahren zu seiner herstellung.
DE59904493D1 (de) Aus mindestens drei komponenten bestehendes beschichtungsmittel, verfahren zu seiner herstellung sowie seine verwendung
JP2003500554A5 (de)
DE69801604D1 (de) Gussteilen aus Superlegierung mit extrem niedrigem Schwefelgehalt und Verfahren zur Herstellung
DE59708634D1 (de) Elektro-keramisches bauelement und verfahren zu seiner herstellung
DE69114697D1 (de) Zeolith vom mfi-typ sowie verfahren zu seiner herstellung.
DE69811055D1 (de) Gegenstand aus stahl mit hoher härte und zähigkeit und verfahren zu seiner herstellung
DE69938845D1 (de) Feines pulver aus modifiziertem polytetrafluorethylen und verfahren zu seiner herstellung
ES2183970T3 (es) Procedimiento de fabricacion de granulos y granulos asi obtenidos.
DE69414488D1 (de) Gesintertes Kontaktbauteil, sowie Verfahren seiner Herstellung
DE69827599D1 (de) Schuh und verfahren zu seiner herstellung
WO2002080706A3 (en) Improved delivery of benefit agents
DE69806093D1 (de) Maske zur Herstellung von laminierten dreidimensionalen Gegenstände, sowie dessen Herstellungs- und Gebrauchsverfahren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1333812

Country of ref document: EP