ATE387435T1 - Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren - Google Patents

Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren

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Publication number
ATE387435T1
ATE387435T1 AT04750131T AT04750131T ATE387435T1 AT E387435 T1 ATE387435 T1 AT E387435T1 AT 04750131 T AT04750131 T AT 04750131T AT 04750131 T AT04750131 T AT 04750131T AT E387435 T1 ATE387435 T1 AT E387435T1
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AT
Austria
Prior art keywords
receptors
potentifiers
benzosulfonamides
glutama
substituted
Prior art date
Application number
AT04750131T
Other languages
English (en)
Inventor
Ian Egle
Jennifer Frey
Methvin Isaac
Abdelmalik Slassi
Gaung Ri Sun
Johnathan Wesley Field
Original Assignee
Astrazeneca Ab
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Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
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Publication of ATE387435T1 publication Critical patent/ATE387435T1/de

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Addiction (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
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  • Hematology (AREA)
  • Otolaryngology (AREA)
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  • Plural Heterocyclic Compounds (AREA)
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AT04750131T 2003-04-15 2004-04-15 Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren ATE387435T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46269703P 2003-04-15 2003-04-15

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ATE387435T1 true ATE387435T1 (de) 2008-03-15

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AT04750131T ATE387435T1 (de) 2003-04-15 2004-04-15 Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren

Country Status (8)

Country Link
US (1) US20070021606A1 (de)
EP (1) EP1615904B1 (de)
JP (1) JP2006523707A (de)
AT (1) ATE387435T1 (de)
CA (1) CA2527170A1 (de)
DE (1) DE602004012083T2 (de)
ES (1) ES2300798T3 (de)
WO (1) WO2004092135A2 (de)

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JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
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JP5690277B2 (ja) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
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DE602004012083T2 (de) 2009-04-23
US20070021606A1 (en) 2007-01-25
EP1615904B1 (de) 2008-02-27
WO2004092135A2 (en) 2004-10-28
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JP2006523707A (ja) 2006-10-19

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