ATE411301T1 - Diphenylurea-derivative und ihre verwendung als chloridkanalblocker - Google Patents

Diphenylurea-derivative und ihre verwendung als chloridkanalblocker

Info

Publication number
ATE411301T1
ATE411301T1 AT04741799T AT04741799T ATE411301T1 AT E411301 T1 ATE411301 T1 AT E411301T1 AT 04741799 T AT04741799 T AT 04741799T AT 04741799 T AT04741799 T AT 04741799T AT E411301 T1 ATE411301 T1 AT E411301T1
Authority
AT
Austria
Prior art keywords
channel blockers
chloride channel
diphenylurea derivatives
diphenylurea
derivatives
Prior art date
Application number
AT04741799T
Other languages
English (en)
Inventor
Bjarne Dahl
Palle Christophersen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE411301T1 publication Critical patent/ATE411301T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04741799T 2003-06-17 2004-06-15 Diphenylurea-derivative und ihre verwendung als chloridkanalblocker ATE411301T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200300898 2003-06-17

Publications (1)

Publication Number Publication Date
ATE411301T1 true ATE411301T1 (de) 2008-10-15

Family

ID=33547538

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04741799T ATE411301T1 (de) 2003-06-17 2004-06-15 Diphenylurea-derivative und ihre verwendung als chloridkanalblocker

Country Status (19)

Country Link
US (1) US7691891B2 (de)
EP (1) EP1638948B1 (de)
JP (1) JP2006527735A (de)
KR (1) KR20060059901A (de)
CN (1) CN1805942B (de)
AT (1) ATE411301T1 (de)
AU (1) AU2004247429B2 (de)
BR (1) BRPI0410576A (de)
CA (1) CA2529806A1 (de)
DE (1) DE602004017175D1 (de)
DK (1) DK1638948T3 (de)
IS (1) IS8211A (de)
MX (1) MXPA05013269A (de)
NO (1) NO20060231L (de)
NZ (1) NZ543595A (de)
RU (1) RU2350607C2 (de)
UA (1) UA81664C2 (de)
WO (1) WO2004111017A1 (de)
ZA (1) ZA200508828B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101287456A (zh) * 2004-12-17 2008-10-15 神经研究公司 用作钾通道激活剂的二苯基脲衍生物
MX2008011409A (es) * 2006-03-14 2008-09-22 Neurosearch As Derivados de difenilurea y su uso como bloqueadores de canal de cloruro o moduladores del canal bkca.
WO2009068557A1 (en) * 2007-11-28 2009-06-04 Neurosearch A/S Novel phenyl-acetamide and phenyl-propionamide derivatives useful as potassium channel modulators
US9834537B2 (en) 2013-11-27 2017-12-05 Korea Institute Of Science And Technology Compounds as chloride channel blocking agent
EP3622953B1 (de) 2016-05-17 2021-03-17 Scandion Oncology A/S Kombinationsbehandlung für krebs
CN117229258B (zh) * 2022-06-07 2024-07-19 杭州壹瑞医药科技有限公司 N-四唑基芳基脲类衍生物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255858C (en) * 1996-05-24 2007-09-11 Neurosearch A/S Phenyl derivatives containing an acidic group, their preparation and their use as chloride channel blockers
US6696475B2 (en) * 1997-04-22 2004-02-24 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
CZ295822B6 (cs) * 1997-04-22 2005-11-16 Neurosearch A/S Substituované fenylderiváty, způsob jejich přípravy a použití a farmaceutické přípravky s jejich obsahem
WO2000020378A1 (en) 1998-10-02 2000-04-13 Neurosearch A/S Diaminocyclobutene-3,4-dione derivatives, their preparation and use
CN1263733C (zh) 1998-10-22 2006-07-12 神经研究公司 取代苯基衍生物,它们的制备和用途
WO2002039987A2 (en) * 2000-11-14 2002-05-23 Neurosearch A/S Use of malaria parasite anion channel blockers for treating malaria
WO2003000245A1 (en) * 2001-06-22 2003-01-03 Poseidon Pharmaceuticals A/S Compounds for use in disorders associated with mast cell or basophil activity
JP2005537336A (ja) * 2002-08-01 2005-12-08 ニューロサーチ、アクティーゼルスカブ 抗血管新生治療に応答する疾患の治療に有用な化合物
EP1537075B1 (de) * 2002-09-05 2009-07-01 Neurosearch A/S Diarylharnstoffderivate und deren verwendung als chloridkanalblocker
CN101287456A (zh) * 2004-12-17 2008-10-15 神经研究公司 用作钾通道激活剂的二苯基脲衍生物

Also Published As

Publication number Publication date
RU2005136532A (ru) 2006-07-27
US20060178413A1 (en) 2006-08-10
ZA200508828B (en) 2008-01-30
DE602004017175D1 (de) 2008-11-27
RU2350607C2 (ru) 2009-03-27
EP1638948B1 (de) 2008-10-15
US7691891B2 (en) 2010-04-06
EP1638948A1 (de) 2006-03-29
AU2004247429B2 (en) 2010-01-28
NO20060231L (no) 2006-01-16
DK1638948T3 (da) 2009-02-02
CN1805942B (zh) 2010-06-02
CA2529806A1 (en) 2004-12-23
UA81664C2 (ru) 2008-01-25
AU2004247429A1 (en) 2004-12-23
JP2006527735A (ja) 2006-12-07
IS8211A (is) 2005-12-30
HK1091816A1 (zh) 2007-01-26
BRPI0410576A (pt) 2006-06-20
WO2004111017A1 (en) 2004-12-23
KR20060059901A (ko) 2006-06-02
NZ543595A (en) 2009-01-31
MXPA05013269A (es) 2006-03-17
CN1805942A (zh) 2006-07-19

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