ATE512966T1 - Pyrazolo-pyrimidin-derivate als mglur2- antagonisten - Google Patents

Pyrazolo-pyrimidin-derivate als mglur2- antagonisten

Info

Publication number: ATE512966T1
Authority: AT; Austria
Prior art keywords: pyrazolo; pyrimidine derivatives; mglur2 antagonists; mglur2; antagonists
Prior art date: 2005-02-11

Application number

AT06706609T

Other languages

English (en)

Inventor

Mcarthur Silvia Gatti

Erwin Goetschi

Juergen Wichmann

Thomas Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-11

Filing date

2006-02-03

Publication date

2011-07-15

2006-02-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE512966T1 publication Critical patent/ATE512966T1/de

Links

101150016175 Grm2 gene Proteins 0.000 title 1
102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT06706609T 2005-02-11 2006-02-03 Pyrazolo-pyrimidin-derivate als mglur2- antagonisten ATE512966T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05101027		2005-02-11
PCT/EP2006/000940 WO2006084634A1 (en)	2005-02-11	2006-02-03	Pyrazolo-pyrimidine derivatives as mglur2 antagonists

Publications (1)

Publication Number	Publication Date
ATE512966T1 true ATE512966T1 (de)	2011-07-15

Family

ID=36090752

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06706609T ATE512966T1 (de)	2005-02-11	2006-02-03	Pyrazolo-pyrimidin-derivate als mglur2- antagonisten

Country Status (18)

Country	Link
US (1)	US7361659B2 (de)
EP (1)	EP1851225B1 (de)
JP (1)	JP4708438B2 (de)
KR (1)	KR100968291B1 (de)
CN (1)	CN101115755B (de)
AR (1)	AR052568A1 (de)
AT (1)	ATE512966T1 (de)
AU (1)	AU2006212457B2 (de)
BR (1)	BRPI0607927A2 (de)
CA (1)	CA2597608C (de)
ES (1)	ES2365406T3 (de)
IL (1)	IL184712A (de)
MX (1)	MX2007009106A (de)
NO (1)	NO20073876L (de)
RU (1)	RU2402553C2 (de)
TW (1)	TW200716120A (de)
WO (1)	WO2006084634A1 (de)
ZA (1)	ZA200706353B (de)

Families Citing this family (26)

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Publication number	Priority date	Publication date	Assignee	Title
EP2085398A1 (de) *	2008-02-01	2009-08-05	Merz Pharma GmbH & Co. KGaA	Pyrazolopyrimidine, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel
EP2268645B1 (de) *	2008-03-06	2014-11-12	Sanofi	Substituierte dihydro-, trihydro- und tetrahydrocycloalkyloxazolopyrimidinone, verfahren und verwendung als allosterische mglur modulatoren
US8207181B2 (en)	2008-03-06	2012-06-26	Sanofi	Substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones, preparation and use thereof
WO2012020820A1 (ja)	2010-08-11	2012-02-16	大正製薬株式会社	ヘテロアリール－ピラゾール誘導体
US9447099B2 (en) *	2011-10-04	2016-09-20	Hoffmann-La Roche Inc.	Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine
RU2014120166A (ru) *	2011-10-20	2015-11-27	ГЛЭКСОСМИТКЛАЙН ЭлЭлСи	Замещенные бициклические аза-гетероциклы и их аналоги в качестве модуляторов сиртуина
EP2666775A1 (de)	2012-05-21	2013-11-27	Domain Therapeutics	Substituierte Pyrazolochinazolinone und Pyrrolochinazolinone als allosterische Modulatoren von metabotropen Glutamatrezeptoren der Gruppe II
KR20150070187A (ko)	2012-10-23	2015-06-24	에프. 호프만-라 로슈 아게	자폐 장애의 치료를 위한 ｍｇｌｕ２／３ 길항제
EP3134089A2 (de)	2014-04-23	2017-03-01	F. Hoffmann-La Roche AG	Mglu2/3-antagonisten zur behandlung von geistigen behinderungen
JOP20150179B1 (ar) *	2014-08-01	2021-08-17	Janssen Pharmaceutica Nv	مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
EP3000814A1 (de)	2014-09-26	2016-03-30	Domain Therapeutics	Substituierte Pyrazolochinazolinone und Pyrrolochinazolinone als allosterische Modulatoren von metabotropen Glutamatrezeptoren der Gruppe II
WO2016073889A1 (en)	2014-11-06	2016-05-12	Lysosomal Therapeutics Inc.	Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
CN107001379B (zh)	2014-11-06	2022-11-01	Bial研发投资股份有限公司	取代的吡唑并[1,5-a]嘧啶以及它们在治疗医学障碍中的用途
AU2015342883B2 (en)	2014-11-06	2020-07-02	Bial - R&D Investments, S.A.	Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders
JP6861154B2 (ja)	2014-12-03	2021-04-21	ヤンセンファーマシューティカエヌ．ベー．	放射標識されたｍＧｌｕＲ２ＰＥＴリガンド
PL236355B1 (pl) *	2015-04-02	2021-01-11	Celon Pharma Spolka Akcyjna	Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3
JP6929285B2 (ja)	2015-12-18	2021-09-01	ヤンセンファーマシューティカエヌ．ベー．	放射性標識ｍＧｌｕＲ２／３ＰＥＴリガンド
LT3389727T (lt)	2015-12-18	2020-10-12	Janssen Pharmaceutica Nv	Radioaktyviai pažymėti mglur2/3 pet ligandai
WO2017176960A1 (en) *	2016-04-06	2017-10-12	Lysosomal Therapeutics Inc.	Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
US10787454B2 (en)	2016-04-06	2020-09-29	BIAL—BioTech Investments, Inc.	Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
WO2017176962A1 (en)	2016-04-06	2017-10-12	Lysosomal Therapeutics, Inc.	Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
MX389579B (es)	2016-05-05	2025-03-20	Bial R&D Invest S A	IMIDAZO[1,2-b]PIRIDAZINAS SUSTITUIDAS, IMIDAZO[1,5-b]PIRIDAZINAS SUSTITUIDAS, COMPUESTOS RELACIONADOS Y SU USO EN EL TRATAMIENTO DE TRASTORNOS MÉDICOS
WO2017192931A1 (en)	2016-05-05	2017-11-09	Lysosomal Therapeutics Inc.	SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
EP3566749A4 (de) *	2017-01-09	2020-09-23	Medshine Discovery Inc.	Thiazolderivat und anwendungen davon
EP3719023B1 (de)	2017-11-24	2024-10-16	Sumitomo Pharma Co., Ltd.	6,7-dihydropyrazolo[1,5-a] pyrazinon-derivat und medizinische anwendung davon
ES2982663T3 (es) *	2018-07-06	2024-10-17	Phaeno Therapeutics Co Ltd	Formas cristalinas de un compuesto de tiazol y aplicación del mismo

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997029109A1 (en)	1996-02-07	1997-08-14	Janssen Pharmaceutica N.V.	Pyrazolopyrimidines as crf receptor antagonists
EP0891978B1 (de)	1997-07-18	2002-03-20	F. Hoffmann-La Roche Ag	5h-Thiazolo[3,2-a]pyrimidinderivate
AU4203500A (en) *	1999-04-06	2000-10-23	Du Pont Pharmaceuticals Company	Pyrazolopyrimidines as crf antagonists
IL157873A0 (en) *	2001-04-12	2004-03-28	Hoffmann La Roche	DIHYDRO-BENZO [b] [1,4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II
ATE387435T1 (de) *	2003-04-15	2008-03-15	Astrazeneca Ab	Substituirte benzosulfonamide als potenzierungsmittel von glutamatrezeptoren
US7329662B2 (en) *	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
WO2005123738A1 (en) *	2004-06-21	2005-12-29	F.Hoffmann-La Roche Ag	Pyrrazolo-pyrimidine derivatives

2006
- 2006-02-03 CN CN2006800046579A patent/CN101115755B/zh not_active Expired - Fee Related
- 2006-02-03 RU RU2007128624/04A patent/RU2402553C2/ru not_active IP Right Cessation
- 2006-02-03 JP JP2007554484A patent/JP4708438B2/ja not_active Expired - Fee Related
- 2006-02-03 MX MX2007009106A patent/MX2007009106A/es active IP Right Grant
- 2006-02-03 AU AU2006212457A patent/AU2006212457B2/en not_active Ceased
- 2006-02-03 AT AT06706609T patent/ATE512966T1/de active
- 2006-02-03 KR KR1020077018345A patent/KR100968291B1/ko not_active Expired - Fee Related
- 2006-02-03 ES ES06706609T patent/ES2365406T3/es not_active Expired - Lifetime
- 2006-02-03 CA CA2597608A patent/CA2597608C/en not_active Expired - Fee Related
- 2006-02-03 WO PCT/EP2006/000940 patent/WO2006084634A1/en not_active Ceased
- 2006-02-03 EP EP06706609A patent/EP1851225B1/de not_active Expired - Lifetime
- 2006-02-03 BR BRPI0607927-0A patent/BRPI0607927A2/pt not_active IP Right Cessation
- 2006-02-06 AR ARP060100412A patent/AR052568A1/es not_active Application Discontinuation
- 2006-02-06 US US11/348,105 patent/US7361659B2/en not_active Expired - Fee Related
- 2006-02-08 TW TW095104260A patent/TW200716120A/zh unknown
2007
- 2007-07-19 IL IL184712A patent/IL184712A/en not_active IP Right Cessation
- 2007-07-24 NO NO20073876A patent/NO20073876L/no not_active Application Discontinuation
- 2007-07-31 ZA ZA200706353A patent/ZA200706353B/xx unknown

Also Published As

Publication number	Publication date
KR100968291B1 (ko)	2010-07-07
JP2008530042A (ja)	2008-08-07
RU2402553C2 (ru)	2010-10-27
RU2007128624A (ru)	2009-03-20
WO2006084634A1 (en)	2006-08-17
AU2006212457B2 (en)	2011-04-14
CN101115755A (zh)	2008-01-30
US7361659B2 (en)	2008-04-22
EP1851225A1 (de)	2007-11-07
ZA200706353B (en)	2009-09-30
CA2597608C (en)	2013-12-24
NO20073876L (no)	2007-09-10
EP1851225B1 (de)	2011-06-15
ES2365406T3 (es)	2011-10-04
US20060183756A1 (en)	2006-08-17
KR20070104592A (ko)	2007-10-26
CA2597608A1 (en)	2006-08-17
IL184712A0 (en)	2007-12-03
TW200716120A (en)	2007-05-01
AR052568A1 (es)	2007-03-21
BRPI0607927A2 (pt)	2009-10-20
CN101115755B (zh)	2013-01-16
JP4708438B2 (ja)	2011-06-22
MX2007009106A (es)	2007-09-11
IL184712A (en)	2013-05-30
AU2006212457A1 (en)	2006-08-17

Legal Events

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2012-02-15

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