ATE512966T1 - Pyrazolo-pyrimidin-derivate als mglur2- antagonisten - Google Patents

Pyrazolo-pyrimidin-derivate als mglur2- antagonisten

Info

Publication number: ATE512966T1
Authority: AT; Austria
Prior art keywords: pyrazolo; pyrimidine derivatives; mglur2 antagonists; mglur2; antagonists
Prior art date: 2005-02-11

Application number

AT06706609T

Other languages

English (en)

Inventor

Mcarthur Silvia Gatti

Erwin Goetschi

Juergen Wichmann

Thomas Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-11

Filing date

2006-02-03

Publication date

2011-07-15

2006-02-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE512966T1 publication Critical patent/ATE512966T1/de

Links

101150016175 Grm2 gene Proteins 0.000 title 1
102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT06706609T 2005-02-11 2006-02-03 Pyrazolo-pyrimidin-derivate als mglur2- antagonisten ATE512966T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05101027		2005-02-11
PCT/EP2006/000940 WO2006084634A1 (en)	2005-02-11	2006-02-03	Pyrazolo-pyrimidine derivatives as mglur2 antagonists

Publications (1)

Publication Number	Publication Date
ATE512966T1 true ATE512966T1 (de)	2011-07-15

Family

ID=36090752

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06706609T ATE512966T1 (de)	2005-02-11	2006-02-03	Pyrazolo-pyrimidin-derivate als mglur2- antagonisten

Country Status (18)

Country	Link
US (1)	US7361659B2 (de)
EP (1)	EP1851225B1 (de)
JP (1)	JP4708438B2 (de)
KR (1)	KR100968291B1 (de)
CN (1)	CN101115755B (de)
AR (1)	AR052568A1 (de)
AT (1)	ATE512966T1 (de)
AU (1)	AU2006212457B2 (de)
BR (1)	BRPI0607927A2 (de)
CA (1)	CA2597608C (de)
ES (1)	ES2365406T3 (de)
IL (1)	IL184712A (de)
MX (1)	MX2007009106A (de)
NO (1)	NO20073876L (de)
RU (1)	RU2402553C2 (de)
TW (1)	TW200716120A (de)
WO (1)	WO2006084634A1 (de)
ZA (1)	ZA200706353B (de)

Families Citing this family (26)

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Publication number	Priority date	Publication date	Assignee	Title
EP2085398A1 (de) *	2008-02-01	2009-08-05	Merz Pharma GmbH & Co. KGaA	Pyrazolopyrimidine, Verfahren zu ihrer Herstellung und Verwendung als Arzneimittel
US8207181B2 (en)	2008-03-06	2012-06-26	Sanofi	Substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones, preparation and use thereof
JP5309162B2 (ja) *	2008-03-06	2013-10-09	サノフイ	置換されたジヒドロ、トリヒドロ及びテトラヒドロシクロアルキルオキサゾロピリミジノン、その製造及び使用
US20130137865A1 (en)	2010-08-11	2013-05-30	Taisho Pharmaceutical Co., Ltd.	Heteroaryl-pyrazole derivative
US9447099B2 (en) *	2011-10-04	2016-09-20	Hoffmann-La Roche Inc.	Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine
RU2014120166A (ru) *	2011-10-20	2015-11-27	ГЛЭКСОСМИТКЛАЙН ЭлЭлСи	Замещенные бициклические аза-гетероциклы и их аналоги в качестве модуляторов сиртуина
EP2666775A1 (de)	2012-05-21	2013-11-27	Domain Therapeutics	Substituierte Pyrazolochinazolinone und Pyrrolochinazolinone als allosterische Modulatoren von metabotropen Glutamatrezeptoren der Gruppe II
EP2925292A1 (de)	2012-10-23	2015-10-07	F. Hoffmann-La Roche AG	Mglu2/3-antagonisten zur behandlung von autistischen störungen
KR20160143853A (ko)	2014-04-23	2016-12-14	에프. 호프만-라 로슈 아게	지적 장애의 치료를 위한 mglu2/3 길항제
JOP20150179B1 (ar) *	2014-08-01	2021-08-17	Janssen Pharmaceutica Nv	مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
EP3000814A1 (de)	2014-09-26	2016-03-30	Domain Therapeutics	Substituierte Pyrazolochinazolinone und Pyrrolochinazolinone als allosterische Modulatoren von metabotropen Glutamatrezeptoren der Gruppe II
WO2016073889A1 (en)	2014-11-06	2016-05-12	Lysosomal Therapeutics Inc.	Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
HRP20240644T1 (hr)	2014-11-06	2024-08-02	Bial-R&D Investments, S.A.	Supstituirani pirazolo(1,5-a)pirimidini i njihova uporaba u liječenju medicinskih poremećaja
AU2015342883B2 (en)	2014-11-06	2020-07-02	Bial - R&D Investments, S.A.	Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders
JP6861154B2 (ja)	2014-12-03	2021-04-21	ヤンセンファーマシューティカエヌ．ベー．	放射標識されたｍＧｌｕＲ２ＰＥＴリガンド
PL236355B1 (pl) *	2015-04-02	2021-01-11	Celon Pharma Spolka Akcyjna	Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3
LT3389727T (lt)	2015-12-18	2020-10-12	Janssen Pharmaceutica Nv	Radioaktyviai pažymėti mglur2/3 pet ligandai
EA037941B1 (ru)	2015-12-18	2021-06-09	Янссен Фармацевтика Нв	ЛИГАНДЫ mGluR2/3 ДЛЯ PET, МЕЧЕННЫЕ РАДИОАКТИВНЫМИ ИЗОТОПАМИ
EP3440081A4 (de)	2016-04-06	2019-09-18	Lysosomal Therapeutics Inc.	Pyrrolo[1,2-a]pyrimidinyl-carboxamid-verbindungen und deren verwendung in der behandlung von medizinischen störungen
US11192892B2 (en) *	2016-04-06	2021-12-07	Bial—R&D Investments, S.A.	Substituted pyrazolo[1,5-a]pyrimidines for the treatment of medical disorders
CA3020305A1 (en)	2016-04-06	2017-10-12	Lysosomal Therapeutics Inc.	Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
SG11201809693SA (en)	2016-05-05	2018-11-29	Lysosomal Therapeutics Inc	SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
EP3452455A4 (de)	2016-05-05	2019-11-13	Lysosomal Therapeutics Inc.	Substituierte imdazo[1,2-]pyridine, substituierte imidazo[1,2-]pyrazine, verwandte verbindungen und deren verwendung bei der behandlung von erkrankungen
US10647710B2 (en) *	2017-01-09	2020-05-12	Medshine Discovery Inc.	Thiazole derivative and applications thereof
KR102688238B1 (ko)	2017-11-24	2024-07-25	스미토모 파마 가부시키가이샤	6, 7-디히드로 피라졸로[1, 5-a]피라지논 유도체 및 그 의약 용도
JP7150368B2 (ja) *	2018-07-06	2022-10-11	フェーノ・セラピューティクス・カンパニー・リミテッド	チアゾール系化合物の結晶形およびその応用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
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JP3356291B2 (ja)	1996-02-07	2002-12-16	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｃｒｆレセプター拮抗薬としてのピラゾロピリミジン類
EP0891978B1 (de)	1997-07-18	2002-03-20	F. Hoffmann-La Roche Ag	5h-Thiazolo[3,2-a]pyrimidinderivate
WO2000059908A2 (en)	1999-04-06	2000-10-12	Du Pont Pharmaceuticals Company	Pyrazolopyrimidines as crf antagonists
SK13682003A3 (sk) *	2001-04-12	2004-07-07	F. Hoffmann-La Roche Ag	Dihydrobenzo[b][1,4]diazepin-2-ónové deriváty ako mGluR2 antagonisty II
JP2006523707A (ja) *	2003-04-15	2006-10-19	アストラゼネカアクツィエボラーグ	治療化合物
US7329662B2 (en) *	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
HRP20080070T3 (en) *	2004-06-21	2008-05-31	F. Hoffmann - La Roche Ag	Pyrrazolo-pyrimidine derivatives

2006
- 2006-02-03 CN CN2006800046579A patent/CN101115755B/zh not_active Expired - Fee Related
- 2006-02-03 JP JP2007554484A patent/JP4708438B2/ja not_active Expired - Fee Related
- 2006-02-03 BR BRPI0607927-0A patent/BRPI0607927A2/pt not_active IP Right Cessation
- 2006-02-03 WO PCT/EP2006/000940 patent/WO2006084634A1/en not_active Ceased
- 2006-02-03 ES ES06706609T patent/ES2365406T3/es not_active Expired - Lifetime
- 2006-02-03 MX MX2007009106A patent/MX2007009106A/es active IP Right Grant
- 2006-02-03 CA CA2597608A patent/CA2597608C/en not_active Expired - Fee Related
- 2006-02-03 AT AT06706609T patent/ATE512966T1/de active
- 2006-02-03 KR KR1020077018345A patent/KR100968291B1/ko not_active Expired - Fee Related
- 2006-02-03 EP EP06706609A patent/EP1851225B1/de not_active Expired - Lifetime
- 2006-02-03 AU AU2006212457A patent/AU2006212457B2/en not_active Ceased
- 2006-02-03 RU RU2007128624/04A patent/RU2402553C2/ru not_active IP Right Cessation
- 2006-02-06 US US11/348,105 patent/US7361659B2/en not_active Expired - Fee Related
- 2006-02-06 AR ARP060100412A patent/AR052568A1/es not_active Application Discontinuation
- 2006-02-08 TW TW095104260A patent/TW200716120A/zh unknown
2007
- 2007-07-19 IL IL184712A patent/IL184712A/en not_active IP Right Cessation
- 2007-07-24 NO NO20073876A patent/NO20073876L/no not_active Application Discontinuation
- 2007-07-31 ZA ZA200706353A patent/ZA200706353B/xx unknown

Also Published As

Publication number	Publication date
JP4708438B2 (ja)	2011-06-22
KR100968291B1 (ko)	2010-07-07
AU2006212457A1 (en)	2006-08-17
US20060183756A1 (en)	2006-08-17
RU2402553C2 (ru)	2010-10-27
WO2006084634A1 (en)	2006-08-17
EP1851225A1 (de)	2007-11-07
JP2008530042A (ja)	2008-08-07
EP1851225B1 (de)	2011-06-15
CN101115755B (zh)	2013-01-16
MX2007009106A (es)	2007-09-11
US7361659B2 (en)	2008-04-22
RU2007128624A (ru)	2009-03-20
IL184712A0 (en)	2007-12-03
KR20070104592A (ko)	2007-10-26
CA2597608A1 (en)	2006-08-17
NO20073876L (no)	2007-09-10
AR052568A1 (es)	2007-03-21
IL184712A (en)	2013-05-30
CN101115755A (zh)	2008-01-30
ZA200706353B (en)	2009-09-30
BRPI0607927A2 (pt)	2009-10-20
TW200716120A (en)	2007-05-01
ES2365406T3 (es)	2011-10-04
CA2597608C (en)	2013-12-24
AU2006212457B2 (en)	2011-04-14

Legal Events

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2012-02-15

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Publication	Publication Date	Title
ATE512966T1 (de)	2011-07-15	Pyrazolo-pyrimidin-derivate als mglur2- antagonisten
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