ATE390441T1 - Niedrigallergene proteinvarianten - Google Patents

Niedrigallergene proteinvarianten

Info

Publication number
ATE390441T1
ATE390441T1 AT02020745T AT02020745T ATE390441T1 AT E390441 T1 ATE390441 T1 AT E390441T1 AT 02020745 T AT02020745 T AT 02020745T AT 02020745 T AT02020745 T AT 02020745T AT E390441 T1 ATE390441 T1 AT E390441T1
Authority
AT
Austria
Prior art keywords
protein
parent protein
immunogenicity
low
parent
Prior art date
Application number
AT02020745T
Other languages
English (en)
Inventor
Erwin Ludo Roggen
Arne Agerlin Olsen
Steffen Ernst
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27221271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE390441(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE390441T1 publication Critical patent/ATE390441T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
    • C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
    • C12N9/0061—Laccase (1.10.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y110/00—Oxidoreductases acting on diphenols and related substances as donors (1.10)
    • C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
    • C12Y110/03002—Laccase (1.10.3.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02020745T 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten ATE390441T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199801402 1998-10-30
DKPA199801645 1998-11-25
DKPA199901417 1999-10-04

Publications (1)

Publication Number Publication Date
ATE390441T1 true ATE390441T1 (de) 2008-04-15

Family

ID=27221271

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02020745T ATE390441T1 (de) 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten
AT99947260T ATE263778T1 (de) 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99947260T ATE263778T1 (de) 1998-10-30 1999-10-12 Niedrigallergene proteinvarianten

Country Status (10)

Country Link
EP (2) EP1124843B1 (de)
JP (1) JP2003500003A (de)
CN (1) CN1206237C (de)
AT (2) ATE390441T1 (de)
AU (1) AU776534B2 (de)
CA (1) CA2348938A1 (de)
DE (2) DE69938435D1 (de)
ES (1) ES2220114T3 (de)
NZ (1) NZ511291A (de)
WO (1) WO2000026230A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
EP1198565A1 (de) * 1999-07-07 2002-04-24 Maxygen Aps Verfahren zur herstellung von modifizierten polypeptiden
WO2001031989A2 (en) * 1999-12-09 2001-05-10 Novozymes A/S High throughput screening (hts) assays for protein variants with reduced antibody binding capacity
CA2739933A1 (en) 2000-02-11 2001-08-16 Bayer Healthcare Llc Factor vii or viia-like molecules
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
EP1280817A2 (de) * 2000-04-28 2003-02-05 Novozymes A/S Identifizierung, produktion und verwendung von proteinvarianten mit veränderten immunogenzität
WO2001098484A1 (en) * 2000-06-21 2001-12-27 Novozymes A/S Method for genome mining for secreted protein genes
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
EP1340085B1 (de) * 2000-10-17 2008-07-30 Besst-Test Aps Test zum direkten nachweisen einer biologischen zelle in einer körperflüssigkeitsprobe
US6933367B2 (en) 2000-10-18 2005-08-23 Maxygen Aps Protein C or activated protein C-like molecules
EP1436627A2 (de) * 2001-10-05 2004-07-14 Novozymes A/S Kit zur vorhersage der bindung eines spezifischen antikörpers an ein potentielles immunogen und screening-verfahren
JP4426307B2 (ja) 2002-02-08 2010-03-03 ノボザイムス アクティーゼルスカブ フィターゼ変異体
WO2003093465A1 (en) 2002-04-30 2003-11-13 Maxygen Holdings Ltd. FACTOR VII OR VIIa POLYPEPTIDE VARIANTS
CN1668737A (zh) * 2002-05-16 2005-09-14 阿尔克-阿贝洛有限公司 重组Bet.V.1过敏原突变体及其方法和制备
DE60335640D1 (de) 2002-10-01 2011-02-17 Novozymes As Polypeptide der gh-61-familie
EP2500423B1 (de) * 2003-02-26 2015-06-17 Danisco US Inc. Amylasen, die eine veränderte immunogene Reaktion bewirken, und Verfahren zu ihrer Herstellung und Verwendung
WO2004078960A1 (en) * 2003-02-26 2004-09-16 Genencor International, Inc. Amylases producing an altered immunogenic response and methods of making and using the same
CA2519873C (en) 2003-03-20 2012-12-18 Maxygen Holdings Ltd. Fvii or fviia variants
CN1791672A (zh) * 2003-03-21 2006-06-21 诺和酶股份有限公司 使用基于jp170三维结构的蛋白质建模修饰枯草杆菌酶
US7727756B2 (en) 2003-03-21 2010-06-01 Novozymes A/S Subtilases
RU2373282C2 (ru) 2003-06-19 2009-11-20 Байер Хелткэр Ллк ВАРИАНТЫ ДОМЕНА GLA ФАКТОРА VII ИЛИ VIIa
EP1639107B1 (de) 2003-06-19 2013-08-14 Novozymes A/S Verbesserte proteasen und methoden zu deren herstellung
CN1809634A (zh) 2003-06-19 2006-07-26 诺维信公司 蛋白酶
DE602004030595D1 (de) 2003-10-10 2011-01-27 Novozymes As Proteasevarianten
JP5059412B2 (ja) 2004-01-06 2012-10-24 ノボザイムス アクティーゼルスカブ アリシクロバシラスｓｐ．のポリペプチド
US7824896B2 (en) 2004-04-02 2010-11-02 Novozymes A/S Subtilase variants having altered lmmunogenicity
ES2380105T3 (es) 2004-06-21 2012-05-08 Novozymes A/S Proteasas de Nocardiopsis
MX285771B (es) 2004-10-04 2011-04-07 Novozymes As Polipeptidos que tienen avtividad de fitasa y polinucleotidos queridos mama y papa: codifican los mismos.
AR050895A1 (es) 2004-10-04 2006-11-29 Novozymes As Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican
EP1967584B1 (de) 2005-08-16 2011-03-23 Novozymes A/S Polypeptide von Stammbakterien SP P203
EP1998793A1 (de) 2006-03-22 2008-12-10 Novozymes A/S Verwendung von polypeptiden mit antimikrobieller wirkung
MX2008012632A (es) 2006-04-04 2008-10-13 Novozymes As Variantes de fitasa.
KR20090101930A (ko) 2006-12-21 2009-09-29 노보자임스 에이/에스 약학적 사용을 위한 리파아제 변형체
US8221743B2 (en) 2006-12-22 2012-07-17 Novozymes A/S Use of polypeptides against diseases caused by protozoans
PL2129781T3 (pl) 2007-03-26 2014-07-31 Novozymes As Fitaza z Hafnia
JP5056193B2 (ja) * 2007-06-21 2012-10-24 味の素株式会社 畜肉加工食品又は水産加工食品の製造方法及び畜肉加工食品又は水産加工食品改質用の酵素製剤
ES2636369T3 (es) 2008-09-26 2017-10-05 Novozymes A/S Variantes de fitasa de Hafnia
JP5230397B2 (ja) * 2008-12-18 2013-07-10 独立行政法人科学技術振興機構 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法
US9526768B2 (en) 2014-11-13 2016-12-27 Jennifer Mai Compositions for the treatment of cancer
CN108690841B (zh) * 2018-02-08 2021-10-01 河南科技学院 一种mPEG-Mal5000修饰β-淀粉酶的方法
BR112023002578A2 (pt) 2020-08-13 2023-03-14 Novozymes As Variantes de fitase e polinucleotídeos codificando as mesmas

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
FI932561L (fi) 1990-12-05 1993-06-04 Novo Nordisk As Proteiner med foeraendrade epitoper och foerfaranden foer deras framstaellning
NZ251582A (en) * 1992-04-01 1997-07-27 Merck & Co Inc Recombinant human anti-hiv antibodies, methods for their cloning and expression and pharmaceutical compositions thereof
JP3475221B2 (ja) * 1994-09-05 2003-12-08 明治乳業株式会社 免疫原性が低下された変異体タンパク質
JPH08289790A (ja) * 1995-01-06 1996-11-05 Leuven Res & Dev Vzw 新規なスタフィロキナーゼ誘導体
JP4044143B2 (ja) 1996-11-04 2008-02-06 ノボザイムス アクティーゼルスカブ ズブチラーゼ変異体及び組成物
WO1998020155A1 (en) 1996-11-08 1998-05-14 New York Society For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery Diagnostic methods using cd40 ligand assay
AU743647B2 (en) * 1998-01-31 2002-01-31 Mt. Sinai School Of Medicine Of New York University Methods and reagents for decreasing allergic reactions

Also Published As

Publication number Publication date
WO2000026230A8 (en) 2000-07-20
EP1124843B1 (de) 2004-04-07
ES2220114T3 (es) 2004-12-01
JP2003500003A (ja) 2003-01-07
EP1277762A3 (de) 2003-04-09
AU776534B2 (en) 2004-09-16
DE69938435D1 (de) 2008-05-08
EP1277762A2 (de) 2003-01-22
EP1124843A1 (de) 2001-08-22
NZ511291A (en) 2003-08-29
DE69916306D1 (de) 2004-05-13
AU6078799A (en) 2000-05-22
EP1277762B1 (de) 2008-03-26
WO2000026230A1 (en) 2000-05-11
CA2348938A1 (en) 2000-05-11
CN1206237C (zh) 2005-06-15
DE69916306T2 (de) 2005-05-04
ATE263778T1 (de) 2004-04-15
CN1325404A (zh) 2001-12-05

Similar Documents

Publication Publication Date Title
ATE263778T1 (de) Niedrigallergene proteinvarianten
DE60322188D1 (de) Zytokin (zcytor17-ligand)
DE60329070D1 (de) Antikörper gegen den fibroblastenwachstumsfaktor 23
DK1144607T3 (da) Fremgangsmåde til præsentation af (poly)peptider/proteiner på bakteriofage partikler via disulfidbindinger
IT1227907B (it) Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
ATE446104T1 (de) Rekombinantes super-verbindungs-interferon zur verwendung als hepatitis b oberflächenatigen und e-antigen-inhibitor
DK1501936T3 (da) Familie af cytokin-proteiner
DK1114156T3 (da) Transformerende vækstfaktor Beta-9 (ZTGFSS9) fra pattedyr
DK1908772T3 (da) Polypeptider og polynucleinsyrer af phorphorymonas gingivalis
CA2137280A1 (fr) Clonage du gene codant pour la proteine gp28.5 de toxoplasma gondii; fragments peptidiques de cette proteine et leurs applications
DK0635025T3 (da) Fremgangsmåde til fremstilling af modificerede proteiner
DE69929454D1 (de) Neue aminosäuresequenzen, deren kodierende dns, antikörper dagegen und deren verwendungen
CA2441187A1 (en) Acetyllysine-recognizing monoclonal antibody and process for producing the same
DK0779297T3 (da) Antigene peptider med glycinsubstitutioner
WO1998001550A3 (en) Vaccine against gastro-intestinal nematodes
WO1994025594A3 (en) Cloning, expression and vaccine composition corresponding to a peptide antigen of toxoplasma gondii
IT9067703A0 (it) Peptidi sintetici contenenti sequenze di aminoacidi che definiscono epitopi immunoreattivi contro anticorpi umani anti hcv, utili per l'alletimento di dosaggi immunologici.
RU97117935A (ru) Свойства пептидов, стимулирующих рост

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties