IT1227907B - Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento - Google Patents

Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Info

Publication number: IT1227907B
Authority: IT; Italy
Prior art keywords: procedure; formula; amino acid; retro; synthesis
Prior art date: 1988-12-23

Application number

IT8823098A

Other languages

English (en)

Other versions

IT8823098A0 (it

Inventor

Massimo Pinori

Felice Centini

Antonio Silvio Verdini

Original Assignee

Eniricerche S P A Milano Sclav

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-23

Filing date

1988-12-23

Publication date

1991-05-14

1988-12-23 Application filed by Eniricerche S P A Milano Sclav filed Critical Eniricerche S P A Milano Sclav

1988-12-23 Publication of IT8823098A0 publication Critical patent/IT8823098A0/it

1988-12-23 Priority to IT8823098A priority Critical patent/IT1227907B/it

1989-12-14 Priority to EP89203194A priority patent/EP0375040B1/en

1989-12-14 Priority to AT89203194T priority patent/ATE102949T1/de

1989-12-14 Priority to US07/450,572 priority patent/US5061811A/en

1989-12-14 Priority to ES89203194T priority patent/ES2061956T3/es

1989-12-14 Priority to DE68913935T priority patent/DE68913935T2/de

1989-12-22 Priority to CA002006560A priority patent/CA2006560A1/en

1989-12-25 Priority to JP1336182A priority patent/JPH02221294A/ja

1991-05-14 Application granted granted Critical

1991-05-14 Publication of IT1227907B publication Critical patent/IT1227907B/it

1991-08-09 Priority to US07/742,873 priority patent/US5116947A/en

Links

238000000034 method Methods 0.000 title abstract 5
230000015572 biosynthetic process Effects 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title 1
235000001014 amino acid Nutrition 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
125000001721 carboxyacetyl group Chemical group 0.000 abstract 2
-1 5-substituted-2,2-dimethyl-1,3-dioxane-4,6-dione Chemical class 0.000 abstract 1
108010033276 Peptide Fragments Proteins 0.000 abstract 1
102000007079 Peptide Fragments Human genes 0.000 abstract 1
150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
IESDGNYHXIOKRW-LEOABGAYSA-N tuftsin Chemical class C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(O)=O IESDGNYHXIOKRW-LEOABGAYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IT8823098A 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento IT1227907B (it)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IT8823098A IT1227907B (it)	1988-12-23	1988-12-23	Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
ES89203194T ES2061956T3 (es)	1988-12-23	1989-12-14	Procedimiento para la preparacion de peptidos retro-inversos y nuevos compuestos intermedios de los mismos.
AT89203194T ATE102949T1 (de)	1988-12-23	1989-12-14	Verfahren zur herstellung von retro-inversopeptiden und dessen zwischenprodukte.
US07/450,572 US5061811A (en)	1988-12-23	1989-12-14	Process for the preparation of retro-inverso peptides and 1,3-dioxane-4,6-dione intermediates thereof
EP89203194A EP0375040B1 (en)	1988-12-23	1989-12-14	Process for the preparation of retro-inverso peptides and new intermediates thereof
DE68913935T DE68913935T2 (de)	1988-12-23	1989-12-14	Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte.
CA002006560A CA2006560A1 (en)	1988-12-23	1989-12-22	Process for the preparation of retro-inverso peptides and new intermediates thereof
JP1336182A JPH02221294A (ja)	1988-12-23	1989-12-25	ペプチド合成法
US07/742,873 US5116947A (en)	1988-12-23	1991-08-09	Process for the preparation of retro-inverso peptides and new intermediates thereof

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8823098A IT1227907B (it)	1988-12-23	1988-12-23	Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Publications (2)

Publication Number	Publication Date
IT8823098A0 IT8823098A0 (it)	1988-12-23
IT1227907B true IT1227907B (it)	1991-05-14

Family

ID=11203765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8823098A IT1227907B (it)	1988-12-23	1988-12-23	Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Country Status (8)

Country	Link
US (2)	US5061811A (it)
EP (1)	EP0375040B1 (it)
JP (1)	JPH02221294A (it)
AT (1)	ATE102949T1 (it)
CA (1)	CA2006560A1 (it)
DE (1)	DE68913935T2 (it)
ES (1)	ES2061956T3 (it)
IT (1)	IT1227907B (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5200506A (en) *	1987-03-19	1993-04-06	Eniricerche S.P.A.	Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
IT1227907B (it) *	1988-12-23	1991-05-14	Eniricerche S P A Milano Sclav	Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
US5218089A (en) *	1988-12-23	1993-06-08	Sclavo S.P.A.	Retro-inverso analogues of thymopentin and the method for their synthesis
AU1194092A (en) *	1991-02-06	1992-09-07	Georgetown University	Receptor blocking peptides of fibroblast growth factor receptor
CN1091138A (zh)	1992-08-27	1994-08-24	迪金研究有限公司	疫苗
EP2823812A1 (en)	1998-02-02	2015-01-14	Trustees Of Tufts College	Dipeptidylpeptidase IV inhibitors for use in the treatment of Type II diabetes
US7396905B1 (en)	1999-05-21	2008-07-08	Mckeon Frank	Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
US8183339B1 (en)	1999-10-12	2012-05-22	Xigen S.A.	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US6610820B1 (en) *	1999-10-12	2003-08-26	University Of Lausanne	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20040082509A1 (en)	1999-10-12	2004-04-29	Christophe Bonny	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
EP2316470A3 (en) *	2001-11-26	2011-08-24	Trustees Of Tufts College	Peptidomimetic inhibitors of post-proline cleaving enzymes
EP1487471A4 (en)	2001-11-26	2010-03-10	Tufts College	METHOD FOR TREATING AUTOIMMUNE DISEASES AND ASSOCIATED REAGENTS
AU2002361385B2 (en) *	2001-12-18	2009-11-19	Centre National De La Recherche Scientifique Cnrs	Novel death associated proteins of the THAP family and related Par4 pathways involved in apoptosis control
US7858297B2 (en) *	2001-12-18	2010-12-28	Centre National De La Recherche Scientifique Cnrs	Chemokine-binding protein and methods of use
EP1485408A2 (en)	2002-03-13	2004-12-15	Bayer CropScience S.A.	Mutagenesis of aspergillus fungi and genes essential for growth
WO2007031098A1 (en)	2005-09-12	2007-03-22	Xigen S.A.	Cell-permeable peptide inhibitors of the jnk signal transduction pathway
US8080517B2 (en)	2005-09-12	2011-12-20	Xigen Sa	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2009143864A1 (en)	2008-05-30	2009-12-03	Xigen S.A.	Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2009143865A1 (en)	2008-05-30	2009-12-03	Xigen S.A.	Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2010072228A1 (en)	2008-12-22	2010-07-01	Xigen S.A.	Novel transporter constructs and transporter cargo conjugate molecules
WO2011160653A1 (en)	2010-06-21	2011-12-29	Xigen S.A.	Novel jnk inhibitor molecules
US9150618B2 (en)	2010-10-14	2015-10-06	Xigen Inflammation Ltd.	Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
WO2013091670A1 (en)	2011-12-21	2013-06-27	Xigen S.A.	Novel jnk inhibitor molecules for treatment of various diseases
WO2014206427A1 (en)	2013-06-26	2014-12-31	Xigen Inflammation Ltd.	New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2014206563A2 (en)	2013-06-26	2014-12-31	Xigen Inflammation Ltd.	New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2015197097A1 (en)	2014-06-26	2015-12-30	Xigen Inflammation Ltd.	New use for jnk inhibitor molecules for treatment of various diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0253190B1 (en) *	1986-07-16	1992-12-30	ENIRICERCHE S.p.A.	Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
IT1227907B (it) *	1988-12-23	1991-05-14	Eniricerche S P A Milano Sclav	Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

1988
- 1988-12-23 IT IT8823098A patent/IT1227907B/it active
1989
- 1989-12-14 US US07/450,572 patent/US5061811A/en not_active Expired - Fee Related
- 1989-12-14 DE DE68913935T patent/DE68913935T2/de not_active Expired - Fee Related
- 1989-12-14 AT AT89203194T patent/ATE102949T1/de not_active IP Right Cessation
- 1989-12-14 EP EP89203194A patent/EP0375040B1/en not_active Expired - Lifetime
- 1989-12-14 ES ES89203194T patent/ES2061956T3/es not_active Expired - Lifetime
- 1989-12-22 CA CA002006560A patent/CA2006560A1/en not_active Abandoned
- 1989-12-25 JP JP1336182A patent/JPH02221294A/ja active Pending
1991
- 1991-08-09 US US07/742,873 patent/US5116947A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0375040A3 (en)	1991-07-03
CA2006560A1 (en)	1990-06-23
EP0375040B1 (en)	1994-03-16
DE68913935D1 (de)	1994-04-21
ATE102949T1 (de)	1994-04-15
US5061811A (en)	1991-10-29
JPH02221294A (ja)	1990-09-04
ES2061956T3 (es)	1994-12-16
US5116947A (en)	1992-05-26
EP0375040A2 (en)	1990-06-27
DE68913935T2 (de)	1994-07-07
IT8823098A0 (it)	1988-12-23

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19931230

Publication	Publication Date	Title
DE68913935D1 (de)	1994-04-21	Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte.
ATE263778T1 (de)	2004-04-15	Niedrigallergene proteinvarianten
RU95112539A (ru)	1997-06-27	Новый полипептид и фармацевтическая композиция против вич-инфекции
NL300192I2 (nl)	2005-08-01	Synthetische peptideremmers van HIV-overdracht.
DE3784799D1 (de)	1993-04-22	Malonsaeurederivate und ihre synthesemethoden.
DK0387231T3 (da)	1995-07-03	Hidtil ukendte inhibitorer for retroviral protease
ATE154036T1 (de)	1997-06-15	Retrovirale protease-inhibitoren
DK1908772T3 (da)	2012-03-19	Polypeptider og polynucleinsyrer af phorphorymonas gingivalis
EA200700062A1 (ru)	2007-04-27	Олигомерные пептиды и их применение для лечения вич инфекций
DE3782880D1 (de)	1993-01-14	Hemmende peptide.
ES2079054T3 (es)	1996-01-01	Peptidilhidroxiglicina n-c-liasa y adn codificante de la misma.
NO994929D0 (no)	1999-10-08	Syntetiske peptider, nyttige i biologiske tester, for paavisning av infeksjoner foraarsaket av gruppe 0 HIV-1 virus
EP0934952A3 (en)	1999-12-29	Peptides containing an N-substituted glycine residue
ATE85077T1 (de)	1993-02-15	Enzym zur alpha-amidierung von c-termini und verfahren zu dessen herstellung.
ATE298347T1 (de)	2005-07-15	Immunodiagnostischer wirkstoff zum nachweiss von maedi-visna virus und caev infektionen
DK0779297T3 (da)	2001-09-17	Antigene peptider med glycinsubstitutioner
EP0959895A4 (en)	2002-07-24	PEPTIDES SPECIFIC FOR ANTIBODIES AGAINST PEPTIDE CONCENSUS SEQUENCES FROM THE CS4-CFA / IPRPTE INFAMILY
WO2002083729A3 (en)	2003-07-31	Polypeptides derived from amyloid precursor peptide (app) and their uses
DE69009224D1 (de)	1994-07-07	Gem-diamino-Derivate und ihre Verwendung bei der Herstellung von Retro-Inverso-Peptiden.