ATE391723T1 - Verfahren zur identifizierung antigener peptide - Google Patents

Verfahren zur identifizierung antigener peptide

Info

Publication number: ATE391723T1
Authority: AT; Austria
Prior art keywords: methods; utilized; sequence; cells; antigens
Prior art date: 2002-10-02

Application number

AT03021521T

Other languages

English (en)

Inventor

Harald Kropshofer

Anne Vogt

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-02

Filing date

2003-09-24

Publication date

2008-04-15

2003-09-24 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-04-15 Application granted granted Critical

2008-04-15 Publication of ATE391723T1 publication Critical patent/ATE391723T1/de

Links

238000000034 method Methods 0.000 title abstract 5
239000000427 antigen Substances 0.000 title abstract 4
102000036639 antigens Human genes 0.000 title abstract 4
108091007433 antigens Proteins 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
230000000890 antigenic effect Effects 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
102000018713 Histocompatibility Antigens Class II Human genes 0.000 abstract 1
108010027412 Histocompatibility Antigens Class II Proteins 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
210000001124 body fluid Anatomy 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
210000004443 dendritic cell Anatomy 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
238000002255 vaccination Methods 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Virology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Neurology (AREA)
Endocrinology (AREA)
Cell Biology (AREA)
Hematology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)

AT03021521T 2002-10-02 2003-09-24 Verfahren zur identifizierung antigener peptide ATE391723T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02022223		2002-10-02

Publications (1)

Publication Number	Publication Date
ATE391723T1 true ATE391723T1 (de)	2008-04-15

Family

ID=32116218

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT07011493T ATE474851T1 (de)	2002-10-02	2003-09-24	Verfahren zur identifizierung antigener peptide
AT03021521T ATE391723T1 (de)	2002-10-02	2003-09-24	Verfahren zur identifizierung antigener peptide

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT07011493T ATE474851T1 (de)	2002-10-02	2003-09-24	Verfahren zur identifizierung antigener peptide

Country Status (8)

Country	Link
US (1)	US20040086521A1 (de)
EP (3)	EP1714981A3 (de)
JP (3)	JP4620339B2 (de)
AT (2)	ATE474851T1 (de)
AU (1)	AU2003248438A1 (de)
CA (1)	CA2441690C (de)
DE (2)	DE60320196T2 (de)
ES (1)	ES2346574T3 (de)

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KR100769338B1 (ko) *	2003-08-07	2007-10-24	에프. 호프만-라 로슈 아게	류마티스성 관절염（ｒａ） 항원성 펩타이드
EP1715343B1 (de)	2005-04-20	2009-12-09	F. Hoffmann-La Roche Ag	Verfahren zur Identifizierung von Epitopen in Zusammenhang mit Immunogenität bei Biopharmazeutika
DE602006010934D1 (de) *	2005-04-20	2010-01-21	Hoffmann La Roche	Verfahren zur Identifizierung von Epitopen in Zusammenhang mit Immunogenität bei Biopharmazeutika
JPWO2007055283A1 (ja) *	2005-11-10	2009-04-30	Jsr株式会社	核内受容体タンパク質複合体のプロテオミクス解析方法
JP4983803B2 (ja) *	2006-11-29	2012-07-25	株式会社島津製作所	免疫沈降を用いた生体試料の質量分析法
SG10201704689XA (en) *	2008-01-18	2017-07-28	Harvard College	Methods of detecting signatures of disease or conditions in bodily fluids
EA201171491A1 (ru) *	2009-05-29	2012-07-30	Новартис Аг	Анализы гемагглютининов вируса гриппа
CA2806304A1 (en)	2010-07-23	2012-01-26	President And Fellows Of Harvard College	Methods of detecting prenatal or pregnancy-related diseases or conditions
AU2011280997A1 (en)	2010-07-23	2013-02-28	President And Fellows Of Harvard College	Methods of detecting autoimmune or immune-related diseases or conditions
WO2013150680A1 (ja)	2012-04-06	2013-10-10	独立行政法人産業技術総合研究所	プロテインタグ、タグ化タンパク質及びタンパク質精製方法
NZ771629A (en)	2013-03-09	2022-12-23	Harry Stylli	Methods of detecting cancer
US20170199186A1 (en) *	2014-06-06	2017-07-13	Singapore Health Services Pte Ltd.	Methods of using cells associated with autoimmune disease
KR101831483B1 (ko)	2014-06-17	2018-02-23	이화여자대학교 산학협력단	Mhc-페리틴 결합체, 이를 포함하는 나노파티클 및 이의 용도
EP3929302A1 (de)	2014-07-14	2021-12-29	Chugai Seiyaku Kabushiki Kaisha	Verfahren zur identifizierung eines epitops auf einem protein
WO2016079143A1 (de)	2014-11-17	2016-05-26	Pharis Biotec Gmbh	Inhibitor der viralen hepatitis c infektion
CN105928771B (zh) *	2016-04-08	2019-01-18	西藏恒久投资有限公司	一种检测疫苗抗原含量的样品前处理方法
CN110809716B (zh) *	2017-02-12	2023-07-07	百欧恩泰美国公司	基于hla的方法和组合物及其用途
CN110709700A (zh)	2017-04-14	2020-01-17	朱诺治疗学股份有限公司	评估细胞表面糖基化的方法
CN110118845A (zh) *	2018-02-06	2019-08-13	北京金则医学科技发展有限公司	检测多种氨基酸和酰基肉碱、甲基丙二酸的方法和试剂盒
JP6712369B2 (ja) *	2018-05-29	2020-06-24	株式会社森永生科学研究所	抗ペプチド抗体の製造方法及び設計方法
WO2019238939A1 (en) *	2018-06-15	2019-12-19	F. Hoffmann-La Roche Ag	A system for identification of antigens recognized by t cell receptors expressed on tumor infiltrating lymphocytes
AU2019301750A1 (en)	2018-07-12	2021-01-28	Board Of Regents, The University Of Texas System	Molecular neighborhood detection by oligonucleotides
WO2020037046A1 (en) *	2018-08-14	2020-02-20	Board Of Regents, The University Of Texas System	Single molecule sequencing peptides bound to the major histocompatibility complex
JP7504891B2 (ja) *	2018-09-11	2024-06-24	ジュノーセラピューティクスインコーポレイテッド	操作された細胞組成物のマススペクトロメトリー分析のための方法
WO2020072907A1 (en)	2018-10-05	2020-04-09	Board Of Regents, The University Of Texas System	Solid-phase n-terminal peptide capture and release
GB202006760D0 (en) *	2020-05-07	2020-06-24	Univ Helsinki	Bioinformatics
JP2021047198A (ja) *	2020-12-04	2021-03-25	ＫａｒｙｄｏＴｈｅｒａｐｅｕｔｉＸ株式会社	心筋梗塞、認知症、および腫瘍からなる群から選択される一種を予防、または治療するための有効成分の候補物質のスクリーニング装置、スクリーニングプログラム、およびスクリーニング方法
CN113406240B (zh) *	2021-07-02	2023-03-24	杭州艾儿默细胞生物科技有限公司	检测pHLA复合物中抗原肽的超滤-高效液相色谱法

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US6017540A (en) *	1997-02-07	2000-01-25	Fordham University	Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes
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2003
- 2003-09-24 EP EP06015737A patent/EP1714981A3/de not_active Withdrawn
- 2003-09-24 DE DE60320196T patent/DE60320196T2/de not_active Expired - Lifetime
- 2003-09-24 EP EP03021521A patent/EP1405862B1/de not_active Expired - Lifetime
- 2003-09-24 ES ES07011493T patent/ES2346574T3/es not_active Expired - Lifetime
- 2003-09-24 DE DE60333500T patent/DE60333500D1/de not_active Expired - Lifetime
- 2003-09-24 AT AT07011493T patent/ATE474851T1/de not_active IP Right Cessation
- 2003-09-24 EP EP07011493A patent/EP1826217B1/de not_active Expired - Lifetime
- 2003-09-24 AT AT03021521T patent/ATE391723T1/de not_active IP Right Cessation
- 2003-09-25 CA CA2441690A patent/CA2441690C/en not_active Expired - Lifetime
- 2003-09-26 AU AU2003248438A patent/AU2003248438A1/en not_active Abandoned
- 2003-10-01 US US10/676,909 patent/US20040086521A1/en not_active Abandoned
- 2003-10-02 JP JP2003343918A patent/JP4620339B2/ja not_active Expired - Lifetime
2007
- 2007-04-05 JP JP2007098939A patent/JP2007211020A/ja active Pending
2010
- 2010-09-22 JP JP2010211787A patent/JP2011012073A/ja active Pending

Also Published As

Publication number	Publication date
DE60320196D1 (de)	2008-05-21
EP1405862A2 (de)	2004-04-07
CA2441690A1 (en)	2004-04-02
JP2004123749A (ja)	2004-04-22
ES2346574T3 (es)	2010-10-18
EP1826217A1 (de)	2007-08-29
JP2011012073A (ja)	2011-01-20
EP1405862B1 (de)	2008-04-09
DE60333500D1 (de)	2010-09-02
JP4620339B2 (ja)	2011-01-26
AU2003248438A1 (en)	2004-04-22
JP2007211020A (ja)	2007-08-23
DE60320196T2 (de)	2009-05-14
EP1714981A3 (de)	2006-12-20
EP1714981A2 (de)	2006-10-25
US20040086521A1 (en)	2004-05-06
EP1826217B1 (de)	2010-07-21
CA2441690C (en)	2011-08-02
ATE474851T1 (de)	2010-08-15
EP1405862A3 (de)	2004-06-09

Legal Events

Date	Code	Title	Description
2008-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60320196D1 (de)	2008-05-21	Verfahren zur Identifizierung antigener Peptide
ES2650236T3 (es)	2018-01-17	Linfocitos T CD4+ con propiedades citolíticas
JP2020532323A (ja)	2020-11-12	Ｔ細胞療法用の新生抗原の特定法
WO2003106692A3 (en)	2004-12-23	Methods for the identification of all-antigens and their use for cancer therapy and transplantation
JP2019502360A (ja)	2019-01-31	Ｃｌｌおよびその他のがんに対する免疫療法において使用するための新規ペプチドおよびペプチドの組み合わせ
US20190170742A1 (en)	2019-06-06	Compositions, kits and methods for in vitro antigen presentation, assessing vaccine efficacy, and assessing immunotoxicity of biologics and drugs
CA3049456A1 (en)	2018-08-02	Cell-targeting molecules comprising de-immunized, shiga toxin a subunit effectors and cd8+ t-cell epitopes
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JP2021534830A (ja)	2021-12-16	腫瘍特異的抗原を特定するためのプロテオゲノミクスに基づいた方法
US12622956B2 (en)	2026-05-12	Methods and vaccines for inducing immune responses to multiple different MHC molecules
CN116097096A (zh)	2023-05-09	多发性骨髓瘤中的免疫治疗靶点及其鉴定方法
EP3004137A1 (de)	2016-04-13	Verbessertes verfahren für nachweis, zubereitung und depletion von cd4+t-lymphozyten
JP5872468B2 (ja)	2016-03-01	アスパラギニル−β−ヒドロキシラーゼ発現腫瘍に対する樹状細胞ワクチン
ATE534909T1 (de)	2011-12-15	Verfahren zur proteomischen profilierung mithilfe nichtnatürlicher aminosäuren
JP2022532409A (ja)	2022-07-14	改変されたシステインを含む酸化還元酵素モチーフを有する免疫原性ペプチド
Beckhove et al.	2010	Rapid T cell–based identification of human tumor tissue antigens by automated two-dimensional protein fractionation
EP3060679A1 (de)	2016-08-31	Verfahren und kit zur bestimmung des vorhandenseins einer immunreaktion einer person
ES2353964T3 (es)	2011-03-08	Procedimiento para la inmunoterapia de tumores.
Alizadeh et al.	2003	Biological effect of varying peptide binding affinity to the BoLA-DRB3* 2703 allele
US20230236172A1 (en)	2023-07-27	T Cells That Respond To Patient Neoepitopes
US20210106668A1 (en)	2021-04-15	Recombinant chlamydia-activated b cell platforms and methods of use thereof
WO2006102901A3 (en)	2007-04-12	Immunogenic egfr peptides comprising foreign t cell stimulating epitope
ATE295419T1 (de)	2005-05-15	Regulatorische sequenz zur spezifischen expression in dendritischen zellen und deren anwendungen
Zimmerman et al.	2021	Vaccination by Two DerG LEAPS Conjugates Incorporating Distinct Proteoglycan (PG, Aggrecan) Epitopes Provides Therapy by Different Immune Mechanisms in a Mouse Model of Rheumatoid Arthritis. Vaccines. 2021; 9: 448