ATE392414T1 - Verfahren zur herstellung von perindoprilerbumin - Google Patents
Verfahren zur herstellung von perindoprilerbuminInfo
- Publication number
- ATE392414T1 ATE392414T1 AT05818419T AT05818419T ATE392414T1 AT E392414 T1 ATE392414 T1 AT E392414T1 AT 05818419 T AT05818419 T AT 05818419T AT 05818419 T AT05818419 T AT 05818419T AT E392414 T1 ATE392414 T1 AT E392414T1
- Authority
- AT
- Austria
- Prior art keywords
- butylamine
- acid
- salt
- ethoxycarbonyl
- tert
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- CQYBNXGHMBNGCG-FXQIFTODSA-N (2s,3as,7as)-2,3,3a,4,5,6,7,7a-octahydro-1h-indol-1-ium-2-carboxylate Chemical compound C1CCC[C@@H]2[NH2+][C@H](C(=O)[O-])C[C@@H]21 CQYBNXGHMBNGCG-FXQIFTODSA-N 0.000 abstract 1
- CQYBNXGHMBNGCG-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-indol-1-ium-2-carboxylate Chemical compound C1CCCC2NC(C(=O)O)CC21 CQYBNXGHMBNGCG-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 229960003767 alanine Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229960003929 perindopril erbumine Drugs 0.000 abstract 1
- IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical compound CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200403168A ES2255872B1 (es) | 2004-12-31 | 2004-12-31 | Procedimiento para la preparacion de perindopril erbumina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE392414T1 true ATE392414T1 (de) | 2008-05-15 |
Family
ID=36218734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05818419T ATE392414T1 (de) | 2004-12-31 | 2005-12-15 | Verfahren zur herstellung von perindoprilerbumin |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1833788B1 (de) |
| AT (1) | ATE392414T1 (de) |
| DE (1) | DE602005006162D1 (de) |
| ES (2) | ES2255872B1 (de) |
| WO (1) | WO2006070276A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| AR036187A1 (es) * | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
| DK1333026T3 (da) * | 2002-01-30 | 2007-10-22 | Servier Lab | Fremgangsmåde til fremstilling af perindopril med höj renhed og nyttige mellemforbindelser til syntesen |
| WO2004099138A2 (en) * | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
-
2004
- 2004-12-31 ES ES200403168A patent/ES2255872B1/es not_active Expired - Fee Related
-
2005
- 2005-12-15 AT AT05818419T patent/ATE392414T1/de not_active IP Right Cessation
- 2005-12-15 EP EP05818419A patent/EP1833788B1/de not_active Expired - Lifetime
- 2005-12-15 DE DE602005006162T patent/DE602005006162D1/de not_active Expired - Lifetime
- 2005-12-15 ES ES05818419T patent/ES2306266T3/es not_active Expired - Lifetime
- 2005-12-15 WO PCT/IB2005/003928 patent/WO2006070276A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2306266T3 (es) | 2008-11-01 |
| EP1833788A1 (de) | 2007-09-19 |
| EP1833788B1 (de) | 2008-04-16 |
| ES2255872A1 (es) | 2006-07-01 |
| WO2006070276A1 (en) | 2006-07-06 |
| ES2255872B1 (es) | 2007-08-16 |
| DE602005006162D1 (de) | 2008-05-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1106721T1 (el) | Μεθοδος παρασκευης υψηλης καθαροτητας περινδοπριλης και ενδιαμεσα χρησιμα στη συνθεση | |
| DE60320362D1 (de) | Verfahren zur Herstellung von Dipeptiden | |
| EP2557160A3 (de) | Mutierte D-Aminotransferase und Verfahren zur Herstellung optisch aktiver Glutaminsäurederivate damit | |
| CY1106620T1 (el) | Μεθοδος για την παραγωγη τριπεπτιδιων | |
| JPS6339237B2 (de) | ||
| Palomo et al. | β-Lactams as versatile intermediates in α-and β-amino acid synthesis | |
| ATE318838T1 (de) | Verfahren zur synthese von (2s,3as,7as)-1-(s)- alanyl-octahydro-1h-2-carbonsäurederivaten und verwendung in der synthese von perindopril | |
| DE60309019D1 (de) | Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase | |
| Saltman et al. | Co‐oligopeptides of aromatic amino acids and glycine with variable distance between the aromatic residues. VII. Enzymatic synthesis of N‐protected peptide amides | |
| DE602005006162D1 (de) | Verfahren zur herstellung von perindoprilerbumin | |
| CA2509765A1 (en) | Novel peptide-producing enzyme, microbe producing the enzyme and method for dipeptide synthesis using them | |
| EA200100407A1 (ru) | Кристалл диуридин тетрафосфата или его соли и способ его получения и способ получения указанного соединения | |
| Zhang et al. | Efficient enzymatic production of angiotensin I-converting enzyme inhibitory peptides from three protein-rich materials by electrolyzed water pretreatment | |
| Ellison et al. | Convenient synthesis of collagen‐related tripeptides for segment condensation | |
| RU2005139158A (ru) | Способ получения соединений, обладающих апф ингибиторной активностью | |
| DE60303825D1 (de) | Verfahren zur herstellung von enantiomeren von indol-2,3-dion-3-oximderivaten | |
| JP2000004799A (ja) | 水溶性ポテトペプチドの製造方法 | |
| DE60301980D1 (de) | Verfahren zur Synthese des (2S,3aS,7aS)-perhydroindol-2-carbonsäures und seiner Estern, Verwendung in der Synthese von Perindopril | |
| DE60300116D1 (de) | Verfahren zur Synthese von (2S,3aS,7aS)-Perhydroindol-2-carbonsäure und seiner Estern, und Verwendung in der Synthese von Perindopril | |
| EP2906536B1 (de) | Verbessertes verfahren zur herstellung eines perindopril-zwischenprodukts | |
| DE602004007265D1 (de) | Verfahren zur herstellung von perindopril unter verwendung von tetramethyluroniumsalzen als kopplungsreagenzien | |
| ATE502045T1 (de) | Verfahren zur herstellung von perindoprilerbumin | |
| US20060178422A1 (en) | Process for making (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl] amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid | |
| Vezenkov et al. | Synthesis of new analogues of antistasin and ghilantens | |
| EP1440977B1 (de) | Verbessertes Verfahren zur Herstellung von diamidischen Derivaten vom Tripeptid KPV |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |