ATE392478T1 - Methode zur bestimmung des gehalts von hydrogen sulfid in einer probe und methode zur identifizierung einer sequenz welche für eine homocysteinase mit der gewünschten spezifizität kodiert - Google Patents
Methode zur bestimmung des gehalts von hydrogen sulfid in einer probe und methode zur identifizierung einer sequenz welche für eine homocysteinase mit der gewünschten spezifizität kodiertInfo
- Publication number
- ATE392478T1 ATE392478T1 AT00943262T AT00943262T ATE392478T1 AT E392478 T1 ATE392478 T1 AT E392478T1 AT 00943262 T AT00943262 T AT 00943262T AT 00943262 T AT00943262 T AT 00943262T AT E392478 T1 ATE392478 T1 AT E392478T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen sulfide
- homocysteine
- cysteine
- desired specificity
- homocysteinase
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 title abstract 4
- 108010079916 homocysteinase Proteins 0.000 title abstract 4
- 229910000037 hydrogen sulfide Inorganic materials 0.000 title abstract 4
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 abstract 5
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 4
- 235000018417 cysteine Nutrition 0.000 abstract 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000013060 biological fluid Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/340,991 US6066467A (en) | 1997-07-24 | 1999-06-28 | High specificity homocysteine assays for biological samples |
| US09/549,098 US6468762B1 (en) | 1997-07-24 | 2000-04-12 | High specificity homocysteinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE392478T1 true ATE392478T1 (de) | 2008-05-15 |
Family
ID=26992329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00943262T ATE392478T1 (de) | 1999-06-28 | 2000-06-28 | Methode zur bestimmung des gehalts von hydrogen sulfid in einer probe und methode zur identifizierung einer sequenz welche für eine homocysteinase mit der gewünschten spezifizität kodiert |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6468762B1 (de) |
| EP (2) | EP1210443B1 (de) |
| JP (1) | JP2003503065A (de) |
| AT (1) | ATE392478T1 (de) |
| AU (1) | AU784803B2 (de) |
| CA (1) | CA2369842C (de) |
| DE (1) | DE60038613T2 (de) |
| WO (1) | WO2001000853A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1456399B1 (de) * | 2001-11-20 | 2006-07-05 | Anticancer, Inc. | Gesamtcystein-assay |
| CA2496910A1 (en) * | 2002-09-03 | 2004-03-18 | Anticancer, Inc. | Homocysteine assay adaptable to screening |
| US9057720B2 (en) * | 2008-03-11 | 2015-06-16 | Urobiologics Llc | Reducing/oxidizing activity of maternal urine as indicator of fetal gender related characteristics |
| US9200251B1 (en) | 2011-03-31 | 2015-12-01 | David Gordon Bermudes | Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith |
| AU2013240277C1 (en) | 2012-03-30 | 2018-06-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Measurement of biologically labile hydrogen sulfide pools |
| CN119372189B (zh) * | 2024-10-30 | 2025-10-31 | 中国科学院上海免疫与感染研究所 | 半胱氨酸转化酶改造及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5963198A (ja) | 1982-10-01 | 1984-04-10 | Toyo Jozo Co Ltd | 酵素を用いる定量法 |
| US4940658A (en) | 1986-11-20 | 1990-07-10 | University Patents, Inc. | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
| JPH0630599B2 (ja) | 1989-03-03 | 1994-04-27 | ユニチカ株式会社 | フルクトース―1,6―二リン酸の製造法 |
| US5438017A (en) | 1989-05-01 | 1995-08-01 | The University Of Colorado Foundation, Inc. | Assays for sulfhydryl amino acids and methylmalonic acid and their application to diagnosis of cobalamin deficiency |
| US6063581A (en) | 1992-01-22 | 2000-05-16 | Axis-Shield Asa | Immunoassay for homocysteine |
| PT726322E (pt) | 1992-01-22 | 2003-09-30 | Axis Shield Asa | Analise para determinacao de homocisteina |
| US5891704A (en) | 1992-11-19 | 1999-04-06 | Anticancer, Inc. | Method to produce high levels of methioninase |
| US5478729A (en) | 1994-04-28 | 1995-12-26 | Syntex (U.S.A.) Inc. | Immunoassay for homocysteine |
| GB9617683D0 (en) | 1996-08-23 | 1996-10-02 | Univ Glasgow | Homocysteine desulphurase |
| WO1998014562A1 (en) | 1996-10-04 | 1998-04-09 | Derek Nigel John Hart | Enzyme having s-adenosyl-l-homocysteine hydrolase (ahcy) type activity |
| US6140102A (en) * | 1997-07-24 | 2000-10-31 | Anticancer, Inc. | High specificity homocysteinases and genes therefor |
| US5985540A (en) | 1997-07-24 | 1999-11-16 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
| US6066467A (en) * | 1997-07-24 | 2000-05-23 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
-
2000
- 2000-04-12 US US09/549,098 patent/US6468762B1/en not_active Expired - Lifetime
- 2000-06-28 CA CA2369842A patent/CA2369842C/en not_active Expired - Fee Related
- 2000-06-28 EP EP00943262A patent/EP1210443B1/de not_active Expired - Lifetime
- 2000-06-28 AU AU57758/00A patent/AU784803B2/en not_active Ceased
- 2000-06-28 EP EP08007369A patent/EP1959008A3/de not_active Withdrawn
- 2000-06-28 JP JP2001506845A patent/JP2003503065A/ja active Pending
- 2000-06-28 DE DE60038613T patent/DE60038613T2/de not_active Expired - Lifetime
- 2000-06-28 WO PCT/US2000/017838 patent/WO2001000853A1/en not_active Ceased
- 2000-06-28 AT AT00943262T patent/ATE392478T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60038613D1 (de) | 2008-05-29 |
| US6468762B1 (en) | 2002-10-22 |
| DE60038613T2 (de) | 2009-04-30 |
| CA2369842A1 (en) | 2001-01-04 |
| AU5775800A (en) | 2001-01-31 |
| EP1210443A1 (de) | 2002-06-05 |
| JP2003503065A (ja) | 2003-01-28 |
| EP1959008A3 (de) | 2008-11-26 |
| EP1959008A2 (de) | 2008-08-20 |
| CA2369842C (en) | 2011-11-22 |
| EP1210443B1 (de) | 2008-04-16 |
| WO2001000853A1 (en) | 2001-01-04 |
| AU784803B2 (en) | 2006-06-22 |
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Legal Events
| Date | Code | Title | Description |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |