ATE393574T1 - Zur glucoseregulierten produktion von menschlichem insulin in somatischen zelllinien geeignete nukleinsäurekonstrukte - Google Patents

Zur glucoseregulierten produktion von menschlichem insulin in somatischen zelllinien geeignete nukleinsäurekonstrukte

Info

Publication number: ATE393574T1
Authority: AT; Austria
Prior art keywords: glucose; sequence encoding; nucleotide sequence; nucleic acid; cell lines
Prior art date: 2001-06-08

Application number

AT02741943T

Other languages

English (en)

Inventor

Revati J Tatake

Richard Schneiderman

Randall Wilber Barton

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-08

Filing date

2002-06-10

Publication date

2008-05-15

2002-06-10 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2008-05-15 Application granted granted Critical

2008-05-15 Publication of ATE393574T1 publication Critical patent/ATE393574T1/de

Links

101000976075 Homo sapiens Insulin Proteins 0.000 title 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1
210000001082 somatic cell Anatomy 0.000 title 1
239000002773 nucleotide Substances 0.000 abstract 5
125000003729 nucleotide group Chemical group 0.000 abstract 5
108010076181 Proinsulin Proteins 0.000 abstract 3
108091005804 Peptidases Proteins 0.000 abstract 2
239000004365 Protease Substances 0.000 abstract 2
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
238000003776 cleavage reaction Methods 0.000 abstract 1
230000008488 polyadenylation Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102200072130 rs139340178 Human genes 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
230000035897 transcription Effects 0.000 abstract 1
238000013518 transcription Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT02741943T 2001-06-08 2002-06-10 Zur glucoseregulierten produktion von menschlichem insulin in somatischen zelllinien geeignete nukleinsäurekonstrukte ATE393574T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US29693601P	2001-06-08	2001-06-08
US29933401P	2001-06-19	2001-06-19

Publications (1)

Publication Number	Publication Date
ATE393574T1 true ATE393574T1 (de)	2008-05-15

Family

ID=26969899

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02741943T ATE393574T1 (de)	2001-06-08	2002-06-10	Zur glucoseregulierten produktion von menschlichem insulin in somatischen zelllinien geeignete nukleinsäurekonstrukte

Country Status (10)

Country	Link
US (2)	US7045346B2 (de)
EP (1)	EP1458240B1 (de)
JP (1)	JP2005501530A (de)
AT (1)	ATE393574T1 (de)
AU (1)	AU2002315010A1 (de)
CA (1)	CA2447658A1 (de)
DE (1)	DE60226343T2 (de)
ES (1)	ES2304444T3 (de)
MX (1)	MXPA03011013A (de)
WO (1)	WO2002101074A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPWO2005053741A1 (ja)	2003-12-04	2007-06-28	協和醗酵工業株式会社	ケモカイン受容体ｃｃｒ４に対する遺伝子組換え抗体を含む医薬
JP2007063225A (ja)	2005-09-01	2007-03-15	Takeda Chem Ind Ltd	イミダゾピリジン化合物
EP2001875A2 (de)	2006-03-08	2008-12-17	Takeda San Diego, Inc.	Glucokinase-aktivatoren
EP2049518B1 (de)	2006-05-31	2011-08-31	Takeda San Diego, Inc.	Indazol- und isoindolderivate als glucokinaseaktivierende stoffe
US8163779B2 (en)	2006-12-20	2012-04-24	Takeda San Diego, Inc.	Glucokinase activators
US8173645B2 (en)	2007-03-21	2012-05-08	Takeda San Diego, Inc.	Glucokinase activators
US7829664B2 (en) *	2007-06-01	2010-11-09	Boehringer Ingelheim International Gmbh	Modified nucleotide sequence encoding glucagon-like peptide-1 (GLP-1), nucleic acid construct comprising same for production of glucagon-like peptide-1 (GLP-1), human cells comprising said construct and insulin-producing constructs, and methods of use thereof
US20090088726A1 (en) *	2007-09-28	2009-04-02	Microsoft Corporation	Symbiotic biological systems as platforms for sensing, production, and intervention
AU2010206374B2 (en) *	2009-01-23	2013-01-17	Gloriana Therapeutics Sarl	Improved cell lines and their use in encapsulated cell biodelivery

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4992418A (en) *	1987-07-17	1991-02-12	Mount Sinai School Of Medicine	Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
US5935815A (en) *	1989-10-25	1999-08-10	Katholieke Universiteit Leuven	Process for micro biological production of proteins
KR0150565B1 (ko) *	1995-02-15	1998-08-17	김정재	유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
US20010007656A1 (en) *	1996-11-08	2001-07-12	Fatima Bosch	Treatment of diabetes with transcription factor gene
US6242426B1 (en) *	1997-07-25	2001-06-05	Avigen, Inc.	Induction of immune response to antigens expressed by recombinant adeno-associated virus
US6537806B1 (en) *	1998-06-02	2003-03-25	University Of Washington	Compositions and methods for treating diabetes

2002
- 2002-06-10 EP EP02741943A patent/EP1458240B1/de not_active Expired - Lifetime
- 2002-06-10 MX MXPA03011013A patent/MXPA03011013A/es active IP Right Grant
- 2002-06-10 AU AU2002315010A patent/AU2002315010A1/en not_active Abandoned
- 2002-06-10 WO PCT/US2002/018291 patent/WO2002101074A2/en not_active Ceased
- 2002-06-10 US US10/166,147 patent/US7045346B2/en not_active Expired - Lifetime
- 2002-06-10 JP JP2003503824A patent/JP2005501530A/ja not_active Ceased
- 2002-06-10 ES ES02741943T patent/ES2304444T3/es not_active Expired - Lifetime
- 2002-06-10 CA CA002447658A patent/CA2447658A1/en not_active Abandoned
- 2002-06-10 DE DE60226343T patent/DE60226343T2/de not_active Expired - Fee Related
- 2002-06-10 AT AT02741943T patent/ATE393574T1/de not_active IP Right Cessation
2006
- 2006-01-17 US US11/335,926 patent/US20070009498A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2005501530A (ja)	2005-01-20
US7045346B2 (en)	2006-05-16
EP1458240A4 (de)	2006-01-25
US20030032144A1 (en)	2003-02-13
WO2002101074A2 (en)	2002-12-19
CA2447658A1 (en)	2002-12-19
ES2304444T3 (es)	2008-10-16
DE60226343T2 (de)	2009-06-18
WO2002101074A3 (en)	2004-07-15
EP1458240B1 (de)	2008-04-30
US20070009498A1 (en)	2007-01-11
EP1458240A2 (de)	2004-09-22
MXPA03011013A (es)	2004-02-27
AU2002315010A1 (en)	2002-12-23
DE60226343D1 (de)	2008-06-12

Legal Events

Date

Code

Title

Description

2008-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1458240

Country of ref document: EP

2011-03-15

REN

Ceased due to non-payment of the annual fee

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