ATE394371T1 - Pyrrolidinesterderivate mit oxytocinmodulierender wirkung - Google Patents
Pyrrolidinesterderivate mit oxytocinmodulierender wirkungInfo
- Publication number
- ATE394371T1 ATE394371T1 AT02726184T AT02726184T ATE394371T1 AT E394371 T1 ATE394371 T1 AT E394371T1 AT 02726184 T AT02726184 T AT 02726184T AT 02726184 T AT02726184 T AT 02726184T AT E394371 T1 ATE394371 T1 AT E394371T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- alkyl
- heteroaryl
- group
- oxytocine
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 2
- -1 PYRROLIDINE ESTER Chemical class 0.000 title 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 150000003235 pyrrolidines Chemical class 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 102000004279 Oxytocin receptors Human genes 0.000 abstract 1
- 108090000876 Oxytocin receptors Proteins 0.000 abstract 1
- 208000005107 Premature Birth Diseases 0.000 abstract 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
- 206010036590 Premature baby Diseases 0.000 abstract 1
- 206010036600 Premature labour Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 208000026440 premature labor Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01106888 | 2001-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE394371T1 true ATE394371T1 (de) | 2008-05-15 |
Family
ID=8176843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02726184T ATE394371T1 (de) | 2001-03-20 | 2002-03-19 | Pyrrolidinesterderivate mit oxytocinmodulierender wirkung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7189754B2 (de) |
| EP (2) | EP1829861A3 (de) |
| JP (1) | JP4350948B2 (de) |
| AT (1) | ATE394371T1 (de) |
| AU (1) | AU2002256685B2 (de) |
| CA (1) | CA2440002A1 (de) |
| DE (1) | DE60226431D1 (de) |
| ES (1) | ES2303854T3 (de) |
| IL (1) | IL157995A0 (de) |
| WO (1) | WO2002074741A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2440002A1 (en) * | 2001-03-20 | 2002-09-26 | Applied Research Systems Ars Holding N.V. | Pyrrolidine ester derivatives with oxytocin modulating activity |
| BR0211030A (pt) * | 2001-06-18 | 2004-06-22 | Applied Research Systems | Derivado de pirrolidina oxadiazole, uso de um derivado de pirrolidina oxadiazole, composição farmacêutica contendo pelo menos um derivado de pirrolidina oxadiazole, método para preparação de um composto de pirrolidina oxadiazole |
| JP4773335B2 (ja) * | 2003-02-27 | 2011-09-14 | メルク セローノ ソシエテ アノニム | オキシトシンアンタゴニストとしてのピロリジン誘導体 |
| EP2040698A4 (de) * | 2006-07-14 | 2011-08-10 | Shionogi & Co | Oximverbindungen und ihre verwendung |
| EP2164325B1 (de) | 2007-05-31 | 2013-04-24 | Shionogi&Co., Ltd. | Oxyiminoverbindungen und ihre verwendung |
| MX2010003621A (es) * | 2007-10-01 | 2010-04-14 | Hoffmann La Roche | N-heterociclil biaril carboxamidas como antagonistas del receptor ccr. |
| WO2009151152A1 (en) | 2008-06-11 | 2009-12-17 | Shionogi & Co., Ltd. | Oxycarbamoyl compounds and the use thereof |
| EP2845850A1 (de) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidinderivate als Oxytocin/Vasopressin-V1a-Rezeptorantagonisten |
| EP2886107A1 (de) | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Orale Formulierungen von Pyrrolydinderivaten |
| AU2015283133B2 (en) | 2014-07-02 | 2019-05-16 | ObsEva SA | Crystalline (3Z,5S)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methyloxime useful in methods of treating conditions related to the OT-R activity |
| TW202435864A (zh) | 2023-02-09 | 2024-09-16 | 大陸商上海葆正醫藥科技有限公司 | 亞胺化合物及其製備方法和應用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5481005A (en) * | 1990-07-31 | 1996-01-02 | Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
| US5521173A (en) * | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
| AU4763896A (en) | 1995-01-24 | 1996-08-14 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5756497A (en) * | 1996-03-01 | 1998-05-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| DE69932293T2 (de) | 1998-02-13 | 2007-07-05 | The Furukawa Electric Co., Ltd. | Isolierter draht |
| US6329418B1 (en) * | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
| CA2440002A1 (en) | 2001-03-20 | 2002-09-26 | Applied Research Systems Ars Holding N.V. | Pyrrolidine ester derivatives with oxytocin modulating activity |
-
2002
- 2002-03-19 CA CA002440002A patent/CA2440002A1/en not_active Abandoned
- 2002-03-19 DE DE60226431T patent/DE60226431D1/de not_active Expired - Lifetime
- 2002-03-19 EP EP07012082A patent/EP1829861A3/de not_active Withdrawn
- 2002-03-19 AU AU2002256685A patent/AU2002256685B2/en not_active Ceased
- 2002-03-19 WO PCT/EP2002/003005 patent/WO2002074741A1/en not_active Ceased
- 2002-03-19 JP JP2002573750A patent/JP4350948B2/ja not_active Expired - Fee Related
- 2002-03-19 US US10/471,290 patent/US7189754B2/en not_active Expired - Fee Related
- 2002-03-19 EP EP02726184A patent/EP1390347B1/de not_active Expired - Lifetime
- 2002-03-19 AT AT02726184T patent/ATE394371T1/de not_active IP Right Cessation
- 2002-03-19 IL IL15799502A patent/IL157995A0/xx unknown
- 2002-03-19 ES ES02726184T patent/ES2303854T3/es not_active Expired - Lifetime
-
2007
- 2007-01-05 US US11/620,359 patent/US20070129381A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2303854T3 (es) | 2008-09-01 |
| US7189754B2 (en) | 2007-03-13 |
| DE60226431D1 (de) | 2008-06-19 |
| WO2002074741A1 (en) | 2002-09-26 |
| EP1390347A1 (de) | 2004-02-25 |
| JP2004525132A (ja) | 2004-08-19 |
| EP1829861A2 (de) | 2007-09-05 |
| JP4350948B2 (ja) | 2009-10-28 |
| US20040147511A1 (en) | 2004-07-29 |
| CA2440002A1 (en) | 2002-09-26 |
| US20070129381A1 (en) | 2007-06-07 |
| EP1390347B1 (de) | 2008-05-07 |
| EP1829861A3 (de) | 2009-01-21 |
| AU2002256685B2 (en) | 2008-01-24 |
| IL157995A0 (en) | 2004-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |